魏东辉

作者: 时间:2021-03-13 点击数:

魏东辉,郑州大学化学学院,副教授,博士生导师,邮箱:donghuiwei@zzu.edu.cn。曾先后获批国家自然科学基金-青年基金项目和面上项目各1项、中国博士后科学基金面上资助和特别资助各1项、2021年河南省自然科学基金-优秀青年科学基金项目,入选河南省高等学校青年骨干教师和郑州大学青年拔尖人才等培养计划。长期围绕有机催化反应(尤其是氮杂环卡宾催化反应)和生物酶催化及抑制反应的机理及其选择性进行理论计算研究工作。近年来,以第一或通讯作者的身份在J. Am. Chem. Soc. (2)Angew. Chem. Int. Ed. (1)Nature Commun. (1)Coord. Chem. Rev. (1)ACS Catal. (4)Chem. Sci. (2)Org. Lett. (2)Chem. Commun. (5)等杂志上正式发表论文105篇。

教育与研究工作经历

2018.01—至今 郑州大学化学与分子工程学院 校直聘教授

2017.01—至今 郑州大学化学与分子工程学院 副教授

2014.012016.12 郑州大学化学与分子工程学院 校直聘副教授

2013.012016.12 郑州大学化学与分子工程学院 讲师

2010.102012.11 美国肯塔基大学药学院 国家公派联合培养博士

2006.092012.12 郑州大学化学分子与工程学院 博士

2002.092006.07 郑州大学化学系 本科

研究方向

1)有机小分子和有机金属催化反应的理论研究(DFT方法),特别是路易斯碱不对称催化反应及其选择性的理论研究。

2)酶催化和抑制反应机理的理论研究(QM/MM方法)。

教授课程

《结构化学》、《理论与计算化学》、《线性代数》、《Gussian程序应用》、《物理化学实验》

主持科研项目(课题)情况:

12020年度河南省高等学校青年骨干教师培养计划,2020GGJS016,氮杂环卡宾催化反应机制研究,2021/01-2023/12,在研,主持;

22021年度河南省自然科学基金-优秀青年科学基金项目,计算非金属酶与有机小分子催化,2021.01-2023.12,在研,主持。

3)国家自然科学基金-面上项目,21773214,不含金属和辅因子的氧化酶和加氧酶催化反应机理的理论研究,2018/01-2021/12,在研,主持;

4)郑州大学优秀青年教师发展基金,氮杂环卡宾催化的环化、C-H活化和C-C活化反应的理论研究,2015/12-2018/12,已结题,主持;

5)中国博士后科学基金第八批特别资助项目,2015T80776,尿酸酶催化氧化和水化反应的理论研究,2015/07-2016/12,已结题,主持;

6)国家自然科学基金-青年科学基金项目,21303167,蛋白酶体与不同类型抑制剂反应的理论研究,2014/01-2016/12,已结题,主持;

7)中国博士后科学基金第53批面上一等资助项目,2013M530340,蛋白酶体催化水解反应的理论研究,2013/05-2016/12,已结题,主持;

以第一或通讯作者身份发表的代表性论文:

(1) Wang, Guanjie, Shi, Qianqian, Chen, Tao, Guo, Yingying, Hu, Zhouli, Gong, Minghua, Guo, Jingcheng, Wei, Donghui*, Fu, Zhenqian*, Huang, Wei*, Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral binary amino acids, Nat. Commun., 2020, 11, 946.

(2) Wang, Junjian, Wei, Donghui*, Duan, Zheng*, Mathey, Fran?ois, Cleavage of the Inert C(sp2)–Ar σ-Bond of Alkenes by a Spatial Constrained Interaction with Phosphinidene, J. Am. Chem. Soc., 2020, 142, 20973-20978.

(3) Wei, Donghui, Lei, Beilei, Tang, Mingsheng, Zhan, Chang-Guo*, Fundamental Reaction Pathway and Free Energy Profile for Inhibition of Proteasome by Epoxomicin, J. Am. Chem. Soc., 2012, 134, 10436-10450.

(4) Wang, Guanjie, Zhang, Qiao-Chu, Wei, Chenlong, Zhang, Ye, Zhang, Linxue, Huang, Juhui, Wei, Donghui*, Fu, Zhenqian*, Huang, Wei, Asymmetric Carbene-Catalyzed Oxidation of Functionalized Aldimines as 1,4-Dipoles, Angew. Chem. Int. Ed., 2021, DOI: 10.1002/anie.202017017.

(5) Chen, Haohua, Li, Yuanyuan*, Liu, Song, Xiong, Qin, Bai, Ruopeng, Wei, Donghui*, Lan, Yu*, On the mechanism of homogeneous Pt-catalysis: A theoretical view, Coord. Chem. Rev., 2021, 437, 213863.

