当今，生命科学已经进入到分子生物学时代。医学作为生命科学的主要分支，它首先面对着两个基本问题：(1)对健康的理解和维护；（2）对疾病的有效诊断和治疗。在分子生物学时代，疾病发生的分子机制，疾病的预防，疾病的诊断和治疗都依赖于生物化学与分子生物学的理论和技术。随着各学科的相互交叉与渗透，本学科在几十年的发展历程中，逐步形成了稳定突出的学科特色和科研方向。
(1) 肿瘤发生的分子机制和干预防治：早在20世纪50-70年代，本学科的老一辈教授在营养与癌（食管癌的早期诊断、病因学研究）、自由基与肿瘤等研究方面取得了颇多成就。1978年老前辈研究小组与美国新泽西医学院杨中枢教授协作开展了对林县食管癌的研究，并承担的国家“八五”科技攻关项目“食管癌的早期诊断”其中分课题研究，于1996年获国家计委、国家科委和国家财政部联合颁发的国家“八五”科技攻关重大科技成果奖。① 食管癌的病因学研究（安玉会教授）：在国家六五和七五重大攻关课题食管癌的病因学研究中，从林县食管癌高发区高污染霉菌中分离出了交链胞霉毒素，为霉菌毒素致食管癌的理论奠定了分子病因学基础。在随后的研究中，安玉会教授先后开展了芦笋，大豆黄酮，灵芝三萜和姜素干预肿瘤干细胞增殖和侵润的一系列化学预防研究。其研制的芦笋饮料和口服液获国家发明专利并开发生产。② 骨肿瘤的分子生物学发病机理及基因调控和干预防治（李月白教授等）：多年以来，对人的骨肉瘤、骨巨细胞瘤等骨肿瘤的基因表达调控及防治方面进行有价值的深入系列研究。通过对骨肉瘤、骨软骨瘤和正常骨组织中的抑癌基因p21wafl /cip1基因表达，P27、cyclinE 和ki-67蛋白等表达检测分析研究，揭示了它们在不同组织中的表达差异与骨肉瘤的发生、发展及临床预后的相关性。通过对骨肉瘤细胞干预研究，揭示了通过激活PPAR信号通路可抑制骨肉瘤细胞的生长、增殖并诱导其分化和凋亡。为恶性骨肿瘤的发生机制及防治途径提供了实验依据，其研究获得科技厅科研资助，科研成果获得科技进步成果奖及发表多篇研究论文。
(2) 氧毒性相关疾病的分子机制和干预防治及植物化学物生物学效应研究（王明臣教授等）：此研究系统揭示了煤矽肺发生的氧毒性分子机制及干预防治路径，研究成果获得河南省医药卫生科技成果一等奖。与加拿大农业部合作，对万寿菊中的植物化学物叶黄素（lutein）进行了生物学效应的综合系统研究，揭示了叶黄素干预阻断恶性肿瘤、动脉硬化的发生及发展和视力促进作用的分子机制，研究成果被国际食品化学权威杂志 Food chem. Toxiol 刊发。
(3) 心血管疾病的分子生物学发病机理与防治研究（臧明玺教授等）：前辈曾对动脉粥样硬化发生机制以及中药的治疗进行研究，揭示高脂可导致动脉粥样硬化的发生并发现多种中药对此疾病有疗效，获河南省教育厅科技成果二等奖。对高血压病及其脑并发症防治的研究，获河南省科技进步奖。目前，臧明玺教授对心脏发育、分化及疾病的调控机制进行了深入研究，并获得了重要进展。本研究获得国家863课题及国家自然科学基金等多项研究课题资助，发表了多篇SCI文章，并获得多项科技进步奖励。
(4) 骨疾病的分子生物学发病机理和干预防治研究（李月白教授等）：多年以来，对疾病的发生机理与防治进行了系列研究。对股骨头坏死及骨质疏松症的发病机理、基因表达调控及防治进行了深入研究。揭示RNA干扰技术或miRNA靶向基因调控成脂关键基因PPARγ，高效阻止细胞成脂分化，促进其成骨分化，为股骨头坏死的发生机理提供了有价值的理论依据、早期防治的新靶点和策略。本研究获得3项国家自然科学基金项目、1项卫生部科研基金项目、4项省级研究项目资助，分别获得河南省科技进步二等奖、三等奖。
本学科将继续坚持业已形成的学科特色和科研方向，将不断在上述研究中取得新进展。学科中拥有河南省学术技术带头人1人、河南省教育厅学术技术带头人2人。近年来承担国家自然基金课题8项、863计划研究项目2项、教育部和人事部留学基金3项、河南省课题12项等， 相关研究成果已经发表在国际主流期刊 ，如Cell Mol Life Sci、RNA Biol、J Mol Biol、Food chem toxicol等。在郑州大学实施“一省一校”及基础医学院加强学科建设的过程中，本学科均被列入重点建设内容。目前，随着高水平基础设施和分子生物学及细胞生物学技术平台的构建，本学科在肿瘤防治及心肌再生等领域的研究将独具特色。
一、 近年重要科研项目
