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1.基本信息晋乐飞,男,1988年出生。博士,讲师。主要研究方向为重症手足口病的分子流行病学研究及发病机制。

2.教育经历

2013-09至2019-06,郑州大学,公共卫生学院,博士,导师:段广才

2017-02至2018-02,杜克大学医学中心,免疫系,博士联合培养,导师: Weiguo Zhang

2008-09至2012-06,河南中医药大学,管理学院,学士

3.科研与学术工作经历

2019-07至现在,郑州大学,公共卫生学院,讲师

2019-07至现在,郑州大学,基础医学院,博士后,导师:臧明玺

4.主持或参加科研项目(课题)情况

河南省高等学校重点科研项目,21A310026,旁斑LncRNA NEAT1与RIG-I交互作用抗EV71的分子机制,2021-01至2022-12,3万,在研,主持

中国博士后科学基金,面上项目,2019M662543,宿主LncRNA NEAT1与RIG-I交互作用抗EV71的分子机制,2019-07至2021-07,16万元,在研,主持

郑州大学拔尖博士科研启动金,补体C5a/C5aR通路在EV71感染致血脑屏障损伤中的作用,32211744,2019-07至2021-07,20万元,在研,主持

5.对个人研究领域的描述

手足口病(hand, foot and mouth disease, HFMD)是一种由肠道病毒感染引起的常见儿童传染病。该病传染性强、流行范围广、易出现暴发,重症病例病死率高,近年该病流行呈上升趋势。能够引起HFMD的肠道病毒有20多种(型),其中肠道病毒71型(Enterovirus 71,EV71)是引起重症HFMD的主要病原体。研究表明,年龄、家庭护理、发热持续时间≥3天、体温≥37.5℃、嗜睡、呕吐、高血糖、中性粒细胞数增加能够增加重症HFMD发病风险。关于重症HFMD的发病机制,国内外研究显示,中枢神经系统感染是重症HFMD的突出特征,且多种免疫细胞和细胞因子参与了重症HFMD的发病进程。目前关于HFMD研究存在的问题是:HFMD的病原谱、感染谱等流行特征、发展规律及主要影响因素不清晰,导致该病预防控制策略和措施的针对性、精准性和有效性大大下降,发病率常年居高不下;HFMD重症化机制不明,也无早期诊断方法,使重症化的早期干预难以施行,不能有效降低该病的病死(残)率。本实验室主要致力于研究HFMD流行特征及影响因素、HFMD病原谱与EV71变异规律、EV71侵袭中枢神经系统及诱发“瀑布样”炎症反应机制、肠道病毒感染诱发天然免疫逃逸机制、肠道病毒感染动物模型构建及疫苗研发。

6.代表性研究成果

6.1代表性论文

期刊论文

(1)Li Dong#, Chen Shuaiyin#, Zhang Weiguo, Zhang Chao, Sun Tiantian, Du Yue, Ding Ronghua, Gao Yanlei,Jin Yuefei*, Guangcai Duan*. MicroRNA-628-5p Facilitates Enterovirus 71 Infection by Suppressing TRAF3 Signaling[J]. Cell Mol Immunol, 2020, doi: 10.1038/s41423-020-0453-4

(2)Jin Yuefei, Zhang Chao, Wang Hui, Zhou Guangyuan, Wang Xiangpeng, Zhang Rongguang, Chen Shuaiyin, Ren Jingchao, Chen Lu, Dang Dejian, Zhang Peng, Xi Yuanlin, Wu Weidong, Zhang Weiguo, Duan Guangcai*. Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice[J]. Lab Invest, 2018, 98(8): 1039-1051

(3)Jin Yuefei, Zhang Chao, Zhang Rongguang, Ren Jingchao, Chen Shuaiyin, Sui Meili, Zhou Guangyuan, Dang Dejian, Zhu Jiehui, Feng Huifen, Xi Yuanlin, Yang Haiyan, Duan Guangcai*. Pulmonary edema following central nervous system lesions induced by a non- mouse-adapted EV71 strain in neonatal BALB/c mice[J]. Virol J, 2017, 14(1): 243

(4)Li Ying, Zhang Chao, Qin Luwei, Li Dong, Zhou Guangyuan, Dang Dejian, Chen Shuaiyin, Sun Tiantian, Zhang Rongguang, Wu Weidong, Xi Yuanlin,Jin Yuefei*, Duan Guangcai*. Characterization of Critical Functions of Long Non-Coding RNAs and mRNAs in Rhabdomyosarcoma Cells and Mouse Skeletal Muscle Infected by Enterovirus 71 Using RNA-Seq[J]. Viruses, 2018, 10(10): pii:E556

