Profile

Dr. Yu Lan, full professor in organic chemistry, Distinguished Professor of Henan Province

Email: lanyu@zzu.edu.cn

 Education

   2003~2008——Ph.D. in Chemistry, Peking University, Supervisor: Professor Yun-Dong Wu

   1999~2003——B.S., Peking University

 Working Experience

   Oct. 2018, he joined Zhengzhou University and was named as a distinguished professor in Henan Province in 2018.

  2018~present——Professor, PhD supervisor, Chongqing University

   2016~2018——Associate Professor, Doctoral Supervisor, Chongqing University

   2012~2016——Researcher, Pre-employment Assistant Professor, Doctoral Supervisor, Chongqing University

   2009~2012——Postdoctoral Researcher, Collaborate Supervisor: Professor K. N. Houk, University of California, Los Angeles

 Research area

   Mechanistic study of transition-metal-catalyzed coupling reactions;

   Study the reactivity and selectivity of bimolecular reactions with distortion-interaction model;

   Reaction model of radical-radical cross-coupling reactions;

   Design and preparation of bulky phosphine ligands based on theoretical predictions.

 Publications

Professor Lan Yu has published more than 50 papers by communication authors in the three major journals of J. Am. Chem. Soc., Angew. Chem., and Nat. Commun. in the past five years. Currently, he has published more than 250 papers in various academic journals. The total number of citations has exceeded 6,000 times. Professor Lan Yu has presided one National Natural Science Foundation Outstanding Youth Fund Project, two surface projects, and one youth project.

Selected publications as the corresponding author:

(1)           “Stereoselective Access to [5.5.0] and [4.4.1] Bicyclic Compounds through Pd-Catalysed Divergent Higher-Order Cycloadditions” Yang, L.-C.; Wang, Y.-N.; Liu, R.; Luo, Y.; Ng, X. Q.; Yang, B.; Rong, Z.-Q.; Lan Y.*; Shao, Z.; Zhao, Y.* Nat. Chem. 2020, 12, 860-868. (DOI: 10.1038/s41557-020-0503-7)

(2)           “Tuning the reactivity of alkoxyl radicals from 1,5-hydrogen atom transfer to 1,2-silyl transfer” Yang, Z.; Niu, Y.; He, X.; Chen, S.; Liu, S.; Li, Z.; Chen, X.; Zhang, Y.; Lan, Y.*; Shen, X.* Nat. Commun. 2021, 12, 2131. (DOI: 10.1038/s41467-021-22382-y)

(3)           “Quadruple C-H activation coupled to hydrofunctionalization and C-H silylation/borylation enabled by weakly coordinated palladium catalyst” Tang, B.-C.; Lin, W.-X.; Chen, X.-L.; He, C.; Ma, J.-T.; Wu, Y.-D.; Lan, Y.*; Wu, A.-X.* Nat. Commun. 2020, 11, 5662. (DOI: 10.1038/s41467-020-19508-z)

(4)           “A unified approach for divergent synthesis of contiguous stereodiads employing a small boronyl group” Zhan, M.; Ding, Z.; Du, S.; Chen, H.; Feng, C.; Xu, M.; Liu, Z.; Zhang, M.; Wu, C.; Lan, Y.*; Li, P.* Nat. Commun. 2020, 11, 792. (DOI: 10.1038/s41467-020-14592-7)

(5)           “Reaction Scope and Mechanistic Insights of Nickel-Catalyzed Migratory Suzuki-Miyaura Cross-Coupling” Li, Y.; Luo, Y.; Peng, L.; Li, Y.; Zhao, B.; Wang, W.; Pang, H.; Deng, Y.; Bai, R.; Lan, Y.*; Yin, G.* Nat. Commun. 2020, 11, 147. (DOI: 10.1038/s41467-019-14016-1)

(6)           “Unveiling How Intramolecular Stacking Modes of Covalently Linked Dimers Dictate Photoswitching Properties” Lu, R.-Q.; Yan, X.-Y.; Zhu, L.; Yang, L.-L.; Qu, H.; Wang, X.-C.*; Luo, M.; Wang, Y.; Chen, R.; Wang, X.-Y.; Lan, Y.*; Pei, J.; Weng, W.; Xia, H.; Cao, X.-Y.* Nat. Commun. 2019, 10, 5480. (DOI: 10.1038/s41467-019-13428-3)