1. 国家自然科学基金（面上项目） “ EZH2介导GATA-4调控miR-29a在骨骼肌发育中的作用机制”, 项目编号：81771631，臧明玺， 2018.1-2021.12，直接费用: 60万。
2. 河南省高校科技创新团队 “先天性心脏病发生的表观遗传机制” 项目编号: 18IRTSTHN029,臧明玺，2018.1-2019.12， 100万。
3. 国家自然科学基金（面上项目）“lncRNA-miRNA-mRNA双重调控BMSCs异常分化预防激素性股骨头坏死的实验研究”项目批准号：81772427，李月白，2018.1~2021.12，直接费用：55万。
4. NSFC-河南联合基金培育项目，“RyR2超活性引起的线粒体钙失衡在糖尿病心肌病中的作用机制”，项目批准号：U1704192，梅英武，2018.01~ 2020.12，直接费用：50.00 万元
5. 国家自然科学基金 “miRNA双靶向基因调控PPARγ和GREM 1预防激素性股骨头坏死的实验研究”, 项目编号：81470106，李月白，2015.1~2016.12，30万
6. 国家自然科学基金 “siRNA阻断PPARγ基因表达预防激素性股骨头坏死的实验研究”, 项目编号：81071520, 李月白，2011.1~2013.12，35万
7. 国家自然科学基金“Polycomb 介导GATA-4/ PPARs 蛋白复合体在心肌分化及先天性心脏病发生中的作用机制”, 项目编号：81571482， 臧明玺, 2016.1-2019.12，直接费用: 60万。
8. 国家自然科学基金“miR-29a "targets" PPAR δ对心力衰竭的作用及作为潜在标志物的研究”， 项目编号：81371895，臧明玺, 2014.1-2017.12，70万。
9. 国家自然科学基金“转录因子GATA-4介导EGF信号调控心肌能量代谢及在心肌肥大中的作用”，项目编号：81141044 （科学部主任基金），臧明玺, 2012.1-2012.12，10万。
10. 国家863计划研究项目“心肌能量代谢关键基因的调控机制及在治疗心肌肥大 中的应用”， 项目编号：2007AA02Z122, 臧明玺, 2007.6-2010.12, 95万。
11. 国家863计划研究项目“小核酸技术的前沿研究”子课题“miRNA调控心肌分化、增殖及凋亡的机制研究”， 项目编号：2012AA022501，臧明玺, 2012.11-2015.12, 29.08万。
二、 近年发表部分论文
1. Si Zhang, Zhongnan Yin, Fei-Fei Dai, Hao Wang, Meng-Jiao Zhou, Ming-Hui Yang, Shu-Feng Zhang, Zhi-Feng Fu, Ying-Wu Mei, Ming-Xi Zang, Lixiang Xue.miR-29a attenuates cardiac hypertrophy through inhibition of PPARδ expression. J Cell Physiol. 2019;234(8):13252-13262
2. Xuefeng Zhao, Yan Xu, Xiaoya Sun, Yuan Ma, Yan Zhang, Yadong Wang, Hongya Guan, Zhen Jia, Yuebai Li, Yisheng Wang 2miR-17-5p promotes proliferation and epithelial-mesenchymal transition in human osteosarcoma cells by targeting SRC kinase signaling inhibitor 1, J Cell Biochem. 2019, 120(4):5495-5504.
3. Hongya Guan, Guowei Shang, Yuanbo Cui, Jiu Liu, Xiaoya Sun, Wei Cao, Yisheng Wang, Yuebai Li.Long noncoding RNA APTR contributes to osteosarcoma progression through repression of miR-132-3p and upregulation of yes-associated protein 1. J Cell Physiol, 2019, 234(6):8998-9007.
