应水利与交通学院邀请,德国国立包豪斯-魏玛大学Timon Rabczuk院士,为广大师生做专题学术报告。欢迎广大师生积极参加!
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报 告 人:Timon Rabczuk院士 报告题目:Computational Modeling of Vesicles in Interaction with Fluid Field and Electric Field 报告时间:2023年7月29日(星期六)上午9:00-12:00 报告地点:水利与交通学院水环馆二楼报告厅(水环馆200) |
专家简介:Timon Rabczuk院士,德国国立包豪斯-魏玛大学计算力学讲席教授 (chair professor),欧洲科学与艺术学院院士、欧洲科学院院士、德国洪堡基金会费-吕楠奖获得者,入选“工程”与“计算科学”双领域科睿唯安ISI全球高被引学者。Rabczuk教授主要从事计算力学与先进材料计算设计方向的研究,十多年来Rabczuk 教授课题组培养了30多名来自中国的博士生与博后,先后8人获得了国家级人才计划或洪堡学者等国际人才奖励。
Abstract: The use of electric fields as an external stimulus has been shown to be an effective technique for engineering vesicle behavior in a wide range of biotechnological applications. Electroporation has been successfully utilized for introducing genes or drugs into cells and cancer treatments. As a powerful cell manipulation method, electric fields have been used in tissue ablation, wound healing, and electroformation and electrofusion of giant vesicles. These important applications have motivated theoretical and computational studies on electrohydrodynamics of vesicles in order to gain a better understanding of the variety of membrane responses under the influence of electric and flow fields. In this talk, the work devoted to developing a robust computational framework using isogeometric analysis and the phase-field method to model the morphological evolution of single- and multi-phase biomembranes will be presented. We developed a three-dimensional isogeometric analysis formulation for the phase-field constrained optimization problem of morphological evolution of vesicles in electrical fields. The effect of the flexoelectricity and the conductivity ratio of the electrolyte on vesicle equilibrium shape were studied through several 3D numerical examples. We captured sphere-oblate and sphere-prolate shape transitions under varying conductivity ratio.