(7)           “Enantiodivergence by Minimal Modification of an Acyclic Chiral Secondary Aminocatalyst” Dai, J.; Wang, Z.; Deng, Y.; Zhu, L.; Peng, F.; Lan, Y.*; Shao, Z.* Nat. Commun. 2019, 10, 5182. (DOI: 10.1038/s41467-019-13183-5)

(8)           “Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives” Yuan, C.; Zhu, L.; Chen, C.; Chen, X.; Yang, Y.; Lan, Y.*; Zhao, Y.* Nat. Commun. 2018, 9, 1189. (DOI: 10.1038/s41467-018-03341-6)

(9)           “Biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone A” Han, Y.; Jiang, Y.; Li, Y.; Yu, H.; Tong, B.; Niu, Z.; Zhou, S.; Liu, S.; Lan, Y.;* Chen, J.;* Yang, Z.;* Nat. Commun. 2017, 8, 14233. (DOI: 10.1038/ncomms14233)

(10)        “Towards a general diastereoselective route to oxabicyclo[3.2.1]octanes via a gold-catalysed cascade reaction” Fu, J.; Gu, Y.; Yuan, H.; Luo, T.; Liu, S.; Lan, Y.*; Gong, J.*; Yang, Z.* Nat. Commun. 2015, 6, 8617. (DOI: 10.1038/ncomms9617)

(11)        “Asymmetric total synthesis of (-)-lingzhiol via a Rh-catalysed [3+2] cycloaddition” Long, R.; Huang, J.; Shao, W.; Liu, S.; Lan, Y.*; Gong, J.*; Yang, Z.* Nat. Commun. 2014, 5, 5707. (DOI: 10.1038/ncomms6707)

(12)        “Desymmetrization of 1,3-Diones by Catalytic Enantioselective Condensation with Hydrazine” Yang, B.; Dai, J.; Luo, Y.; Lau, K. K.; Lan, Y.*; Shao, Z.*; Zhao, Y.* J. Am. Chem. Soc. 2021, 143, 4179-4186. (DOI: 10.1021/jacs.1c01366)

(13)        “Aryne 1,2,3,5-Tetrasubstitution Enabled by 3?Silylaryne and Allyl Sulfoxide via an Aromatic 1,3-Silyl Migration” Shi, J.; Li, L.; Shan, C.; Wang, J.; Chen, Z.; Gu, R.; He, J.; Tan, M.; Lan, Y.*; Li, Y.* J. Am. Chem. Soc. 2021, 143, 2178-2184. (DOI: 10.1021/jacs.0c11119)

(14)        “Chemoselective Union of Olefins, Organohalides, and Redox-Active Esters Enables Regioselective Alkene Dialkylation” Yang, T.; Jiang, Y.; Luo, Y.; Li, J. J. H.; Lan, Y.*; Koh, M. J.* J. Am. Chem. Soc. 2020, 142, 21410-21419. (DOI: 10.1021/jacs.0c09922)

(15)        “Nickel-Catalyzed C-F/N-H Annulation of Aromatic Amides with Alkynes: Activation of C-F Bonds under Mild Reaction Conditions” Nohira, I.; Liu, S.; Bai, R.; Lan, Y.*; Chatani, N.* J. Am. Chem. Soc. 2020, 142, 17306-17311. (DOI: 10.1021/jacs.0c08512)

(16)        “C(sp³)-CF₃ Reductive Elimination from a Five-Coordinate Neutral Copper(III) Complex” J. Am. Chem. Soc. 2020, 142, 9785–9791. (DOI: 10.1021/jacs.0c03304)

(17)        “Highly Selective and Catalytic Generation of Acyclic Quaternary Carbon Stereocenters via Functionalization of 1,3-Dienes with CO₂” Chen, X.-W.; Zhu, L.; Gui, Y.-Y.; Jing, K.; Jiang, Y.-X.; Bo, Z.-Y.; Lan, Y.*, Li, J.; Yu, D.-G.* J. Am. Chem. Soc. 2019, 141, 18825-18835. (DOI: 10.1021/jacs.9b09721)

(18)        “Unmasking the Ligand Effect in Manganese-Catalyzed Hydrogenations: Mechanistic Insight and Catalytic Application” Wang, Y.; Zhu, L.; Shao, Z.; Li, G.; Lan, Y.*; Liu, Q.* J. Am. Chem. Soc. 2019, 141, 17337-17349. (DOI: 10.1021/jacs.9b09038)

