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徐如强

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徐如强,教授,中国农业大学,博士;中国农业科学院,博士后(出站)。曾先后就职于河南省农业科学院、北京市农林科学院、日本国立农业生物资源研究所(National Institute of Agrobiological Sciences)、日本国际农林水产业研究中心(Japan International Research Center for Agricultural Sciences),以及美国肯塔基大学(University of Kentucky)、迈阿密大学(Miami University)吉尼亚联邦大学(Virginia Commonwealth University)和普渡大学(Purdue University)从事研究工作。获得国家科技进步奖1(第三完成人)和省部级科技进步奖2项;在国内外学术期刊发表论文46篇,其中SCI收录25篇;在国际基因库注册基因5个;参加编写学术著作1多次受邀在国内外学术会议和科研机构作学术报告。

研究方向:

分子生物学与植物遗传改良; 信号转导机制与药物筛选。

发表论文:

1. 徐如强, Watts VJ. Gαi/o偶联受体介导的腺苷酸环化酶“超敏化”研究进展. 药学学报, 2016 (印刷中).

2. Xu R, El-Hage N, Dever SM. Fluorescently-labeled RNA packaging into HIV-1 particles: direct examination of infectivity across central nervous system cell types. Journal of Virological Methods, 2015, 224: 20-29.

3. Haham YK, McLaughlin J, Wood C, Masvekar RR, Xu R, Hauser KF, Knapp PE. Chronic HIV-1 Tat and HIV reduce Rbfox3/NeuN: evidence for sex-related effects. Current HIV Research, 2015, 13(1): 10-20.

4. 曹廷杰, 谢菁忠, 吴秋红, 陈永兴, 王振忠, 赵虹, 王西成, 詹克慧, 徐如强, 王际睿, 罗明成, 刘志勇. 河南省近年审定小麦品种基于系谱和SNP 标记的遗传多样性分析. 作物学报, 2015, 41(2): 197-206.

5. Liu M, Xu R, Merrill C, Hunt AG, Li QQ. Integration of developmental and hormonal signals via a polyadenylation factor in plants. PLoS ONE , 2014, 9(12): e115779.

6. Conley JM, Brust TF, Xu R, Burris KD, Watts VJ. Drug-induced sensitization of adenylyl cyclase: assay streamlining and miniaturization for small molecule and siRNA screening applications. Journal of Visualized Experiments, 2014, (83): e51218.

7. Dever SM, Costin BN, Xu R, El-Hage N, Balinang J, Samoshkin A, O’Brien MA, McRae MP, Diatchenko L, Knapp PE, Hauser KF. Differential expression of the alternatively-spliced OPRM1 isoform MOR-1K in HIV-infected Subjects. AIDS, 2014, 28(1): 19-30.

8. Conley JM, Brand CS, Borgard AS, Pratt EPS, Xu R, Hockerman GH, Ostrom RS, Dessauser CW, Watts VJ. Development of a high-throughput screening paradigm for the discovery of small molecule modulators of adenylyl cyclase: Identification of an inhibitor of adenylyl cyclase 2. Journal of Pharmacology and Experimental Therapeutics, 2013, 347(2): 276-287.

9. Xing D, Wang Y, Xu R, Ye X, Yang D, Li QQ. The regulatory role of Pcf11-similar-4 (PCFS4) in Arabidopsis development by genome-wide interactions with target loci. BMC Genomics, 2013, 14: 598.

10. Fitting S, Scoggins KL, Xu R, Dever SM, Knapp PE, Dewey WL, Hauser KF. Morphine efficacy is altered in conditional HIV-1 Tat transgenic mice. European Journal of Pharmacology, 2012, 689: 96-103.

