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1.基本信息:杨永利,女,1974年出生,博士,教授,硕士研究生导师。主要研究方向:卫生服务统计方法与应用;临床试验设计与评价。

2.教育经历

(1)2016-092017-09,耶鲁大学,医学院,访问学者

(2)2005-092009-12,郑州大学,流行病与卫生统计学专业,博士,导师:胡东生

(3)1999-092002-06,郑州大学,流行病与卫生统计学专业,硕士,导师:段广才

(4)1993-091998-06,河南医科大学,预防医学专业,学士

3.科研与学术工作经历

(1)2020-05至今,郑州大学,公共卫生学院,教授

(2)2011-042020-04,郑州大学,公共卫生学院,副教授

(3)2006-052011-03,郑州大学,公共卫生学院,讲师

(4)2002-072006-04,郑州大学,公共卫生学院,助教

4.主要学术荣誉和学术兼职

学术荣誉

(1)2021年 郑州大学科技服务社会先进个人

(2)2021年 郑州大学教师教学创新大赛一等奖

(3)2016年 郑州大学三育人先进个人

(4)2015年 郑州大学网络教育精品课程

学术兼职

(1)河南省药品临床综合评价评审专家(2020-2021

(2)国家药品监督管理局药品审评专家(2019-2021

(3)河南省预防医学会流行病学专业委员会第三届委员会委员(2019-2021

(4)中国医药教育协会医药统计专业委会会委员 (2017-2021

(5)河南省中西医结合循证医学专业委员会副主任委员(2013-2021

5.主持或参加科研项目(课题)情况

(1)国家自然科学基金面上项目:基于多元统计建模的代谢综合征遗传易感性和生物机制研究(项目编号:820736702021-202457万元,在研2.

(2)中国生物技术股份有限公司:新型冠状病毒灭活疫苗国际多中心期临床试验2020-2024100万元,在研,主持.

(3)中国生物技术股份有限公司:新型冠状病毒灭活疫苗(Vero细胞)Ⅰ/Ⅱ期临床试验2020-2024154.2万元在研,主持.

(4)北京中生恒益医药科技有限公司:AC-Hib和肺炎疫苗期临床试验2019-2024115万元在研,主持.

(5)国家卫生计生委医药卫生科技发展研究中心,国家十三五科技重大专项,普通人群HIV新发感染监测队列研究(项目编号:2018ZX10715009. 2018-2020753.72万元,结项,第4.

(6)中华人民共和国卫生部,国家十二五科技重大专项,示范区重大传染病规模化现场流行病学调查和干预质量控制研究(项目编号:2014ZX10004008. 2014-201712万元,结项,任务负责人.

(7)中华人民共和国卫生部,国家十二五科技重大专项,河南省防治艾滋病规模化现场流行病学和干预研究(项目编号:2012ZX10004905. 2012-2015年,258万元,结项,任务负责人.

6.研究领域

(1)艾滋病综合防治和干预研究:作为课题骨干,连续参与了国家十一五十二五十三五科技重大专项《河南省防治艾滋病规模化现场流行病学和干预研究》,以艾滋病国家科技重大专项综合示范区信息平台为依托,建立艾滋病预防和治疗新模式,科学指导艾滋病的预防和治疗,显著降低了河南省HIV新发感染率。

(2)临床试验设计与评价:长期从事药品、疫苗及医疗器械临床试验方案设计、统计分析计划撰写与实施,并对药品、医疗器械和疫苗的安全性和有效性进行评价,为其临床注册申请提供数据支撑,已上市的有四价流感疫苗、新冠灭活疫苗、AC流脑疫苗和ACYW135流脑疫苗。

7.代表性研究成果

7.1 代表性期刊论文

(1)HuiliZhu, XiaocanJia, YupingWang, ZhijuanSong, NanaWang, YongliYang* and XuezhongShi*. M6A Classification Combined With Tumor Microenvironment Immune Characteristics Analysis of Bladder Cancer. Frontiers in Oncology. 202111).