(19)        “Theoretical Study of the Addition of Cu–Carbenes to Acetylenes to Form Chiral Allenes” Zhong, K.; Shan, C.; Zhu, L.; Liu, S.; Zhang, T.; Liu, F.; Shen, B.; Lan, Y.*; Bai, R.* J. Am. Chem. Soc. 2019, 141, 5227-5280. (DOI: 10.1021/jacs.8b13055)

(20)        “Asymmetric Propargylic Radical Cyanation Enabled by Dual Organophotoredox and Copper Catalysis” Lu, F.-D.; Liu, D.; Zhu, L.; Lu, L.-Q.*; Yang, Q.; Zhou, Q.-Q.; Wei, Y.; Lan, Y.*; Xiao, W.-J.* J. Am. Chem. Soc. 2019, 141, 6167-6172. (DOI: 10.1021/jacs.9b02338)

(21)        “Kinetic Resolution of Allylic Alcohol with Chiral BINOL-based Alkoxides: A Combination of Experimental and Theoretical Studies” Liu, Y.; Liu, S.; Li, D.; Zhang, N.; Peng, L.; Ao, J.; Eui, C.; Lan, Y.*; Yan, H. J. Am. Chem. Soc. 2019, 141, 1150-1159. (DOI: 10.1021/jacs.8b12796)

(22)        “Well-Designed Phosphine–Urea Ligand for Highly Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Methacrylonitrile: A Combined Experimental and Theoretical Study” Xiong, Y.; Du, Z.; Chen, H.; Yang, Z.; Tan, Q.; Zhang, C.; Zhu, L.; Lan, Y.*; Zhang, M.* J. Am. Chem. Soc. 2019, 141, 961-971. (DOI: 10.1021/jacs.8b10939)

(23)        “Palladium-Catalyzed Intermolecular Ditrifluoromethoxylation of Unactivated Alkenes: CF₃O^- Palladation Initiated by Pd(IV)” Chen, C.; Luo, Y.; Fu, L.; Chen, P.; Lan, Y.*; Liu, G.* J. Am. Chem. Soc. 2018, 140, 1207-1210. (DOI: 10.1021/jacs.7b11470)

(24)        “Rhodium/Copper Cocatalyzed Highly trans-Selective 1,2- Diheteroarylation of Alkynes with Azoles via C?H Addition/Oxidative Cross-Coupling: A Combined Experimental and Theoretical Study” Tan, G.; Zhu, L.; Liao, X.; Lan, Y.*; You, J.* J. Am. Chem. Soc. 2017, 139, 15724-15737. (DOI: 10.1021/jacs.7b07242)

(25)        “Nine-Membered Benzofuran-Fused Heterocycles: Enantioselective Synthesis by Pd-Catalysis and Rearrangement via Transannular Bond Formation” Rong, Z.-Q.; Yang, L.-C.; Liu, S.; Yu, Z.; Wang, Y.-N.; Tan, Z. Y.; Huang, R.-Z.; Lan, Y.*; Zhao, Y.* J. Am. Chem. Soc. 2017, 139, 15304-15307. (DOI: 10.1021/jacs.7b09161)

(26)        “C?O Functionalization of α?Oxyboronates: A Deoxygenative gemDiborylation and gem-Silylborylation of Aldehydes and Ketones” Wang, L.; Zhang, T.; Sun, W.; He, Z.; Xia, C.; Lan, Y.*; Liu, C.* J. Am. Chem. Soc. 2017, 139, 5257-5264. (DOI: 10.1021/jacs.7b02518)

(27)        “Regiodivergent Enantioselective γ?Additions of Oxazolones to 2,3-Butadienoates Catalyzed by Phosphines: Synthesis of α,α-Disubstituted α?Amino Acids and N,O?Acetal Derivatives” Wang, T.; Yu, Z.; Hoon, D. L.; Phee, C. Y.; Lan, Y.*; Lu, Y.* J. Am. Chem. Soc. 2016, 138, 265-271. (DOI: 10.1021/jacs.5b10524)

(28)        “Rhodium-Catalyzed C?H Activation of Phenacyl Ammonium Salts Assisted by an Oxidizing C?N Bond: A Combination of Experimental and Theoretical Studies” Yu, S.; Liu, S.; Lan, Y.*; Wan, B.*; Li, X.* J. Am. Chem. Soc. 2015, 137, 1623-1631. (DOI: 10.1021/ja511796h)

