基本信息
王敏灿，男，理学博士，化学学院教授。
手机：13523069237
邮件：wangmincan@zzu.edu.cn
通讯地址:郑州市科学大道100号，郑州大学化学学院
教育背景
1986年毕业于河南师范大学化学系，1993在北京大学化学系获得硕士学位，2004年在郑州大学化学系获得博士学位。
工作履历
1993年至今在郑州大学化学系工作，1994年任讲师，1998年晋升副教授，2005年晋升教授。
研究领域
1. 有机合成方法学
2. 催化不对称合成
3. 手性高分子合成
研究成果（Selected publications）
已主持完成国家自然科学基金4项(20172147，20672102，20972140，21272216)、河南省杰出青年计划基金1项(084100410001)、河南省高等学校创新人才工程基金(2003KYCX007)。
目前主持在研国家自然科学基金1项，2019-2022年，项目编号：21871237。
2004年以来在国内、外有影响的专业期刊上发表的代表性成果：
1Yu-Huan Geng, Yuan-Zhao Hua*, Shi-Kun Jia*,Min-Can Wang* “DirectAsymmetric α-Selective Mannich Reaction of β,γ-Unsaturated Ketones with Cyclic α-Imino Ester:Divergent Synthesis of Cyclocanaline and Tetrahydro Pyridazinone Derivatives”Chem. Eur. J.2021,27, 5130-5135.
2.Wen-Bo Hu, Xixi Song,Min-Can Wang* “A New Asymmetric Activation Strategy for Hydrazones as Acyl Anion Equivalents in Bimetallic Catalyzed Carbonyl-Ene Reaction”Org. Biomol. Chem.2021,19, 2055.
3.Yang Yi, Yuan-Zhao Hua,* Hui-Jie Lu, Lan-Tao Liu,Min-Can Wang* “Br?nsted Base and Lewis Acid Cooperatively Catalyzed Asymmetricexo’-Selective [3+2] Cycloaddition of Trifluoromethylated Azomethine Ylides and Methyleneindolinones”Org. Lett.2020,22. 2527.
4.Ya-Jun Guo, Xin Guo, De-Zhi Kong, Hui-Jie Lu, Lan-Tao Liu, Yuan-Zhao Hua,*Min-Can Wang*“Catalytic Asymmetric Synthesis of Tetrahydrofuran SpirooxindolesviaDinuclear Zinc Catalyst”J. Org. Chem.2020,85, 4195.
5. Xiao-Chao Yang, Meng Xu, Jin-Bao Wang, Meng-Meng Liu, Fran?ois Mathey, Yuan-Zhao Hua,*Min-Can Wang* “Enantioselective Synthesis of Indanone Spiro-Isochromanone Derivatives via Dinuclear Zinc-Catalyzed Michael/Transesterification Tandem Reaction”Org. Biomol. Chem.2020,18, 3917.
6.Xin Guo, Ya-Jun Guo, De-Zhi Kong, Hui-Jie Lu, Yuan-Zhao Hua,*Min-Can Wang*“Efficient construction of the spiro-carbon, ring A (oxindole), and ring B (tetrahydrofuran) in one-pot reaction to synthesizetetrahydrofuran spirooxindoles”Chin. J. Org. Chem.2020,40, 1999
7.Meng-Meng Liu, Xiao-Chao Yang, Yuan-Zhao Hua, Jun-Biao Chang*, andMin-Can Wang*“Synthesis of Chiral Bispirotetrahydrofuran oxindoles by Cooperative Bimetallic Catalyzed Asymmetric Cascade Reaction”Org. Lett.2019,21. 2111.
8.Meng-Meng Liu, Xiao-Chao Yang, Yuan-Zhao Hua,* Jun-Biao Chang,* andMin-Can Wang* “Dinuclear Zinc Catalyzed Asymmetric Tandem Reaction ofα-Hydroxy 1-Indanone: Access toSpiro[1-indanone-5,2’-γ-butyrolactones]”Org. Lett.2019,21. 7089.
