孙远强

作者: 时间:2021-04-03 点击数:

SunYQ.png

姓名:孙远强

性别:

出生年月:1987.11

职称:副教授

民族:

电子邮箱:sunyq@zzu.edu.cn

最终学位:博士

主要学习、科研和工作经历

教育背景

2011/09-2016/07,山西大学,化学化工学院,博士,导师:郭炜教授

2004/09-2008/06,山西大学,化学化工学院,学士

工作经历

2017/01-至今,郑州大学, 化学与分子工程学院,教师

研究方向

荧光探针、碳点与生物医学传感

个人简介

副教授,硕士生导师,郑州大学首批青年拔尖人才。主要从事荧光探针与生物医学传感的研究。开发了氯代香豆素半花菁、氯代吡啰红等新型荧光染料,将有机合成逆合成分析设计理念首次引入荧光碳点领域。在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Coordin. Chem. Rev.、Anal. Chem.、Chem. Commun.、Nanoscale、Small、Chinese Chem. Lettt.等杂志发表论文五十余篇,被引用2900余次。入选2019年度“河南省青年人才托举工程项目”,主持国家自然科学基金项目1项,中国博士后基金特别资助资助1项,中国博士后基金一等资助1项,河南省博士后基金科研项目一等资助1项,河南省科技攻关项目1项。

主持项目

1. 基于邻位硼酸催化点击反应的半胱氨酸和同型半胱氨酸新型有机荧光探针及生物成像研究,国家自然科学基金,主持

2. 程序传感β-淀粉样蛋白、二氧化硫和双氧水的荧光探针,中国博士后科学基金特别资助,主持

3. 基于芳基酮醛的半胱氨酸有机荧光探针及生物成像研究,中国博士后科学基金一等资助,主持

4. 基于端基炔酮的半胱氨酸和同型半胱氨酸荧光探针及生物成像研究,河南省博士后科研项目一等资助,主持

5. 基于花色素的β-淀粉样蛋白荧光探针及其在阿尔茨海默病早期检测中的应用,河南省青年人才托举工程,主持

发表论文

(1) Sun, Y.; Sun, P.; Guo, W. Fluorescent Probes for Iron, Heme, and Related Enzymes.Coordination Chemistry Reviews2020, 213645. https://doi.org/10.1016/j.ccr.2020.213645.

(2) Sun, P.; Zhang, H.; Sun, Y.; Liu, J. The Recent Development of Fluorescent Probes for the Detection of NADH and NADPH in Living Cells and in Vivo.Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2021,245, 118919. https://doi.org/10.1016/j.saa.2020.118919.

(3) Zhang, H.; Liu, J.; Sun, Y.-Q.; Liu, M.; Guo, W. Carbon–Dipyrromethenes: Bright Cationic Fluorescent Dyes and Potential Application in Revealing Cellular Trafficking of Mitochondrial Glutathione Conjugates.J. Am. Chem. Soc.2020. https://doi.org/10.1021/jacs.0c06916.

(4) Sun, Y.; Qin, H.; Geng, X.; Yang, R.; Qu, L.; Kani, A. N.; Li, Z. Rational Design of Far-Red to Near-Infrared Emitting Carbon Dots for Ultrafast Lysosomal Polarity Imaging.ACS Appl. Mater. Interfaces2020,12(28), 31738–31744. https://doi.org/10.1021/acsami.0c05005.

(5) Huo, X.; Wang, X.; Yang, R.; Li, Z.; Sun, Y.; Qu, L.; Zeng, H. A Novel Fluorescent Probe for Highly Selective and Sensitive Detection of Hypobromous Acid in Arthritis Model Mice.Sensors and Actuators B: Chemical2020,315, 128125. https://doi.org/10.1016/j.snb.2020.128125.

(6) Wang, L.; Liu, J.; Zhao, S.; Zhang, H.; Sun, Y.; Wei, A.; Guo, W. Fluorescence Imaging of Hypochlorous Acid and Peroxynitrite in Vitro and in Vivo with Emission Wavelength beyond 750 Nm.Chem. Commun. 2020,56(56), 7718–7721. https://doi.org/10.1039/D0CC02322A.

