汤进录，男，
1989
年生，副教授，博士，硕士生导师。
研究方向：肿瘤相关核酸类分子探针的设计、肿瘤早期检测与治疗
地址：郑州市科学大道
100
号郑州大学 基础医学院 组织学与胚胎学系
邮箱：
tangjl@zzu.edu.cn
学习、工作经历 ：
2023.4-
至今
郑州大学，基础医学院，组织学与胚胎学系，副教授
2017.12-2023.3
郑州大学，基础医学院，组织学与胚胎学系，直聘副教授
2013.9-2017.10
湖南大学，化学化工学院，化学，博士
2010.9-2013.6
湖南大学，生物学院，生物医学工程，硕士
2006.9-2010.6
湖南大学，化学化工学院，化学，学士
教学承担：
《组织学与胚胎学》本科课程、《
Histology and Embryology
》留学生课
程、《分子生物学》研究生课程
研究方向与特色：
主要以开发新型的功能核酸（如核酸适配体、
siRNA
等）为目标，在肿瘤
细胞特异性核酸适配体的筛选和性能研究、肿瘤早期诊断的功能核酸分子探针
的设计和构建以及肿瘤的化学治疗、基因干预、蛋白调控等领域开展相关研究
工作。
主持项目：
1.
国家自然科学基金委员会
,
青年科学基金项目
, 21804120,
基于裂开型核酸
适配体
-
核苷衍生物自组装体的肿瘤诊疗探针构建及应用研究，
2019-01
至
2021-
12, 25
万，已结题，主持。
2.
河南省科技厅
,
河南省科技攻关项目
, 232102311137,
开关型多功能核酸纳
米探针介导
NK
细胞的肿瘤免疫治疗
, 2023-01
至
2024-12, 10
万元
,
在研
,
主持。
3.
国家自然科学基金委员会
,
面上项目
, 22274143,
碳点脂滴靶向性的定量构
效关系研究及其在肝脏脂质代谢紊乱监测中的应用
, 2023-01-01
至
2026-12-31,
54
万元
,
在研
,
参与。
发表文章：
1.
Jinlu Tang
; Cuihua Qi; Xue Bai; Mengmeng Ji; Zhaoting Wang; Yanchao Luo;
Shanshan Ni; Tianlu Zhang; Kangdong Liu*; Baoyin Yuan*; Cell Membrane
Anchored DNA Nanoinhibitor for Inhibition of Receptor Tyrosine Kinase
Signaling Pathways via Steric Hindrance and Lysosome-Induced Protein
Degradation,
ACS Pharmacology Translational Science
,
2024
, 7(1): 110-119
2. Dongfang Liu;
Jinlu Tang*
; Hui Xu; Kun Yuan; Aaron Albert Aryee; Cuijie Zhang;
Hongmin Meng; Lingbo Qu; Zhaohui Li*; Split-aptamer mediated regenerable
temperature-sensitive electrochemical biosensor for the detection of tumour
exosomes,
Analytica Chimica Acta
,
2022
, 1219: 340027-340027
3.
Jinlu Tang
; Bo Li; Cuihua Qi; Zhaoting Wang; Kai Yin; Linyan Guo; Weihang
Zhang; BaoyinYuan*; Imaging specific cell-surface sialylation using DNA
dendrimer-assisted FRET,
Talanta
,
2022
, 243: 123399
4.
Jinlu Tang
; Yanli Lei; Xiaoxiao He; Jianbo Liu; Hui Shi*; Kemin Wang*;
Recognition-Driven Remodeling of Dual-Split Aptamer Triggering In Situ
Hybridization Chain Reaction for Activatable and Autonomous Identification of
Cancer Cells,
Analytical Chemistry
,
2020
, 92(15): 10839-10846.
5.