9. Shanshan Liu, Wen-Chao Gao, Yu-Hang Miao andMin-Can Wang* “Dinuclear Zinc-AzePhenol Catalyzed Asymmetric Aza-Henry Reaction ofN-Boc Imines and Nitroalkanes under Ambient Conditions”J. Org. Chem.2019,84, 2652.
10.Xiao-Chao Yang, Meng-Meng Liu, Fran?ois Mathey,Hua Yang,Yuan-Zhao Hua,* andMin-Can Wang*“Access to Chiral 2,5-Pyrrolidinyl Dispirooxindoles via Dinuclear Zinc Catalyzed Asymmetric Cascade Reactions”J. Org. Chem.2019,84, 7762.
11. Shanshan Liu, Xi Wang, Hao-Ran Zhu, Zhi-Hua Xu,Min-Can Wang* “Azetidine-Derived Dinuclear Zinc-Catalyzed Asymmetric Conjugate Addition of Bioactive Heterocycles to β,γ-Unsaturated α-Ketoesters”J. Org. Chem.2019,84, 13881.
12. Bing-Kai Tao, Hua Yang, Yuan-Zhao Hua,*Min-Can Wang*“Dinuclear Zinc Synergistic Catalytic Asymmetric Phospha-Michael/Michael Cascade Reaction: Synthesis of 1,2,3-Trisubstituted Indanes Bearing Phosphoryl Group”Org. Biomol. Chem.2019,17, 4301.
13. Yu-Hang Miao,Yuan-Zhao Hua, andMin-Can Wang*“Dinuclear Zinc Cooperative Catalytic Three-Component Reactions for Highly Enantioselective Synthesis of 3,3′-Dihydrofuran Spirooxindoles”Org. Biomol. Chem.2019,17, 7172.
14. Yuan-Yuan Gao, Yuan-Zhao Hua,* andMin-Can Wang* “Asymmetric 1,6-Conjugate Addition ofpara-Quinone Methides for the Synthesis of Chiralβ,β-Diaryl-α-Hydroxy Ketones”Adv. Synth. Catal.2018,360, 80–85.
15.Wang, Mincan* “Enantioselective analysis: the Logic of Chiral Ligand Design for Asymmetric Addition of Diethylzinc to Benzaldehyde”Chin. J. Org. Chem.2018,38, 162-170.
16. Hua, Yuanzhao Han, Xingwang Huang, Lihua*Wang, Mincan* “ Asymmetric Friedel–Crafts Alkylation of Pyrrole with Chalcones Catalyzed by a Dinuclear Zinc Catalyst”Chin. J. Org. Chem.2018,38, 237-245.
17. Yuan-Zhao Hua, Jun-Wei Chen, Hua Yang,*Min-Can Wang* “Asymmetric Friedel–Crafts Alkylation of Indoles with Trifluoromethyl Pyruvate Catalyzed by a Dinuclear Zinc Catalyst”J. Org. Chem.2018,83,1160-1166.
18. Zhao-Fei Zhang, Xiao-Chao Yang, Hui-Jie Lu, andMin-Can Wang* “Enantioselective Direct Synthesis ofsyn- andanti-α,β-Dihydroxy γ-Ketoesters by a Dinuclear Zinc-AzePhenol Complex”Eur. J. Org. Chem.2018, 785-793.
19. Na Shao, Yong-Yang Luo, Hui-Jie Lu, Yuan-Zhao Hua* andMin-Can Wang* “Enantioselective Phospha-Michael Reaction of Diethyl Phosphite with Exocyclicα,β-Unsaturated Benzocyclic Ketones Catalyzed by a Dinuclear Zinc Catalyst”Tetrahedron,2018,74, 2130-2142.
20.Shanshan Liu,aGao-Wei Li,bXiao-Chao Yang,bDe-Yang ZhangbandMin-Can Wang*b“Dinuclear zinc complex catalyzed asymmetric methylation and alkynylation of aromatic aldehydes”Org. Biomol. Chem.2017,15, 7147.
