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李小盟 

副教授

硕士生导师

郑州大学力学与安全工程学院 工程力学

E-mail: xiaomeng.li@zzu.edu.cn


学术研究:

研究聚焦力学超材料、柔性传感和水凝胶功能材料、骨软骨组织工程、丝素蛋白医疗器械研发。发表包括Advanced Materials、ACS Nano、Advanced Healthcare Materials等多篇SCI。担任中国生物材料学会康复器械与生物材料分会委员、组织工程与再生医学国际学会亚太分会(TERMIS-AP)地区发展委员会委员、BMT青年编委等。

主要方向包括:

1、力学超材料:研究力学超材料设计优化方法、增材制造工艺及实验表征方法,以实现轻量化、多功能集成。

2、水凝胶功能材料:面向柔性传感与生物医学工程的智能响应水凝胶和组织再生水凝胶,开展水凝胶的力学性能调控、环境响应行为、生物相容性特性系统设计及优化,为先进医疗器械与柔性机器人提供智能材料解决方案。

3、组织工程与医疗器械:包括骨、软骨、跟腱韧带等运动系统组织缺损的再生修复。聚焦力学、电学和结构等因素在促组织再生和功能恢复中的关键作用。

教育背景:

2014-09至2017-09,日本筑波大学/日本国立物质材料研究所,博士,导师:陈国平

2011-09至2014-06,华中科技大学,生物医学工程,硕士,导师:张胜民

2006-09至2010-06,郑州大学,材料科学与工程学院,高分子加工,学士,导师:黄霞

工作履历:

2018-01至今,郑州大学,力学与安全工程学院,郑州大学青年骨干教师,副教授,硕士生导师

2018-07至2021-10,郑州大学,力学与安全工程学院,博士后,导师:李倩

2010-07至2011-08,郑州宇通客车股份有限公司,技术工艺工程师。

教学工作:

讲授《材料力学》、《生物力学》、《生命科学导论》和《专业英语》等课程,指导国家级大学生创新创业等创新实践项目,获河南省大学生创新创业训练计划优秀成果奖。获评优秀班主任、三育人等奖励称号。

研究生招生:

欢迎力学、材料、生物医学工程、机械等相关专业学生报考研究生;

欢迎对科研感兴趣、学有余力的本科生参加双创项目等。

科研项目:

9,2026-2027 骨软骨一体化再生材料研发及应用,河南省科技攻关

8,2025-2026 力学和血管化差异微环境水凝胶构建及促骨软骨修复作用研究、河南省高等学校重点科研项目

7,2022-2024 力学和血管化差异微环境对MSC软骨-骨分化调控机制研究,河南省干细胞医学联合实验室开放课题

6,2021-2025 可调控力学性能丝素基管状医疗器械的研发,企业合作创新团队项目

5,2020-2022 仿生软骨细胞周基质的构建及其成分和硬度对MSC软骨分化的调控研究,国自然青年项目

4,2020-2021 仿生软骨周基质水凝胶的制备及其对软骨再生的作用研究,河南省科技攻关

3,2020-2021 可注射梯度硬度水凝胶促软骨-骨复合缺损再生机制研究,郑州大学青年骨干教师项目

2,2018-2019 不同力学特性水凝胶的制备及其对MSCs分化作用研究,中国博士后面上项目

1,2018-2020 人工PCM的构建及其对MSC软骨分化和软骨组织再生的作用研究,郑州大学拔尖博士启动支持项目

代表性学术成果:

[34] Silk Fibroin Hydrospongel with Interconnected Porosity and Robust Adhesion for Rapid Hemostasis and Scarless Repair, Biomacromolecules, 2026, 通讯(中科院一区)

[33] Amphiphilic Hemin-based nanoparticles with hypoxia tolerance and inflammation inhibition for osteoarthritis therapy, Journal of Controlled Release, 2026, 通讯(中科院一区)

[32] Dual-crosslinkable alginate hydrogel with dynamic viscoelasticity for chondrogenic and osteogenic differentiation of mesenchymal stem cells, International Journal of Biological Macromolecules, 2025, 通讯(中科院二区)

[31] Perfusable and toughening cardiac patch with hierarchically branched microchannels for myocardial infarction revascularization, Materials Horizons, 2025, 通讯(中科院二区)

[30] Bioinspired Hyperboloid Mechanical Metamaterial for Shock Absorption and Strain Regulation in Cartilage Remodeling, Advanced Materials, 2025, 通讯(中科院一区)

[29] α-Ketoglutaric acid reprograms macrophages by altering energy metabolism to promote the regeneration of small-diameter vascular grafts, ACS Biomaterials Science & Engineering, 2024, 通讯(中科院二区)

[28] Lymphocyte-derived engineered apoptotic bodies with inflammation regulation and cartilage affinity for osteoarthritis therapy, ACS nano, 2024, 通讯(中科院一区)

[27] Trilayered biomimetic hydrogel scaffolds with dual-differential microenvironment for articular osteochondral defect repair, Materials Today Bio, 2024, 第一(中科院一区)

