石岩

郑州大学药学院教授，郑州大学学科特聘教授，博士生导师，入选中原英才计划“引才系列”（青年项目）

邮箱：yanshi@zzu.edu.cn

个人简介

   石岩，教授，郑州大学学科特聘教授，博士生导师，入选中原英才计划“引才系列”（青年项目）。2013年在南京大学获博士学位；2014年至2022年，在美国南佛罗里达大学从事博士后研究（University of South Florida，合作导师：Prof. Jianfeng Cai）；2022年8月入职郑州大学药学院。主要从事合成药物化学、药物化学生物学研究，通过高通量组合筛选和合理设计两种手段实现拟肽类药物先导化合物发现。

代表性成果

1. Yan Shi, Guangqiang Yin, Zhiping Yan, Peng Sang, Minghui Wang, Robert Brzozowski, Prahathees Eswara, Lukasz Wojtas, Youxuan Zheng,* Xiaopeng Li,* and Jianfeng Cai.* Helical Sulfono-γ-AApeptides with Aggregation-Induced Emission and Circularly Polarized Luminescence. J. Am. Chem. Soc., 2019, 141, 12697-12706.

2. Yan Shi, Peng Sang, Junhao Lu, Pirada Higbee, Lihong Chen, Leixiang Yang, Timothy Odom, Gary Daughdrill,* Jiandong Chen,* and Jianfeng Cai.* Rational Design of Right-Handed Heterogeneous Peptidomimetics as Inhibitors of Protein−Protein Interactions. J. Med. Chem. 2020, 63, 21, 13187–13196.

3. Yan Shi, Sridevi Challa, Peng Sang, Fengyu She, Chunpu Li, Geoffrey M. Gray, Alekhya Nimmagadda, Peng Teng, Timothy Odom, Yan Wang, Arjan van der Vaart, Qi Li,* and Jianfeng Cai.* One-Bead- Two-Compound Thioether Bridged Macrocyclic γ-AApeptide Screening Library against EphA2, J. Med. Chem., 2017, 60, 9290-9298.

4. Yan Shi, Sajan Parag, Rekha Patel, Ashley Lui, Michel Murr, Jianfeng Cai*, and Niketa A. Patel*. Stabilization of lncRNA GAS5 by a small molecule and its implications in diabetic adipocytes. Cell. Chem. Biol., 2019, 26, 319-330.

5. Yan Shi, Peng Teng, Peng Sang, Fengyu She, Lulu Wei, and Jianfeng Cai.* γ-AApeptides: design, structure, and applications. Acc. Chem. Res., 2016, 49, 428-441.