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药理学系

学术研究

学术研究

一、研究方向

1、临床药理:主要进行药物代谢与药物动力学、CYP2E1与肿瘤等炎症相关疾病研究等，目的是为临床个体化用药、以及肿瘤等炎症相关疾病防治提供依据。在药物代谢与药物动力学研究方面，创建了国内领先、国际先进的肝脏CYP450药物代谢的体外研究技术平台，对CYP450的生理和病理进行了系统研究，证明CYP450基因多态性以及酶含量对药物代谢影响的有限性，为指导临床个体化用药奠定了基础；肝癌患者肝CYP450各亚型代谢活性改变不一，有的降低，有的不变，有的增高；发现CYP2E1为炎症反应中的新靶点，证明其与肿瘤等炎症相关性疾病的发生发展有关，并研发了CYP2E1特异性抑制剂。上述研究得到了重大新药创制国家科技重大专项和5项国家自然科学基金项目的资助，所创制的国家1.1类抗脑缺血新药正在进行临床研究，相关研究成果被编入人民卫生出版社出版的研究生教材《高级药理学》中。

2、遗传药理：该方向依托河南省高校药物基因组学重点实验室，在药物代谢、代谢调控及药物基因组学等方面已有近20年的研究积累；团队已建立完善的药物基因组学、代谢组学、表观遗传学检测和分析平台，重点围绕肝脏药物代谢酶的个体差异和表达调控，结合“药物基因组学”和“表观遗传学”的原理，从遗传多态性、表观遗传调控及发育早期环境因素等方面开展一系列研究，以期揭示个体对药物不同反应的机制、药物代谢酶基因表达调控机制等。近年来，团队致力于揭示表观遗传调控因子如miRNAs、组蛋白修饰和lncRNAs等在药物代谢酶个体差异性表达、发育表达及外源物诱导表达中的调控机制，取得了原创性的研究结果，形成了明显的优势。基于药物代谢酶的表达具有“时空性”，团队专注于核受体/代谢酶/转运体介导下的内/外源物代谢调控对疾病发生发展转归、合理用药及发育早期药物暴露对药物代谢酶表达的影响，对指导临床精准用药具有重要理论意义。以上相关研究获得了科技部国际合作项目、国家重点研发计划子课题、国家自然科学基金、河南省杰出人才等科研项目的资助。

3、肿瘤药理：主要进行外泌体与肿瘤标志物、消化道肿瘤及微管蛋白聚合抑制剂等方面的研究。在外泌体与肿瘤标志物研究方面，依托郑州大学“外泌体与肿瘤标志物研究中心平台”，采用多种方法联合应用筛选人体液外泌体中的肿瘤标志物，分别在细胞水平、动物模型及临床水平验证筛选出来的肿瘤标志物应用于液体活检的可行性；在消化道肿瘤研究方面，近年来通过体外和体内试验，从分子、基因、蛋白和细胞生物学行为等多个方面对其发病机制、侵袭转移及逆转肿瘤多药耐药进行了深入研究，为寻找消化道肿瘤转移和评价预后的分子标志物以及发现消化道肿瘤潜在的分子治疗靶点提供新思路；同时，还进行了微管蛋白聚合抑制剂、NEDDylation抑制剂的设计、合成、活性评价等研究，近年来设计合成得到相关500余个并探讨了其中10余个重点化合物的作用机制，并首次报道了NEDDylation激动剂作为抗胃癌药物的机制。

4、神经药理：我们的神经药理研究包括慢性疼痛发生机制的研究、小胶质细胞在神经发育和疾病中的作用研究以及新药药理研究。在慢性疼痛发生机制的研究方面，我们参与制作了国际上第二个癌痛小鼠模型，并对其发生机制进行多方面的探索。在小胶质细胞在神经发育和疾病中的作用研究方面，我们对星型胶质细胞和小胶质细胞在大鼠神经痛发生机制中的作用进行了初步探讨，同时研究小胶质细胞中P2X受体以及其相互作用蛋白在神经疾病发生过程中的作用。在新药药理研究，近年来通过体内和体外研究，开发并申请了国家1·1类新药：新型抗脑缺血药物6-溴-3-正丁基-1（3H）-异苯并呋喃酮的研发。不仅深入研究开发治疗脑缺血新药，同时通过新药药理学的研究寻找脑缺血的发病机制，为临床合理用药提供实验及理论依据。

5、心血管药理：主要方向为心血管相关疾病的机制研究，研究领域包括：心脏方面，探讨心肌缺血性疾病的发病机制，通过建立心肌梗死、缺血再灌注和基因敲除鼠的动物模型，从免疫反应参与心肌缺血损伤的角度，探讨NLRP3炎性小体活化参与心肌重构的分子机制，同时从离子通道和缝隙连接蛋白角度研究心肌缺血后心律失常发生的病理机制，从而为心肌缺血性疾病寻求新的药物治疗靶点。血管方面，通过应用组织特异性表达的模式动物，开展在血管内皮和平滑肌细胞中表达的前列腺素E2受体4亚型（EP4）在血管重塑、高血压以及高血压肾病中的作用及相关机制的研究。已获得国家自然科学基金面上项目一项，青年基金两项，河南省自然科学基金一项。

6、药物设计及纳米药物：（1）计算驱动的创新药物发现与作用机制研究：通过计算生物学、计算化学、生物信息学、分子生物学、药物化学、结构生物学等多学科交叉手段，从源头开展创新药物发现。发现药物靶标的构象动态变化机制、新口袋和新分子，并在分子、细胞和动物水平开展分子作用机理研究，为疾病的诊断和治疗提供新的探针分子、新的药物作用位点和新的先导结构，为开发具有自主知识产权的创新药物奠定基础。近年来，系统研究了G蛋白偶联受体的动态构象和激活机制，发现一批具有开发前景的活性化合物，研究结果在Nature、Science、Nature Structural & Molecular Biology、Nature Communications、Journal of Medicinal Chemistry、Journal of Biological Chemistry等国际权威杂志发表。（2）结合纳米技术、生物化学、纳米生物学和肿瘤药理学方面的理论知识和技术手段，研究纳米载体的设计、构建以及其在肿瘤药理研究中的作用。（3）纳米酶和铁蛋白的生物医学应用，探索铁蛋白药物载体和纳米材料酶学特性在肿瘤诊疗上的应用。

二、承担的国家级科研项目（2016年至今）

  1. 国家自然科学基金面上项目：CYP2E1作为炎症靶点通过调控ROS/Nrf2/HO-1通路促进类风湿性关节炎的发生发展（82173889），55万元，2022.01-2025.12（郜娜）

  2. 靶向肿瘤炎性微环境中新靶点 CYP2E1 的新型广谱抗肿瘤药的研发，2020CXZX0076，200万元，郑州市科技重大科技创新专项，2020.09-2023.08 (乔海灵，方艳)

  3. 2022年度河南省青年人才托举工程项目(2022HYTP046):靶向性纳米药物通过调控 NLRP3/caspase-1/IL-1β信号通路缓解心肌梗死后炎症损伤的研究(2022. 1 - 2024.12)，5 万,（祁迎秋）

  4. 国家自然科学基金面上项目：基于肿瘤微环境蛋白质组研究CYP2E1作为肝癌防治靶点的关键基础，56万元，2021.01-2024.12（乔海灵）

  5. 国家自然科学基金面上项目：HNF4α-AS1/HNF4α-PXR通路参与异源物质暴露后细胞色素P450酶系稳态调控的机制研究 2021.1-2024.12（张莉蓉）。

  6. 国家自然科学基金青年项目：用于增强光动力治疗的多功能仿生纳米药物在食管癌中的应用研究，2021.1-2023.12 24万（祁迎秋）

  7. 国家自然科学基金青年基金，一种改善PD-L1阻断治疗响应率的多功能纳米药物载体设计及其抗肿瘤研究，2021.1-2023.12，24万（江冰）

  8. 中国博士后科学基金第68批面上资助二等，批准号：2020M682358，铁蛋白纳米酶协同增强光热/光动力治疗肿瘤，2020.11-2021.12，8万，在研，主持（江冰）。

