个人简历：于文全，男，1984年1月生，博士，校聘教授，博士生导师。
学习经历：
2003–2007 天津大学 药物科学与技术学院，本科
2007–2012 天津大学 药物科学与技术学院，博士（硕博连读）
2008–2012 美国Institute for Hepatitis and Virus Research（现Baruch S. Blumberg Institute），Research Scholar（博士联培）
工作经历：
2012–2015 郑州大学 化学与分子工程学院，讲师、校聘副教授，硕士生导师
2015–现今 郑州大学 化学与分子工程学院，副教授，硕士生导师
2018–现今 郑州大学 化学与分子工程学院，校聘教授，博士生导师
联系方式：
地址：河南省郑州市科学大道100号，郑州大学 化学与分子工程学院
邮箱：wenquan_yu@zzu.edu.cn
学术兼职：
中国化学会会员；担任Med. Res. Rev.；Org. Lett.；Adv. Synth. Catal.；J. Org. Chem.；Org. Biomol. Chem. 等10余种国际学术期刊通讯审稿人。
研究方向：
药物化学；有机合成
主持科研项目：
1. 国家自然科学基金－面上项目（#81773570）
2. 横向项目（#20170418R）
3. 国家科技重大专项子课题（#2015ZX09J15105-003-001）
4. 郑州大学优秀青年教师发展基金（#1521316004）
5. 横向项目（#20150167R）
6. 国家自然科学基金－青年基金（#81302637）
获奖与荣誉：
1. 郑州大学青年拔尖人才，2018年
2. 郑州大学青年骨干教师，2017年
3. 郑州大学三育人先进个人，2017年
4. 郑州大学化学与分子工程学院优秀共产党员，2017年
5. 河南省科学技术进步壹等奖，2016年
6. 第23届国际抗病毒研究大会（ICAR）Poster贰等奖，2010年
代表性论文：
1. Qiongli Zhao, Linning Ren, Jiao Hou, Wenquan Yu,* Junbiao Chang.* "Annulation Reactions of In-situ Generated N-(Het)aroyldiazenes with Isothiocyanates Leading to 2-Imino-1,3,4-oxadiazolines." Organic Letters, 2019, 21 (1), 210-213.
2. Manman Wang, Jiao Hou, Wenquan Yu,* Junbiao Chang.* "Synthesis of 2H-Azirines via Iodine-Mediated Oxidative Cyclization of Enamines." Journal of Organic Chemistry, 2018, 83 (24), 14954-14961.
3. Ertong Li, Manman Wang, Zhen Wang, Wenquan Yu,* Junbiao Chang.* "NBS-Mediated Practical Cyclization of N-Acyl Amidines to 1,2,4-Oxadiazoles via Oxidative N−O Bond Formation." Tetrahedron, 2018, 74 (35), 4613-4618.
4. Zhiyuan Hu, Jiao Hou, Jie Liu, Wenquan Yu,* Junbiao Chang.* "Synthesis of Imidazo[1,5-a]pyridines via I2-Mediated sp3 C−H Amination." Organic & Biomolecular Chemistry, 2018, 16 (31), 5653-5660.
5. Yinggao Meng, Bingnan Wang, Linning Ren, Qiongli Zhao, Wenquan Yu,* Junbiao Chang.* "I2-Mediated Transition-Metal-Free Aromatic C−H Amination for the Synthesis of Benzimidazol-2-ones and Related Heterocycles." New Journal of Chemistry, 2018, 42 (16), 13790-13796.
6. Shufeng Jiao, Zhen Wang, Qiongli Zhao, Wenquan Yu,* and Junbiao Chang.* "Synthesis of Fused 3-Amino-1,2,4-triazoles via Sequential Addition of Aryl Hydrazines to Isothiocyanates and I2-Mediated Cyclodesulfurization." Tetrahedron, 2018, 74 (24), 3069-3073.
7. Zhen Wang, Qiongli Zhao, Jiao Hou, Wenquan Yu,* and Junbiao Chang.* "Iodine-Mediated Direct Synthesis of Multifunctional 2-Aminobenzimidazoles from N-Substituted o-Diaminoarenes and Isothiocyanates." Tetrahedron, 2018, 74 (19), 2324-2329.
