教师基本信息

姓名：张硕

职称：直聘研究员，硕士生导师

电子邮箱：zhangshuo95@zzu.edu.cn

教育经历

2013.09-2017.06 北京师范大学，生物学，学士；

2017.09-2022.06 清华大学，结构生物学，博士

工作经历

2023.08-现在 郑州大学生命科学学院 直聘研究员

研究方向

结合冷冻电镜、晶体学等手段，膜蛋白结构进行解析并进行功能研究

代表性论著

1.共同第一作者

Xin Jiang#; Yafei Yuan#; Jian Huang#; Shuo Zhang#; Shuchen Luo; Nan Wang; Debing Pu; Na Zhao; Qingxuan Tang; Kunio Hirata; Xikang Yang; Yaqing Jiao; Tomoyo Sakata-Kato; Jia-Wei Wu; ChuangyeYan; Nobutaka Kato; Hang Yin; Nieng Yan. Structural Basis for Blocking Sugar Uptake into theMalaria Parasite Plasmodium falciparum, Cell, 2020, 183(1): 258-268.

2.其他作者

Nan Wang; Shuo Zhang; Yafei Yuan; Hanwen Xu; Elisabeth Defossa; Hans Matter; Melissa Besenius; Volker Derdau; Matthias Dreyer; Nis Halland; Kaihui Hu He; Stefan Petry; Michael Podeschwa; Norbert Tennagels; Xin Jiang; Nieng Yan. Molecular basis for inhibiting human glucose transporters by exofacial inhibitors, Nature Communications, 2022, 13(1).

Nan Wang; Xin Jiang; Shuo Zhang; Angqi Zhu; Yafei Yuan; Hanwen Xu; Jianlin Lei; ChuangyeYan. Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drugcandidates, Cell, 2021, 184(2): 370-383.

Jian Huang; Yafei Yuan; Na Zhao; Debing Pu; Qingxuan Tang; Shuo Zhang; Shuchen Luo; Xikang Yang; Nan Wang; Yu Xiao; Tuan Zhang; Zhuoyi Liu; Tomoyo Sakata-Kato; Xin Jiang; Nobutaka Kato; Nieng Yan; Hang Yin. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents, PNAS, 2021, 118(3).

Xin Jiang; Jianping Wu; Meng Ke; Shuo Zhang; Yafei Yuan; Jason Ye Lin; Nieng Yan. Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs, Cell Discovery, 2019, 5(1): 14