  9. 中国博士后科学基金第2批特别资助（站前），批准号：2020TQ0280，铁蛋白纳米酶靶向治疗脑梗死，2020.8-2021.12，18万，在研，主持。

  10. 国家自然科学基金河南省联合培育基金 NAE1 激动剂作为抗胃癌药物的设计、合成及机制研究 2021.1-2023.12（张赛扬）

  11. 国家自然科学基金青年项目，新型跨膜区变构调节剂调控胰高血糖素受体GCGR激活的分子机制研究（31900895），24万，2020/01-2022/12,(杨琳琳)

  12. 国家自然科学基金面上项目，经典和替代激活小胶质细胞中钙池操控钙内流在体作用和机制的研究（81870956），56万元，2019.01-2022.12 (徐霁）

  13. 国家自然科学基金面上项目，基于肝癌患者CYP2E1活性增高研究CYP2E1特异性抑制剂（81872931），57万元，2019.01-2022.12(乔海灵)

  14. 国家自然科学基金河南联合项目，乙醇脱氢酶I诱导肝星状细胞活化和PAI-1表达从而促进肝纤维化（U1804169），49万元，2019.01.01-2021.12.31 (郜娜)。

  15. 国家自然科学基金青年项目，CAR-HNF1A/HNF4A调控网络对新生鼠苯巴比妥暴露诱导II相酶长期表达的作用及机制（81803617），21万，2019.01-2021.12，聂亚莉

  16. 国家重点研发计划“蛋白质机器与生命过程调控”青年项目，基于GPCR 和离子通道结构的动态调控机制研究与变构调控分子发现（2018YFA0508100） ， 93万，2018.05-2023.04,(杨琳琳)

  17. 国家自然科学基金面上项目，lnc-HNF1A/HNF1A通路调控CYP3A4表达的分子机制（81773815），57.5万，2018.1-2021.12，(张莉蓉)

  18. 国家自然科学基金青年项目，内皮细胞前列腺素E2受体4亚型在血管紧张素II诱导的慢性肾损伤中的作用和机制（81700638），20万,2018.01-2020.12，(杜胜男）。

  19. 国家自然科学基金青年项目，以Flavokawain A为先导的NEDDylation抑制剂的设计、合成及作用机制研究，20.1万元，2018.1-2020.12（张赛扬）

  20. 国家自然科学基金面上项目，基于肝癌病人CYP2E1活性增高研究亚硝胺类致肝癌作用（81673507），65万元，2017.01-2020.12(乔海灵)

  21. 国家自然科学基金面上项目， GSK-3β通过调控NLRP3炎性复合体的活化介导心肌电重构的作用机（81670311），57万，2017.01-2020.12（韩圣娜）

  22. 国家自然科学基金河南联合基金，发育早期Pxr激动剂暴露对小鼠成年后药物代谢和效应的影响及表观遗传记忆机制（U1604163），46万；2017.1-2019.12，（张莉蓉）

  23. 国家博士后面上基金：GCGR和GLP-1R跨膜区激活机制的研究（2017M622365），资助金额：5万，2017/11-2019/09，（杨琳琳）

  24. 国家自然科学基金青年项目：小胶质细胞P2X4受体互作蛋白的鉴定及功能研究（31500833），20万元，2016.01-2018.12，（徐霁）。

     

     

    三、发表论文（中科院分区二区及以上SCI收录文章， 2016年至今）

    【2022年】

  25. Zhu Y, Jin L, Shi R, Li J, Wang Y, Zhang L, Liang CZ, Narayana VK, De Souza DP, Thorne RF, Zhang LR*, Zhang XD*, Wu M*. The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis. Mol Cell. 2022, 82(3):542-554. (中科院一区)

  26. Su XL, Wang SH, Komal S, Cui LG, Ni RC, Zhang LR*, Han SN*. The caspase-1 inhibitor VX765 upregulates connexin 43 expression and improves cell-cell communication after myocardial infarction via suppressing the IL-1β/p38 MAPK pathway. Acta Pharmacol Sin. 2022. doi: 10.1038/s41401-021-00845-8. （中科院一区）

  27. Wang XF, Yu YH, Wang P, Yang K, Wang YT, Yan L, Zhong XB, Zhang LR*. Long noncoding RNAs hepatocyte nuclear factor 4A antisense RNA 1 and hepatocyte nuclear factor 1A antisense RNA 1 are involved in ritonavir-induced cytotoxicity in hepatoma cells. Drug Metab Dispos. 2022, 50(5):704-715.（中科院二区）

  28. Jian Song, Yong-Feng Guan, Wen-Bo Liu, Chun-Hong Song, Xin-Yi Tian, Ting Zhu, Xiang-Jing Fu, Ying-Qiu Qi*, Sai-Yang Zhang*. Discovery of novel coumarin-indole derivatives as tubulin polymerization inhibitors with potent anti-gastric cancer activities[J]. European Journal of Medicinal Chemistry, 2022, 238, 114467(中科院一区)

  29. Yin-Ru Li#, Fang-Fang Liu#, Wen-Bo Liu, Yi-Fan Zhang, Xin-Yi Tian, Xiang-Jing Fu, Yan Xu, Jian Song*, Sai-Yang Zhang*. A novel aromatic amide derivative SY-65 co-targeted tubulin and histone deacetylase 1 with potent anticancer activity in vitro and in vivo[J]. Biochemical Pharmacology, 2022, 201, 115070(中科院二区)

  30. Gu Y#, Guo Y#, Gao N#, Fang Y#, Xu C, Hu G, Guo M, Ma Y, Zhang Y, Zhou J, Luo Y, Zhang H, Wen Q, Qiao H*. The proteomic characterization of the peritumor microenvironment in human hepatocellular carcinoma. Oncogene. 2022;41(17):2480-2491.

  31. Wang C#, Gao N#, Yang L, Guo Y, Fang Y, Wang T, Xu C, Li GF, Zhou J, Zhang Y, Wen Q, Qiao H*. Stat4 rs7574865 polymorphism promotes the occurrence and progression of hepatocellular carcinoma via the Stat4/CYP2E1/FGL2 pathway. Cell Death Dis. 2022; 13(2):130.

  32. Fang Y, Yang H, Hu G, Lu J, Zhou J, Gao N, Gu Y, Zhang C, Qiu J, Guo Y, Zhang Y, Wen Q, Qiao H*. The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcino ma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics. J Transl Med. 2022;20(1):88.