[26] Dynamic Stiffening Hydrogel with Instructive Stiffening Timing Modulates Stem Cell Fate In Vitro and Enhances Bone Remodeling In Vivo, Advanced Healthcare Materials, 2023, 第一(中科院二区)

[25] Erythrocyte membrane-camouflaged and double-factor sequential delivery nanocarriers postpone the progression of osteoarthritis, Chemical Engineering Journal, 2023, 通讯,(中科院一区)

[24] An intrinsically non-flammable organic electrolyte for wide temperature range supercapacitors, Chemical Engineering Journal, 2023, 通讯(中科院一区)

[23] Extracellular matrix mimicking dynamic interpenetrating network hydrogel for skin tissue engineering, Chemical Engineering Journal, 2023(中科院一区)

[22] Solution-processed electronics for artificial synapses, Materials Horizons, 2021, 第一(中科院一区)

[21] 3D Electrospun Nanofiber-Based Scaffolds: From Preparations and Properties to Tissue Regeneration Applications, Stem Cells International, 2021, 通讯,(中科院二区)

[20] Enzyme-crosslinked electrospun fibrous gelatin hydrogel for potential soft tissue engineering, Polymers, 2020, 通讯,(中科院二区)

[19] Functional hydrogels with tunable structures and properties for tissue engineering applications, Frontiers in Chemistry, 2018, 第一(中科院二区)

[18] Influence of microporous gelatin hydrogels on chondrocyte functions, Journal of Materials Chemistry B, 2017, 第一 (中科院一区)

[17] Fabrication of Highly Crosslinked Gelatin Hydrogel and Its Influence on Chondrocyte Proliferation and Phenotype, Polymers, 2017, 第一 (中科院二区)

[16] 3D culture of chondrocytes in gelatin hydrogels with different stiffness, 2016, Polymers, 第一 (中科院二区)

[15] Silk fibroin/poly (vinyl alcohol) blend scaffolds for controlled delivery of curcumin, 2015, Regenerative biomaterials, 第一(中科院二区)

[14] Development of a silk fibroin/HTCC/PVA sponge for chronic wound dressing, 2014, Journal of Bioactive and Compatible Polymers,第一(影响因子2.352)

[13] Polymer-based dielectrics with high permittivity and low dielectric loss for flexible electronics, 2022, Journal of Materials Chemistry C(中科院二区)

[12] Endothelial cell migration regulated by surface topography of poly (ε-caprolactone) nanofibers, 2021, ACS Biomaterials Science & Engineering(中科院二区)

[11] Layer‐By‐Layer Printing Strategy for High‐Performance Flexible Electronic Devices with Low‐Temperature Catalyzed Solution‐Processed SiO2, 2021, Small Methods(中科院一区)

[10] Influence of viscosity on chondrogenic differentiation of mesenchymal stem cells during 3D culture in viscous gelatin solution-embedded hydrogels, 2021, Journal of Materials Science & Technology(中科院一区)

[9] Preparation of PLGA-collagen hybrid scaffolds with controlled pore structures for cartilage tissue engineering, 2020, Progress in Natural Science: Materials International(中科院二区)

[8] Electronic biopolymers: From molecular engineering to functional devices, 2020, Chemical Engineering Journal(中科院一区)

[7] Effect of particle size on the cellular uptake and anti-inflammatory activity of oral nanotherapeutics, 2020, Colloids and Surfaces B: Biointerfaces(中科院二区)

[6] Promotion of endothelial cell adhesion and antithrombogenicity of polytetrafluoroethylene by chemical grafting of chondroitin sulfate, 2019, ACS Applied Bio Materials(影响因子2.536)

[5] Programmed release of multimodal, cross-linked vascular endothelial growth factor and heparin layers on electrospun polycaprolactone vascular grafts, 2019, ACS applied materials & interfaces (中科院一区)

[4] Solution viscosity regulates chondrocyte proliferation and phenotype during 3D culture, 2019, Journal of Materials Chemistry B(中科院二区)

[3] Induction of chondrogenic differentiation of human mesenchymal stem cells by biomimetic gold nanoparticles with tunable RGD density, 2017, Advanced Healthcare Materials(中科院一区)

[2] Nanoencapsulation of individual mammalian cells with cytoprotective polymer shell, 2017, Biomaterials (中科院一区)

[1 Single mammalian cell encapsulation by in situ polymerization, 2016, Journal of Materials Chemistry B(中科院一区)

授权发明专利:

1. 一种酶光双交联水凝胶的制备方法及采用酶光双交联水凝胶负载细胞的方法(ZL 2021 1 0561292.6)

2. 一种组织工程材料及其制备方法(ZL 2022 1 1078490.8)

3. 架橋ゼラチンハイドロゲル及びその作製方法(日本发明专利,特许第7050296号)

4. 泡沫填充仿生点阵复合结构及其制备方法(ZL 2022 1 0453384.7)

5. 一种双微环境三层仿生水凝胶支架及其制备方法和应用(ZL 2023 1 1635480.4)

6. 一种单分散核壳微球及其制备方法(ZL 2024 1 1444565.9)