(29)        “Cu(II)?Cu(I) Synergistic Cooperation to Lead the Alkyne C?H Activation” Bai, R.; Zhang, G.; Yi, H.; Huang, Z.; Qi, X.; Liu, C.; Miller, J. T.; Kropf, A. J.; Bunel, E. E.; Lan, Y.*; Lei, A.* J. Am. Chem. Soc. 2014, 136, 16760-16763. (DOI: 10.1021/ja5097489)

(30)        “Rhodium-Catalyzed Atroposelective Construction of Indoles via C-H Bond Activation” Sun, L.; Chen, H.; Liu, B.; Chang, J.; Kong, L.; Wang, F.*; Lan, Y.*; Li, X. Angew. Chem. Int. Ed. 2021, 60, 8391-8395. (DOI: 10.1002/anie.202012932)

(31)        “Elemental sulfur enabled divergent synthesis of disulfides, diselenides and polythiophenes from β-CF₃-1,3-enynes” Jin, S.; Li, S.-J.; Ma, X.; Su, J.; Chen, H.; Lan, Y.*; Song, Q.* Angew. Chem. Int. Ed. 2021, 60, 881-888. (DOI: 10.1002/anie.202009194)

(32)        “Manganese-Catalyzed Asymmetric Hydrogenation of Quinolines Enabled by π-π Interaction” Liu, C.; Wang, M.; Liu, S.; Wang, Y.; Peng, Y.; Lan, Y.*; Liu, Q.* Angew. Chem. Int. Ed. 2021, 60, 5108-5113. (DOI: 10.1002/anie.202013540)

(33)        “Iron-Catalyzed Radical Relay Enabling the Modular Synthesis of Fused Pyridines from Alkyne-Tethered Oximes and Alkenes” Du, F.; Li, S.-J.; Jiang, K.; Zeng, R.; Pan, X.-C.*; Lan, Y.*; Chen, Y.-C.*; Wei, Y.* Angew. Chem. Int. Ed. 2020, 59, 23755-23762. (DOI: 10.1002/anie.202010752)

(34)        “Hydrogen-Bonding-Promoted Cascade Rearrangement Involving the Enlargement of Two Rings: Efficient Access to Polycyclic Quinoline Derivatives” Cao, W.-B.; Li, S.; Xu, M.-M.; Li, H.; Xu, X.-P.*; Lan, Y.*; Ji, S.-J.* Angew. Chem. Int. Ed. 2020, 59, 21425-21430. (DOI: 10.1002/anie.202008110)

(35)        “Visible-Light Photoredox-Catalyzed Remote Difunctionalizing Carboxylation of Unactivated Alkenes with CO₂” Song, L.; Fu, D.-M.; Chen, L.; Jiang, Y.-X.; Ye, J.-H.; Zhu, L.; Lan, Y.*; Fu, Q.; Yu, D.-G.* Angew. Chem. Int. Ed. 2020, 59, 21121-21128. (DOI: 10.1002/anie.202008630)

(36)        “Utilizing Vinylcyclopropane Reactivity: Palladium-Catalyzed Asymmetric [5+2] Dipolar Cycloadditions” Li, M.-M.; Xiong, Q.; Qu, B.-L.; Xiao, Y.-Q.; Lan, Y.*; Lu, L.-Q.; Xiao, W.-J. Angew. Chem. Int. Ed. 2020, 59, 17429-17434. (DOI: 10.1002/anie.202006366)

(37)        “Palladium-Catalyzed Asymmetric [8+2] Dipolar Cycloadditions of Vinyl Carbamates and Photogenerated Ketenes” Zhang, Q.-L.; Xiong, Q.; Li, M.-M.; Xiong, W.; Shi, B.; Lan, Y.*; Lu, L.-Q.*; Xiao, W.-J. Angew. Chem. Int. Ed. 2020, 59, 14096-14100. (DOI: 10.1002/anie.202005313)

(38)        “Inverse Electron-Demand, Pd-Catalyzed Asymmetric [4+2] Cycloadditions Enabled by Chiral P,S-Ligand and Hydrogen Bonding” Wang, Y.-N.; Xiong, Q.; Lu, L.-Q.*; Zhang, Q.-L.; Wang, Y.; Lan, Y.*; Xiao, W.-J.* Angew. Chem. Int. Ed. 2019, 58, 11013-11017. (DOI: 10.1002/anie.201905993)

(39)        “Key Intermediate in Copper-Mediated Arene Trifluoromethylation [nBu₄N][Cu(Ar)(CF₃)₃]: Synthesis, Characterization and C(sp²)-CF₃ Reductive Elimination” Lu, Z.; Liu, H.; Liu, S.; Leng, X.; Lan, Y.*; Shen, Q.* Angew. Chem. Int. Ed. 2019, 58, 8510-8514. (DOI: 10.1002/anie.201904041)