  33. Ya-Xin Sun#, Jian Song#, Li-Jun Kong, Bei-Bei Sha, Xin-Yi Tian, Xiu-Juan Liu, Tao Hu, Ping Chen*, Sai-Yang Zhang*. Design, synthesis and evaluation of novel bis-substituted aromatic amide dithiocarbamate derivatives as colchicine site tubulin polymerization inhibitors with potent anticancer activities[J]. European Journal of Medicinal Chemistry, 2022, 229, 114069(中科院一区)

  34. Chong Liu#*, Jian Song #, Xin-Xin Cui#, Wen-Bo Liu, Yin-Ru L, Guang-Xi Yu, Xin-Yi Tian, Ya-Feng Wang*, Yang Liu*, Sai-Yang Zhang*. Discovery of novel 1,2,4-triazine-chalcone hybrids as anti-gastric cancer agents via an axis of ROS-ERK-DR5 in vitro and in vivo[J]. Arabian Journal of Chemistry, 2022, 15(3), 103644(中科院二区

     

    【2021年】

  35. Hongtao Liu#*, Qing Zhang#, Yinsen Song, Yibin Hao, Yunxia Cui, Xin Zhang, Xueying Zhang, Yue Qin, Guangzhao Zhu, Feng Wang, Jinghan Dang, Shanshan Ma, Yanting Zhang, Wenna Guo, Shenglei Li*, Fangxia Guan*, Tianli Fan*. Long non-coding RNA SLC2A1-AS1 induced by GLI3 promotes aerobic glycolysis and progression in esophageal squamous cell carcinoma by sponging miR-378a-3p to enhance Glut1 expression, J Exp Clin Cancer Res, 2021 Sep 13;40(1):287, doi: 10.1186/s13046-021-02081-8（中科院一区；IF：11.161）

  36. Jing Li, Na Gao, Zhengfan Gao, Wei Liu, Bairen Pang, Xingli Dong, Yong Li*, Tianli Fan*. The emerging role of exosomes in cancer chemoresistance. Front Cell Dev Biol. 2021, 28;9:737962. doi: 10.3389/fcell.2021.737962. eCollection 2021（中科院二区；IF：6.684

  37. Zhengfan Gao, Bairen Pang, Jing Li, Na Gao, Tianli Fan*, Yong Li* Emerging role of exosomes as liquid biopsy for monitoring prostate cancer invasion and metastasis. Front Cell Dev Biol 2021;5:679527（中科院二区；IF：6.684）

  38. Bai X, Ni J, Beretov J, Wasinger WC, Wang S, Zhu Y, Graham P, Li Y*. Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis. Redox Biol, 2021;43:101993 (中科院一区，IF: 12)

  39. Tian W, Lei N, Zhou J, Chen M, Guo R, Qin B, Li Y*, Chang L*. Exosomes in ovarian cancer chemoresistance, metastasis and immune evasion. Cell Death Dis, in revision 2021 (中科院二区，IF: 8.3)

  40. Bai X, Ni J, Beretov J, Wang S, Dong X, Graham P, Li Y*. Thoc2 and Thoc5 regulate stemness and radioresistance in triple-negative breast cancer. Adv Sci, 2021 Dec;8(24):e2102658. doi: 10.1002/advs.202102658. (中科院一区，IF:16.8)

  41. Wang RJ, Cao LX, Thorne RF, Zhang XD, Li JM, Shao FM*, Zhang LR*, Wu M*. LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation. Sci Adv. 2021,7(13)   2375-2548. (中科院一区)

  42. Zhang Z, Lu SS, Dunmall LSC, Wang ZZ, Cheng ZG, Zhang ZX, Yan WL, Chu YC, Gao DL, Wang N, Li Y, Wang JW, Li YN, Ji YP, Shan DY, Li KK, Wang PP, Dong YS, Dong JZ, Lemoine NR, Pei DQ, Zhang LR*, Wang YH*. Treatment and prevention of lung cancer using a Virus-Infected Reprogrammed Somatic Cell-Derived Tumor Cell Vaccination (VIReST) regime. Front Immunol. 2020, 11:1996.(中科院二区)

  43. Lan Q, Liu PY, Bell JL, Wang JY, Hüttelmaier S, Zhang XD*, Zhang LR*, Liu T*. The Emerging Roles of RNA m(6)A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance. Cancer Res. 2021,81(13):3431-40. (中科院一区)

  44. Wang P, Chen ST, Wang YT, Wang XF, Yan L, Yang K, Zhong XB, Han SN, Zhang LR*. The long noncoding RNAhepatocyte nuclear factor 4α antisense RNA 1 negatively regulates cytochrome P450 enzymes in huh7 cells via histone modifications. Drug Metab Dispos. 2021,49(5):361-368. (中科院二区)

  45. Jin-Bo Niu*, Chun-Hua Quan, Yuan Liu, Guang-Xi Yu, Jia-Jia Yang, Yin-Ru Li,Yan-Bing Zhang, Ying-Qiu Qi, Jian Song*, Cheng-Yun Jin* & Sai-Yang Zhang*. Discovery of N-aryl sulphonamide-quinazoline derivatives as anti-gastric cancer agents invitro and invivo via activating the Hippo signalling pathway[J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 36:1, 1715-1731, DOI: 10.1080/14756366.2021.1958211(中科院二区)

  46. Jian Song, Yuan Liu, Xin-Ying Yuan, Wen-Bo Li, Yin-Ru Li, Guang-Xi Yu, Xin-Yi Tian, Yan-Bing Zhang, Xiang-Jing Fu*, Sai-Yang Zhang*. Discovery of 1,2,4-triazine dithiocarbamate derivatives as NEDDylation agonists to inhibit gastric cancers[J]. Eur J Med Chem. 2021 Aug 26;225:113801. doi: 10.1016/j.ejmech.2021.113801. (中科院一区)

  47. Xiu-Juan Liu, Xu-Liu, Xiao-Jing Pang, Xin -Ying Yuan, Guang-Xi Yu, Yin-Ru Li, Yong-Feng Guan, Yan-Bing Zhang, Jian Song*, Qiu-Rong Zhang*, Sai-Yang Zhang*. Progress in the development of small molecular inhibitors of the Bruton's tyrosine kinase (BTK) as a promising cancer therapy[J]. Bioorg Med Chem. 2021 Aug 10;47:116358. doi: 10.1016/j.bmc.2021.116358(中科院二区)

  48. Shu-Yu Wang, Xu Liu, Ling-Wei Meng, Miao-Miao Li, Yin-Ru Li, Guang-Xi Yu, Jian Song, Hong-Yu Zhang, Ping Chen, Sai-Yang Zhang*, Tao Hu*. Discovery of indoline derivatives as anticancer agents via inhibition of tubulin polymerization [J]. Bioorg Med Chem Lett. 2021, 45, 128131. DOI: 10.1016/j.bmcl.2021.128131. (中科院二区)

  49. Ting Zhu, Sheng-Hui Wang, Dong Li, Shu-Yu Wang, Xu Liu, Jian Song, Ya-Ting Wang*, Sai-Yang Zhang*, Progress of tubulin polymerization activity detection methods[J]. Bioorg Med Chem Lett. 2021, 37, 127698. DOI: 10.1016/j.bmcl.2020.127698. (中科院二区)

  50. Dong-Jun Fu*, Xin-Xin Cui, Ting Zhu, Yan-Bing Zhang, Yang-Yang Hu, Li-Rong Zhang, Sheng-Hui Wang, Sai-Yang Zhang*, Discovery of novel indole derivatives that inhibit NEDDylation and MAPK pathways against gastric cancer MGC803 cells[J]. Bioorganic chemistry. 2021, 107, 104634. DOI: 10.1016/j.bioorg.2021.104634. (中科院一区)

  51. Ting Zhu, Xu Liu, Jian Song, Dong Li, Xiao-Jing Pang, Sheng-Hui Wang, Qing-Rong Li, Dong-Jun Fu, Sai-Yang Zhang*, Han-Zhong Xie*, Ras/Raf/MEK/ERK pathway axis mediated neurotoxicity induced by high-risk pesticide residue-Avermectin[J]. Environmental Toxicology, 2021;36:984–993. DOI: 10.1002/tox.23086. (中科院二区)

  52. Bing Jiang#, Xiaohua Jia#, Tianjiao Ji, Meng Zhou, Kun Wang, Jie Tian*, Xiyun Yan*, Kelong Fan*. Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting. Science China Life Sciences, 2021, 1-13. （第一作者，IF: 6.038，中科院1区）

  53. Hu G, Gao F, Wang G, Fang Y, Guo Y, Zhou J, Gu Y, Zhang C, Gao N, Wen Q, Qiao H*. Use of proteomics to identify mechanisms of hepatocellular carcinoma with the CYP2D6*10 polymorphism and identification of ANGPTL6 as a new diagnostic and prognostic biomarker. J Transl Med. 2021;19(1):359.

