职称：教授

      头衔：国家海外高层次人才计划、博导

      邮箱：jinlei_2024@163.com

      地址：郑州大学医学科学院

个人简介

金雷教授任郑州大学医学科学院教授、博士生导师。在国际高水平杂志发表论文60余篇，H指数为33。其中以第一/通讯作者(或共同)在Nature Cell Biology、 Molecular Cell、Advanced Science、Nature Communications（×4）、Proc Natl Acad Sci（×3）、Cancer Research（×3）、Oncogene（×2）等高水平杂志发表论文23篇，论文被引超过3700余次。担任澳大利亚国家健康与医学研究委员会（NHMRC）的会评专家（panel member），以及中国国家自然科学基金（NSFC）、澳大利亚国家研究理事会（ARC）、奥地利科学基金会（FWF）、英国医学研究委员会(MRC UK)、Worldwide Cancer Research基金会等国家级科研基金的评审专家。

主要研究方向

      主要以肺癌、结直肠癌和黑色素瘤等为疾病模型，研究非编码RNA对癌症生存、增殖、代谢和抗药性等方面的调控和作用机制，以及RNA靶向药物的研发。

课题组成员

朱治溥（博士生）

荣誉及获奖情况

1. Field Leader in Cell Biology. Research Magazine 2023. Australia’s top researchers and research institutions in 250 fields of academic endeavour.

2. Research Excellence Awards. Australian Association of Chinese Biomedical Scientists (AACBS). October 2020.

3. Rising Star Awards. Australian Association of Chinese Biomedical Scientists (AACBS). October 2018.

4. AACR Scholar-in-Training Award in Memory of William Maness. American Association for Cancer Research, April 2017.

代表性成果

1.La T, Chen S, Zhao XH, Zhou S, Xu R, Teng L, Zhang YY, Ye K, Xu L, Guo T, Jamaluddin MF, Feng YC, Tang HJ, Wang Y, Xu Q, Gu Y, Cao H, Liu T, Thorne RF, Shao FM^#, Zhang XD^#, Jin L^#. LncRNA LIMp27 regulates the DNA damage response through p27 in p53-defective cancer cells. Adv Sci, 2023 Jan 13; e2204599. Doi: 10.1002/advs.202204599. (^#通讯作者) (影响因子: 17.521)

2.La T, Chen S, Guo T, Zhao XH, Teng L, Li DD, Carnell M, Zhang YY, Feng YC, Cole N, Brown AC, Zhang D, Dong Q, Wang JY, Cao H, Liu T, Thorne RF, Shao F-M^#, Zhang XD^#, Jin L^#. Visualization of endogenous p27 and Ki67 reveals the importance of a c-Myc-driven metabolic switch in promoting survival of quiescent cancer cells. Theranostics. 2021; 11(19): 9605-9622. doi: 10.7150/thno.63763. (^#通讯作者) (影响因子: 11.600)

3.Zhu YM*, Jin L*, Shi R, Li J, Wang Y，Zhang L, Liang C-Z, Narayana VK, De Souza DP, Thorne RF, Zhang LR, Zhang XD, Wu M. Long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis. Mol Cell. 2022； 82(3):542-554.e6. doi: 10.1016/j.molcel.2021.11.017. (^*第一作者) (影响因子: 19.328)

4.Teng L, Feng YC, Guo ST, Wang PL, Qi TF, Yue YM, Wang SX, Zhang SN, Tang CX, La T, Zhang YY, Zhao XH, Gao JN, Wei LY, Zhang D, Wang JY, Shi Y, Liu XY, Li JM, Cao H, Liu T, Thorne RF, Jin L^#, Shao F-M^#, Zhang XD^#. The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis. Nat Commun. 2021 Jun 18;12(1):3734. doi: 10.1038/s41467-021-24099-4. (^#通讯作者) (影响因子: 17.694)