4. Wang M, Li Y, Yang Y, Liu X, Zang M, Li Y, Yang K, Yang W, Zhang SF. Long non coding RNA DLX6 AS1 is associated with malignant progression and promotes, Mol Med Rep,2019 Mar;19(3):1942-1950.
5. Tao Hu#; Jingyang Zhang#; Beibei Sha; Miaomiao Li; Longhao Wang; Yi Zhang; Xingge Liu; Ziming Dong; Zhenzhen Liu; Pei Li*; Ping Chen*; Targeting the overexpressed USP7 inhibits esophageal squamous cell carcinoma cell growth by inducing NOXA-mediated apoptosis, Molecular Carcinogenesis, 2019, 58(1): 42-54.
6. Sha, Beibei#; Chen, Xiaoyu#; Wu, Han; Li, Miaomiao; Shi, Jianxiang; Wang, Longhao; Liu, Xingge; Chen, Ping; Hu, Tao*; Li, Pei*; Deubiquitylatinase inhibitor b-AP15 induces c-Myc-Noxa-mediated apoptosis in esophageal squamous cell carcinoma , Apoptosis, 2019, 24(9-10): 826-836.
7. Fu, Dong Jun#; Li, Miaomiao#; Zhang, Sai Yang#; Li, Jiang Feng; Sha, Beibei; Wang, Longhao; Zhang, Yan Bing; Chen, Ping*; Hu, Tao*; Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosis , Bioorganic Chemistry, 2019, 92: 0-UNSP 103190.
8. Shan Lin#, Zhaoyang Shang, Shuo Li, Peng Gao, Yi Zhang, Shuaiheng Hou, Peng Qin, Ziming Dong, Tao Hu, Ping Chen*, Neddylation inhibitor MLN4924 induces G2 cell cycle arrest, DNA damage and sensitizes esophageal squamous cell carcinoma cells to cisplatin, Oncology Letters, 2018, 15(2): 2583-2589.
9. Ping Chen#, Miaomiao Li, Qianyun Hao, Xuesong Zhao, Tao Hu*, Targeting the overexpressed CREB inhibits esophageal squamous cell carcinoma cell growth, Oncology Reports, 2018, 39(3): 1369-1377.
10. Guan H, Mei Y, Mi Y, Li C, Sun X, Zhao X, Liu J, Cao W, Li Y*, Wang Y. Downregulation of lncRNA ANRIL suppresses growth and metastasis in human osteosarcoma cells. Onco Targets Ther. 2018 Aug 14;11:4893-4899.
11. Shang G, Wang Y, Xu Y, Zhang S, Sun X, Guan H, Zhao X, Wang Y*, Li Y*. Long non-coding RNA TCONS_00041960 enhances osteogenesis and inhibits adipogenesis of rat bone marrow mesenchymal stem cell by targeting miR-204-5p and miR-125a-3p. J Cell Physiol. 2018 Aug;233(8):6041-6051.
12. Shang G, Mi Y, Mei Y, Wang G, Wang Y, Li X, Wang Y*, Li Y*, Zhao G. MicroRNA-192 inhibits the proliferation, migration and invasion of osteosarcoma cells and promotes apoptosis by targeting matrix metalloproteinase-11. Oncol Lett. 2018 May;15(5):7265-7272.
13. Sun X, Xu Y, Zhang S, Li X, Wang Y, Zhang Y, Zhao X, Li Y*, Wang Y. MicroRNA-183 suppresses the vitality, invasion and migration of human osteosarcoma cells by targeting metastasis-associated protein 1. Exp Ther Med. 2018 Jun;15(6):5058-5064.
14. Chang JinZhang Y, Li Yichuan, Zhang Shanfeng*,etal. NrF2/ARE and NF-κB pathway regulation may be the mechanism for lutein inhibition of human breast cancer cell. Future Oncol. 2018 Apr;14(8):719-726.
15. Li Yuan, Zhang Yuekun,Zhang Shanfeng*,etal. proliferation, invasion and migration of hypoxic breast cancer cells via downregulation of HES1. Int J Oncol. 2018 Jun;52(6):2119-2129.