  54. Zhang HF, Zhu LL, Yang XB, Gao N, Fang Y, Wen Q, Qiao HL*. Variation in the expression of cytochrome P450-related miRNAs and transcriptional factors in human livers: Correlation with cytochrome P450 gene phenotypes. Toxicol Appl Pharmacol. 2021;412:115389.

  55. J. Wang#, D. H. Yang#, X. Cheng#, L. L. Yang#, Z. H. Wang, A. T. Dai, X. Q. Cai, C. Zhang, E. Yuliantie, Q. F. Liu, H. L. Jiang, Hong Liu*, M. W. Wang*, H. Y. Yang*. Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site. ACS chemical biology. 2021 Nov 19;16(11):2444-2452.doi: 10.1021/acschembio.1c00552. Epub 2021 Sep 27. (中科院二区)

  56. S.K. Zuo, B. Wang, J. Liu, D.P. Kong, H. Cui, Y.N. Jia, C.Y. Wang, X. Xu, G.L. Chen, Y.Y. Wang, L.L. Yang, K. Zhang, D. Ai, J. Du, Y.J. Shen*, Y. Yu*. ER-anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6. EMBO J. 2021 Aug 16; 40(16):e107403. doi: 10.15252/embj.2020107403. Epub 2021 Jul 5  (中科院一区)

    【2020年】

  57. Na Gao, Yueheng Li, Jing Li, Zhengfan Gao, Zhenzhen Yang, Yong Li, Hongtao Liu*,Tianli Fan*, Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers. Front Oncol. 2020 Dec 18;10:598817. doi: 10.3389/fonc.2020.598817. eCollection 2021（中科院二区；IF：6.244）

  58. Bing Jiang#, Xuehui Chen#, Guoming Sun, Xiangru Chen, Yufang Yin, Yiliang Jin, Qian Mi, Long Ma, Yili Yang, Xiyun Yan*, Kelong Fan*. A natural drug entry channel in the ferritin nanocage. Nano Today, 2020; 35: 100948. （第一作者，IF:20.722，中科院1区）

  59. Bing Jiang, Long Fang, Kongming Wu, Xiyun Yan*, Kelong Fan*. Ferritins as natural and artificial nanozymes for theranostics. Theranostics, 2020,10(2): 687-706. （第一作者，IF: 11.556，中科院1区）B

  60. B Pang, Y Zhu, J Ni, J Thompson, D Malouf, J Bucci, P Grahamand, Y Li. Extracellular vesicles: the next generation of biomarkers for liquid biopsy-based prostate cancer diagnosis. Theranostics, 2020,10(5): 2309-2326.（通讯作者，中科院一区）

  61. J. Ni, B. B. Cheung, J. Beretov, W. Duan, J. Bucci, D. Malouf, P. Grahamand, Y. Li. 2020. CD44 variant 6 is associated with prostate cancer growth and chemo-radiotherapy response in vivo. 2020, Exp Cell Res, 388(2): 111850. （通讯作者，中科院二区）

  62. J Wang, J Ni, J Beretov, J Thompson, P Grahamand, Y Li. Exosomal microRNAs as liquid biopsy biomarkers in prostate cancer. Critical Reviews in Oncology/Hematology, 2020, 145:102860, （通讯作者，中科院二区）

  63. P.H.L Tran, D. Xiang, T.T.D Tran, W. Yin, Y. Zhang, L. Kong, K. Chen, M. Sun, Y Li, Y. Hou, Y. Zhu and W. Duan. Exosomes and Nanoengineering: A Match Made for Precision Therapeutics. 2020，32(18). e1904040.（中科院一区）

  64. Gao Y, Cao XY, Zhang XJ, Wang YJ, Huang H, Meng YG, Chang JB. Brozopine Inhibits 15-LOX-2 Metabolism Pathway After Transient Focal Cerebral Ischemia in Rats and OGD/R-Induced Hypoxia Injury in PC12 Cells. Frontiers in Pharmacology. 2020, Feb 21;11:99. （中科院二区）

  65. Xu H, Fang B, Du S, Wang S, Li Q, Jia X, Bao C, Ye L, Sui X, Qian L, Luan Z, Yang G, Zheng F, Wang N, Chen L, Zhang X, Guan Y. Endothelial cell prostaglandin E2 receptor EP4 is essential for blood pressure homeostasis. JCI Insight. 2020;5(13):138505. Published 2020 Jul9. (中科院二区)

  66. Xu H, Du S, Fang B, Li C, Jia X, Zheng S, Wang S, Li Q, Su W, Wang N, Zheng F, Chen L, Zhang X, Gustafsson JÅ, Guan Y. VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure. Proc Natl Acad Sci U S A. 2019;116(17):8457-8462. （中科院一区）

  67. Jian Song, Qiu-Lei Gao, Bo-Wen Wu, Ting Zhu, Xin-Xin Cui, Cheng-Jun Jin, Shu-Yu Wang, Sheng-Hui Wang, Dong-Jun Fu, Hong-Min Liu,  Sai-Yang Zhang*, Yan-Bing Zhang*, Yong-Chun Li*,Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents invitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway[J]. European Journal of Medicinal Chemistry, 2020, 203, 112618. (共同通讯作者，中科院一区)

  68. Dong-Jun Fu, Jian Song, Ting Zhu, Xiao-Jing Pang, Sheng-Hui Wang, Yan-Bing Zhang, Bo-Wen Wu, Jun-Wei Wang, Xiao-lin Zi, Sai-Yang Zhang*, Hong-Min Liu. Discovery of novel tertiary amide derivatives as NEDDylation pathway activators to inhibit the tumor progression in vitro and in vivo[J]. European Journal of Medicinal Chemistry, 2020, 192, 112153.(通讯作者，中科院一区)

  69. Q Zhang#, F Guan#, T Fan#, S Li ,S Ma ,Y Zhang, W Guo, H Liu. LncRNA WDFY3-AS2 suppresses proliferation and invasion in oesophageal squamous cell carcinoma by regulating miR-2355-5p/SOCS2 axis. J Cell Mol Med，2020 Jun 14;24(14):8206-8220.(中科院二区)

  70. Wasnik S, Tang X, Bi H, Abdipour A, E Carreon E, Sutjiadi B, Lyu J, Zhang J, Wilson S, Baylink DJ. IGF-1 Deficiency Rescue and Intracellular Calcium Blockade Improves Survival and Corresponding Mechanisms in a Mouse Model of Acute Kidney Injury. International journal of molecular science, 2020 Jun 8;21(11):4095. (中科院二区)

  71. Zhang L, Li Y, Dong X, Zhou W, Wang C, Mao Z, Yang X, Fan M, Han S, Li L. Effect of the Age at Menarche and Menopause Status Interaction on Type 2 Diabetes: The Henan Rural Cohort Study. J Clin Endocrinol Metab. 2020 Mar 1;105(3). (中科院二区)

  72. Qiao XM, Zhu YS, Dang W, Wang RZ, Sun MZ, Chen YY, Shi YH, Zhang LR. Dual-specificity phosphatase 15 (DUSP15) in the nucleus accumbens is a novel negative regulator of morphine-associated contextual memory [J]. Addiction Biology, 2020. (中科院二区)

  73. Wang P, Shao XY, Bao YF, Zhu JJ, Chen LM, Zhang LR, Ma XC, Zhong XB. Impact of obese levels on the hepatic expression of nuclear receptors and drug-metabolizing enzymes in adult and offspring mice [J]. Acta Pharmaceutica Sinica B, 2020, 10(1): 171-185. (中科院一区)

  74. Li SP, Zhang YL, Ho SH, Li BZ, Wang MF, Deng XW, Yang N, Liu GN, Lu ZF, Xu JC, Shi QW, Han JY, Zhang LR, Wu Y, Zhao YL, Nie GJ. Combination of tumour-infarction therapy and chemotherapy via the co-delivery of doxorubicin and thrombin encapsulated in tumour-targeted nanoparticles [J]. Nature Biomedical Engineering, 2020, 4(7): 732-742. 62 (中科院一区)