8. Zhigang Li, Zechun Wang, Ning Wang, Xinxin Han, Wenquan Yu,* Ruiyong Wang,* Junbiao Chang.* "Identification of the Binding between Three Fluoronucleoside Analogues and Fat Mass and Obesity-Associated Protein by Isothermal Titration Calorimetry and Spectroscopic Techniques." Journal of Pharmaceutical and Biomedical Analysis, 2018, 149, 290-295.
9. Manman Wang, Yinggao Meng, Wei Wei, Jie Wu, Wenquan Yu,* Junbiao Chang.* "Iodine/Copper(I)-Catalyzed Direct Annulation of N-Benzimidazolyl Amidines with Aldehydes for the Synthesis of Ortho-Fused 1,3,5-Triazines." Advanced Synthesis & Catalysis, 2018, 360 (1), 86-92.
10. Ertong Li,# Yafeng Wang,# Wenquan Yu,# (#co-first authors) Zhigang Lv, Youmei Peng, Bingjie Liu, Shiliang Li, Wenzhe Ho, Qingduan Wang, Honglin Li, Junbiao Chang.* "Synthesis and Biological Evaluation of a Novel β-D-2'-Deoxy-2'-α-fluoro-2'-β-C-(fluoromethyl)uridine Phosphoramidate Prodrug for the Treatment of Hepatitis C Virus Infection." European Journal of Medicinal Chemistry, 2018, 143, 107-113.
11. Wei Wei, Zhen Wang, Xikang Yang, Wenquan Yu,* and Junbiao Chang.* "Divergent Synthesis of 1H-Indazoles and 1H-Pyrazoles from Hydrazones via Iodine-Mediated Intramolecular Aryl and sp3 C−H Amination." Advanced Synthesis & Catalysis, 2017, 359 (19), 3378-3387.
12. Wenquan Yu, Ertong Li, Zhigang Lv, Ke Liu, Xiaohe Guo, Yuan Liu, Junbiao Chang.* "Synthesis and Anti-HCV Activity of a Novel 2',3'-Dideoxy-2'-α-fluoro-2'-β-C-methyl Guanosine Phosphoramidate Prodrug." ACS Medicinal Chemistry Letters, 2017, 8 (6), 682-684.
13. Bingnan Wang, Yinggao Meng, Yiming Zhou, Linning Ren, Jie Wu, Wenquan Yu,* and Junbiao Chang.* "Synthesis of 5-Amino and 3,5-Diamino Substituted 1,2,4-Thiadiazoles by I2-Mediated Oxidative N−S Bond Formation." Journal of Organic Chemistry, 2017, 82 (11), 5898-5903.
14. Zhiyuan Hu, Ting Zhao, Manman Wang, Jie Wu, Wenquan Yu,* Junbiao Chang.* "I2-Mediated Intramolecular C–H Amidation for the Synthesis of N-Substituted Benzimidazoles." Journal of Organic Chemistry, 2017, 82 (6), 3152-3158.
15. Zhigang Lv, Bingnan Wang, Zhiyuan Hu, Yiming Zhou, Wenquan Yu,* Junbiao Chang.* "Synthesis of Quinazolines from N,N'-Disubstituted Amidines via I2/KI-Mediated Oxidative C−C Bond Formation." Journal of Organic Chemistry, 2016, 81 (20), 9924-9930.
16. Jing Liu, Wei Wei, Ting Zhao, Xuanyu Liu, Jie Wu, Wenquan Yu,* Junbiao Chang.* "Iodine/Copper Iodide-Mediated C‒H Functionalization: Synthesis of Imidazo[1,2-a]pyridines and Indoles from N-Aryl Enamines." Journal of Organic Chemistry, 2016, 81 (19), 9326-9336.
17. Zhigang Lv, Jing Liu, Wei Wei, Jie Wu, Wenquan Yu,* and Junbiao Chang.* "Iodine-Mediated Aryl C–H Amination for the Synthesis of Benzimidazoles and Pyrido[1,2-a]benzimidazoles." Advanced Synthesis & Catalysis, 2016, 358 (17), 2759-2766.
18. Ertong Li, Zhiyuan Hu, Lina Song, Wenquan Yu,* and Junbiao Chang.* "Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles via Sequential Condensation and I2-Mediated Oxidative Cyclization." Chemistry-A European Journal, 2016, 22 (31), 11022-11027.