(40)        “Enantioselective Synthesis of Biaryl Atropisomers via Pd‐Catalyzed C–H Olefination using Chiral Spiro Phosphoric Acid Ligands” Luo, J.; Zhang, T.; Wang, L.; Liao, G.; Yao, Q.-J.; Wu, Y.-J.; Zhan, B.-B.; Lan, Y.*; Lin, X.-F.*; Shi, B.-F.* Angew. Chem. Int. Ed. 2019, 58, 6708-6712. (DOI: 10.1002/anie.201902126)

(41)        “Author Profile” Lan, Yu* Angew. Chem. Int. Ed. 2018, 57, 11852. (DOI: 10.1002/anie.201804435)

(42)        “Ruthenium(II)-catalyzed C-H Difluoromethylation of Ketoxime: Tuning the Regioselectivity from meta to para Position” Yuan, C.; Zhu, L.; Zeng, R.; Lan, Y.*; Zhao, Y.* Angew. Chem. Int. Ed. 2018, 57, 1277-1281. (DOI: 10.1002/anie.201711221)

(43)        “Bioinspired Total Synthesis of Homodimericin A” Huang, J.; Gu, Y.; Guo, K.; Zhu, L.; Lan, Y.*; Gong, J.*; Yang, Z.* Angew. Chem. Int. Ed. 2017, 56, 7890-7894. ( DOI: 10.1002/anie.201702768)

(44)        “Bioinspired Asymmetric Synthesis of Hispidanin A” Li, F.; Tu, Q.; Chen, S.; Zhu, L.; Lan, Y.*; Gong, J.*; Yang, Z.* Angew. Chem. Int. Ed. 2017, 56, 5844-5848. (DOI: 0.1002/anie.201700838)

(45)        “Regioselective ?-Addition of Deconjugated Butenolides: Enantioselective Synthesis of Dihydrocoumarins” Wu, B.; Yu, Z.; Gao, X.; Lan, Y.*; Zhou, Y.* Angew. Chem. Int. Ed. 2017, 56, 4006-4010. (DOI:10.1002/anie.201700437)

(46)        “Asymmetric Transfer Hydrogenation of Imines using Alcohol: Efficiency and Selectivity are Influenced by the Hydrogen Donor” Pan, H. J.; Zhang, Y.; Shan, C.; Yu, Z.; Lan, Y.;* Zhao, Y.* Angew. Chem. Int. Ed. 2016, 55, 9615-9619. (DOI:10.1002/anie.201604025)

(47)        “Anthranil: An Aminating Reagent Leading to Bifunctionality for Both C(sp³)-H and C(sp²)-H under Rhodium(III) Catalysis” Yu, S.; Tang, G.; Li, Y.; Zhou, X.; Lan, Y.;* Li, X.* Angew. Chem. Int. Ed. 2016, 55, 8696-8700. (DOI: 10.1002/anie.201602224)

(48)        “Iron-Catalyzed Decarboxylative (4+1) Cycloadditions: Exploiting the Reactivity of Ambident Iron-Stabilized Intermediates” Wang, Q.; Qi, X.; Lu, L. Q.*; Li, T. R.; Yuan, Z. G.; Zhang, K.; Li, B. J.; Lan, Y.*; Xiao, W. J.* Angew. Chem. Int. Ed. 2016, 55, 2840-2844. (DOI: 10.1002/anie.201510413)

(49)        “Transition-Metal-Free Formal Decarboxylative Coupling of a-Oxocarboxylates with a-Bromoketones under Neutral Conditions: A Simple Access to 1,3-Diketones” He, Z.; Qi, X.; Li, S.; Zhao, Y.; Gao, G.*; Lan, Y.*; Wu, Y.; Lan, J.; You, J.* Angew. Chem. Int. Ed. 2015, 54, 855-859. (DOI: 10.1002/anie.201409361)

(50)        “Chemoselective Carbophilic Addition of a-Diazoesters through Ligand-Controlled Gold Catalysis” Xi, Y.; Su, Y.; Yu, Z.; Dong, B.; McClain, E. J.; Lan, Y.*; Shi, X.* Angew. Chem. Int. Ed. 2014, 53, 9817-9821. (DOI: 10.1002/anie.201404946)

