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孙默然
副教授,硕士生导师。
联系方式:sunmr@zzu.edu.cn
研究方向: 药物分子设计与合成
个人简介
孙默然,女,1976年出生,硕士,副教授,硕士生导师,河南省药学会药物化学专业委员会委员。1999年毕业于燕山大学精细化工专业;1999-2001年,于浙江新和成股份有限公司从事科研管理及工艺研究;2001年-2004年,兰州大学,金属有机化学硕士专业,从事二茂铁衍生物的合成。2004-2005,上海药明康德公司工作;2005年进入郑州大学药学院,任讲师、副教授。2007年,美国佐治业州立大学访问学者;主持国家青年基金项目一项,参编教材、专著2部,主讲《药物合成》《文献检索》和《药物化学实验》,先后在SCI期刊上发表论文20余篇,其中中科院二区期刊《Journal of Organic Chemistry》3篇,并获得国家发明专利授权2项。已毕业研究生3名,课题组现有研究生6名。专长于天然产物全合成和反应方法学,现阶段与国内多个药理组合作,共同致力于新药研发。
研究与成果
(1) Hua Yang; Jinling Qin; Yuanyuan Pei; Sumeng Guan; Mei Zhao; Yingge Wang; Yongfang Yao;
Yongtao Duan; Moran Sun Discovery of the cereblon-recruiting tubulin PROTACs effective in
overcoming Taxol resistance in vitro and in vivo, European Journal of Medicinal Chemistry, 2024,
265: 116067.
(2) Jinling Qin; Hongliang Li; Xuan Wang; Yixin Zhang; Yongtao Duan; Yongfang Yao; Hua Yang; Moran Sun ; Discovery of a novel piperlongumine analogue as a microtubule polymerization inhibitor with potent anti-angiogenic and anti-metastatic efficacy, European Journal of Medicinal Chemistry, 2022, 243: 114738.
(3) Moran Sun; Jinling Qin; Yingying Kang; Yixin Zhang; Mengyu Ba; Hua Yang; Yongtao Duan;Yongfang Yao ; 2-Methoxydiol derivatives as new tubulin and HDAC dual-targeting inhibitors,displaying antitumor and antiangiogenic response, Bioorganic Chemistry, 2022, 120:105625
(4) Moran Sun; Yixin Zhang; Jinling Qin; Mengyu Ba; Yongfang Yao; Yongtao Duan; Hongmin Liu; Dequan Yu ; Synthesis and biological evaluation of new 2-methoxyestradiol derivatives: Potent inhibitors of angiogenesis and tubulin polymerization, Bioorganic Chemistry, 2021, 113:104988
(5) Wang, Yingge; Sun, Moran; Wang, Yuyang; Qin, Jinling; Zhang, Yixin; Pang, Yingyue; Yao,
Yongfang; Yang, Hua; Duan, Yongtao ; Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 225: 113790.