(5)Jin Yuefei, Zhang Rongguang, Wu Weidong, Duan Guangcai*. Innate Immunity Evasion by Enteroviruses Linked to Epidemic Hand-Foot-Mouth Disease[J]. Front Microbiol, 2018, 9: 2422

(6)Jin Yuefei, Zhang Rongguang, Wu Weidong, Duan Guangcai*. Antiviral and Inflammatory Cellular Signaling Associated with Enterovirus 71 Infection[J]. Viruses, 2018, 10(4): pii:E155

(7)Jin Yuefei, Zhu Minghua, Guo Yanli, Foreman Daniel, Feng Feifei, Duan Guangcai*, Wu Weidong*, Zhang Weiguo*. Fine particulate matter (PM2.5) enhances FcεRI-mediated signaling and mast cell function[J]. Cell Signal, 2019, 57: 102-109

(8)Jin Yuefei, Yang Haiyan, Ji Wangquan, Wu Weidong, Chen Shuaiyin, Zhang Weiguo, Duan Guangcai*. Virology, Epidemiology, Pathogenesis, and Control of COVID-19[J]. Viruses, 2020, 12(4): pii: E372

(9)Qin Luwei, Dang Dejian, Wang Xinhong, Zhang Rongguang, Feng Huifen, Ren Jingchao, Chen Shuaiyin, Zhou Guangyuan, Huang Ping, Wang Bin, Xi Yuanlin, Wu Weidong,Jin Yuefei*, Duan Guangcai*. Identification of immune and metabolic predictors of severe hand-foot-mouth disease[J]. PLoS One, 2019, 14(5): e0216993

(10)Jin Yuefei#, Wu Zhaoke#, Wang Na, Duan Shuyin, Wu Yongjun, Wang Jing, Wu Weidong*, Feng Feifei*. Association of EGF Receptor and NLRs signaling with Cardiac Inflammation and Fibrosis in Mice Exposed to Fine Particulate Matter[J]. J Biochem Mol Toxicol, 2016, 30(9): 429-437

(11)Jin Yuefei#, Wu Weidong#, Zhang Weiguo, Zhao Yang, Wu Yongjun, Ge, Guoyin, Ba Yue, Guo Qiang, Gao Tianyu, Chi Xuejing, Hao Huiyun, Wang Jing*, Feng Feifei*. Involvement of EGF receptor signaling and NLRP12 inflammasome in fine particulate matter-induced lung inflammation in mice[J]. Environ Toxicol, 2017, 32(4): 1121-1134

(12)Wu Weidong#,Jin Yuefei#, Carlsten Chris#*. Inflammatory health effects of indoor and outdoor particulate matter[J]. J Allergy Clin Immunol, 2018, 141(3): 833-844

(13)Feng Feifei#,Jin Yuefei#, Duan Liju, Yan Zhen, Wang Shouying, Li Fangfang, Liu Yingying, Samet James M., Wu Weidong*. Regulation of ozone-induced lung inflammation by the epidermal growth factor receptor in mice[J]. Environ Toxicol, 2016, 31(12): 2016-2027

(14)Yan Zhen#,Jin Yuefei#, An Zhen#, Liu Yingying, Samet James M., Wu Weidong*. Inflammatory cell signaling following exposures to particulate matter and ozone[J]. Biochim Biophys Acta, 2016, 1860(12): 2826-2834

(15)Zhu Minghua, Foreman Daniel P., O'Brien Sarah A.,Jin Yuefei, Zhang Weiguo*. Phospholipase D in TCR-Mediated Signaling and T Cell Activation[J]. J Immunol, 2018, 200(6): 2165-2173

会议论文

(1)Jin Yuefei. Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice,8thEuroSciConInternational Conference on InfectiousDisease(2018),London,UK, 2018-6-7至2018-6-8.

6.2专利

冯斐斐;张鹏;吴卫东;张巧;陆红显;姚武;王威;晋乐飞;周舫;李春阳;杨永利;郝长付;燕贞;王娜.快速吸入式气管滴注给药系统, 2015-05-06,中国,ZL201510048160.8.

7.学术奖励

晋乐飞(2/10);空气污染对呼吸道和心血管系统的毒性作用及其机制,河南省教育厅,教育厅科技成果,一等奖, 2020(吴卫东,晋乐飞,燕贞,冯斐斐,李海斌,王守英,李娟,张丰泉,李宏彬,徐光翠,张瑞芳,帅建飞).

8.个人风采展示



2017年在美国杜克大学医学中心进行博士联合培养