11. Dever SM#, Xu R#, Fitting S, Knapp PE, Hauser KF. Differential expression and HIV-1 regulation of μ opioid receptor splice variants across central nervous system cell types. Journal of NeuroVirology, 2012, 18(3): 181-190 (封面文章). [#共同第一作者]

12. Fitting S, Xu R, Bull C, Buch SK, El-Hage N, Nath A, Knapp P E, Hauser KF. Interactive co-morbidity between opioid drugs of abuse and HIV-1 Tat: Inflammation and disruptions in endogenous opioid signaling accelerate neuronal injury in the striatum. American Journal of Pathology, 2010, 177(3): 1397-1410.

13. Duncan MJ, Bruce-Keller AJ, Conner C, Knapp PE, Xu R, Nath A, Hauser KF. Effects of chronic expression of the HIV-induced protein, transactivator of transcription (Tat), on circadian activity rhythms in mice with or without morphine. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 2008, 295: R1680-R1687.

14. Bruce-Keller AJ, Turchan-Cholewo J, Smart EJ, Geurin T, Chauhan A, Reid R, Xu R, Nath A, Knapp PE, Hauser KF. Morphine causes rapid increases in glial activation and neuronal injury in the striatum of inducible HIV-1 tat transgenic mice. Glia, 2008, 56: 1414-1427.

15. Zhang J, Addepalli B, Yun KY, Hunt AG, Xu R, Rao S, Li QQ, Falcone DL. A polyadenylation factor subunit implicated in regulating oxidative signaling in Arabidopsis thaliana. PLoS ONE, 2008, 3(6): e2410.

16. Hunt AG, Xu R, Addepalli B, Rao S, Forbes KP, Meeks LR, Xing DH, Mo M, Zhao HW, Bandyopadhyay A, Dampanaboina L, Marion A, Von Lanken C, Li QQ. Arabidopsis mRNA polyadenylation machinery: comprehensive analysis of protein-protein interactions and gene expression profiling. BMC Genomics, 2008, 9: 220-234.

17. Xing DH, Zhao HW, Xu R, Li QQ. Arabidopsis PCFS4, a homologue of yeast polyadenylation factor Pcf11p, regulates FCA alternative processing and promotes flowering time. Plant Journal, 2008, 54: 899-910.

18. Xu R, Li QQ. Streamline cloning of genes into binary vectors in Agrobacterium via the GatewayÒ TOPO vector system. Plant Methods, 2008, 4:4.

19. Xu R, Zhao H, Dinkins RD, Chen XW, Carberry G, Li QQ. The 73 kD subunit of cleavage and polyadenylation specificity factor (CPSF) complex affect reproductive development in Arabidopsis. Plant Molecular Biology, 2006, 61: 799-815.

20. Balasubrahmanyam A#, Xu R#, Dattaroy T, Li BC, Bass WT, Li QQ, Hunt AG. Disease resistance in plants that carry a feedback-regulated yeast poly(A) binding protein gene. Plant Molecular Biology, 2006, 61: 383-397. [#共同第一作者]

21. Delaney KJ, Xu R, Zhang JX, Li QQ, Yun KY, Falcone DL, Hunt AG. Calmodulin interacts with and regulates the RNA-binding activity of an Arabidopsis polyadenylation factor subunit. Plant Physiology, 2006, 140: 1507-1521.

22. Xu R, Ye XF, Li Q. AtCPSF73-II encoding a homologue of the 73 kDa subunit of CPSF is critical for early embryo development. Gene, 2004, 324: 35-45.

23. Xu R, Li Q. A RING-H2 zinc finger protein RIE is essential for seed development in Arabidopsis. Plant Molecular Biology, 2003, 53: 37-50 (封面文章).

24. Tomooka N, Vaughan DA, Xu R, Kashiwaba K, Kaga A. Japanese native Vigna genetic resources. Japan Agricultural Research Quarterly, 2001, 35 (1): 1-9.

25. Xu R, Tomooka N, Vaughan DA, Doi, K. The Vigna angularis complex: Genetic variation and relationships revealed by RAPD analysis, and their implications for in situ conservation and domestication. Genetic Resources and Crop Evolution, 2000, 47: 123-134.

