职称：讲师

        邮箱：rensumei@zzu.edu.cn

        地址：大学路40号博士后楼116室

个人简介

2009年6月在郑州大学药学院获学士学位；2012年6月在复旦大学药学院获硕士学位；2012年7月-2015年8月在复旦大学药学院从事科研助理工作；2019年1月在复旦大学药学院获博士学位；2019年4月至2022年3月，在深圳大学医学部从事博士后研究；2022年7月入职郑州大学医学科学院。

主要研究方向

Toll样受体7激动剂的合成及其在生物免疫治疗中的应用；免疫靶向偶联物的合成及生物活性研究

代表性成果

1.Sumei Ren, Junbiao Chang, Ruiqi Liu*, Guangyi Jin*. The novel selective TLR7 agonist GY101 suppresses colon cancer growth by stimulating immune cells. Eur J Pharmacol. 2024, 967:176383.

2.Weizhao Weng^⊥, Sumei Ren^⊥, Changcai Teng^⊥, Jia Guo, Qiuyu Guo, Wei Zhang, Chengli Zong*, Ning Ding*. Chemoenzymatic synthesis and immunological evaluation of sialyl-Thomsen-Friedenreich (sTF) antigen conjugate to CRM197. Bioorg Med Chem. 2024, 100:117615.

3.Sumei Ren, Xiaodong Wang*, Guangyi Jin*. Conjugate of ibrutinib with a TLR7 agonist suppresses melanoma progression and enhances antitumor immunity. Int J Biol Sci. 2022, 18(1): 166−179.

4.Sumei Ren, Xiaodong Wang, Jun Song, Guangyi Jin*. Discovery of novel ibrutinib analogues to treat malignant melanoma. Bioorg Chem. 2021, 117: 105419.

5.Sumei Ren^⊥, Minmin Zhang^⊥, Yujie Wang, Jia Guo, Junfei Wang, Yingxia Li, Ning Ding*. Synthesis and biological evaluation of novel cabazitaxel analogues. Bioorg Med Chem. 2021, 41:116224.

6.Sumei Ren, Ruiqi Liu, Yujie Wang, Ning Ding*, Yingxia Li*. Synthesis and Biological Evaluation of Ginsenoside Compound K Analogues as a Novel Class of Anti-asthmatic Agents. Bioorg Med Chem Lett. 2019, 59:51−55.

7.Sumei Ren, Yujie Wang, Junfei Wang, Dingding Gao, Minmin Zhang, Ning Ding* , Yingxia Li**. Synthesis and biological evaluation of novel larotaxel analogues. Eur J Med Chem. 2018, 156:692−710.

8.Xianglai Liu^⊥, Sumei Ren^⊥, Qi Gao, Chun Hu*, Yingxia Li, and Ning Ding*. Glycosylation of a Ketone with an O‑Glycosyl Trichloroacetimidate Provides an Enol Glycoside. Org Lett. 2018, 20:5186−5189.

9.Sumei Ren, Qing Chen, Ning Ding, Wei Zhang, Ying Guo*, Yingxia Li*. Synthesis and biological evaluation of analogues of methyl ursolate 3-O-β-chacotrioside as H5N1 viral entry inhibitors. J Carbohydr Chem. 2012, 31:647–658.