曹书霞,教授,主持完成国家自然科学基金两项,河南省教育厅基金项目两项,河南省科技厅产学研项目1项,主持完成横向科研项目3项。已发表学术论文70余篇, 其中50余篇被SCI、EI收录。获郑州市科技进步二等奖1项,河南省优秀论文奖8项,参与出版著作1部,编写教材2部。
联系方式:csx@zzu.edu.cn
学习经历:1986 ~ 1990年,郑州大学化学系获理学学士学位;1990 ~ 1993年,郑州大学化学系获理学硕士学位;2001 ~ 2004年,郑州大学化学系获理学博士学位。
工作经历:1993 ~ 1996年,郑州大学化学系助教;1996 ~ 2004年,郑州大学化学系任讲师;2004 ~ 2009年,郑州大学化学学院副教授;2006 ~ 2007年,英国牛津大学化学系国家公派访问学者;2009年至今,郑州大学化学学院教授。
研究方向:有机磷化学、有机波谱学
主持项目:
1. 2007.01-2009.12, “磷试剂辅助环肽的模版合成及其超分子识别作用研究”,国家自然科学基金项目,编号:20672104,主持且已完成结项;
2. 2012.01 – 2015.12, “磷中心手性氨基酸螺环氢膦烷的类Atherton-Todd反应研究”,国家自然科学基金项目,编号:21172201,主持且已完成结项。
3. 2014.10 – 2016.10,“沙坦类原料药的质量控制及其合成工艺研究”,河南省科技厅产学研合作项目,编号:142107000009,主持且已完成结项;
代表论文:
1. Kehui Han, Yanyan Wang, Pei Zhao, Xiaohui You, Jun Wang, Yanchun Guo, Yufen Zhao, Shuxia Cao*,Investigation of the stereochemical mechanism of the nucleophilic substitution reaction at pentacoordinate phosphorus of spirophosphorane, Journal of Orgnic Chemistry, 2021, 86 (6), 4512-4531.
2. Shuxia Cao*, Peng Gao, Yanchun Guo, Huamin Zhao, Jun Wang, Yifan Liu, Yufen Zhao, Unexpected insertion of CO2 into the pentacoordinate P–N Bond: Atherton–Todd-type reaction of hydrospirophosphorane with amines, Journal of Orgnic Chemistry, 2013, 78 (22), 11283-11293.
3. Shanqi Guo, Kehui Han, Di Wang, Yanchun Guo*, Yufen zhao, Shuxia Cao*, Phosphine-catalyzed hydrophosphonylation reaction of pentacoordinate hydrospirophosphane and electron-deficient alkenes, Asian Journal of Organic Chemistry, 2021, 10 (11), 3028-3033.
4. Wenwen Ma, Wang Dai, Qiangqiang Liu,Yonghong Chen, Yufen Zhao, Shuxia Cao*, Synthesis of novel spirophosphanes containing a pentacoordinated P-C bond by P-alkylation reaction, Tetrahedron, 2020, 76, 130886.
5. Yanchun Guo*, Han Xue, Shigai Li, Yanyan Wang, Yuexiu Wang, Shuxia Cao*, Yufen Zhao, Electrospray ionization collision induced dissociation of thieno[3,2-d]pyrimidine derivatives, International Journal of Mass Spectrometry, 2020, 457, 116411.
6. Can Sun, Shuxia Cao*, Pei Zhao, Wenwen Ma, Yanchun Guo, Yufen Zhao, The investigation on the N-H reactivity of pentacoordinate spirophosphoranes by H/D exchange and NMR experiments, Tetrahedron Letters, 2018, 59, 3833-3838.
7. Xiaoyan Cui, Can Sun, Pei Zhao, Yanyan Wang, Yanchun Guo, Yufen Zhao, Shuxia Cao*, The investigation of substituent effects on the fragmentation pathways of pentacoordinated phenoxyspirophosphoranes by ESI-MSn, Journal of Mass Spectrometry, 2018, 53, 314-322.
8. Miaomiao Peng, Shaozhu Li, Jing Wu, Yanchun Guo*, Shuxia Cao*, Yufen Zhao, Fragmentation studies of sartans by electrospray ionization mass spectrometry, Journal of Mass Spectrometry, 2017, 52, 591-596.
9. Pei Zhao, Shuxia Cao*, Yanchun Guo, Peng Gao, Yanyan Wang, Miaomiao Peng, Yufen Zhao, Investigation of the C-N bond rotation of spirophosphorane carbamates by dynamic NMR and DFT calculation, Tetrahedron, 2015, 71, 8738-8745.
10. 曹书霞*, 赵玉芬, Atherton-Todd反应及其立体化学机理研究进展, 中国科学:化学, 2015, 45(3), 251-261.