职称：讲师

        邮箱：sx0507@zzu.edu.cn

        地址：郑州大学医学科学院博士后楼401

个人简介

2020.10 - 至今，郑州大学医学科学院，讲师

2016.03 – 2020.08, 韩国建国大学, 应用生命科学, 博士

2012.09 – 2015.08, 韩国建国大学, 应用生命科学, 硕士

2008.09 – 2012.06, 延边大学, 食品科学与工程, 学士

主要研究方向

NLRP3炎症小体是在免疫监测中发挥关键作用的蛋白质复合体。NLRP3炎症小体是目前研究最多的一种炎症小体，不仅能被许多细菌、病毒等病原体所激活，也能被体内自身产生的“危险信号”激活。NLRP3炎症小体异常激活导致的过度炎症与多种自身免疫疾病密切相关，如：2型糖尿病、肥胖、败血症、痛风和炎症性肠病等。申请人围绕炎症小体及其相关疾病的发生发展机制开展研究，

荣誉及获奖情况：

2019，KAI International Meeting，优秀壁报

2017/2018/2020，BK21⁺ 优秀研究论文奖学金

主持项目

1.河南省科技厅，河南省自然科学青年基金，NLRP3乳酸化修饰抑制炎症小体激活的机制研究，2024-01 至 2025-12，在研，主持

2.河南省教育厅，河南省重点研发项目，222102310602，NLRP3 炎症小体的靶向小分子抗炎药物的筛选及其药理机制研究，2022-01 至 2023-12，在研，主持

代表性成果

(#共同第一作者; *通讯作者)

1.Chen Sun, Hangyuan Zhao, Yunze Han, Yiqing Wang, Xiao Sun*. The role of inflammasomes in COVID-19: potential therapeutic targets, J Interferon Cytokine Res, 2022,42(8): 406-420.

2.Jun Jiang#, Xiao Sun#, Akther Mahbuba, et al., Ginsenoside metabolite 20(S)-protopanaxatriol from Panax ginseng attenuates inflammation-mediated NLRP3 inflammasome activation, J Ethnopharmacol, 2019, 251(2019): 112564.

3.Sang-Hyeun Yu#, Xiao Sun#, Myong-Ki Kim, et al., Chrysanthemum indicum extract inhibits NLRP3 and AIM2 inflammasome activation via regulating ASC phosphorylation, J Ethnopharmacol, 2019, 239(2019):111917.

4.Kang-Hyuck Heo#, Xiao Sun#, Do-Wan Shim, et al., Actinidia arguta extract attenuates inflammasome activation: potential involvement in NLRP3 ubiquitination, J Ethnopharmacol, 2017, 213(2018):159-165.

5.Young-Eun Ji#, Xiao Sun#, Myong-Ki Kim, et al., Eucalyptus globulus Labill. extract inhibits inflammasome-activated pro-inflammatory responses and ameliorate monosodium urate-induced peritonitis in murine experimental model, Am J Chi Med, 2018, 46(2):423-433.

6.Xiao Sun, Do-Wan Shim, Ji-Won Han, et al., Anti-inflammatory effect of Impatiens textori Miq. extract via inhibition of NLRP3 inflammasome activation in in vitro and in vivo experimental models, J Ethnopharmacol, 2015, 170(2015): 81-87.

授权专利

1.Kwang-Ho Lee, Tae-Bong Kang, Xiao Sun. Compositions containing fermented extract of Panax ginseng, 2020.07.08, Korea, 10-2172224.

2.Kwang-Ho Lee, Seon-Won Hwang, Xiao Sun. Composition for prevention or treatment of allergic skin diseases comprising fermented extract of ginseng, 2019.10.08, Korea, 10-2032110.

3.Kwang-Ho Lee, Xiao Sun, Do-Wan Shim. Pharmaceutical composition and functional food comprising lysimachia clethroides extracts for preventing and treating inflammatory diseases, 2015.11.30, Korea, 10-1574731.

4.Tae-Kwon Kim, Kwang-Ho Lee, Young-Seon Song, Xiao Sun, Do-Wan Shim. Granular tea containing extract of Sophora Flos Forcronic allergic diseases and manufacturing method thereof, 2015.03.24, Korea, 10-1506947.