(51)        “Visible-Light-Mediated Decarboxylation/Oxidative Amidation of α-Keto Acids with Amines under Mild Reaction Conditions Using O₂” Liu, J.; Liu, Q.; Yi, H.; Qin, C.; Bai, R.; Qi, X.; Lan, Y.*; Lei, A.* Angew. Chem. Int. Ed. 2014, 53, 502-506. (DOI: 10.1002/anie.201308614)

(52)        “Ligand coordination- and dissociation induced divergent allylic alkylations using alkynes” Huang, Y.; Ma, C.; Liu, S.; Yang, L.-C.; Lan, Y.*; Zhao, Y.* Chem 2021, 7, 812-826. (DOI: 10.1016/j.chempr.2021.02.018)

(53)        “Cu-Catalyzed Regio- and Stereodivergent Chemoselective sp²/sp³ 1,3- and 1,4-Diborylations of CF₃-Containing 1,3-Enynes” Kuang, Z.; Chen, H.; Qiu, J.; Ou, Z.; Lan, Y.*; Song, Q.* Chem 2020, 6, 2347-2363. (DOI: 10.1016/j.chempr.2020.06.034)

(54)        “Photoredox Catalysis Modulated Nickel-Catalyzed Divergent Difunctionalization of Ethylene” Li, J.; Luo, Y.; Cheo, H. W.; Lan, Y.*; Wu, J.* Chem 2019, 5, 192-203. (DOI: 10.1016/j.chempr.2018.10.006)

(55)        “Catalytic Atroposelective Catellani Reaction Enables to Construct Axially Chiral Biaryl Monophosphine Oxides” Feng, Q.; Ma, X.; Bao, W.; Li, S.-J.; Lan, Y.*; Song, Q.* CCS Chem. 2021, 3, 377-387. (DOI: 10.31635/ccschem.021.202000725)

(56)        “Visible Light-Driven Anti-Markovnikov Hydrocarboxylation of Acrylates and Styrenes with CO₂” Huang, H.; Ye, J.-H.; Zhu, L.; Ran, C.-K.; Miao, M.; Wang, W.; Chen, H.; Zhou, W.-J.; Lan, Y.*, Yu, B.; Yu, D.-G.* CCS Chem. 2020, 2, 1746-1759. (DOI: 10.31635/ccschem.020.202000374)

(57)        “Synergistic Dinuclear Rhodium Induced Rhodium-Walking Enabling Alkene Terminal Arylation: A Theoretical Study” Heng, D.; Chen, H.; He, X.; Liu, S.; Zhu, L.; Zhong, K.; Zhang, T.; Bai, R.*; Lan, Y.* ACS Catal. 2021, 11, 3975-3987. (DOI: 10.1021/acscatal.0c05554)

(58)        “Multiple Functional Organocatalyst-Promoted Inert C–C Activation: Mechanism and Origin of Selectivities” Zhang, M.; Wang, Y.; Li, S.-J.; Wang, X.; Shi, Q.; Li, X.; Qu, L.-B.; Wei, D.*; Lan, Y.* ACS Catal. 2021, 11, 3443-3454. (DOI: 10.1021/acscatal.0c05511)

(59)        “Palladium-Catalyzed Intermolecular trans-Selective Carbofunctionalization of Internal Alkynes to Highly Functionalized Alkenes” Lv, W.; Liu, S.; Chen, Y.; Wen, S.; Lan, Y.*; Cheng, G.* ACS Catal. 2020, 10, 10516-10522. (DOI: 10.1021/acscatal.0c02522)

(60)        “Dynamic Kinetic Asymmetric Amination of Alcohols Assisted by Microwave: Stereo-convergent Access to Tetralin- and Indane-Derived Chiral Amines” Rong, Z.-Q.; Yu, Z.; Weng, C.; Yang, L.-C.; Lu, S.; Lan, Y.*; Zhao, Y.* ACS Catal. 2020, 10, 9464-9475. (DOI: 10.1021/acscatal.0c02468)

(61)        “Nucleophilicity versus Br?nsted basicity controlled chemoselectivity: mechanistic insight into silver- or scandium-catalyzed diazo functionalization” Liu, F.; Zhu, L.; Zhang, T.; Zhong, K.; Xiong, Q.; Shen, B.; Liu, S.; Lan, Y.*; Bai, R.* ACS Catal. 2020, 10, 1256-1263. (DOI: 10.1021/acscatal.9b02040)