Jinlu Tang
; Yanru Yu; Hui Shi*; Xiaoxiao He; Yanli Lei; Jingfang Shangguan;
Xue Yang; Zhenzhen Qiao; Kemin Wang*; Polyvalent and thermosensitive DNA
nanoensembles for cancer cell detection and manipulation,
Analytical Chemistry
,
2017
, 89(12): 6637-6644
6. Baoyin Yuan; Yanan Xi; Cuihua Qi; Mingzhu Zhao; Xiaoyan Zhu*;
Jinlu Tang*
;
A sequentially triggered DNA nanocapsule for targeted drug delivery based on pH-
responsive i-motif and tumor cell-specific aptamer.
Frontiers in Bioengineering
and Biotechnology
,
2022
, 10: 965337.
7. Chen, Juan#;
Tang, Jinlu
#; Meng, Hong-Min*; Liu, Zhuo; Wang, Lin; Geng, Xin;
Wu, Yanan; Qu, Lingbo; Li, Zhaohui*; Recognition triggered assembly of split
aptamers to initiate a hybridization chain reaction for wash-free and amplified
detection of exosomes ,
Chemical Communications
,
2020
, 56(63): 9024-9027.
8.
Tang, Jinlu
; He, Xiaoxiao; Lei, Yanli; Shi, Hui*; Guo, Qiuping; Liu, Jianbo; He,
Dinggeng; Yan, Lv'an; Wang, Kemin*; Temperature-responsive split aptamers
coupled with polymerase chain reaction for label-free and sensitive detection of
cancer cells ,
Chemical Communications
,
2017
, 53(87): 11889-11892.
9.
Tang, Jinlu
#
; Shi, Hui
#
; He, Xiaoxiao; Lei, Yanli; Guo, Qiuping; Wang, Kemin*;
Yan, Lv'an; He, Dinggeng; Tumor cell-specific split aptamers: target-driven and
temperature-controlled self-assembly on the living cell surface,
Chemical
Communications
,
2016
, 52(7): 1482-148.
10. Like Yang; Jia Ge*; Demiao Ma;
Jinlu Tang
*; Hongqi Wang; Zhaohui Li*; MoS
2
quantum dots as fluorescent probe for methotrexate detection.
Spectrochimica Acta
Part A: Molecular and Biomolecular Spectroscopy
, 2021, 279: 121443.
11. Hui Xu; Yue Xiao;
Jinlu Tang
*; Dongfang Liu; Xinxin Shi; Aaron Albert Aryee;
Hongmin Meng; Lingbo Qu; Zhaohui Li*; Prodrug-based self-assembled
nanoparticles formed by 3’,5’-dioleoyl floxuridine for cancer chemotherapy.
New
Journal of Chemistry.
,
2021
, 45: 8306.
12. Simin Wei; Yaqing Yang; Junjie Li; Jialin Wang;
Jinlu Tang
; Ningning Wang*;
Zhaohui Li*; The Mn/Yb/Er triple-doped CeO2 nanozyme with enhanced oxidase
like activity for highly sensitive ratiometric detection of nitrite.
Chinese Chemical
Letters
,
2024
, 35: 109114.
13. Yaqing Yang; Simin Wei;Jialin Wang;Junjie Li;
Jinlu Tang
; Albert Aryee Aaron;
Qiyong Cai*; Ningning Wang*; Zhaohui Li; Highly sensitive and ratiometric
detection of nitrite in food based on upconversion-carbon dots nanosensor.
Analytica Chimica Acta
,
2023
, 1263: 341245.
14. Yanli Lei;
Jinlu Tang
; Xiaoxiao He; Hui Shi*; Yu Zeng; Haiyan Sun; Kemin
Wang*; In Situ Modulating DNAzyme Activity and Internalization Behavior with
Acid-Initiated Reconfigurable DNA Nanodevice for Activatable Theranostic.
Analytical Chemistry
.
2021
, 93, 13, 5629–5634.
15. Ke Quan; Jing Li; Jiaoli Wang; Nuli Xie; Qiaomei Wei;
Jinlu Tang
; Xiaohai Yang;
Kemin Wang*; Jin Huang*; Dual-microRNA-controlled double-amplified
cascaded logic DNA circuits for accurate discrimination of cell subtypes.
Chemical
Science
,
2019
, 10: 1442-1449.