16. Wei Zhang, Shanfeng Zhang, Jiaqiang Zhang,etal. Paravertebral dexmedetomidine as an adjuvant to ropivacaine protects against independent lung injury during one-lung ventilation: a preliminary randomized clinical trial.BMC Anesthesiol. 2018; 18: 67.
17. Jingyang Zhang#, Shu Li#, Zhaoyang Shang, Shan Lin, Pen Gao, Yi Zhang, Shuaiheng Hou, Saijun Mo, Wenbo Cao, Ziming Dong, Tao Hu*, Ping Chen*, Targeting the overexpressed ROC1 induces G2 cell cycle arrest and apoptosis in esophageal cancer cells, Oncotarget, 2017, 8(17): 29125-29137.
18. Jingyang Zhang#, Shu Li#, Zhaoyang Shang, Shan Lin, Pen Gao, Yi Zhang, Shuaiheng Hou, Saijun Mo, Wenbo Cao, Ziming Dong, Tao Hu*, Ping Chen*, Targeting the overexpressed ROC1 induces G2 cell cycle arrest and apoptosis in esophageal cancer cells, Oncotarget, 2017, 8(17): 29125-29137.
19. Tao Hu#，Pei Li，Zhongguang Luo，Xiaoyu Chen，Jingyang Zhang，Chunyao Wang，Ping Chen*，Ziming Dong*, Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo, Oncology Reports, 2016, 35(1): 43-49.
20. Chen, Ping#; Hu, Tao#; Liang, Yupei; Li, Pei; Chen, Xiaoyu; Zhang,Jingyang; Ma, Yangcheng; Hao, Qianyun; Wang, Jinwu; Zhang, Ping; Zhang, Yanmei;Zhao, Hu; Yang, Shengli; Yu, Jinha; Jeong, Lak Shin; Qi, Hui; Yang, Meng; Hoffman, Robert M.; Dong, Ziming*; Jia, Lijun*; Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4-CHOP-DR5 Axis in Human Esophageal Cancer Cells, Clinical Cancer Research, 2016, 22(16): 4145-4157.
21. Gu Chenxi, Xu Yan,Zhang Shanfeng,Guan Hongya,Song Shi,Wang Xiuli, Wang Yisheng*，Li Yuebai *, Zhao Guoqiang. miR-27a attenuates adipogenesis and promotes osteogenesis in steroid-induced rat BMSCs by targeting PPARγ and GREM1. Sci. Rep. 2016, 6：38491.
22. Yadong Wang, Shanfeng Zhang，Yan Xu，Yan Zhang，Hongya Guan，Xinjie Li，Yuebai Li*，Yisheng Wang. Upregulation of miR-192 inhibits cell growth and invasion and induces cell apoptosis by targeting TCF7 in human osteosarcoma. Tumor Biol. 2016，37: 15211–15220
23. Hu Tao; Qi Hui; Li Pei; Zhao Guoqiang; Ma Yangcheng; Hao Qianyun; Gao Chunzhi; Zhang Yilin; Wang Chunyao; Yang Meng; Hoffman Robert M; Chen Ping*; Dong Ziming*; Comparison of GFP-Expressing Imageable Mouse Models of Human Esophageal Squamous Cell Carcinoma Established in Various Anatomical Sites, Anticancer Research, 2015, 35(9): 4655-4663.
24. Ma CX, Song YL, Xiao L, Xue LX, Li WJ, Laforest B, Komati H, Wang WP, Jia ZQ, Zhou CY, Zou Y, Nemer M, Zhang SF, Bai X, Wu H*, Zang MX*. EGF is required for cardiac differentiation of P19CL6 cells through interaction with GATA-4 in a time- and dose-dependent manner. Cell Mol Life Sci. 2015; 72(10):2005–2022.
25. Yao CX, Shi JC, Ma CX, Xiong CJ, Song YL, Zhang SF, Zhang SF, Zang MX*, Xue LX*. EGF Protects Cells Against Dox-Induced Growth Arrest Through Activating Cyclin D1 Expression. J Cell Biochem. 2015; 116:1755–1765.
26. Yuqi Huo ,Xuhui Chen ,Lijun Zheng, Jinling Huo, Shanfeng Zhang ,Mingchen Wang *, Yumei Wang. Characterization of virus-like particles derived from a GII.3 norovirus strain distantly related with current dominating strains. Virus Genes. 2016,52:613–619.