19. Xianhai Tian, Lina Song, Manman Wang, Zhigang Lv, Jie Wu, Wenquan Yu,* and Junbiao Chang.* "Synthesis of Novel Imidazo[1,2-a]pyridin-2-amines from Arylamines and Nitriles via Sequential Addition and I2/KI-Mediated Oxidative Cyclization." Chemistry-A European Journal, 2016, 22 (22), 7617-7622.
20. Youmei Peng,# Wenquan Yu,# (#co-first authors) Ertong Li, Jinfeng Kang, Yafeng Wang, Qinghua Yang, Bingjie Liu, Jingmin Zhang, Longyu Li, Jie Wu, Jinhua Jiang, Qingduan Wang, and Junbiao Chang.* "Discovery of An Orally-Active and Liver-Targeted Prodrug of 5-Fluoro-2'-Deoxyuridine for the Treatment of Hepatocellular Carcinoma." Journal of Medicinal Chemistry, 2016, 59 (8), 3661-3670.
21. Lingling Yang, Wenquan Yu, Zhigang Li, Xinting Zhang, Ting Ren, Lijiao Zhang, Ruiyong Wang,* and Junbiao Chang.* "Comparative study of the binding between FTO protein and five pyrazole derivatives by spectrofluorimetry." Journal of Molecular Liquids, 2016, 218, 156-165.
22. Huagang Lu, John Rogowskyj, Wenquan Yu, Anu Venkatesh, Noshena Khan, Shigeki Nakagawa, Nicolas Goossens, Anna P Koh, Takaaki Higashi, Ganesh Gunasekaran, Myron E Schwarz, Spiros P Hiotis, Xiaodong Xu, William Kinney, Yujin Hoshida, Timothy Block, Andrea Cuconati,* Yanming Du.* "Novel Substituted Aminothiazoles as Potent and Selective Anti-Hepatocellular Carcinoma Agents." Bioorganic & Medicinal Chemistry Letters, 2016, 26 (23), 5819-5824.
23. Xianhai Tian, Lina Song, Ertong Li, Qiang Wang, Wenquan Yu,* Junbiao Chang.* "Metal-Free One-Pot Synthesis of 1,3-Diazaheterocyclic Compounds via I2-Mediated Oxidative C−N Bond Formation." RSC Advances, 2015, 5 (76), 62194-62201.
24. Lina Song, Xianhai Tian, Zhigang Lv, Ertong Li, Jie Wu, Yangxue Liu, Wenquan Yu,* Junbiao Chang.* "I2/KI-Mediated Oxidative N−N Bond Formation for the Synthesis of 1,5-Fused 1,2,4-Triazoles from N-Aryl Amidines." Journal of Organic Chemistry, 2015, 80 (14), 7219-7225.
25. Zhigang Lv, Wu He, Xianhai Tian, Jinfeng Kang, Yangxue Liu, Youmei Peng, Liyun Zheng, Qingduan Wang, Wenquan Yu,* Junbiao Chang.* "Design, Synthesis, and Biological Evaluation of New N4-Substituted 2'-Deoxy-2'-fluoro-4'-azido Cytidine Derivatives as Potent Anti-HBV Agents." European Journal of Medicinal Chemistry, 2015, 101, 103-110.
26. Qinghua Yang, Jinfeng Kang, Liyun Zheng, Xue-Jun Wang, Na Wan, Jie Wu, Yan Qiao, Pengfei Niu, Sheng-Qi Wang, Youmei Peng, Qingduan Wang, Wenquan Yu,* Junbiao Chang.* "Synthesis and Biological Evaluation of 4-Substituted Fluoronucleoside Analogs for the Treatment of Hepatitis B Virus Infection." Journal of Medicinal Chemistry, 2015, 58 (9), 3693-3703.
27. Pengfei Niu, Jinfeng Kang, Xianhai Tian, Lina Song, Hongxu Liu, Jie Wu, Wenquan Yu,* Junbiao Chang.* "Synthesis of 2-Amino-1,3,4-oxadiazoles and 2-Amino-1,3,4-thiadiazoles via Sequential Condensation and I2-Mediated Oxidative C–O/C–S Bond Formation." Journal of Organic Chemistry, 2015, 80 (2), 1018-1024.
