吴亚红,医学博士,讲师,硕士生导师,邮箱:yahongwu@zzu.edu.cn
工作经历:
2015/11-至今,郑州大学,生命科学学院,讲师
教学工作:
承担免疫学课程,生物化学综合实验等课程的教学
研究方向:
肿瘤免疫与多肽药物,抗原表位的鉴定等方面的研究,至今发表学术论文14篇,其中SCI论文11篇,获授权发明专利16项。
承担科研项目:
[1] 国家自然科学基金-青年基金(81601448):HLA-A2限制性食管癌特异性突变抗原CTL新表位的鉴定和免疫活性研究,2017/01-2019/12,主持
[2] 河南省高等学校重点科研项目(19A180007):肿瘤特异性突变抗原PIK3CA突变位点功能改变研究,2019/01-2020/12,主持
[3] 河南省科技厅基础与前沿技术研究(162300410125):肿瘤特异性突变抗原TP53特异性CTL表位的鉴定及活性研究,主持
发表的主要论文:
[1] Wu Y, Zhai W, Zhou X, Wang Z, Lin Y, Ran L, Qi Y, Gao Y*. HLA-A2- Restricted Epitopes Identified from MTA1 Could Elicit Antigen-Specific Cytotoxic T Lymphocyte Response. J Immunol Res. 2018, 2018:2942679.
[2] Yahong Wu, Wenjie Zhai, Meng Sun, Zhe Zou, Xiuman Zhou, Guodong Li, Zhongyi Yan,Yuanming Qi* and Yanfeng Gao*. A Novel Recombinant Multi-Epitope Vaccine Could Induce Specific Cytotoxic T Lymphocyte Response In Vitro and In Vivo, Protein Pept Lett, 2017, 24(6): 573-580
[3] Du J, Qin Y, Wu Y, Zhao W, Zhai W, Qi Y, Wang C, Gao Y*. The design of high affinity human PD-1 mutants by using molecular dynamics simulations (MD). Cell Commun Signal. 2018,16(1):25.
[4] Zhou XM, Li WQ, Wu YH, Han L, Cao XG, Yang XM, Wang HF, Zhao WS, Zhai WJ, Qi YM, Gao YF*. Intrinsic Expression of Immune Checkpoint Molecule TIGIT Could Help Tumor Growth in vivo by Suppressing the Function of NK and CD8+ T cells. Front Immunol. 2018, 9:2821.
[5] Yan ZY, Wu YH, Du JF, Li GD, Wang SD, Cao WP, Zhou XM, Wu CJ, Zhang D, Jing XL, Li YF, Wang HF, Gao YF*, Qi YM*. A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy. Oncotarget. 2016, 7( 26): 40437-50.
[6]Chen ZZ#, Huang L#, Wu YH, Zhai WJ, Zhu PP*, Gao YF*. LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression. Nat Commun. 2016, 7:12598.
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