27. Yuqi Huo, Wenhui Wang, Tong Ling, Xin Wan, Li Ding, Shuo Shen ,Jinling Huo, Shanfeng Zhang, MingchenWang*, YumeiWang, Yubing Liu. Chimeric VLPs with GII.3 P2 domain in a backbone of GII.4 VP1 confers novel HBGA binding ability. Virus Research. 2016,224: 1–5.
28. Zhang HF, Wang HH, Gao N, Wei JY, Tian X, Zhao Y, Fang Y, Zhou J, Wen Q, Gao J, Zhang YJ, Qian XH, Qiao HL*.Physiological content and intrinsic activities of 10 cytochrome P450 isoforms in human normal liver microsomes. J Pharmacol Exp Ther，2016, 358:1–11.
29. Zhang HF, Li ZH, Liu JY, Liu TT, Wang P, Fang Y, Zhou J, Cui MZ, Gao N, Tian X, Gao J, Wen Q, Jia LJ, Qiao HL*. Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver. Drug Metab Dispos, 2016;44(8):1193-200.
30. Lihong Zhao, Yang Mi, Hongya Guan, Yan Xu, Yingwu Mei*.Velvet antler peptide prevents pressure overload-induced cardiac fibrosis via transforming growth factor (TGF)-β1 pathway inhibition. European Journal of Pharmacology, 2016,783:33–46.
31. Zhang H, Gao N, Liu T, Fang Y, Qi B, Wen Q, Zhou J, Jia L, Qiao H*. Effect of Cytochrome b5 Content on the Activity of Polymorphic CYP1A2, 2B6, and 2E1 in Human Liver Microsomes. PLoS One. 2015 ,10(6):e0128547.
32. Sun J, Wang Y*, Li Y*, Zhao G. Downregulation of PPARγ by miR-548d-5p suppresses the adipogenic differentiation of human bone marrow mesenchymal stem cells and enhances their osteogenic potential. J Transl Med. 2014; 12:168.
33. Li JF, Li YB*, Wang Y*, Liu M, Zhao GQ. Preventive Effects of siRNA targeting PPARγ gene on steroid-induced Osteonecrosis in Rabbits. Connective Tissue Research. 2014, 55（5-6）：322-330.
34. Wang YS, Li JF, Liu M, Zhao GQ, Hao LY, Li YB*. Inhibition of peroxisome proliferator-activated receptor-γ in steroid-induced adipogenic differentiation of the bone marrow mesenchymal stem cells of rabbit using small interference RNA. Chinese Medical Journal (CMJ). 2014; 127（1）：130-136.
35. Yao CX, Wei QX, Zhang YY, Wang WP, Xue LX, Yang F, Zhang SF, Xiong CJ, Li WY, Wei ZR, Zou Y, Zang MX*. miR-200b targets GATA-4 during cell growth and differentiation. RNA Biol. 2013; 10(4):465-80.
36. Li WY, Song YL, Xiong CJ, Lu PQ, Xue LX, Yao CX, Wang WP, Zhang SF, Zhang SF, Wei QX, Zhang YY, Zhao JM, Zang MX*. Insulin induces proliferation and cardiac differentiation of P19CL6 cells in a dose-dependent manner. Dev Growth Differ. 2013; 55(7):676-86.
37. Yao CX, Wei QX, Zhang SF, Zhang SF, Zhang YY, Zhao JM, Wang TQ, Guo MF, Zang MX*. Insulin induces C2C12 cell proliferation and apoptosis through regulation of cyclin D1 and BAD expression. J Cell Biochem. 2013; 114(12):2708-17.
38. Yao CX, Xiong CJ, Wang WP, Yang F, Zhang SF, Wang TQ, Wang SL, Yu HL, Wei ZR, Zang MX*. Transcription factor GATA-6 recruits PPARα to cooperatively activate Glut4 gene expression. J Mol Biol. 2012; 415(1):143-58.
39. Li WY, Yao CX, Zhang SF, Wang SL, Wang TQ, Xiong CJ, Li YB, Zang MX*. Improvement of myocardial lipid accumulation and prevention of PGC-1α induction by fenofibrate. Mol Med Rep. 2012; 5(6):1396-400.