  75. Lu SS, Zhang Z, Du P, Chard LS, Yan WL, El Khouri M, Wang ZZ, Zhang ZX, Chu YC, Gao DL, Zhang QX, Zhang LR, Nagano A, Wang J, Chelala C, Liu J, Chen JK, Liu PT, Dong YS, Wang SD, Li XZ, Dong JZ, Lemoine NR, Pei DQ*, Wang YH*. A Virus-Infected, Reprogrammed Somatic Cell-Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer [J]. Clinical Cancer Research, 2020, 26(2): 465-476. (中科院一区)

  76. Wu F, Yang L, Hang K, Laursen M, Wu L, Han GW, Ren Q, Roed NK, Lin G, Hanson MA, Jiang H, Wang MW, Reedtz-Runge S, Song G, Stevens RC. Full-length human GLP-1 receptor structure without orthosteric ligands. Nature Communications. 2020 Mar 9; 11(1):1272.（中科院一区）

  77. Yang Chen#, Linlin Yang#, Hui Qiao, Zhongyu Cheng, Jiahao Xie, Wenjuan Zhou, Xin Huang, Yaoxuan Jiang, Bin Yu*, Wen Zhao*. Discovery of new thieno[3,2-d]pyrimidine derivatives targeting EGFRL858R/T790M NSCLCs by the conformation constrained strategy. European Journal of Medicinal Chemistry. 2020.199 (2020). (中科院一区）

  78. S. Wang#, S. Q. Wang#, Q. X. Teng#, L. L. Yang#, Z. N. Lei, X. H. Yuan, J. F. Huo, X. B. Chen, M. R. Wang, B. Yu*, Z. S. Chen*, H. M. Liu*. Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5- a]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators. Journal of Medicinal Chemistry. 2020 Dec 24;63(24):15979-15996 (中科院一区)

  79. Min H,Qi Y, Zhang Y, Han X, Cheng K, Liu Y, Liu H, Hu J, Nie G, Li Y. A Graphdiyne Oxide-Based Iron Sponge with Photothermally Enhanced Tumor-Specific Fenton Chemistry. Adv. Mater. 2020 Jun 28:e2000038. (中科院一区)

  80. Wang SH, Su XL, Xu LN, Chang C, Yao Y, Komal S, Cha XX, Zang MX, Ouyang XS, Zhang LR*, Han SN*. Glycogen synthase kinase-3β inhibition alleviates activation of the NLRP3 inflammasome in myocardial infarction. J Mol Cell Cardiol. 2020, 149:82-94.(中科院二区)

    【2019年】

  81. Ni J, Bucci J, Malouf D, Knox M, Graham P, Li Y. Exosomes in Cancer Radioresistance. Front Oncol. 2019 Sep 6;9:869. 2019. (2区)

  82. Tsao T, Beretov J, Ni J, Bai X, Bucci J, Graham P, Li Y. Cancer stem cells in prostate cancer radioresistance. Cancer Lett. 2019 Nov 28;465:94-104. (1区)

  83. Feng X, Bai X, Ni J, Wasinger VC, Beretov J, Zhu Y, Graham P, Li Y. CHTOP in Chemoresistant Epithelial Ovarian Cancer: A Novel and Potential Therapeutic Target. Front Oncol. 2019 Jun 27;9:557. ( 2区)

  84. Chang L, Ni J, Zhu Y, Pang B, Graham P, Zhang H, Li Y＊. Liquid biopsy in ovarian cancer: recent advances in circulating extracellular vesicle detection for early diagnosis and monitoring progression. Theranostics. 2019 May 31; 9(14):4130-4140. (1区)

  85. Wang Y, Yan L, Liu J, Chen S, Liu G, Nie Y, Wang P, Yang W, Chen L, Zhong X, Han S, Zhang L. The HNF1α-regulated lncRNA HNF1α-AS1 is involved in the regulation of cytochrome P450 expression in human liver tissues and huh7 Cells. J Pharmacol Exp Ther. 2019 Mar;368(3):353-362. （中科院二区）

  86. Wang P, Liu GM, Nie YL, Han SN, Li JF, Zhong XB, Zhang LR. Epigenetic Memory Is Involved in the Persistent Alterations of Drug-Processing Genes in Adult Mice Due to PCN-Activated PXR During Early Life. Toxicological Sciences, Volume 172, Issue 1, November 2019, Pages 98–108. （中科院二区）

  87. Cha X, Han S, Yu J, Zhang S, Yu S, Fu D, Yao M, Zhang L, Feng G. Inulin with a low degree of polymerization protects human umbilical vein endothelial cells from hypoxia/reoxygenation-induced injury. Carbohydr Polym. 2019 Jul 15;216:97-106. （第一作者，中科院一区）

  88. Jian-Song#, Qiu-Lei Gao#, Bo-Wen Wu, Dong Li, Lei Shi, Ting Zhu, Jian-Feng Lou, Cheng-Yun Jin, Yan-Bing Zhang, Sai-Yang Zhang*,Hong-Min Liu, Novel tertiary sulfonamide derivatives containing benzimidazole moiety as potent anti-gastric cancer agents: Design, synthesis and SAR studies[J]. European Journal of Medicinal Chemistry, 2019, 183, 111731.(通讯作者，中科院一区)

  89. Dong-Jun Fu#, Miao-Miao Li#, Sai-Yang Zhang#, Jiang-Feng Li, Bei-Bei Sha, Long-Hao Wang, Yan-Bing Zhang, Ping Chen*, Tao Hu*, Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosis[J]. Bioorganic Chemistry, 2019, 92, 103190. （中科院二区）

  90. Dong-Jun Fu, Ping Li, Bo-Wen Wu, Xin-Xin Cui, Cheng-Bin Zhao, Sai-Yang Zhang*，Molecular diversity of trimethoxyphenyl-1,2,3-triazole hybrids as novel colchicine site tubulin polymerization inhibitors[J]. European Journal of Medicinal Chemistry, 2019, 165, 309. (通讯作者，中科院一区)

  91. Dong-Jun Fu, Jia-Huan Li, Jia-Jia Yang, Ping Li, Yan-Bing Zhang, Simeng Liu, Zhong-Rui Li, Sai-Yang Zhang*, Discovery of novel chalcone-dithiocarbamates as ROS-mediated apoptosis inducers by inhibiting catalase[J]. Bioorganic Chemistry, 2019, 86, 375. （中科院二区）

  92. Song DK, Powles T, Shi L, Zhang LR, Ingersoll MA, Lu YJ. Bladdercancer, a unique model to understand cancer immunity and develop immunotherapy approaches. J Pathol. 2019 Oct; 249(2):151-165. （中科院一区）

  93. S. Wang#, L.J. Zhao#, X. J. Shi#, L. N. Ding#, L. L. Yang, Z. Z. Wang, D. D. Shen, K. Tang, X. J. Li, M. Mamun, H. J. Li, B. Yu*, Y. C. Zheng*, S. M. Wang*, and H. M. Liu* The Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5-a]pyrimidine-Based Inhibitors Targeting the DCN1–UBC12 Protein–Protein Interaction. Journal of Medicinal Chemistry, 2019 Mar 14; 62 (5): 2772–2797. (中科院一区)

  94. Z. R. Li, S. Wang, L. L. Yang, X. H. Yuan, F. Z. Suo, B. Yu*，H. M. Liu* Experience-based discovery (EBD) of aryl hydrazines as new scaffolds for the development of LSD1/KDM1A inhibitors. European Journal of Medicinal Chemistry. 2019 Mar 15; 166:432-444.(中科院一区）

