研究生培养

马珊珊

作者:   更新时间:2020-04-23 来源:本站点 (已浏览次)


姓名:马珊珊 副教授

学院:生命科学学院

导师类别:硕士生导师

研究方向:干细胞与神经修复

研究领域:细胞生物学、基础医学


教育背景:

20029月~20067月,郑州大学生命科学学院 学士学位;

20069月~20119月,浙江大学生命科学学院 博士学位;

个人简述:

马珊珊,女,博士,郑州大学生命科学学院副教授,硕士生导师。主要从事干细胞生物学特性和神经功能恢复的研究。20119月毕业于浙江大学发育生物学专业,获得博士学位。2011年进入郑州大学生命科学学院,主要从事干细胞与神经恢复相关的研究。先后主持1NSFC-河南人才培养联合基金1NSFC-青年基金项目、1项河南省高等学校重点科研项目计划、1项开放课题,先后参加国家自然科学基金、河南省科技创新人才项目、河南省教育厅科技创新团队、河南省产学研项目等多项科研项目。在Stem Cell Res Ther.Front. Cell. Neurosci. J. Mater. Chem. B, EpigeneticsSCI期刊及中文核心期刊上发表科研论文40余篇,其中SCI收录约20篇。荣获1项河南省科技进步二等奖、1项河南省科技进步三等奖、2项河南省教育厅科技成果一等奖;参编2本专著;申请5项国家发明专利,授权5项实用新型专利。


主要荣誉:

荣获郑州大学“优秀共产党员”、“网上教评优秀教师”、“青年教师讲课大赛三等奖”、优秀班主任等荣誉称号。荣1项河南省科技奖励二等奖和2项河南省教育厅科技成果一等奖。


科研项目:

河南省科技攻关项目:MG53/SA/Col缓释水凝胶支架的制备及其负载hUC-MSCs对小鼠皮肤损伤的修复作用,2020/01-2022/12,主持

国家自然科学基金青年项目:81601078MG53调控SDF-1/CXCR4信号促进脐带干细胞治疗脑缺血再灌注损伤的机制研究,2017/01-2019/12,主持

NSFC-河南人才培养联合基金:U1404313HDAC1双向调控在脐带MSCs向神经元样细胞定向分化过程中的作用和机制,2015/01-2017/12,主持

河南省高等学校重点科研项目计划:17A310012,神经炎症在阿尔茨海默鼠疾病发展中的作用及干细胞移植后的效果观察,2017/01-2018/12,主持

微纳成型技术国家级国际联合研究中心河南省微成型技术重点实验室联合开放基金:MMT2017-04SDF-1复合胶原/海藻酸钠水凝胶对hUC-MSCs迁移和神经分化的影响,2017/03-2018/10,主持


代表性论文:

1. Yao M*#, Chen Y#, Zhang J, Gao F, Ma S*, Guan F*. Chitosan-based thermosensitive hydrogel promotes the therapeutic effect of human umbilical cord MSC on TBI rat model. Materials Today Chemistry. 2019,14: 100192

2. Guan F#, Huang T#, Wang X, Xing Q, Gumpper K, Li P, Song J, Tan T, Yang GL, Zang X, Zhang J, Wang Y, Yang Y, Liu Y, Zhang Y, Yang B, Ma J*, Ma S*. The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury. Stem Cell Res Ther. 2019,10(1):352.

3. Cui Y, Zhang L, Wang W, Ma S, Liu H, Zang X, Zhang Y*, Guan F*. Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/β-catenin pathway. Mol Cell Biochem. 2019, 460(1-2):93-103.

4. Guan F#, Zhou X#, Li P#, Wang Y, Liu M, Li F, Cui Y, Huang T, Yao M, Zhang Y, Ma J*, Ma S*. MG53 attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation via inhibiting TLR4/NF-κB pathway in vitro and in vivo. Prog Neuropsychopharmacol Biol Psychiatry. 2019, 95:109684.

5. Li Y#, Ma S#, Zhang Y, Yao M, Zhu X, Fangxia G. (-)-Epicatechin mitigates radiation-induced intestinal injury and promotes intestinal regeneration via suppressing oxidative stress. Free Radic Res. 2019, 53(8):851-864.

