姓名：关方霞 教授

学院：生命科学学院

导师类别：硕士生、博士生导师

研究方向：干细胞与再生医学、肿瘤发生机制与防治

教育背景：

1999年获山东医科大学临床医学博士学位，美国爱因斯坦医学院神经科学系、生物医学专业博士后、fellow

个人简介

关方霞，女，博士，教授，博士生导师。1999年获临床医学博士学位，留学美国8年，被郑州大学引进为特聘教授全职回国，致力于干细胞再生医学、肿瘤防治基础与转化研究。先后在Nature communication, Cerebral cortex, Biological psychiatry, Molecular psychiatry, JACS, Stem Cell Res Ther, Biomater Sci等重要期刊上发表170余篇论文，其中SCI收录90余篇，获13项国家专利授权，3项河南省科技进步二等奖，主编2本专著。是河南省科技厅“生物医学工程技术与转化医学” 科技创新团队和河南省“再生医学与神经功能修复”高校科技创新团队负责人。已完成多项国家和省部级科研项目，是国家和多个省科研项目和成果评审专家，国内外多家杂志的执行编委和审稿人。

主要荣誉：

荣获“全国巾帼文明岗”、“宝钢优秀教师奖”、“教育部新世纪优秀人才”、“中原XX-科技创新领军人才”、“河南省学术技术带头人”、“河南省教育厅学术技术带头人”、“河南省高校优秀青年骨干教师”、“中华医学会医学细胞生物学分会第四届青年委员会副主任委员“等荣誉称号。

科研项目：

⑴ 中原XX-科技创新领军人才支持项目：干细胞与再生医学。2020.1-2022.12，主持

⑵ 国家自然基金面上项目：Resveratrol联合MSCs移植对阿尔茨海默鼠的干预效果及Sirt1分子信号的介导作用（81471306），2015.01-2018.12，主持

⑶ 国家自然基金面上项目：β-catenin对羊膜间质干细胞移植治疗Alzheimer鼠的细胞转归与疗效调控（81071008），2011.01-2013.12，主持

⑷ 国家自然基金面上项目：触屏式视知觉学习对成年大鼠海马神经细胞可塑性影响及BDNF分子信号的介导作用（31272318），2013.01-2013.12，主持

⑸ 国家科技支撑计划：泌尿激光手术治疗系统开发-组织相容性研究，2011.1-2014.12，子课题负责人

⑹ 国家“十二五” 科技支撑计划项目：基层常见多发病防治适宜技术评价与推广研究（2014BAI08B00），2014.01-2016.12，子课题负责人

⑺ 卫生部重大专项：艾滋病综合防治，2012.1-2014.12，子课题负责人

⑻ 中国科学院战略性先导科技专项：支架材料功能修饰和人工组织器官构建（XDA01030000），2011.1-2014.12，子课题负责人

⑼ 教育部新世纪优秀人才支持项目：缺氧特异的ATM siRNA对胶质瘤的治疗作用（NCET-0610），2007.1-2009.12，主持

⑽ 河南省科技创新杰出人才计划：再生医学新技术对中枢神经系统功能的修复与重建，2015.01-2017.12，主持

⑾ 河南省杰出青年基金：双功能磁性荧光纳米颗粒标记新型间质干细胞在中枢神经疾患中的活体示踪研究（114100510005），2010.01-2013.12，主持

⑿ 河南省高校科技创新团队：再生医学与神经功能修复（15IRTSTHN022），2015.01-2017.12，主持

⒀ 人事部留学回国人员择优资助项目：羊膜间质干细胞移植治疗老年痴呆的安全有效性评价，2011.1-2014.12，主持

⒁ 河南省产学研合作项目：新型高效干细胞低温保护剂的研发及产业化（142107000008），2015.01-2017.12，主持

⒂ 河南省科技攻关项目：间充质干细胞三维培养体系构建及新产品研发在脊髓损伤修复中的应用研究（122102310203），2012.01-2014.12，主持

科研奖励：

⑴ 脑胶质瘤干细胞生物学特性及放化疗增敏研究，河南省人民政府，河南省科学技术进步奖，2019年河南省科技进步三等奖

⑵ 羊膜脐带间充质干细胞对中枢神经系统损伤的修复作用，河南省人民政府，河南省科学技术进步奖，2014年河南省科技进步二等奖

⑶ 视黄酸经TGF-beta3信号途径诱发腭裂的生物学机制. 2012年河南省科技进步二等奖

⑷ 外排泵系统在幽门螺杆菌多重耐药中的机理研究. 2011年河南省科技进步二等奖

近五年代表性论文：

⑴ John P, Wei Y, Liu W, Du M, Guan F, Zang X. The B7x Immune Checkpoint Pathway: From Discovery to Clinical Trial. Trends Pharmacol Sci 2019, 40(11):883-896.