  95. Xiao Kang, Gao Jie, Weng Shi-Jia, Fang Yan, Gao Na, Wen Qiang, Jin Han, Qiao Hai-Ling*. CYP3A4/5 activity probed with testosterone and midazolam: Correlation between two substrates at the microsomal and enzyme levels. Mol Pharm 2019, 16(1):382-392  （中科院二区）

  96. Wen Qiang, Jiao Xin-Wei, Kuang Fei, Hou Bei-Bei, Zhu Ya-Jing, Guo Wen-Yu, Sun Guang-Xin, Ba Yu-Feng, Yu Dan-Dan, Wang David, Zhang Fa-Ya, Qiao Hui- Chao, Wang Shuo-Lin, Tang Shu*, Qiao Hai-Ling*. FoxO3ainhibiting expression of EPS8 to prevent progression of NSCLC: A new negative loop of EGFR signaling. E Bio Medicine 2019, 40:198-209 （中科院二区）

  97. Guo Yuan-Yuan, Xu Chen, Fang Yan, Wang Cai-E, Gao Na, Wen Qiang, Qiao Hai-Ling*. High CYP2E1 activity aggravates hepatofibrosis by limiting macrophage polarization towards the M2 phenotype. Mol Carcinog. 2019; 58(8):1481-1491（中科院二区）

  98. Fang Yan, Wang Tong, Guo Yuan-Yuan, Zhang Hai-Feng, Wen Qiang, Xing Yu-Rong*, Gao Na*, Qiao Hai-Ling*. From Genotype to Phenotype: Content and Activities of Cytochromes P450 2A6 in Human Liver In Vitro and Predicted In Vivo. J Pharmacol Exp Ther 2020,372:320-330 （中科院二区）

  99. Min H, Qi Y, Chen Y, Zhang Y, Han X, Xu Y, Liu Y, Hu J, Liu H, Li Y, Nie G. Synthesis and Imaging of Biocompatible Graphdiyne Quantum Dots. ACS Appl. Mater. Interfaces 2019. 11(36)，32798-32807.（中科院一区）

  100. Zhang L, Qi Y, Min H, Ni C, Wang F, Wang B, Qin H, Zhang Y, Liu G, Qin Y, Duan X, Li F, Han X, Tao N, Zhang L, Qin Z, Zhao Y, Nie G. Cooperatively Responsive Peptide Nanotherapeutic that Regulates Angiopoietin Receptor Tie2Activity in Tumor Microenvironment To Prevent Breast Tumor Relapse after Chemotherapy. ACS Nano 2019, 13 (5), 5091-5102.（中科院一区）

  101. Min H, Wang J, Qi Y, Zhang Y, Han X, Xu Y, Xu J, Li Y, Chen L, Cheng K, Liu G, Yang N, Li Y, Nie G. Biomimetic Metal-Organic Framework Nanoparticles for Cooperative Combination of Antiangiogenesis and Photodynamic Therapy for Enhanced Efficacy. Adv. Mater. 2019, 31 (15). （中科院一区）

  102. Han X, Xu Y, Li Y, Zhao X, Zhang Y, Min H, Qi Y, Anderson GJ, You L, Zhao Y, Nie G.  An Extendable Star-Like Nanoplatform for Functional and Anatomical Imaging-Guided Photothermal Oncotherapy. ACS Nano 2019, 13 (4), 4379-4391.（中科院一区）

  103. Taleb M, Ding Y, Wang B, Yang N, Han X, Du C, Qi Y, Zhang Y, Sabet ZF, Alanagh HR, Mujeeb A, Khajeh K, Nie G. Dopamine Delivery via pH-Sensitive Nanoparticles for Tumor Blood Vessel Normalization and an Improved Effect of Cancer Chemotherapeutic Drugs. Adv. Healthc. Mater. 2019. （中科院一区）

  104. Xu J, Zhang Y, Xu J, Wang M, Liu G, Wang J, Zhao X, Qi Y, Shi J, Cheng K, Li Y, Qi S, Nie G. Reversing tumor stemness via orally targeted nanoparticles achieves efficient colon cancer treatment. Biomaterials2019, 216. （中科院一区）

  105. Lang J, Zhao X, Qi Y, Zhang Y, Han X, Ding Y, Guan J, Ji T, Zhao Y, Nie G. Reshaping Prostate Tumor Microenvironment To Suppress Metastasis via Cancer-Associated Fibroblast Inactivation with Peptide-Assembly-Based Nanosystem. ACS Nano 2019, （中科院一区）

  106. Liu S, Zhang Y, Zhao X, Wang J, Di C, Zhao Y, Ji T, Cheng K, Wang Y, Chen L, Qi Y, Li S, Nie G. Tumor-Specific Silencing of Tissue Factor Suppresses Metastasis and Prevents Cancer-Associated Hypercoagulability. Nano Letters 2019, 19 (7), 4721-4730.（中科院一区）

  107. Kuai Q, Wang Y, Gao F, Qi Y, Wang R, Wang Y, Lu X, Zhao Y, Nie G, He M, Zhou H, Jiang X, Ren S, Yu Q. Peptide Self-Assembly Nanoparticles Loaded with Panobinostat to Activate Latent Human Immunodeficiency Virus. Journal of Biomedical Nanotechnology 2019, 15 (5), 979-992. （中科院二区）

     

    【2018年】

  108. Zhang H, Qiao A, Yang L, Van Eps N, Frederiksen KS, Yang D, Dai A, Cai X,Zhang H, Yi C,Cao C, He L, Yang H, Lau J, Ernst OP, Hanson MA, Stevens RC, Wang MW, Reedtz-Runge S, Jiang H, Zhao Q, Wu B. Structure of the glucagon receptor in complex with a glucagon analogue. Nature. 2018 Jan 3;553(7686):106-110. （中科院一区）

  109. Cao C, Tan Q, Xu C, He L, Yang L, Zhou Y, Zhou Y, Qiao A, Lu M, Yi C, Han GW,Wang X, Li X, Yang H, Rao Z, Jiang H, Zhao Y, Liu J, Stevens RC, Zhao Q, Zhang XC, Wu B. Structural basis for signal recognition and transduction by platelet-activating-factor receptor. Nat Struct Mol Biol. 2018 Jun;25(6):488-495. （中科院一区）

  110. Ouyang X, Han SN, Zhang JY, Dioletis E, Nemeth BT, Pacher P, Feng D, Bataller R, Cabezas J, Stärkel P, Caballeria J, LePine Pongratz R, Cai SY, Schnabl B,Hoque R, Chen Y, Yang WH, Garcia-Martinez I, Wang FS, Gao B, Torok NJ, Kibbey RG, Mehal WZ. Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis. Cell Metab. 2018 May 1;27(5):1156. （中科院一区）

  111. Liming Chen, Yifan Bao, Stephanie C. Piekos, Kexin Zhu, Lirong Zhang, and Xiao-bo Zhong. A Transcriptional Regulatory Network Containing Nuclear Receptors and lncRNAs Controls Basal and Drug-Induced Expression of Cytochrome P450s in HepaRG Cells， Molecular Pharmacology（中科院二区）

  112. Dong-Jun Fu , Jia-Jia Yang , Ping Li , Yu-Hui Hou, Sheng-Nan Huang, Matthew Alexander Tippin, Victor Pham, Lian-kun Song, Xiao-lin Zi, Wei-Li Xue, Li-Rong Zhang, Sai-Yang Zhang. Bioactive heterocycles containing a 3,4,5-trimethoxyphenyl fragment exerting potent antiproliferative activity through microtubule destabilization. European Journal of Medicinal Chemistry 157 (2018) 50e61（中科院二区）

  113. Pei Wang, Ya-li Nie, Shu-jie Wang, Lin-lin Yang, Wei-hong Yang, Jiang-feng Li, Xiao-tian Li2 & Li-rong Zhang. Regulation of UGT1A expression by miR-298 in human livers from the Han Chinese population and in human cell lines. Epigenomics (2018) 10(1), 43–57（中科院二区）

