Junhui Si, Zhixiang Cui, Qianting Wang, Qiong Liu, Chuntai Liu,Biomimetic composite scaffolds based on mineralization ofhydroxyapatite on electrospun poly( _-caprolactone)/nanocellulosefibers, Carbohydrate Polymers，2016,143: 270–278

ABSTRACT:A biomimetic nanocomposite scaffold with HA formation on the electrospun poly( _-caprolactone)(PCL)/nanocellulose (NC) fibrous matrix was developed in this study. The electrospun PCL/NC fiber matwas built and then biomineralized by treatment in simulated body fluid (SBF). Using such a rapid andeffective procedure, a continuous biomimetic crystalline HA layer could be successfully formed withoutthe need of any additional chemical modification of the substrate surface. The results showed that theintroduction of NC into composite fibers is an effective approach to induce the deposition of HA nucleusas well as to improve their distribution and growth of a crystalline HA layer on the fibrous scaffolds.The water contact angle (WCA) of the PCL/NC/HA scaffolds decreases with increasing NC content andmineralization time, resulting in the enhancement of their hydrophilicity. These results indicated thatHA-mineralized on PCL/NC fiber can be prepared directly by simply using SBF immersion.