40. Yao CX, Li WY, Zhang SF, Zhang SF, Zhang HF, Zang MX*. Effects of Doxorubicin and Fenofibrate on the activities of NADH oxidase and citrate synthase in mice. Basic Clin Pharmacol Toxicol. 2011; 109(6):452-6.
41. Yue W, Wang JP, Li Y, Fan P, Liu G, Zhang N, Conaway M, Wang H, Korach KS,Bocchinfuso W, Santen R*. Effects of estrogen on breast cancer development: Role of estrogen receptor independent mechanisms. Int J Cancer. 2010 Oct 15;127(8):1748-57.
42. Kou X1, Shen K, An Y, Qi S, Dai WX, Yin Z. Ampelopsin inhibits H2O2-induced apoptosis by ERK and Art signaling pathways and up-regulation of heme oxygenase-1. Phytother Res. 2012, 26(7):988-94.
43. Li J, Wang Y*, Li Y, Sun J, Zhao G. The effect of combined regulation of the expression of peroxisome proliferator-activated receptor-γ and calcitonin gene-related peptide on alcohol-induced adipogenic differentiation of bone marrow mesenchymal stem cells. Molecular and Cellular Biochemistry (MCBI), 2014,392(1-2):39-48.
44. Liu M, Wang YS*, Li YB, Zhao GQ. Construction and identification of the recombinant adenovirus vector carrying a small interfering RNA targeting the peroxisome proliferator-activated receptor-γ. Chin Med J (Engl), 2012, 125:671-675.
45. Wang YS, Wang YH, Zhao GQ, Li YB. Osteogenic potential of human calcitonin gene-related peptide alpha gene-modified bone marrow mesenchymal stem cells. Chin Med J (Engl), 2011,124(23):3976-3981.
46. Wang Y, Yin L, Li Y, Liu P, Cui Q*. Preventive effects of puerarin on alcohol-induced osteonecrosis. Clin Orthop Relat Res，2008, 466(5):1059-1067.
47. Mingchen Wang， Rong Tsao. Antioxidant activity of lutein and its protective effects on ischemia-hypoxia injury in cultured rat cortical neurons. 240th American Chemical Society National meeting , August 22 - 26, in Boston，2010.
48. Mingchen Wang，Rong Tsao. The proliferation inhibition and apoptosis induction effects of Lutein on SGC-7901and MCF-7 cell lines and their relevant molecular mechanism. 2010 International Chemical Congress of Pacific Basin Societies p246（2010 pacifichem）.
49. Mingchen Wang，Rong Tsao. Protective effects of lutein on ischemia-hypoxia injury in cultured rat cortical neuron. 2010 International Chemical Congress of Pacific Basin Societies . p249（2010 pacifichem）.
50. Wang Mingchen, Zhao Guoqiang , Wang Zhiju, et al. Study on DNA polymerase β gene mutation in prostate cancer and benign prostatic hyperplasia tissues. Cell Biology International, 2005,29(10):s32.
51. Huanhuan Wang, Haifeng Zhang#, Jiabin Li, Junying Wei, Rui Zhai, Bo Peng, Hailing Qiao,Yangjun Zhang and Xiaohong Qian. A new calibration curve calculation method for absolute quantification of drug metabolizing enzymes in human liver microsomes by stable isotope dilution mass spectrometry. Anal. Methods, 2015, 7, 5934–5941.
52. Wang S, Wang M, Zhang S, Zhao L.Oxidative stress in rats with hyperhomo-cysteinemia and intervention effect of lutein.Oxidative stress in rats with hyperhomocysteinemia and intervention effect of lutein. European Review for Medical and Pharmacological Sciences 2014; 18: 359-364
53. Zhou Y, Li HR, Huang J, Jin G, Fu XD. Multiplex Analysis of polyA-linked sequences (MAPS):An RNA-Seq Strategy to Profile Poly(A+)RNA. Methods Mol Biol. 2014;1125:169-78.
54. Jimin Zhao, Kangdong Liu, Jing Lu, Junfen Ma, Xiaoyan Zhang, Yanan Jiang, Hongyan Yang, Ge Jin, Guoqiang Zhao,Mingyao Zhao and Ziming Dong. Alternatiol Induces DNA Polymerase β Expression through PKA-CRE3 Signaling Pathing. International Journal of Oncology. 40(6):1923-1928.2012 Jun.