  114. Dong-Jun Fu, Ping Li, Jian-Song, Sai-Yang Zhang*, Han-Zhong Xie*. Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues –Chlorpyrifos and Carbofuran via oxidative stress [J]. Toxicology in Vitro, 2019, 54, 338. (通讯作者，中科院二区)

  115. Dong-Jun Fu, Jia-Jia Yang, Ping Li, Yu-Hui Hou, Sheng-Nan Huang, Matthew Alexander Tippin, Victor Pham, Lian-kun Song, Xiao-lin Zi, Wei-Li Xue, Li-Rong Zhang*, Sai-Yang Zhang*. Bioactive heterocycles containing a 3,4,5-trimethoxyphenyl fragment exerting potent antiproliferative activity through microtubule destabilization [J]. European Journal of Medicinal Chemistry, 2018, 157(5): 50. (通讯作者，中科院二区)

  116. Gao Jie, Wang Zhao, Wang Gao-Ju, Zhang Hong-Xin, Gao Na, Wang Jie, Wang Cai-E,Chang Zhao, Fang Yan, Zhang Yun-Fei, Zhou Jun, Jin Han，Qiao Hai-Ling*. Higher CYP2E1 activity correlates with hepatocarcinogenesis induced by diethylnitrosamine.  J Pharmacol Exp Ther 2018,365(2):398-407 （中科院二区）

  117. Fang Yan, Gao Na, Tian Xin, Zhou Jun, Zhang Hai-Feng, Gao Jie, He Xiao-Pei, Wen Qiang, Jia Lin-Jing, Jin Han, Qiao Hai-Ling*. Effect of P450 oxidoreductase polymorphisms on the metabolic activities of ten cytochrome P450s varied by polymorphic CYP genotypes in human liver microsomes. Cell PhysiolBiochem2018;47:1604-1616 （中科院二区）

  118. Xu Chen, Gao Jie, Zhang Hai-Feng, Gao Na, Guo Yuan-yuan, Fang Yan, Wen Qiang, Qiao Hai-Ling*. Content and Activities of UGT2B7 in Human Liver In Vitro and Predicted In Vivo: A Bottom-Up Approach. Drug Metab Dispos 2018, 46 (9):1351-1359 （中科院二区）

  119. Gao Jie, Wang Zhao, Wang Gao jv, Gao Na, Li Jing, Zhang Yun Fei, Zhou Jun, Zhang Hong Xin, Wen Qiang, Jin Han, Qiao Hai Ling*. From hepatofibrosis to hepatocarcinogenesis: Higher cytochrome P450 2E1 activity is a potential risk factor. Mol Carcinog. 2018, 57(10):1371-1382  (通讯作者，中科院二区)

  120. Gao Na, Li Jing, Li Ming-Rui, Qi Bing, Wang Zhao, Wang Gao-Ju, Gao Jie, Qiao Hai-Ling*. Higher Activity of Alcohol Dehydrogenase Is Correlated with Hepatic Fibrogenesis. J Pharmacol Exp Ther 2018,367(3):473-482 （中科院二区）

  121. Fang Yan, Gao Jie, Wang Tong, Tian Xin, Gao Na, Zhou Jun, Zhang Hai-Feng, Wen Qiang, Jin Han, Xing Yu-Rong*, Qiao Hai-Ling*. Intraindividual Variation and Correlation of Cytochrome P450 Activities in Human Liver Microsomes. Mol Pharm 2018, 15(11):5312-5318 （中科院二区）

     

     

    【2017年】

  122. Yan L, Wang YT, Liu JY, Nie YL, Zhong XB, Kan QC, Zhang LR. Alterations of Histone Modifications Contribute to Pregnane X Receptor-Mediated Induction of CYP3A4 by Rifampicin. Mol Pharmacol. 2017; 92(2):113-123. （中科院二区）

  123. H. N. Zhang#, A. N. Qiao#, D. H. Yang#, L. L. Yang#, C. de Graaf, S. Reedtz-Runge, V. Dharmarajan, H. Zhang, G. W. Han, T. D. Grant, Y. H. Wu, L. M. Ma, Z. Geng, Y. H. Dong, P. R. Griffin, J. La, V. Cherezov, H. Y. Yang, M. A. Hanson, R. C. Stevens, H. L. Jiang, M. W. Wang, Q. Zhao and B. L. Wu. Structure of the full-length glucagon class B G protein-coupled. Nature. 2017 Jun 8;546(7657):259-264.9（中科院一区）

  124. Gao Y, Li M, Wang Y, Li Z, Fan C, Wang Z, Cao X, Chang J, Qiao H. Protective Effects of Sodium (±)-5-Bromo-2-(α-Hydroxypentyl) Benzoate in a Rodent Model of Global Cerebral Ischemia. Front Pharmacol. 2017 Sep 27;8:691. （中科院二区）

  125. Yi-xian Liu, Bing-jie Liu, Yan Zhang, You-mei Peng, Chen-zheng Huang, Ning Wang, Jin-hua Jiang, Qing-duan Wang, Jun-biao Chang. Intestinal absorption mechanisms of 2′-deoxy-2′-β-fluoro-4′-azidocytidine, a cytidine analog for AIDS treatment, and its interaction with P-glycoprotein, multidrug resistance-associated protein 2 and breast cancer resistance protein. Eur J PharmSci. 2017 Jul 15; 105:150-158.（中科院二区）

  126. Nie YL, Meng XG, Liu JY, Yan L, Wang P, Bi HZ, Kan QC, Zhang LR*. Histone Modifications Regulate the Developmental Expression of Human Hepatic UDP-Glucuronosyltransferase 1A1. Drug Metab Dispos. 2017;45(12):1372-1378（中科院二区）

  127. Dong-Jun Fu, Jian Song, Yu-Hui Hou, Ruo-Han Zhao, Jia-Huan Li, Ruo-Wang Mao, Jia-Jia Yang, Ping Li, Xiao-Lin Zi, Zhong-Hua Li, Qing-Qing Zhang, Fei-Yan Wang, Sai-Yang Zhang*, Yan-Bing Zhang*, Hong-Min Liu*. Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers [J]. European Journal of Medicinal Chemistry, 2017, 138, 1076. (通讯作者，中科院一区)

  128. Dong-Jun Fu, Li Zhang, Jian Song, Ruo-Wang Mao, Ruo-Han Zhao, Ying-Chao Liu, Yu-Hui Hou, Jia-Huan Li, Jia-Jia Yang, Cheng-Yun Jin, Ping Li, Xiao-Lin Zi, Hong-Min Liu, Sai-Yang Zhang*, Yan-Bing Zhang*. Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways [J]. European Journal of Medicinal Chemistry, 2017, 127, 87. (通讯作者，中科院一区)

  129. Gao Jie, Tian Xin, Zhou Jun, Cui Ming-Zhu, Zhang Hai-Feng, Gao Na, Wen Qiang, Qiao Hai-Ling*. From genotype to phenotype: cytochrome P450 2D6-mediated drug clearance in humans. Mol Pharm 2017, 14(3):649-657IF 4.556 （中科院二区）

  130. Gao Yuan, Li Miao, Wang Yan, Li Zhen-qi, Fan Chen-yu, Wang Zheng, Cao Xin-yu, Chang Jun-biao*, Qiao Ha-iling*. Protective Effects of Sodium (±)-5-Bromo-2-(α-Hydroxypentyl) Benzoate in a Rodent Model of Global Cerebral Ischemia. Front Pharmacol  2017;8:691 （中科院二区）

  131. Gao Jie, Wang Gao-Ju, Wang Zhao, Gao Na, Li Jing, Zhang Yun-Fei, Zhou Jun, Zhang Hong-Xin, Wen Qiang, Jin Han, Qiao Hai-Ling*. High CYP2E1 activity correlates with hepatofibrogenesis induced by nitrosamines. Oncotarget2017, 8:112199-112210 （中科院二区）