(7) Geng, X.; Sun, Y.-Q.; Guo, Y.; Zhao, Y.; Zhang, K.; Xiao, L.; Qu, L.-B.; Li, Z. Fluorescent Carbon Dots for in Situ Monitoring of Lysosomal ATP Levels.Anal. Chem.2020. https://doi.org/10.1021/acs.analchem.0c01335.

(8) Liu, Y.; Liang, Z.; Li, Z.; Zhao, K.; Sun, Y.; Zhang, X.; Yang, R.; Qu, L. Anti-Solvatochromic Fluorescence of Thiazole [5, 4-d] Thiazole by Forming Hydrogen Bond Network and Its Application in Fast Detection of Trace Water.Microchemical Journal2020,154, 104640. https://doi.org/10.1016/j.microc.2020.104640.

(9) Yin, X.; Sun, Y.; Yang, R.; Qu, L.; Li, Z. RNA-Responsive Fluorescent Carbon Dots for Fast and Wash-Free Nucleolus Imaging.Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2020, 118381. https://doi.org/10.1016/j.saa.2020.118381.

(10) Qin, H.; Sun, Y.; Geng, X.; Zhao, K.; Meng, H.; Yang, R.; Qu, L.; Li, Z. A Wash-Free Lysosome Targeting Carbon Dots for Ultrafast Imaging and Monitoring Cell Apoptosis Status.Analytica Chimica Acta2020, 1106, 207–215. https://doi.org/10.1016/j.aca.2020.02.002.

(11) Geng, X.; Sun, Y.; Li, Z.; Yang, R.; Zhao, Y.; Guo, Y.; Xu, J.; Li, F.; Wang, Y.; Lu, S.; Qu, L. Retrosynthesis of Tunable Fluorescent Carbon Dots for Precise Long‐Term Mitochondrial Tracking.Small 2019,15(48), 1901517. https://doi.org/10.1002/smll.201901517.

(12) Liu, H.; Sun, Y.; Li, Z.; Yang, R.; Yang, J.; Aryee, A. A.; Zhang, X.; Ge, J.; Qu, L.; Lin, Y. SciFinder-Guided Rational Design of Fluorescent Carbon Dots for Ratiometric Monitoring Intracellular PH Fluctuations under Heat Shock.Chinese Chemical Letters2019,30 (9), 1647–1651. https://doi.org/10.1016/j.cclet.2019.06.012.

(13) Liu, H.; Yang, J.; Li, Z.; Xiao, L.; Aryee, A. A.; Sun, Y.; Yang, R.; Meng, H.; Qu, L.; Lin, Y.; Zhang, X. Hydrogen-Bond-Induced Emission of Carbon Dots for Wash-Free Nucleus Imaging.Anal. Chem.2019, 91(14), 9259–9265. https://doi.org/10.1021/acs.analchem.9b02147.

(14) Liu, H.; Sun, Y.; Li, Z.; Yang, J.; Aryee, A. A.; Qu, L.; Du, D.; Lin, Y. Lysosome-Targeted Carbon Dots for Ratiometric Imaging of Formaldehyde in Living Cells.Nanoscale2019,11(17), 8458–8463. https://doi.org/10.1039/C9NR01678C.

(15) Yang, Y.; Qu, C.; Chen, X.; Sun, K.; Qu, L.; Bi, W.; Hu, H.; Li, R.; Jing, C.; Wei, D.; Wei, S.; Sun, Y.; Liu, H.; Zhao, Y. A Multiheteroatom [3,3]-Sigmatropic Rearrangement: Disproportionative Entries into 2-(N-Heteroaryl)Methyl Phosphates and α-Keto Phosphates.Org. Lett.2017,19(21), 5864–5867. https://doi.org/10.1021/acs.orglett.7b02852.

 

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