⑵ Bian Z, Wang Q, Zhou X, Tan T, Park KH, Kramer HF, McDougal A, Laping NJ, Kumar S, Adesanya TMA, Sermersheim M, Yi F, Wang X, Wu J, Gumpper K, Jiang Q, He D, Lin PH, Li H, Guan F, Zhou J, Kohr MJ, Zeng C, Zhu H, Ma J. Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function.Nat Commun 2019, 10(1):4659

⑶ Guan F^#, Huang T^#, Wang X, Xing Q, Gumpper K, Li P, Song J, Tan T, Yang GL, Zang X, Zhang J, Wang Y, Yang Y, Liu Y, Zhang Y, Yang B, Ma J*, Ma S*. The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury. Stem Cell Res Ther. 2019, 10(1):352.

⑷ Cui Y, Zhang L, Wang W, Ma S, Liu H, Zang X, Zhang Y*, Guan F*. Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/β-catenin pathway. Mol Cell Biochem. 2019, 460(1-2):93-103.

⑸ Guan F^#, Zhou X^#, Li P^#, Wang Y, Liu M, Li F, Cui Y, Huang T, Yao M, Zhang Y, Ma J*, Ma S*. MG53 attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation via inhibiting TLR4/NF-κB pathway in vitro and in vivo. Prog Neuropsychopharmacol Biol Psychiatry. 2019, 95:109684.

⑹ Yao M*^#, Gao F^#, Xu R, Zhang J, Chen Y, Guan F*. A dual-enzymatically cross-linked injectable gelatin hydrogel loaded with BMSC improves neurological function recovery of traumatic brain injury in rats. Biomater Sci. 2019, 7(10):4088-4098.

⑺ Yao M*^#, Chen Y^#, Zhang J, Gao F, Ma S*, Guan F*. Chitosan-based thermosensitive hydrogel promotes the therapeutic effect of human umbilical cord MSC on TBI rat model. Materials Today Chemistry. 2019,14: 100192

⑻ Li Y^#, Ma S^#, Zhang Y, Yao M, Zhu X, Guan F*. (-)-Epicatechin mitigates radiation-induced intestinal injury and promotes intestinal regeneration via suppressing oxidative stress. Free Radic Res. 2019, 53(8):851-864.

⑼ Ma S^#, Liu T^#, Xu L, Wang Y, Zhou J, Huang T, Li P, Liu H, Zhang Y, Zhou X, Cui Y, Zang X, Wang Y, Guan F*. Histone deacetylases inhibitor MS-275 suppresses human esophageal squamous cell carcinoma cell growth and progression via the PI3K/Akt/mTOR pathway. J Cell Physiol. J Cell Physiol. 2019, 234(12):22400-22410.

⑽ Tang Y, Ma S, Wang X, Xing Q, Huang T, Liu H, Li Q, Zhang Y, Zhang K, Yao M, Yang GL, Li H, Zang X, Yang B, Guan F*. Identification of chimeric RNAs in human infant brains and their implications in neural differentiation. Int J Biochem Cell Biol. 2019,111:19-26.

⑾ Xu L^#, Xing Q^#, Huang T, Zhou J, Liu T, Cui Y, Cheng T, Wang Y, Zhou X, Yang B, Yang GL, Zhang J, Zang X, Ma S*, Guan F*. HDAC1 silence promotes neuroprotective effects of human umbilical cord-derived mesenchymal stem cells in a mouse model of traumatic brain injury via PI3K/AKT pathway. Front. Cell. Neurosci. 2019, 4; 12: 498.

⑿ Zhang K^#, Shi Z^#, Zhou J^#, Xing Q, Ma S, Li Q, Zhang Y, Yao M, Wang X, Li , LiJ, GuanF*.  Potential application of an injectable hydrogel scaffold loaded with mesenchymal stem cells for treating traumatic brain injury. J. Mater. Chem. B, 2018, 6, 2982-2992

⒀ Mao K, Quipildor GF, Tabrizian T, Novaj A, Guan F, Walters RO, Delahaye F, Hubbard GB, Ikeno Y, Ejima K, Li P, Allison DB, Salimi-Moosavi H, Beltran PJ, Cohen P, Barzilai N, Huffman DM. Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nat Commun. 2018, 9(1):2394.