21. Shanshan Liu,aNa Shao,bFeng-Zhen Li,bXiao-Chao Yang,bandMin-Can Wang*b“Azetidine-derived dinuclear zinc catalyzed asymmetric phospha-Michael addition of dialkyl phosphite toα,β-unsaturated carbonyl compounds”Org. Biomol. Chem.2017,15, 9465.
22.Guo, Yifei; Hao, Chunying; Wang, Xiangkang; Zhao, Yanna; Han, Meihua;Wang, Mincan*; Wang, Xiangtao*“Well-defined podophyllotoxin polyprodrug brushes: preparation via RAFT polymerization and evaluation as drug carriers”Polymer Chemistry,2017.2.7, 8(5): 901~909 ; SCIE
23.Xin-Wei Wang, Yuan-Zhao Hua,* andMin-Can Wang* “Synthesis of 3?Indolylglycine Derivatives via Dinuclear Zinc Catalytic Asymmetric Friedel?Crafts Alkylation ReactionJ. Org. Chem.2016,81, 9227-92347.”
24.Yuan-Zhao Hua, Xiao-Chao Yang, Meng-Meng Liu, Xixi Song,Min-Can Wang* and Jun-Biao Chang* “Asymmetric copolymerization ofcyclopenteneoxide and CO2using a dinuclear zinc-AzePhenol catalyst:enlightenedby DFT calculations,Macromolecules,2015,48, 1651-1657.”
25.Yuan-Zhao Hua, Meng-Meng Liu, Pei-Jin Huang, Xixi Song,Min-Can Wang,* andJun-Biao Chang* “ANewStrategy forEnantioselectiveConstruction ofMultisubstitutedFive-memberedOxygenHeterocyclesviaDominoMichael/HemiketalizationReaction,Chem. Eur. J.2015,21, 11994-11998.”
26.Yuan-Zhao Hua, Liu-Jie Lu, Pei-Jin Huang, Dong-Hui Wei, Ming-Sheng Tang,Min-Can Wang* and Jun-Biao Chang* “Highly Enantioselective Catalytic System for Asymmetric Copolymerization of Carbon Dioxide and Cyclohexene Oxide at One Atmosphere Pressure and Room Temperature”Chem. Eur. J.2014,20, 12394-12398.
27.Xixi Song, Jing-Guo Shi, Ping-Ping Sun,Min-Can Wang* and Jun-Biao Chang* “Diastereomeric Aziridine Carbinol Catalyzed Enantioselective Arylation Reaction: towards the Asymmetric Synthesis of Both Enantiomers of Chiral 3-Aryl Phthalide”J. Org. Chem.2014,79, 6087-6093.
28.Yuan-Zhao Hua, Xing-Wang Han, Xiao-Chao Yang, Xixi Song,Min-Can Wang* and Jun-Biao Chang* “Enantioselective Friedel-Crafts Alkylation of Pyrrole with Chalcones Catalyzed by a Dinuclear Zinc Catalyst”J. Org. Chem.2014,79, 11690-11699.
29.Xixi Song, Ai-Xiang Liu, Shan-Shan Liu, Wen-Chao Gao,Min-Can Wang* and Junbiao Chang* “Enantiopure azetidine-2-carboxamides as organocatalysts for direct asymmetric aldol reactions in aqueous and organic media”Tetrahedron2014,70, 1464-1470.
30.Xixi Song, Jing Liu, Meng-Meng Liu, Xi Wang, Zhao-Fei Zhang,Min-Can Wang* and ??Junbiao Chang* “Dinuclear zinc catalyzed asymmetric tandem Michael addition/acetalization reactions of cyclic diketones andβ,γ–unsaturatedα-ketoesters”Tetrahedron2014,70, 5468-5474.
31.Min-Can Wang,* Pei-Jin Huang, Xiao-Chao Yang, Xixi Song and Hui-Jie Lu “Effect of conformational equilibrium on enantioselectivity of catalysts: a quantitative relationship for the evaluation, design, and prediction of chiral ligand in addition of diethylzinc to benzaldehyde”Tetrahedron: Asymmetry2014,25, 781-786.
