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正高


1.基本信息:李文杰,男,1958年出生,中共党员,硕士研究生学历,二级教授,博士/硕士研究生导师。主要研究方向为营养与营养相关疾病、食品安全。


2.教育经历:


1985.7—1988.7河南医科大学营养生化硕士导师:关连

1978.9—1983.7河南医科大学卫生系学士


3.科研与学术工作经历:

1983.7--1985.9河南医科大学营养与食品卫生学教研室助教

1989.9—1993.9河南医科大学营养与食品卫生学教研室讲师/室副主任

1993.9—1998.2河南医科大学营养与食品卫生学教研室副教授/室主任

1998.2—2001.8 University of Medicine and Dentistry of New Jersey预防医学系,博士后,导师:John D.Bogden

2001.8—2003.6University ofmedicineand dentistry of New Jersey ,Department of Preventive Medicine ,Teacher and ResearcherSpecialist.

2001.6—至今郑州大学公共卫生学院营养与食品卫生学教授

4.主要学术荣誉和学术兼职

学术荣誉:

2015.08 河南省科技创新杰出人才 河南省科技创新人才建设工作领导小组(河南省科技厅)

2015.05百名英才中国营养学会

2013.02享受国务院特殊津贴专家 中华人民共和国国务院

1996.05 河南省跨世纪学时技术带头人 河南省人社厅

学术兼职:

2020.10中国医学救援协会公共卫生分会常务理事

2020.04郑州大学食品安全与营养健康专家委员会主任

2018.01河南省医学会公共卫生学分会副主任委员

2018.03中国医防整合联盟常务理事

2017.12中国环境诱变剂学会常务理事致癌专业委员会主任委员

2017.08中国营养学会第九届理事会基金专家委员会委员

2017.08中国营养学会第九届理事会教育工作委员会副主任委员

2017.05中国营养学会常务理事营养教育工作委员会副主任委员

2016.11国家医师资格考试公共卫生类别试题开发专家委员会委员

2016.11《中华预防医学杂志》第十一届编辑委员会编辑委员

2016.9教育部高等教育教学评估专家教育部高等教育教学评估中心

2016.01郑州大学学术委员会委员

2015.07河南省预防医学会副会长河南省预防医学会

2014.12河南省食品安全专家委员会委员河南省人民政府食品安全委员会

2014.09中华预防医学会公共卫生教育分会委员会委员

2013.10教育部公共卫生与预防医学教学指导委员会委员

2013.08 河南省营养学会副理事长河南省营养学会

2010.09《中华预防医学杂志》第九届编辑委员会通讯编委

1995.10河南省首届青年学术年会执行委员会委员

5.主持或参加科研项目(课题)情况

1.中国营养学会明月海藻基金,CNS-BMSG2020A63,基于肠道微生态探讨岩藻多糖干预对2型糖尿病的改善作用和机制研究,2020.7—2022.6,29万元,在研,主持

2.国家自然科学基金委员会,面上项目,81872626,维生素D干预对农村地区糖尿病前期人群的作用及机制研究,2019.01—2022.12,59万元,在研,主持

3.国家自然科学基金委员会,面上项目,81573151,维生素D代谢相关基因拷贝数变异及甲基化水平与2型糖尿病关系研究,2016.01—2019.12,70万元,结项,主持

4.河南省科技厅,河南省科技创新杰出人才项目,154200510010,维生素D基因拷贝数变异及甲基化水平与2型糖尿病关系研究,2016.01—2017.12,50万元,结项,主持

5.中国营养学会达能基金,DI2013-06,基于家系设计的维生素D和维生素D受体基因多态性与2型糖尿病交互作用,2013.12—2014.12,19.8万元,结项,主持

6.科技部973计划课题,2012CB526709,维生素D和维生素D受体基因多态性与2型糖尿病关系研究,2012.6-2014.8,56万元,结项,主持

7.国家自然科学基金委员会,面上项目,81172716,表观遗传调控在发育早期铅暴露致LOAD进程中的分子机制,2012.01—2015.12,50万元,结项,主持

8.教育部博士点基金,20070459010,低浓度铅暴露对小鼠海马神经元EAK/MAPK信号通路损伤作用与膳食干预研究,2007.12-2008.12,2万元,结项,主持


6.近三年文章

英文文章:

[1]Chang Liu,Yuan Xue,Yan Wang,Yujing Zhang,Dongdong Zhang,Dou Qiao,Bingya Wang,Fang Shen,Zhenxing Mao,Songcheng Yu,Chongjian Wang,Wenjie Li,Xing Li. Association between daily egg intake and lipid profiles in adults from the Henan rural cohort study[J]. Nutrition, Metabolism and Cardiovascular Diseases,2020.