(6) Min Zhang, Yang Wang, Shi-Jun Li, Xinghua Wang, Qianqian Shi, Xue Li, Ling-Bo Qu, Wei, Donghui*, and Yu Lan*, Multiple Functional Organocatalyst-Promoted Inert C–C Activation: Mechanism and Origin of Selectivities, ACS Catal., 2021, DOI: 10.1021/acscatal.0c05511, 3443-3454.

(7) Liu, Ning*, Xie, Ya-Fei, Wang, Chuan, Li, Shi-Jun, Wei, Donghui*, Li, Min, Dai, Bin*, Cooperative Multifunctional Organocatalysts for Ambient Conversion of Carbon Dioxide into Cyclic Carbonates, ACS Catal., 2018, 8, 9945-9957.

(8) Wei, Donghui, Huang, Xiaoqin, Qiao, Yan, Rao, Jingjing, Wang, Lu, Liao, Fei, Zhan, Chang-Guo*, Catalytic Mechanisms for Cofactor-Free Oxidase-Catalyzed Reactions: Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid, ACS Catal., 2017, 7, 4623-4636.

(9) Wang, Yanyan, Wei, Donghui*, Wang, Yang, Zhang, Wenjing, Tang, Mingsheng*, N-Heterocyclic Carbene (NHC)-Catalyzed sp3 β-C-H Activation of Saturated Carbonyl Compounds: Mechanism, Role of NHC, and Origin of Stereoselectivity, ACS Catal., 2016, 6, 279-289.

(10) Li, Xue, Xu, Jun, Li, Shi-Jun, Qu, Ling-Bo, Li, Zhongjun, Chi, Robin Yonggui, Wei, Donghui*, Lan, Yu*, Prediction of NHC-catalyzed chemoselective functionalizations of carbonyl compounds: a general mechanistic map, Chem. Sci., 2020, 11, 7214-7225.

(11) Guo, Xiao-Kang, Zhang, Lin-Bao, Wei, Donghui*, Niu, Jun-Long*, Mechanistic insights into cobalt(ii/iii)-catalyzed C-H oxidation: a combined theoretical and experimental study, Chem. Sci., 2015, 6, 7059-7071.

(12) Wang, Xinghua, Li, Shi-Jun, Wang, Ya-Nan, Wei, Donghui*, Lan, Yu*, Insight into the organocatalytic arylation of azonaphthalenes with α-chloroaldehydes: the general mechanism and origin of selectivities, Org. Lett., 2021, Accepted.

(13) Li, Sha, Tang, Ziwei, Wang, Yang, Wang, Dan, Wang, Zhanlin, Yu, Chenxia, Li, Tuanjie, Wei, Donghui*, Yao, Changsheng*, NHC-Catalyzed Aldol-Like Reactions of Allenoates with Isatins: Regiospecific Syntheses of γ-Functionalized Allenoates, Org. Lett., 2019, 21, 1306-1310.

(14) Wang, Xinghua, Wang, Yang, Wei, Donghui*, Lan, Yu*, Insight into the organocatalytic arylation of azonaphthalenes with α-chloroaldehydes: the general mechanism and origin of selectivities, Chem. Commun., 2021, 57, 219-222.

(15) Li, Shi-Jun, Li, Xue, Mo, Huilin, Qu, Ling-Bo, Wei, Donghui*, Lan, Yu*, With metal or not? a computationally predicted rule for a dirhodium catalyst in [3+3] cycloadditions of triazole with thiirane, Chem. Commun., 2020, 56, 4732-4735.

(16) Wang, Min, Yang, Tingting, Tian, Rongqiang*, Wei, Donghui*, Duan, Zheng*, Mathey, Fran?ois, The chemistry of phosphirane-substituted phosphinidene complexes, Chem. Commun., 2020, 56, 9707-9710.

(17) Sun, Kai, Li, Shi-Jun, Chen, Xiao-Lan*, Liu, Yan, Huang, Xian-Qiang, Wei, Donghui*, Qu, Ling-Bo, Zhao, Yu-Feng, Yu, Bing*, Silver-catalyzed decarboxylative radical cascade cyclization toward benzimidazo[2, 1-a]isoquinolin6(5H)-ones, Chem. Commun., 2019, 55, 2861-2864.

(18) Chen, Xi-Meng, Liu, Si-Cong, Xu, Cong-Qiao, Jing, Yi, Wei, Donghui*, Li, Jun*, Chen, Xuenian*, Unravelling a general mechanism of converting ionic B/N complexes into neutral B/N analogues of alkanes: Hδ+…Hδ- dihydrogen bonding assisted dehydrogenation, Chem. Commun., 2019, 55, 12239-12242.

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