32.Min-Can Wang,* Gao-Wei Li, Wen-Bo Hu, Yuan-Zhao Hua, Xixi Song and Hui-Jie Lu* “A mathematical expression for enantioselectivity and thermodynamic factors in conformational equilibrium of catalysts in addition of diethylzinc to benzaldehyde”Tetrahedron: Asymmetry2014,25, 1360-1365.
33. De-Yang Zhang, Chang-Bin Yu,Min-Can Wang,* Kai Gao, Yong-Gui Zhou* “A new electronically de?cient atropisomeric diphosphine ligand (S)-CF3O-BiPhep and its application in asymmetric hydrogenation”Tetrahedron Lett.2012,53, 2556-2559.
34.Min-Can Wang,* Yong-Hui Wang, Gao-Wei Li, Ping-Ping Sun, Jie-Xi Tian, and Hui-Jie Lu “Applications of Conformational Design: Rational Design of Chiral Ligands Derived from a Common Chiral Source for Highly Enantioselective preparation of (R)- and (S)-Enantiomers of Secondary Alcohol”Tetrahedron: Asymmetry2011,22, 761-768.
35. De-Yang Zhang, Duo-Sheng Wang,Min-Can Wang,* Chang-Bin Yu, Kai Gao, Yong-Gui Zhou*“Synthesis of Electronically Deficient Atropisomeric Bisphosphine Ligands and Their Application in Asymmetric Hydrogenation of Quinolines”Synthesis2011,2796-2802.
36.Min-Can Wang,* Zhi-kang Liu, Song Li, Xue Ding, Yuan Li and Ming-Sheng Tang “An Experimental and Theoretical Study on Free Ligand Conformational Preferences and Enantioselectivity Relationship for the Asymmetric Addition of Diethylzinc to Benzaldehyde”Tetrahedron: Asymmetry2010,21, 486-493.
37.Min-Can Wang,*Qing-Jian Zhang, Gao-Wei Li and Zhi-Kang Liu “Highly enantioselective addition of dimethylzinc to arylaldehydes catalyzed by (2S)-1-ferrocenyl-methylaziridin-2- yl(diphenyl)methanol”.Tetrahedron: Asymmetry2009,20, 288-292.
38.Jun-Long Niu,Min-Can Wang,* Pei-Pei Kong, Qing-Tao Chen, Yu Zhu, Mao-Ping Song*“Origin of Enantioselectivity with Heterobidentate Sulfide-Tertiary Amine (sp3) Ligands in Palladium-Catalyzed Allylic Substitution”.Tetrahedron2009,65, 8869-8878.
39. Jun-Long Niu,Min-Can Wang,* Liu-jie Lu, Guo-Liang Ding, Hui-Jie Lu, Qing-Tao Chen, Mao-Ping Song* “Enantioselective addition of alkynylzinc to arylaldehydescatalyzed byazetidino amino alcohols with an additional chiral centre”.Tetrahedron: Asymmetry2009,20, 2616-2621.
40.Min-Can Wang,* Qing-Jian Zhang, Wen-Xian Zhao, Xiao-Dan Wang, Xue Ding, Tao-Tao Jing and Mao-Ping Song. “Evaluation of EnantiopureN-Ferrocenylmethyl Azetidin-2-yl(diphenyl)methanol for Catalytic Asymmetric Addition of Organozinc Reagents to Aldehydes”.J. Org. Chem.2008,73, 168-176.
41.Min-Can Wang,* Xiao-Dan Wang, Xue Ding and Zhi-Kang Liu. “Catalytic asymmetric aryl transfer: highly enantioselective preparation of (R)- and (S)-diarylmethanols catalyzed by the same chiral ferrocenyl aziridino alcohol”.Tetrahedron2008,64, 2559-2564.
42.Min-Can Wang,* Wen-Xian Zhao, Xiao-Dan Wang, and Mao-Ping Song*. “New enantiopureN-ferrocenylmethyl azetidin-2-yl(diphenyl)methanol and its application in catalytic asymmetric ethylation and arylation of arylaldehydes”.Synlett.2006, 3443-3445.