(2)Yongli Yang, Yang Li, Xuening Zhang, Weiping Zhang, Yanmin Ma, Xiaocan Jia, Theodore Gondwe, Yuping Wang ,  Xuezhong Shi* . Effect of antiretroviral therapy initiation time and baseline CD4+ cell counts on AIDS-related mortality among former plasma donors in China: a 21-year retrospective cohort study. Global health action.2021 (14).

(3)Jingwen Fan, Xuezhong Shi, Xiaocan Jia, Yuping Wang, Yang Zhao, Junzhe Bao, Haomin Zhang, and Yongli Yang*. Birthweight, childhood obesity and risk of hypertension: a Mendelian randomization study. Journal of Hypertension. 202139.

(4)Xuening Zhang, Hao Zhao, Xuezhong Shi, Jie Lu, Xiaocan Jia, Yongli Yang*. Identification and validation of an immune-related gene signature predictive of overall survival in colon cancer. Aging US. 2020 (12).

(5)Shengli Xia, Yuntao Zhang, Yanxia Wang, Hui Wang, Yunkai Yang, George Fu Gao, Wenjie Tan, Guizhen Wu, Miao Xu, Zhiyong Lou, Weijin Huang, Wenbo Xu, Baoying Huang, Huijuan Wang, Wei Wang, Wei Zhang, Na Li, Zhiqiang Xie, Ling Ding, Wangyang You, Yuxiu Zhao, Xuqin Yang, Yang Liu, Qian Wang, Lili Huang, Yongli Yang, Guangxue Xu, Bojian Luo, Wenling Wang, Peipei Liu, Wanshen Guo, Xiaoming Yang. Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial. Lancet Infect Dis .2020 (21).

(6)Shengli Xia, Kai Duan, Yuntao Zhang, Dongyang Zhao, Huajun Zhang, Zhiqiang Xie, Xinguo Li, Cheng Peng, Yanbo Zhang, Wei Zhang, Yunkai Yang, Wei Chen, Xiaoxiao Gao, Wangyang You, XueweiWang, ZejunWang, Zhengli Shi, YanxiaWang, Xuqin Yang, Lianghao Zhang, Lili Huang, QianWang, Jia Lu, Yongli Yang, Jing Guo, Wei Zhou, XinWan, CongWu, WenhuiWang, Shihe Huang, Jianhui Du, Ziyan Meng, An Pan, Zhiming Yuan, Shuo Shen, Wanshen Guo, Xiaoming Yang. Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes Interim Analysis of 2 Randomized Clinical Trials. JAMA.2020 (8).

(7)Shilei Wang, Zhiqiang Xie,Lili Huang, Xu Zhou, Jian Luo, Yuelian Yang, Changgui Li, Peng Duan, Wenting Xu, Dandan Chen, Bing Wu, Yongli Yang, Xueying Liu, Yanxia Wang, Zhenghong Yuan, Di Qu, Ze Chen*, Shengli Xia*. Safety and immunogenicity of an alum-adjuvanted whole-virion H7N9 influenza vaccine: a randomized, blinded, clinical trial. Clinical microbiology and infection. 2020 (29).

(8)Xiaoran Duan, Daping Zhang, Sihua Wang, Xiaolei Feng, Tuanwei Wang, Pengpeng Wang, Mingcui Ding, Hui Zhang, Bin Liu, Wan Wei, Reuben Mensah Acquaye, Wu Yao, Liuxin Cui, Xiaoshan Zhou, Wei Wang, Yongli Yang*. Effects of polycyclic aromatic hydrocarbon exposure and miRNA variations on peripheral blood leukocyte DNA telomere length: A cross-sectional study in Henan Province, China. Science of the Total Environment.2020 (703).

(9)Xiaocan Jia, Nian Shi, Yu Feng, Yifan Li, Jiebing Tan, Fei Xu, Wei Wang, Changqing Sun, Hongwen Deng, Yongli Yang* and Xuezhong Shi*. Identification of 67 Pleiotropic Genes Associated With Seven Autoimmune/Autoinflammatory Diseases Using Multivariate Statistical Analysis. Frontiers in Immunology. 2020(11).

