Abstract: Mandarin voles (Lasiopodomys mandarinus) spend almost all their lives underground and must have evolved remarkable physiological adaptations to subterranean hypoxic stress. To understand the response to hypoxia in blood system of this rodent in a region with lower altitude, we tested and compared the responding characteristics between Mandarin vole and Kunming mouse (Mus musculus) under chronic normobaric hypoxic treatment (10.0% O2, 4 w). The results showed that: 1) as for responses to chronic hypoxia, HIF-1α, EPO and VEGF exhibited similar patterns in two species......

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