43.Min-Can Wang,* Cui-Lian XU, Fu Cheng and Xue Ding. “Chiral ferrocenyl amidophosphine ligand for highly enantioselective addition of diethylzinc toN-diphenylphosphinoylimines”.Tetrahedron2006,62, 12220-12226.
44.Min-Can Wang,* Xue-Hui Hou, Chao-Xian Chi, Ming-Sheng Tang* “The effect of direct steric interaction between substrate substituents and ligand substituents on enantioselectivities in asymmetric addition of diethylzinc to aldehydes catalyzed by sterically congested ferrocenyl aziridino alcohols”.Tetrahedron: Asymmetry2006, 17, 2126-2132.
45. Lan-Tao Liu,Min-Can Wang,* Wen-Xian Zhao, Yan-Li Zhou, Xiao-Dan Wang. “Theorthoeffect: copper-catalyzed highly enantioselective 1,4-conjugate addition of diethylzinc to chalcones”.Tetrahedron: Asymmetry2006, 17, 136-141.
46.Min-Can Wang,* Xue-Hui Hou, Cui-Lian Xu, Lan-Tao Liu, Gui-Lan Li, De-Kun Wang. “NovelC2-Symmetric 1,1’-Disubstituted Ferrocenyl Aziridino Alcohols Ligands: Remarkable Improvement of Enantioselectivity in the Catalytic Asymmetric Addition of Diethylzinc to Aldehydes”Synthesis2005,3620-3626.
47. XU, Cui-Lian,WANG, Min-Can*, HOU, Xue-Hui, LIU, Hong-Min and WANG, De-Kun. “Synthesis of New Chiral [2-(1-hydroxyalkyl)pyrrolidino]methylferrocenes and Application to the Catalytic Asymmetric Addition of Diethylzinc to Arylaldehydes”Chin. J. Chem.2005,23, 1443-1448.
48.Min-Can Wang,* Lan-Tao Liu, Yuan-Zhao Hua, Jun-song Zhang, Yan-Yan Shi and De-Kun Wang. “Novel chiral copper complexes ofN,P-ferrocenyl ligands with central and planar chirality as efficient catalyst for asymmetric addition of diethylzinc to imines”Tetrahedron: Asymmetry2005, 16, 2531-2534.
49.Min-Can Wang,* Cui-Lian Xu, Yu-Xi Zou, Hong-Min Liu* and De-Kun Wang. “New chiral ferrocenyl amidophosphine ligand for remarkable improvement of enantioselectivities in copper-catalyzed addition of diethylzinc toN-sulfonylimines”Tetrahedron Lett.2005,46, 5413-5416.
50.Junsong Zhang,Mincan Wang*, Jianhai Wang, Yanyan Shi,Jingchao Tao* and Dekun Wang. “Group transfer polymerization of acrylonitrile in bulk at ambient temperature”Polymer Bulletin,2005,54(3), 157-161.
51.WANG, Min-Can?? WANG, De-Kun*LOU, Jian-Ping? HUA, Yuan-Zhao. “Novel chiral ferrocenyl aziridino alcohol catalysts promoting asymmetric addition of diethylzinc to aldehydes”Chin. J. Chem.2004,22, 512-514.
52.Min-Can Wang,*Lan-Tao Liu, Jun-Song Zhang, Yan-Yan Shi and De-Kun Wang. “Synthesis of chiral ferrocenyl aziridino alcohols and use in the catalytic asymmetric addition of diethylzinc to aldehydes”Tetrahedron: Asymmetry2004,15, 3853-3859.
53.Min-Can Wang, De-Kun Wang,*Yu Zhu, Lan-Tao Liu and Yi-Fei Guo. “EnantiopureN-ferrocenylmethylaziridin-2-ylmethanols fromL-serine: Synthesis, crystal structure and application” Tetrahedron: Asymmetry2004, 15,1289-1294.