(62)        “Oxidative Addition Promoted C?C Bond Cleavage in Rh-Mediated Cyclopropenone Activation: A DFT Study” Luo, Y.; Shan, C.; Liu, S.; Zhang, T.; Zhu, L.; Zhong, K.; Bai, R.*; Lan, Y.* ACS Catal. 2019, 9, 10876-10886. (DOI: 10.1021/acscatal.9b03361)

(63)        “Origin of Regiochemical Control in Rh(III)/Rh(V)-Catalyzed Reactions of Unsaturated Oximes and Alkenes to Form Pyrdines” Li, Y.; Chen, H.; Qu, L.-B.; Houk, K. N.*; Lan, Y.* ACS Catal. 2019, 9, 7154-7165. (DOI: 10.1021/acscatal.9b02085)

(64)        “Experimental and Theoretical Studies on Ru(II)-Catalyzed Oxidative C?H/C?H Coupling of Phenols with Aromatic Amides Using Air as Oxidant: Scope, Synthetic Applications and Mechanistic Insights” Zhang, L.; Zhu, L.; Zhang, Y.; Yang, Y.; Wu, Y.; Ma, W.; Lan, Y.*; You, J.* ACS Catal. 2018, 8, 8324-8335. (DOI: 10.1021/acscatal.8b02816)

(65)        “Regioselective Palladium-Catalyzed C?H Bond Trifluoroethylation of Indoles: Exploration and Mechanistic Insight” Zhang, H.; Wang, H.-Y.; Luo, Y.; Chen, C.; Cao, Y.; Chen, P.; Guo, Y.-L.; Lan, Y.*; Liu, G.* ACS Catal. 2018, 8, 2173-2180. (DOI: 10.1021/acscatal.7b03220)

(66)        “Radical Trifluoromethylative Dearomatization of Indoles and Furans with CO₂” Ye. J.-H.; Zhu, L.; Yan, S.-S.; Miao, M.; Zhang, X.-C.; Zhou, W.-J.; Li, J.; Lan, Y.*; Yu, D.-G.* ACS Catal. 2017, 7, 8324-8330. (DOI: 10.1021/acscatal.7b02533)

(67)        “Cp*CoIII-Catalyzed Branch-Selective Hydroarylation of Alkynes via C?H Activation: Efficient Access to α-gem-Vinylindoles” Zhou, X.; Luo, Y.; Kong, L.; Xu, Y.; Zheng, G.; Lan, Y.*; Li, X.* ACS Catal. 2017, 7, 7296-7304. (DOI: 10.1021/acscatal.7b02248)

(68)        “Mild Acylation of C(sp3)?H and C(sp2)?H Bonds under Redox-Neutral Rh(III) Catalysis” Yu, S.; Li, Y.; Kong, L.; Zhou, X.; Tang, G.; Lan, Y.;* Li, X.* ACS Catal. 2016, 6, 7744-7748. (DOI: 10.1021/acscatal.6b02668)

(69)        “Rhodium(III)-Catalyzed Annulation between N?Sulfinyl Ketoimines and Activated Olefins: C?H Activation Assisted by an Oxidizing N?S Bond” Wang, Q.; Li, Y.; Qi, Z.; Xie, F.; Lan, Y.*; Li, X.* ACS Catal. 2016, 6, 1971-1980. (DOI: 10.1021/acscatal.5b02297)

(70)        “Silver Migration Facilitates Isocyanide-Alkyne [3+2] Cycloaddition Reactions: Combined Experimental and Theoretical Study” Qi, X.; Zhang, H.; Shao, A.; Zhu, L.; Xu, T.; Gao, M.*; Liu, C.*; Lan, Y.* ACS Catal. 2015, 5, 6640-6647. ( DOI: 10.1021/acscatal.5b02009)

(71)        “Metal-free C(sp³)–H functionalization of sulfonamides via strain-release rearrangement” Hu, J.*; Yang, X.; Shi, S.; Cheng, B.; Luo, X.*; Lan, Y.*; Loh, T.-P.* Chem. Sci. 2021, 12, 4034-4340. (DOI: 10.1039/d0sc06603f)

(72)        “Prediction of NHC-catalyzed chemoselective functionalizations of carbonyl compounds: A general mechanistic map” Li, X.; Xu, J.; Li, S.-J.; Qu, L.-B.; Li, Z.; Chi, Y. R.; Wei, D.*; Lan, Y.* Chem. Sci. 2020, 11, 7214-7225. (DOI: 10.1039/D0SC01793K)