6. Cai B, Wang X, Liu H, Ma S, Zhang K, Zhang Y, Li Q, Wang J, Yao M, Guan F, Yin G. Up-regulated lncRNA5322 elevates MAPK1 to enhance proliferation of hair follicle stem cells as a ceRNA of microRNA-19b-3p. Cell Cycle. 2019 Jul;18(14):1588-1600.

7. Ma S#, Liu T#, Xu L, Wang Y, Zhou J, Huang T, Li P, Liu H, Zhang Y, Zhou X, Cui Y, Zang X, Wang Y, Guan F*. Histone deacetylases inhibitor MS-275 suppresses human esophageal squamous cell carcinoma cell growth and progression via the PI3K/Akt/mTOR pathway. J Cell Physiol. 2019 Dec;234(12):22400-22410.

8. Zhou J#, Zhang K#, Ma S #, Liu T, Yao M, Li J (*), Wang X, Guan F *. Preparing an injectable hydrogel with sodium alginate and Type I collagen to create better MSCs growth microenvironment. e-Polymers, 2019, 19(1): 87-91

9. Xu L#, Xing Q#, Huang T, Zhou J, Liu T, Cui Y, Cheng T, Wang Y, Zhou X, Yang B, Yang GL, Zhang J, Zang X, Ma S*, Guan F*. HDAC1 silence promotes neuroprotective effects of human umbilical cord-derived mesenchymal stem cells in a mouse model of traumatic brain injury via PI3K/AKT pathway. Front. Cell. Neurosci. 2019, 4; 12: 498.

10. Zhang K#, Shi Z#, Zhou J#, Xing Q, Ma S, Li Q, Zhang Y, Yao M, Wang X, Li J*, Guan F*. Potential application of an injectable hydrogel scaffold loaded with mesenchymal stem cells for treating traumatic brain injury. J. Mater. Chem. B, 2018, 6, 2982-2992

11. Zhang T#, Wang P#, Liu Y, Zhou J, Shi Z, Cheng K, Huang T, Wang X, Yang GL, Yang B, Ma S*, Guan F*. Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo. Cell Tissue Res. 2018, 373(2):379-393. Aug;373(2):379-393.

12. Cai B, Zheng Y, Ma S, Xing Q, Wang X, Yang B, Yin G, Guan F(*).Long noncoding RNA regulates hair follicle stem cell proliferation and differentiation through PI3K/AKT signal pathway. Mol Med Rep. 2018, 17(4):5477-5483.

13. Wang X*#, Ma S#, Yang B*, Huang T, Meng N, Xu L, Xing Q, Zhang Y, Zhang K, Li Q, Zhang T, Wu J, Yang GL, Guan F*, Wang J. Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer's disease. Behav Brain Res. 2018, 339:297-304

14. Cui Y#, Ma S#, Zhang C, Li D, Yang B, Lv P, Xing Q, Huang T, Yang GL, Cao W*, Guan F*. Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease. Behav Brain Res. 2018, 336:219-226.

15. Cui Y#, Ma S#, Zhang C, Cao W, Liu M, Li D, Lv P, Xing Q, Qu R, Yao N, Yang B*, Guan F*. Human umbilical cord mesenchymal stem cells transplantation improves cognitive function in Alzheimer's disease mice by decreasing oxidative stress and promoting hippocampal neurogenesis. Behav Brain Res. 2017, 320:291-301.

16. Zhang Y#, Zhu X#, Huang T, Chen L, Liu Y, Li Q, Song J, Ma S, Zhang K, Yang B*, Guan F*. β-Carotene synergistically enhances the anti-tumor effect of 5-fluorouracil on esophageal squamous cell carcinoma in vivo and in vitro. Toxicol Lett. 2016, 261:49-58.

17. Wang X#, Ma S#, Meng N, Yao N, Zhang K, Li Q, Zhang Y, Xing Q, Han K, Song J, Yang B*, Guan F*. Resveratrol exerts dosage-dependent effects on the self-renewal and neural differentiation of hUC-MSCs, Mol Cells, 2016, 39(5):418-25

18. Li D#, Ma S#, Guo D, Cheng T, Li H, Tian Y, Li J, Guan F*, Yang B*, Wang J. Environmental circadian disruption worsens neurologic impairment and inhibits hippocampal neurogenesis in adult rats after traumatic brain injury, Cell Mol Neurobiol,2016, 36(7):1045-55



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