⒁ Zhang T^#, Wang P^#, Liu Y, Zhou J, Shi Z, Cheng K, Huang T, Wang X, Yang GL, Yang B, Ma S*, Guan F*. Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo. Cell Tissue Res. 2018, 373(2):379-393.

⒂ Cai B, Zheng Y, Ma S, Xing Q, Wang X, Yang B, Yin G, Guan F*.Long non‑coding RNA regulates hair follicle stem cell proliferation and differentiation through PI3K/AKT signal pathway. Mol Med Rep. 2018, 17(4):5477-5483.

⒃ Wang X^#, Ma S^#, Yang B*, Huang T, Meng N, Xu L, Xing Q, Zhang Y, Zhang K, Li Q, Zhang T, Wu J, Yang GL, Guan F*, Wang J. Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer's disease. Behav Brain Res. 2018, 339:297-304.

⒄ Cui Y^#, Ma S^#, Zhang C, Li D, Yang B, Lv P, Xing Q, Huang T, Yang GL, Cao W, Guan F*. Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease. Behav Brain Res. 2018, 336:219-226.

⒅ Cai B, Zheng Y, Ma S, Xing Q, Wang X, Yang B, Yin G, Guan F*. BANCR contributes to the growth and invasion of melanoma by functioning as a competing endogenous RNA to upregulate Notch2 expression by sponging miR‑204. Int J Oncol. 2017, 51(6):1941-1951.

⒆ Wang P, Lv C, Zhang T, Liu J, Yang J, Guan F*, Hong T^#. FOXQ1 regulates senescence-associated inflammation via activation of SIRT1 expression. Cell Death Dis. 2017, 8(7):e2946

⒇ Cui Y^#, Ma S^#, Zhang C, Cao W, Liu M, Li D, Lv P, Xing Q, Qu R, Yao N, Yang B*, Guan F*.Human umbilical cord mesenchymal stem cells transplantation improves cognitive function in Alzheimer's disease mice by decreasing oxidative stress and promoting hippocampal neurogenesis. Behav Brain Res. 2017, 320:291-301.

(21) Chi L, Fan B, Liu Z, Fang Y, ChenZ , Ren X, Liu L, Guan F*, Zhang X*.The Dorsoventral Patterning of Human Forebrain Follows an Activation/Transformation Model. Cerebral cortex, 2017, 27(5):2941-2954

(22) Li Q^#, Yang L^#, Han K^#, Zhu L, Zhang Y, Ma S, Zhang K, Yang B, Guan F*, Ets2 knockdown inhibits tumorigenesis in esophageal squamous cell carcinoma in vivo and in vitro，Oncotarget. 2016, 7(38):61458-61468.

(23)Cheng T, Wang W, Li Q, Han X, Xing J, Qi C, Lan X, Wan J, Potts A, Guan F*, Wang J*. Cerebroprotection of flavanol (-)-epicatechin after traumatic brain injury via Nrf2-dependent and -independent pathways．Free Radical Biology and Medicine, 2016, 92：15-28

(24) Wang X^#, Ma S^#, Meng N, Yao N, Zhang K, Li Q, Zhang Y, Yang B*, Guan F*. Resveratrol exerts dosage-dependenteffects on the self-renewal and neural differentiation of hUC-MSCs．Mol Cells, 2016, 39(5):418-25

(25) Li D^#, Ma S^#, Guo D, Cheng T, Li H, Tian Y, Li J, Guan F*, Yang B*, Wang Jian. Environmental Circadian Disruption Worsens Neurologic Impairment and Inhibits Hippocampal Neurogenesis in Adult Rats After Traumatic Brain Injury. Cellular and Molecular Neurobiology, 2016, 36(7):1045-55

(26) Zhu X^#, Zhang Y^#, Li Q, Yang L, Zhang N, Ma S, Zhang K, Song J, Guan F*. beta-Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-kappaB Signaling Pathway．J Biochem Mol Toxicol, 2016, 30(3):148-57

(27) Zhang Y^#, Zhu X^#, Huang T, Chen L, Liu Y, Li Q, Song J, Ma S, Zhang K, Yang B, Guan F*.β-Carotene synergistically enhances the anti-tumor effect of 5-fluorouracil on esophageal squamous cell carcinoma in vivo and in vitro. Toxicol Lett. 2016;261:49-58