赵慧智，女，博士学位，2009年于中国科学院自动化研究所获得模式识别与智能系统博士学位，于2009年7月入职首都儿科研究所，2012年8月入职郑州大学生命科学学院。

主要研究方向为：

1. 高通量数据研究：从DNA-seq、RNA-seq、ChIP-seq、ATAC-seq等多种高通量数据中获取信息基因表达、转录本剪切、结合能力等信息，为后续生物问题研究提供方向。

2. 红系发育研究：红系发育是从造血干细胞经过增殖、分化、成熟为无核红细胞的过程，受到内源基因调控和外源微环境的影响。利用高通量数据构建红系发育中生物网络挖掘红系增殖和脱核的关键基因，为体外产生红细胞和红系疾病提供帮助。

在研项目

2018.1-2019.12，国家自然科学基金青年基金项目，红系发育阶段特异性转录调控网络的构建与应用

发表文章

1. Huili Li, Xiaowei Wang, Huizhi Zhao, Fang Wang, Yihua Bao, Jin Guo, Shaoyan Chang, Lihua Wu, Haiqin Cheng, Shuyuan Chen, Jizhen Zhou, Xiaodai Cui, Lee Niswander, Richard H Finnel, Hongyan Wang, Ting Zhang. Low folate concentration impacts mismatch repair deficiency in neural tube defects. Epigenomics. November 2019

2. Jieying Zhang^#, Huizhi Zhao^#, Kunlu Wu, Yuanliang Peng, Xu Han1, Huan Zhang, Long Liang, Huiyong Chen, Jingping Hu, Xiaoli Qu, Shijie Zhang, Lixiang Chen, Jing Liu*,. Knockdown of splice some U2AF1 significantly inhibits the development of human erythroid cells. Journal of Cellular and Molecular Medicine. 2019 Aug; 23(8): 5076–5086

3. Wei Li^#, Yaomei Wang^#, Huizhi Zhao^#, Huan Zhang^#, Yuanlin Xu, Shihui Wang, Xinhua Guo, Yumin Huang, Shijie Zhang, YongShuai Han, Xianfang Wu, Charles M. Rice, Gang Huang, Patrick G. Gallagher, Avital Mendelson, Karina Yazdanbakhsh, Jing Liu, Lixiang Chen, Xiuli An. Identification and transcriptome analysis of erythroblastic island macrophages. Blood, 2019, 134(5):480-491

4. Xiaoli Qu#, Shijie Zhang#, Shihui Wang#, Yaomei Wang, Wei Li, Yumin Huang, Huizhi Zhao, Xiuyun Wu, Chao An, Xinhua Guo, John Hale, Jie Li, Christopher D. Hillyer, Narla Mohandas, Jing Liu, Karina Yazdanbakhsh, Francesca Vinchi, Lixiang Chen, Qiaozhen Kang, Xiuli An. TET2 deficiency leads to stem cell factor dependent clonal expansion of dysfunctional erythroid progenitors. Blood. 2018. 132(22) :2406-2417

5. Yumin Huang^#, John Hale^#, Yaomei Wang, Wei Li, Shijie Zhang, Jieying Zhang, Huizhi Zhao, Xinhua Guo, Jing Liu, Hongxia Yan, Karina Yazdanbakhsh, Gang Huang, Christopher D Hillyer, Narla Mohandas, Lixiang Chen, Ling Sun, Xiuli An. SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS. Journal of hematology & oncology. 2018, Feb 12;11(1).