[2]Liu C, Xue Y, Wang Y, et al. Association between dietary patterns and dyslipidemia in adults from the Henan Rural Cohort Study[J]. Asia Pacific journal of clinical nutrition, 2020,29(2):299-308.

[3]Zhang D, Liu Y, Cheng C, et al. Dose-related effect of secondhand smoke on cardiovascular disease in nonsmokers: Systematic review and meta-analysis[J]. International Journal of Hygiene and Environmental Health, 2020,228:113546.

[4]ZHANG Y J, SUN H L, WANG T, et al. Pterostilbene Ameliorates Glycemic Control, Dyslipidemia and Liver Injury in Type 2 Diabetes Rats[J]. Biomedical and environmental sciences, 2020,33(5):365-368.

[5]Yu S, Feng Y, Qu C, et al. CYP27B1 as an instrument gene to investigate the causal relationship between vitamin D deficiency and obesity: a family-based study[J]. European Journal of Clinical Nutrition, 2020,74(5):806-810.

[6]Wang B, Liu L, Qiao D, et al. The association between frequency of away-from home meals and type 2 diabetes mellitus in rural Chinese adults: the Henan Rural Cohort Study[J]. European Journal of Nutrition, 2020,59(8):3815-3825.

[7]Yu S, Li X, Yu F, et al. New evidence for associations between vitamin D receptor polymorphism and obesity: case-control and family-based studies[J]. Journal of Human Genetics, 2020,65(3):281-285.

[8]Zhang S, Xue R, Geng Y, et al. Fisetin Prevents HT22 Cells From High Glucose-Induced Neurotoxicity via PI3K/Akt/CREB Signaling Pathway[J]. Frontiers in Neuroscience, 2020,14.

[9]Zhang Y, Sun H, Wang T, et al. Selenium level does not differ in blood but increased in cerebrospinal fluid in Parkinson's disease: a meta-analysis[J]. International journal of neuroscience, 2020:1-7.

[10]Xue Y, Yang K, Wang B, et al. Reproducibility and validity of an FFQ in the Henan Rural Cohort Study[J]. Public Health Nutrition, 2020,23(1):34-40.

[11]Zhang D, Cheng C, Wang Y, et al. Effect of Vitamin D on Blood Pressure and Hypertension in the General Population: An Update Meta-Analysis of Cohort Studies and Randomized Controlled Trials[J]. Preventing chronic disease, 2020,17:E3.

[12]Li X, Qu C, Wang Y, et al. Associations of CYP24A1 copy number variation with vitamin D deficiency and insulin secretion[J]. Applied Physiology, Nutrition, and Metabolism, 2019,44(12):1367-1370.

[13]Shen F, Guo C, Wang Y, et al. Low serum 25-hydroxyvitamin D levels may increase the detrimental effect of VDR variants on the risk of essential hypertension[J]. European Journal of Clinical Nutrition, 2020,74(7):1091-1099.

[14]Sun H, Liu X, Long S R, et al. Antidiabetic effects of pterostilbene through PI3K/Akt signal pathway in high fat diet and STZ-induced diabetic rats[J]. European journal of pharmacology, 2019,859:172526.

[15]WANG Yan,HAN Han,WANG Jun,SHEN Fang,YU Fei,WANG Ling,YU Song Cheng,ZHANG Dong Dong,SUN Hua Lei,XUE Yuan,BA Yue,WANG Chong Jian,LI Wen Jie.Polymorphisms in CYP2R1 Gene Associated with Serum Vitamin D Levels and Status in a Chinese Rural Population[J].Biomedical and Environmental Sciences,2019,32(07):550-553.

[16]Yu S, Li X, Wang Y, et al. Family‐based Association between Allele T of rs4646536 inCYP27B1 and vitamin D deficiency[J]. Journal of Clinical Laboratory Analysis, 2019,33(6).

[17]Wang T, Sun H, Ge H, et al. Association between vitamin D and risk of cardiovascular disease in Chinese rural population[J]. PLOS ONE, 2019,14(5):e217311.

[18]WANG Jun,WANG Yan,HAN Han,WANG Teng,SHEN Fang,LI Wen Jie,LI Xing.Association of Vitamin D Receptor Gene Polymorphisms with Metabolic Syndrome in Rural Areas of China[J].Biomedical and Environmental Sciences,2019,32(04):304-308.

[19]Shen F, Wang Y, Sun H, et al. Vitamin D receptor gene polymorphisms are associated with triceps skin fold thickness and body fat percentage but not with body mass index or waist circumference in Han Chinese[J]. Lipids in Health and Disease, 2019,18(1).