(10)Yongli Yang, Jiebing Tan, Xiaoran Duan, Hui Zhang, Xiaolei Feng, Tuanwei Wang, Pengpeng Wang, Mingcui Ding, Suxiang Liu, Lei Li, Haiyong Liang, Wu Yao, Wei Wang, Xiaoshan Zhouc. The association between polymorphisms in tankyrase gene and telomere length in omethoate-exposed workers. Chemosphere. 2020 (238).

(11)Yang YongliZhiwei Cheng, Xiaocan Jia, Nian Shi, Zhenhua Xia, Weiping Zhang, Xuezhong Shic. Mortality trends of bladder cancer in China from 1991 to 2015: an age-period-cohort analysis. Cancer Management and Research. 2019 (11).

(12)Wei Wang, Pengpeng Wang, Sihua Wang, Xiaoran Duan, Tuanwei Wang, Xiaolei Feng, Lei Li, Yuhong Zhang, Guoyu Li, Junfeng Zhao, Leike Li, Yanbin Wang, Zhen Yan, Feifei Feng, Xiaoshan Zhou, Wu Yao, Yawei Zhang, Yongli Yang*. Benchmark dose assessment for coke oven emissions-induced telomere length effects in occupationally exposed workers in China. Ecotoxicol Environ Saf. 2019 (182).

(13)Wang Wei, Zhang Hui, Duan Xiaoran, Feng Xiaolei, Wang Tuanwei, Wang Pengpeng, Ding Mingcui, Zhou Xiaoshan, Liu Suxiang, Li Lei, Liu Junling, Tang Lixia, Niu Xinhua, Zhang Yuhong, Li Guoyu, Yao Wu, Yongli Yang*. Association of genetic polymorphisms of miR-145 gene with telomere length in omethoate-exposed workers. Ecotoxicol Environ Saf. 2019 (172).

(14)XiaoCan Jia, YongLi Yang, YuanCheng Chen, Zhenhua Xia, Weiping Zhang, Yu Feng, Yifan Li ,Jiebing Tan, Chao Xu, Qiang Zhang, Hongwen Deng, XueZhong Shi. Multivariate analysis of genome-wide data to identify potential pleiotropic genes for type 2 diabetes, obesity and coronary artery disease using MetaCCA. International Journal of Cardiology. 2019 (283).

(15)Jia XiaoCan, Yang YongLi, Chen YuanCheng, Cheng Zhiwei, Du Yuhui, Xia Zhenhua, Zhang Weiping, Xu Chao, Zhang Qiang, Xia Xin, Deng HongWen, Shi XueZhong. Multivariate analysis of genome-wide data to identify potential pleiotropic genes for five major psychiatric disorders using MetaCCA. Journal of Affective Disorders. 2019 (242).

7.2 著作

(1)杨永利 编委.Statistical Methods for Biomedical ResearchWorld Scientific2021.

(2)杨永利 编委.生物医学研究的统计方法,高等教育出版社,2019.

(3)杨永利 编委.临床医学导论,人民卫生出版社,2018.

(4)杨永利 编委.卫生统计学学习指导与习题集,人民卫生出版社,2018.

7.3专利

(1)杨永利;施念;王威;施学忠;李琳琳;姚武;周舫;画宝勇;郝长付;用 BsrFI鉴定人MTHFR基因多态性rs2274976的试剂盒,2013-9-4, 中国,ZL201210091430.X.

(2)杨永利;施念;施学忠;卢洁;平智广;姚武;王威;周舫;李春阳;燕贞;人对氧磷酶2基因148位点G/A多态检测试剂盒,2013-9-4, 中国,ZL201110440646.8.

8.学术奖励

(1)杨永利(4/10);氯乙烯作业工人染色体损伤生物标志物评价与应用,河南省人民政府,河南省科技进步二等奖,2019

(2)杨永利(3/10);艾滋病综合防治居民健康档案信息管理平台设计与应用,河南省人民政府,河南省科技进步二等奖,2014

(3)杨永利(1/6)PBLCBL相结合教学模式在医学统计学教学改革中的应用,郑州大学,郑州大学教学成果特等奖,2014