28. Xinting Zhang, Jinfeng Kang, Pengfei Niu, Jie Wu, Wenquan Yu,* Junbiao Chang.* "I2-Mediated Oxidative C−N Bond Formation for Metal-free One-pot Synthesis of Di-, Tri- and Tetra-substituted Pyrazoles from alpha,beta-Unsaturated Aldehydes/Ketones and Hydrazines." Journal of Organic Chemistry, 2014, 79 (21), 10170-10178.
29. Bingjie Liu, Yueteng Zhang, Gang Huang, Xinting Zhang, Pengfei Niu, Jie Wu, Wenquan Yu,* Junbiao Chang.* "A Concise Approach to Polysubstituted Oxazoles from N-Acyl-2-bromo Enamides via a Copper(I)/Amino Acid-catalyzed Intramolecular C–O Bond Formation." Organic & Biomolecular Chemistry, 2014, 12 (23), 3912–3923.
30. Wenquan Yu,* Gang Huang, Yueteng Zhang, Hongxu Liu, Lihong Dong, Xuejun Yu, Yujiang Li, and Junbiao Chang.* "I2-Mediated Oxidative C–O Bond Formation for the Synthesis of 1,3,4-Oxadiazoles from Aldehydes and Hydrazides." Journal of Organic Chemistry, 2013, 78 (20), 10337-10343.
31. Jie Wu, Wenquan Yu, Leixia Fu, Wu He, Yao Wang, Baoshan Chai, Chuanjun Song,* Junbiao Chang.* "Design, Synthesis, and Biological Evaluation of New 2'-Deoxy-2'-fluoro-4'-triazole Cytidine Nucleosides as Potent Antiviral Agents." European Journal of Medicinal Chemistry, 2013, 63, 739-745.
32. Baoshan Chai, Shuyang Wang, Wenquan Yu, Huichao Li, Chuanjun Song, Ying Xu, Changling Liu,* Junbiao Chang.* "Synthesis of Novel Strobilurin-pyrimidine Derivatives and Their Antiproliferative Activity against Human Cancer Cell Lines." Bioorganic & Medicinal Chemistry Letters, 2013, 23 (12), 3505-3510.
33. Andrea Cuconati,* Courtney Mills, Cally Goddard, Xianchao Zhang, Wenquan Yu, Haitao Guo, Xiaodong Xu, Timothy M. Block.* "Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells." PLoS ONE, 2013, 8 (1), e54595.
34. Wenquan Yu, Tina Gill, Lijuan Wang, Yanming Du, Hong Ye, Xiaowang Qu, Ju-Tao Guo, Andrea Cuconati, Kang Zhao, Timothy M. Block, Xiaodong Xu,* Jinhong Chang.* "Design, Synthesis, and Biological Evaluation of N-Alkylated Deoxynojirimycin (DNJ) Derivatives for the Treatment of Dengue Virus Infection." Journal of Medicinal Chemistry, 2012, 55 (13), 6061-6075.
35. Dawei Cai, Courtney Mills, Wenquan Yu, Ran Yan, Carol E. Aldrich, Jeffry R. Saputelli, William S. Mason, Xiaodong Xu, Ju-Tao Guo, Timothy M. Block, Andrea Cuconati,* Haitao Guo.* "Identification of the Disubstituted Sulfonamide Compounds as Specific Inhibitors of Hepatitis B Virus Covalently Closed Circular DNA Formation." Antimicrobial Agents and Chemotherapy, 2012, 56 (8), 4277-4288.
36. Wenquan Yu, Cally Goddard, Elizabeth Clearfield, Courtney Mills, Tong Xiao, Haitao Guo, John D. Morrey, Neil E. Motter, Kang Zhao, Timothy M. Block, Andrea Cuconati,* Xiaodong Xu.* "Design, Synthesis, and Biological Evaluation of Triazolo-pyrimidine Derivatives as Novel Inhibitors of Hepatitis B Virus Surface Antigen (HBsAg) Secretion." Journal of Medicinal Chemistry, 2011, 54 (16), 5660-5670.
37. Wenquan Yu, Yunfei Du, Kang Zhao.* "PIDA-Mediated Oxidative C-C Bond Formation: Novel Synthesis of Indoles from N-Aryl Enamines." Organic Letters, 2009, 11 (11), 2417-2420.