[20]Sun H, Long S R, Li X, et al. Serum vitamin D deficiency and vitamin D receptor gene polymorphism are associated with increased risk of cardiovascular disease in a Chinese rural population[J]. Nutrition Research, 2019,61:13-21.

[21]HAN Han,ZHAO Ming Xu,WANG Yan,WANG Jun,REN Bing Nan,GE Hui Na,WANG Teng,SUN Bei Bei,BA Yue,LI Wen Jie.Significant Polymorphisms of Vitamin D Receptor Gene(rs2189480 and rs3847987) Related to the Risk of Type 2 Diabetes in Henan Rural Area[J].Biomedical and Environmental Sciences,2019,32(01):58-62.

[22]Wang Y, Yu F, Yu S, et al. Triangular relationship between CYP2R1 gene polymorphism, serum 25(OH)D3 levels and T2DM in a Chinese rural population[J]. Gene, 2018,678:172-176.

[23] Wang Yan,Duan Leizhen,Yu Songcheng,Liu Xinxin,Han Han,Wang Jun,Li Wenjie. Association between "solute carrier family 30 member 8" (SLC30A8) gene polymorphism and susceptibility to type 2 diabetes mellitus in Chinese Han and minority populations: an updated meta-analysis.[J]. Asia Pacific journal of clinical nutrition,2018,27(6).

[24]Li X, Zhao L, Han J, et al. Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis[J]. Frontiers in Immunology, 2018,9.

[25]Yu S, Li X, Liu X, et al. Characteristic and influencing factors of Taqman genotyping calling error[J]. Journal of Clinical Laboratory Analysis, 2018,32(9):e22613.

[26]Yu S, Wang Y, Li X, et al. Methylation in 3′near region of GC gene and its association with the level of vitamin D binding protein and type 2 diabetes mellitus[J]. Nutrition Research, 2018,54:52-59.

[27]Yu S, Li X, Wang Y, et al. Transmission disequilibrium of rs4809957 in type 2 diabetes mellitus families and its association with vitamin D deficiency: A family-based case-control study[J]. Journal of Diabetes and its Complications, 2018,32(4):406-410.

[28]Yu S, Li X, Wang Y, et al. Maternal transmission disequilibrium of rs2248359 in type 2 diabetes mellitus families and its association with vitamin D level in offspring[J]. Scientific Reports, 2018,8(1).

中文文章:

[1]张玉晶,孙华磊,刘欣欣,等.紫檀芪对2型糖尿病大鼠肝损伤的作用[J].郑州大学学报(医学版), 2020,55(3):360-364.

[2]王腾,孙华磊,葛惠娜,等.紫檀芪对3T3-L1前脂肪细胞分化的影响[J].郑州大学学报(医学版), 2020,55(1):45-48.

[3]王腾,孙华磊,葛惠娜,等.河南农村人群维生素D水平与高血压患病风险的关联[J].中华疾病控制杂志, 2019,23(7):780-784, 795.

[4]赵帆,王艳,李文杰.血清维生素D水平与2型糖尿病患者糖脂代谢指标的相关性[J].河南医学研究, 2019,28(5):789-792.

[5]刘欣欣,孙华磊,葛惠娜,等.紫檀芪对2型糖尿病大鼠肾脏的影响[J].中国食物与营养, 2019,25(3):53-56.

[6]刘欣欣,孙华磊,葛惠娜,等.紫檀芪对2型糖尿病大鼠学习记忆能力及海马氧化应激水平的影响[J].郑州大学学报(医学版), 2019,54(1):51-54.

[7]栗英,张东芳,李星,底瑞青.消毒供应中心信息管理系统“外来医疗器械”管理模块的应用效果[J].河南医学研究,2019,28(17):3217-3219.[J].

[8]]梁燕,王丽,舒礼良,李星.曲克芦丁预处理对大鼠缺血再灌注心肌的保护作用[J].中华实验外科杂志,2019(06):1073-1075.

[9]赵帆,王艳,李文杰.血清维生素D水平与2型糖尿病患者糖脂代谢指标的相关性[J].河南医学研究, 2019,28(5):789-792.

[10]刘欣欣,孙华磊,葛惠娜,王腾,李文杰.紫檀芪对Ⅱ型糖尿病大鼠血脂的改善及对PPARγ的调控作用[J].现代食品科技,2018,34(09):6-11.[J].

[11]李星,高宁,林楠,何巍.血管化腓骨瓣修复下颌骨缺损患者的生命质量调查[J].中华显微外科杂志,2018,41(02):174-176.