5.Feng YC, Liu XY, Teng L, Ji Q, Wu Y, Li JM, Gao W, Zhang YY, La T, Tabatabaee H, Yan XG, Jamaluddin MFB, Zhang D, Guo ST, Scott RJ, Liu T, Thorne RF, Zhang XD^#, Jin L^#. c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis. Nat Commun. 2020 Oct 5;11(1):4980.  doi: 10.1038/s41467-020-18735-8. (^#通讯作者) (影响因子: 17.694)

6.Yari H*, Jin L*, Teng L, Wang YF, Wu YY, Liu GZ, Gao W, Liang J, Xi YF, Feng YC, Zhang CM, Zhang YY, Tabatabaee H, La T, Yang RH, Wang FH, Yan XG, Farrelly M, Scott R, Liu T, Thorne RF, Guo ST, Zhang XD. LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription. Nat Commun. 2019 Nov 25;10(1):5334. doi: 10.1038/s41467-019-13313-z. (^*第一作者) (影响因子: 17.694)

7.Sang B, Zhang YY, Guo ST, Kong LF, Chen Q, Liu GZ, Thorne RF, Zhang XD, Jin L^#, Wu M^#. Dual functions for lncRNA OVAAL in initiation of RAF/MEK/ERK pro-survival signals and evasion of p27-mediated cellular senescence. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11661-E11670. doi: 10.1073/pnas.1805950115. (^#通讯作者) (影响因子: 12.779)

8.La T, Liu GZ, Farrelly M, Cole N, Feng YC, Zhang YY, Sherwin SK, Yari H, Tabatabaee H, Yan XG Guo ST, Liu T, Thorne RF, Jin L^#, Zhang XD^#. A p53-responsive microRNA network promotes cancer cell quiescence. Cancer Res. 2018 Oct 9. pii: canres.1886.2018. doi: 10.1158/0008-5472.CAN-18-1886. (^#通讯作者) (影响因子: 13.312)

9.Hu WL*, Jin L*, Xu A, Wang YF, Thorne RF, Zhang XD, Wu M. GUARDIN is a p53-responsive long noncoding RNA that is essential for genomic stability. Nat Cell Biol. 2018;20:492-502. doi: 10.1038/s41556-018-0066-7. (*第一作者) (影响因子: 28.213)

10.Xiang S*, Gu H*, Jin L*, Thorne RF, Zhang XD, Wu M. LncRNA IDH1-AS1 links the functions of c-Myc and HIF1 via IDH1α to regulate the Warburg effect. Proc Natl Acad Sci U S A. 2018; 115:E1465-E1474. doi: 10.1073/pnas.1711257115. (*第一作者) (影响因子: 12.779)

11.Wang JY, Liu GZ, Wilmott JS, La T, Feng YC, Yari H, Yan XG, Thorne RF, Scolyer RA, Zhang XD^#, Jin L^#.  Skp2-mediated stabilization of MTH1 promotes survival of melanoma cells upon oxidative stress. Cancer Res. 2017; 77(22): 6226-6239. (^#通讯作者) (影响因子: 13.312)

12.Ye Y*, Jin L*, Wilmott, JS, Hu WL, Yosufi B, Thorne RF, Liu T, Rizos H, Yan XG, Dong L, Tay KH, Tseng H-Y, Guo ST, de Bock CE, Jiang CC, Wang CY, Wu M, Zhang LJ, Hersey P, Scolyer RA, Zhang XD. PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma. Nat Commun. 2013; 4:1508. (*第一作者) (影响因子: 17.694)

13.Jin L*, Hu WL*, Jiang CC*, Wang JX, Han CC, Chu P, Zhang LJ, Thorne R, Wilmott J, Scolyer R, Hersery P, Zhang XD, Wu M.  MiRNA-149*, A p53-Responsive microRNA, Functions as an Oncogenic Regulator in Human Melanoma.  Proc Natl Acad Sci U S A. 2011; 108:15840-5. (*第一作者) (影响因子: 13.312)