26. Xu R, Tomooka N, Vaughan DA. AFLP markers for characterizing the azuki bean complex. Crop Science, 2000, 40: 808-815 (封面文章).

27. Potokina E, Tomooka N, Vaughan DA, Alexandrova T, Xu R. Phylogeny of Vicia subgenus Vicia (Fabaceae) based on analysis of RAPD’s and RFLP of PCR-amplified chloroplast genes. Genetic Resources and Crop Evolution, 1999, 46: 149-161.

28. Vaughan DAKobayashi NXu R. Collection of the wild relatives of crops 1997. 3. The Azuki bean (Vigna angularis var angularis) genepool and soybean(Glycin max) genepool in the Kinki region of Honshu, Japan, 4-11th November. 植探報, 1998, 14: 85-97.

29. Tomooka N, Vaughan D, Xu R, Doi K. Wild relatives of crops conservation in Japan with a focus on Vigna spp. Introduction. 植探報, 1998, 14: 45-61.

30. 徐如强, 孙其信, 张树榛. 小麦细胞膜热稳定性的配合力与杂种优势分析. 作物学报, 1998, 24(1): 55-60.

31. 徐如强, 孙其信, 张树榛. 不同冬小麦品种对高温胁迫反应的研究. 中国农业大学学报, 1998, 3(1): 99-104.

32. 徐如强, 孙其信, 张树榛. 小麦耐热性研究现状与展望(综述). 中国农业大学学报, 1998, 3(3): 110-123.

33. 徐如强, 孙其信, 张树榛. 小麦光合作用与耐热性的关系初探. 作物品种资源, 1997, (1): 28-29, 46.

34. 徐如强, 孙其信, 张树榛. 春小麦耐热性的筛选方法与指标. 华北农学报, 1997, 12(3): 22-29.

35. 徐如强, 孙其信, 张树榛. 普通小麦品种Hope细胞膜热稳定性基因的染色体定位. 遗传, 1996, (4): 1-3.

36. 徐如强, 孙其信, 张树榛. 不同耐热性小麦品种的籽粒灌浆特性及其对高温反应的初步研究. 中国农学通报, 1996, 12(6): 7-10.

37. 徐如强, 孙其信, 张树榛. 小麦耐热性的配合力分析. 中国农学通报, 1996, 12(3): 1-3.

38. 徐如强, 孙其信, 张树榛. 小麦耐热性的杂种优势表现. 北京农业科学, 1996, 14(1): 15-17.

39. 孙其信, 高立峰, 徐如强. 异源细胞质对小麦耐热性的遗传影响. 北京农业大学学报, 1994, 20(4): 361-367.

40. 徐如强, 黄铁城, 张爱民.BAU-2 诱导普通小麦雄性不育的研究 I. 化学杀雄效果. 北京农业大学学报, 1993, 19 (增刊): 1-8.

41. 徐如强, 黄铁城, 张爱民.BAU-2 诱导普通小麦雄性不育的研究 II. 化学杀雄技术. 北京农业大学学报, 1993, 19 (增刊): 9-18.

42. 徐如强, 黄铁城, 张爱民.BAU-2 诱导普通小麦雄性不育的研究 III. 化学杀雄机制. 北京农业大学学报, 1993, 19 (增刊): 19-24.

43. 王继华, 孙其信, 徐如强. K型不育系恢复系筛选及花粉败育机理比较研究. 北京农业大学学报, 1993, 19 (增刊)91-97.

44. 柳家荣, 郑永战, 徐如强. 芝麻的耐涝性与基因型及根系活力的关系. 华北农学报, 1993, 8(3): 82-86.

45. 柳家荣, 郑永战, 徐如强. 芝麻种质营养品质研究. 华北农学报, 1992, 7(3): 110-116.

46. 柳家荣, 郑永战, 徐如强. 芝麻种质营养品质分析及优质资源筛选. 中国油料, 1992, (1): 24-26.

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