55. Xu Y, Feng Y, Li H, Gao Z. Ferric citrate CYP2E1-independently promotes alcohol-induced apoptosis in HepG2 cells via oxidative/nitrative stress which is attenuated by pretreatment with baicalin，Food and Chemical Toxicology, 2012,50（9）：3264-3272.
56. Yan Zhang，Yi Huang，Xiaorong Deng，Yan Xu，Zhonghong Gao，Hailing Li，Iron overload-induced rat liver injury: Involvement of protein tyrosine nitration and the effect of baicalin，European Journal of Pharmacology，2012，680（1–3）：95-101.
57. Chi Z, Nie L, Peng Z, Yang Q, Yang K, Tao J, Mi Y, Fang X, Balajee AS, Zhao Y. RecQL4 cytoplasmic localization: implications in mitochondrial DNA oxidative damage repair. Int J Biochem Cell Biol. 2012, 44(11): 1942-51.
58. Mi Y, Zhang Y, Shen YF. Mechanism of JmjC-containing protein Hairless in the regulation of vitamin D receptor function. Biochim Biophys Acta, 2011, 1812(12): 1675-80
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三、 部分科研获奖和专利
1. 芦笋饮料和浓缩液的制备工艺 获国家发明专利，专利号：88.1 01978.X,安玉会 第1名。
2. 牛脑神经肽的制备方法 获国家发明专利，专利号：ZL.97.1.12508.2，安玉会 第1名。
3. 激素诱导骨髓基质细胞成脂的实验研究 获河南省科技进步二等奖，李月白 第1名。
4. 糖皮质激素性骨质疏松症发病机理和预防的实验研究 获河南省科技进步三等奖，证书号：2007－J-306-R01/07，李月白 第1名。
5. 慢性酒精中毒导致股骨头缺血性坏死的实验 获河南省科技进步三等奖，李月白,第3名。
6. 葛根素预防酒精性股骨头坏死的实验研究 获河南省科技进步三等奖，李月白，第5名 。
7. 超氧化物歧化酶和质脂过氧化物受药物影响对消化性溃疡发病和愈合作用的研究 获河南省获省科技进步三等奖，李月白，第2名。
8. DNA pol基因敲除细胞株建立及pol突变基因功能分析 获河南省科学技术进步成果奖三等奖（证书号：2013-J-322-R06/07），，李月白 第6名。
9. 骨巨细胞瘤中PCNA、P16、RB、与BCl-2基因表达及凋亡的检测研究 获河南省省教委科技进步二等奖，李月白 第1名。
10. siRNA阻断PPARγ基因表达预防酒精性股骨头坏死的实验研究 获河南省医药卫生科技成果二等奖，证书号：2010YJ026 ，李月白 第5名。
11. 煤工尘肺发生的氧毒性机理及干预途径研究 河南省医药卫生科技成果一等奖，河南省人民政府科技进步三等奖 王明臣 第1名。
12. 非小细胞肺癌个体化治疗基础与临床研究 河南省医药卫生科技成果一等奖，河南省人民政府科技进步二等奖（2008-J-137-R04/10），王明臣 第4名。
13. 我国食物成分的研究 1992年卫生部科技进步一等奖，王明臣河南课题组主要成员之一。
14. 食管癌发生的自由基机理研究––食管癌及癌前增生人群无活性SOD发现 河南省第三届自然科学优秀论文二等奖 王明臣 第1名。
15. Transcription factor GATA-6 recruits PPARα to cooperatively activate Glut4 gene expression 2013年获河南省自然科学优秀学术论文奖一等奖, 臧明玺 第1名。
16. Exendin-4高产工程菌的选育及纯化工艺 获河南省科学技术进步二等奖，证书号：2010-J-084-R03/10，张贵星 第3名。
17. 臧明玺“心肌能量代谢关键基因的鉴定及在心肌肥大中的作用”获 “河南省科学技术进步奖”二等奖.2017.
18. 臧明玺 “心肌能量代谢关键基因的鉴定及在心肌肥大中的作用” 获 “河南省教育厅科技成果奖” 二等奖.2017
19. 张海风获：“刘昌孝人才奖励基金”优秀博士生奖，2017.11.3荣誉证书，2017年11月，第三届全国药物代谢动力学青年科学家论坛暨刘昌孝人才奖颁奖大会”
20.