     

    【2016年】

  132. Xu, Hu(#) ，Fu, Jia-Lin(#) ，Miao, Yi-Fei，Wang, Chun-Jiong，Han, Qi-Fei，Li, Sha，Huang, Shi-Zheng， Du, Sheng-Nan，Qiu, Yu-Xiang，Yang, Ji-Chun，Gustafsson, Jan-Ake，Breyer, Richard M，Zheng, Feng，Wang, Nan-Ping，Zhang, Xiao-Yan，Guan, You-Fei (*) ，Prostaglandin E2 receptor EP3 regulates both adipogenesis and lipolysis in mouse white adipose tissue.，J Mol Cell Biol，2016.12.01，8（6）：518~529（中科院二区）

  133. J. Xu, A.M. Bernstein, A. Wong, X.H. Lu, S. Khoja, X.W. Yang, D.L. Davies, P. Micevych, M.V. Sofroniew, and B.S. Khakh, P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus. J Neurosci, 2016. 36(34): p. 8902-20. （中科院二区）

  134. R. Srinivasan, T.Y. Lu, H. Chai, J. Xu, B.S. Huang, P. Golshani, G. Coppola, and B.S. Khakh, New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo. Neuron, 2016. 92(6): p. 1181-1195. （中科院一区）

  135. Fan T＊, Chen J, Zhang L, Gao P，Hui Y，Xu P , Zhang X, Liu H＊. Bit1 knockdown contributes to growth suppression as well as the decreases of migration and invasion abilities in esophageal squamous cell carcinoma via suppressing FAK-paxillin pathway. Mol Cancer, 2016, 15(1):23.（中科院一区）

  136. Xu, Hu(#) ，Fu, Jia-Lin(#) ，Miao, Yi-Fei，Wang, Chun-Jiong，Han, Qi-Fei，Li, Sha，Huang, Shi-Zheng， Du, Sheng-Nan，Qiu, Yu-Xiang，Yang, Ji-Chun，Gustafsson, Jan-Ake，Breyer, Richard M，Zheng, Feng，Wang, Nan-Ping，Zhang, Xiao-Yan，Guan, You-Fei (*) ，Prostaglandin E2 receptor EP3 regulates both adipogenesis and lipolysis in mouse white adipose tissue.，J Mol Cell Biol，2016.12.01，8（6）：518~529（中科院二区）

  137. J. Xu, A.M. Bernstein, A. Wong, X.H. Lu, S. Khoja, X.W. Yang, D.L. Davies, P. Micevych, M.V. Sofroniew, and B.S. Khakh, P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus. J Neurosci, 2016. 36(34): p. 8902-20. （中科院二区）

  138. R. Srinivasan, T.Y. Lu, H. Chai, J. Xu, B.S. Huang, P. Golshani, G. Coppola, and B.S. Khakh, New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo. Neuron, 2016. 92(6): p. 1181-1195. （中科院一区）

  139. Sai yang Zhang#, Ting yu Li#, Yan bing Zhang, Hong de Xu, Yong chun Li, Xiao lin Zi, Haiyang Yu, Jin feng Li, Cheng Yun Jin⁎, Hong Min Liu⁎. A new brominated chalcone derivative suppresses the growth of gastric cancer cells in vitro and in vivo involving ROS mediated up-regulation of DR5 and 4 expression and apoptosis [J]. Toxicology and Applied Pharmacology,2016, 309, 77. (第一作者，中科院二区))

  140. Gao Jie，Zhou Jun，He Xiao-pei，Zhang Yun-fei，Gao Na，Tian Xin，Fang Yan，Wen Qiang，Jia Lin-jing，Jin Han，Qiao Hai-ling*(Corresponding author). Changes in cytochrome P450s-mediated drug clearance in patients with hepatocellular carcinoma in vitro and in vivo: a bottom-up approach. Oncotarget2016, 7（19）：28612-28623 （中科院二区）

  141. Zhou Jun，Wen Qiang，Li Sai fei，Zhang Yun fei，Gao Na，Tian Xin，Fang Yan，Gao Jie，Cui Ming zhu，He Xiao pei，Jia Ling jing，Jin Han，Qiao Hai ling*. Significant change of cytochrome P450s activities in patients with hepatocellular carcinoma. Oncotarget2016，7(31):50612-50622 IF 5.168 （中科院二区）

  142. Zhang Hai-Feng, Wang Huan-Huan, Gao Na, WeiJun-Ying, Tian Xin, Zhao Yan, Fang Yan, Zhou Jun, Wen Qiang, Gao Jie, Zhang Yang-Jun, Qian Xiao-Hong, Qiao Hai-Ling *. Physiological content and intrinsic activities of 10 cytochrome P450 isoforms in human normal liver microsomes. J Pharmacol Exp Ther 2016, 358(1):83–93IF 3.867 （中科院二区）

  143. Zhang Hai-Feng, Li Zhi-Hui, Liu Jia-Yu, Liu Ting-Ting, Wang Ping, Fang Yan, Zhou Jun, Cui Ming-Zhu, Gao Na, Tian Xin, Gao Jie, Wen Qiang, Jia Lin-Jing, Qiao Hai-Ling*. Correlation of Cytochrome P450Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450in Human Liver. Drug Metab Dispos2016, 44(8):1193-200 IF 4.242 （中科院二区）

  144. Gao Na, Tian Xin, Fang Yan, Zhou Jun, Zhang Hai feng, Wen Qiang, Jia Lin jing, Gao Jie, Sun Bao, Wei Jing yao, Zhang Yun fei, Cui Ming zhu, Qiao Hailing*. Gene polymorphisms and contents of cytochrome P450shave only limited effects on metabolic activities in human liver microsomes. Eur J Pharm Sci 2016, 92:86–97 （中科院二区）

  145. Tian Xin, Li Hong-Meng, Wei Jing-Yao, Liu Bing-Jie, Zhang Yu-Hai, Wang Gao-Ju, Chang Jun-Biao, Qiao Hai-Ling*. Preclinical pharmacokinetics, tissue distribution, and plasma protein binding of sodium(±)-5-bromo-2-(α-hydroxypentyl) benzoate (BZP), an innovative potent anti-ischemic stroke agent. Front Pharmacol 2016, 7:255 （中科院二区）

     

    四、科研成果和奖励（2010年至今）

  146. 河南省第三届自然科学学术奖-河南省自然科学优秀学术论文二等奖 （2015年12月）韩圣娜（第1名）

  147. 河南省医学科学技术进步奖一等奖 （2014年9月）范天黎

  148. 河南省教育厅科技成果二等奖（2014年5月）完成人：冯国清（第1名），于爽（第2名），察雪湘（第3名）。

  149. 河南省科技进步奖三等奖（2014年12月）范天黎（第2名）

  150. 河南省自然科学优秀学术论文一等奖（2014年），黄晨征（第1名）

  151. 河南省自然科学优秀学术论文二等奖（2014年），韩圣娜（第1名）

  152. 河南省科技进步奖三等奖（2013年1月） 张莉蓉（第1名）韩圣娜（第2名）范天黎（第5名）

  153. 河南省第二届自然科学学术奖-河南省自然科学优秀学术论文二等奖 （2013年12月）范天黎（第2名）

  154. 郑州市科技进步奖二等奖（2013年7 月）范天黎（第2名）

  155. 河南省医学科学技术进步奖二等奖（2012年），韩圣娜（第2名）；

  156. 河南省医学科学技术进步奖二等奖（2012年），韩圣娜（第2名）；

  157. 河南省自然科学优秀学术论文二等奖（2011年），韩圣娜（第1名）

  158. 郑州市科技进步奖二等奖（2010年7 月）冯国清（第5名）

  159. 河南省自然科学优秀学术论文一等奖（2011年），黄晨征（第1名）

 

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