孔旭辉，女，医学博士，毕业于中山大学。主要研究方向为：胎盘发育与妊娠相关疾病、代谢相关脂肪性肝病等代谢性疾病。致力于通过已搭建的滋养层干细胞培养和定向分化系统、高通量数据分析平台（如RNA-seq、scRNA-seq、CUT&Tag、ChIP-seq、ATAC-seq、irCLIP等分析平台）以及基于转座子和CRISPR系统的基因组和表观遗传编辑平台，揭示复发性流产、子痫前期等胎盘发育性疾病的分子机理，为相关疾病的临床诊治和干预策略提供理论依据。

目前以第一/通讯作者等发表SCI论文4篇，参与发表SCI论文2篇。研究成果主要发表在PNAS、Cell Stem Cell、Cell Reports等国际一流期刊。主持河南省科技攻关项目一项；以项目骨干参与国家重点研发计划项目一项、参与国家自然科学基金面上项目两项、参与河南省优青项目一项。欢迎优秀的研究生、本科生加入本团队，联系邮箱：kongxh@zzu.edu.cn。

发表文章：

(1)  Xuhui Kong; Ruiqi Li; Manqi Chen; Rongyan Zheng; Jichang Wang; Chuanbo Sun; Yuliang Qu ; Endogenous retrovirus HERVH- derived lncRNA UCA1 controls human trophoblast development,  The Proceedings of the National Academy of Sciences , 2024, Vol. 121(No. 12): 1-9

(2) Xuhui Kong; Xin Chen; Songbang Ou; Wenjun Wang; Ruiqi Li ; Derivation of human triploid trophoblast stem cells,  Journal of Assisted Reproduction and Genetics , 2022, 39(5): 1183-1193

(4) Hanwen Yu; Manqi Chen; Yuanlang Hu; Songbang Ou; Xiu Yu; Shiqi Liang; Niannian Li; Mingzhu Yang; Xuhui Kong; Chuanbo Sun; Shiqi Jia; Qingxue Zhang; Lin Liu; Laurence D Hurst; Ruiqi Li; Wenjun Wang; Jichang Wang ; Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development,  Cell Stem Cell , 2022, 29(7): 1031-1050.e12

(5) Xiu Yu; Shiqi Liang; Manqi Chen; Yu Hatano; Ruiqi Li; Yuliang Qu; Xuhui Kong; Ruirui Guo; Rongyan Zheng; Zsuzsanna Izsvák; Chuanbo Sun; Mingzhu Yang; Junwen Wang ; Recapitulating early human development with 8C-like cells, Cell Reports , 2022, 39(12): 110994-110994

(3) Hu Zhao*; Junqiu Chen*; Jin Chen*; Xuhui Kong*; Hehuan Zhu; Yongping Zhang; Huiyue Dong; Jie Wang; Qun Ren; Qinghua Wang; Shushang Chen; Zhen Deng; Zhan Chen; Qiang Cui; Junqiong Zheng; Jun Lu; Shuiliang Wang; Jianming Tan ; miR‐192/215‐5p act as tumor suppressors and link Crohn's

disease and colorectal cancer by targeting common metabolic pathways: An integrated informatics analysis and experimental study, Journal of Cellular Physiology , 2019, 234(11): 1-16