(73)        “S₈-Catalyzed Triple Cleavage of Bromodifluoro Compounds for the Assembly of N-containing Heterocycles” Deng, S.; Chen, H.; Ma, X.; Zhou, Y.; Yang, K.; Lan, Y.*; Song, Q.* Chem. Sci. 2019, 10, 6828-6833. (DOI: 10.1039/c9sc01333d)

(74)        “Ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2” Yan, S.-S.; Zhu, L.; Ye, J.-H.; Zhang, Z.; Huang, H.; Zeng, H.; Li, C.-J.*; Lan, Y.*; Yu, D.-G.* Chem. Sci. 2018, 9, 4873-4878. (DOI: 10.1039/c8sc01299g)

(75)        “Catalyst-controlled regioselectivity in phosphine catalysis: the synthesis of spirocyclic benzofuranones via regiodivergent [3+2] annulations of aurones and an allenoate” Ni, H.; Yu, Z.; Yao, W.; Lan, Y.*; Ullah, N.*; Lu, Y.* Chem. Sci. 2017, 8, 5699-5704. (DOI: 10.1039/c7sc02176c)

(76)        “Chiral phosphine-mediated intramolecular [3+2] annulation: enhanced enantioselectivity by achiral Br?nsted acid” Yao, W.; Yu, Z.; Wen, S.; Ni, H.; Ullah, N.*; Lan, Y.*; Lu, Y.* Chem. Sci. 2017, 8, 5196-5200. (DOI: 10.1039/c7sc00952f)

(77)        “Highly enantioselective construction of tertiary thioethers and alcohols via phosphine-catalyzed asymmetric γ-addition reactions of 5H-thiazol-4-ones and 5H-oxazol-4-ones: scope and mechanistic understandings” Wang, T.; Yu, Z.; Hoon, D. L.; Huang, K.-W.; Lan, Y.*; Lu, Y.* Chem. Sci. 2015, 6, 4912-4922. (DOI: 10.1039/c5sc01614b)

(78)        “Lewis acid–catalyzed domino generation/[2,3]-sigmatropic rearrangement of ammonium ylidesto access chiral azabicycles” Xi, S.; Dong, J.; Chen, H.; Dong, Q.; Yang, J.; Tan, Q.; Zhang, C.; Lan, Y.*; Zhang, M.* Sci. Adv. 2021, 7, eabd5290. (DOI: 10.1126/sciadv.abd5290)

(79)        “Copper-catalyzed aerobic oxidative coupling: From ketone and diamine to pyrazine” Wu, K.; Huang, Z.; Qi, X.; Li, Y.; Zhang, G.; Liu, C.; Yi, H.; Meng, L.; Bunel, E. E.; Miller, J. T.; Pao, C. W.; Lee, J. F.; Lan, Y.*; Lei, A.* Sci. Adv. 2015, 1, e1500656. (DOI: 10.1126/sciadv.1500656)

(80)        “Mechanistic View of Ru-Catalyzed C–H Bond Activation and Functionalization: Computational Advances” Shan, C.; Zhu, L.; Qu, L.-B.; Bai, R.*; Lan, Y.* Chem. Soc. Rev. 2018, 47, 7552-7576. (DOI: 10.1039/c8cs00036k)

(81)        “Mechanism of Rhodium-Catalyzed C?H Functionalization: Advances in Theoretical Investigation” Qi, X.; Li, Y.; Bai, R.; Lan, Y.* Acc. Chem. Res. 2017, 50, 2799-2808. (DOI: 10.1021/acs.accounts.7b00400)

(82)        “On the mechanism of homogeneous Pt-catalysis: A theoretical view” Chen, H.; Li, Y.*; Liu, S.*; Xiong, Q.; Bai, R.; Wei, D.*; Lan, Y.* Coor. Chem. Rev. 2021, 437, 213863. (DOI: 10.1016/j.ccr.2021.213863)

(83)        “Mechanism of Ir-catalyzed hydrogenation: A theoretical view” Cui, C.-X.; Chen, H.; Li, S.-J.; Zhang, T.; Qu, L.-B.; Lan, Y.* Coor. Chem. Rev. 2020, 412, 213251. (DOI: 10.1016/j.ccr.2020.213251)

(84)        “Computational Advances Aiding Mechanistic Understanding of Silver-Catalyzed Carbene/Nitrene/Silylene Transfer Reactions” Zhang, J.; Shan, C.; Zhang, T.; Liu, T.*; Song, J.*; Lan, Y.* Coor. Chem. Rev. 2019, 382, 69-84. (DOI: 10.1016/j.ccr.2018.12.009)