可钰
郑州大学药学院教授，硕士生导师
联系方式：0371-67781908
邮箱：ky@zzu.edu.cn
个人简介
2006年进入郑州大学药学院开展教学与科研工作，教授《药物化学》等多门本专业本科生主干课程及《组学研究进展》等研究生课程，曾获2009-2010和2018-2019年度郑州大学“三育人”先进个人，第十届郑州大学 “我最喜爱的老师”，2018年度河南省优秀药学工作者，2023年度郑州大学创新创业先进工作者等奖励。主持国家自然科学基金项目1项、河南省重大科技攻关基金项目1项、作为主要完成人参与完成国家“重大新药创制”科技重大专项、国家科技支撑计划、河南省重大科技专项等，指导郑州大学本科生创新创业项目多项。在Antioxidants & Redox Signaling等国际知名SCI期刊发表学术论文60余篇，获授权中国发明专利10余件。
教学与教研
讲授课程：
1、本科生《药物化学》
2、本科生《创新设计性综合教学实验》
3、研究生《波谱解析》
4、研究生《组学研究进展》
5、研究生《药物代谢》
教研：
1、河南省研究生教育优质课程《波谱学解析》
2、郑州大学研究生教育研究项目《高等学校药学硕士专业学位研究生人才培养模式的研究与探讨》
3、郑州大学大学生创新创业项目多项
科研：
纵向：
1、国家自然科学基金河南省联合基金“源于冬凌草的新型对映贝壳杉烷二萜分子构建及抗消化道肿瘤作用研究”，主持
2、国家自然科学基金“UBC12-DCN1靶向小分子抑制剂的设计、合成及其在胃癌中对NEDDylation的调控机制研究”，第二完成人
2. 国家自然科学基金青年基金：“有肿瘤细胞糖酵解及氧化磷酸化双重抑制功能的天然二萜衍生物的发现及作用机制研究”具，第二完成人
3.河南省教育厅自然科学研究计划项目“济源冬凌草活性成分提取与衍生物合成及构效关系研究”，主持
4. 河南省高等学校重点科研项目计：冬凌草活性成分、指纹图谱及相关研究，主持
5、河南省杰出人才创新基金项目“国家一类抗癌新药OGP46的临床前研究”；第四完成人
6、11.5国家重大科技攻关项目“新药创制”项目“抗肿瘤新药JD27的临床前研究”，药学组组长，第三完成人
7、新型呔嗪类衍生物的合成及抗肿瘤活性研究，第二完成人
横向：
1、减轻烟草重金属污染的植物修复技术研究，主持
2、新型复合农药ZY-6的研究开发，主持
3、中原地区汉族非瓣膜房颤高出血风险人群靶向抗凝药物疗效和安全评价及个体化给药方案的研究，主持
4、替格瑞洛(原料+片)临床前药学研究，第五完成人
研究与成果
代表性文章：
1. Chen Zhou, Jun-Yuan Zhang, Han-Bo Liu, Xiang-Yu Tian, Yue Liu, Ya-Lei Wang, Zi-Jun Zheng, Ni Wang, Zhi-Jia Wang, Xia Xu*, Hong-MinLiu*, Yu Ke*. Synthesis, biological evaluation and cellular localization study of fluorescent derivatives of Jiyuan Oridonin A. European Journal of Medicinal Chemistry, Volume 229, 5 February 2022, 114048
2. Limin Liu, Zhengjie Wang, Chao Gao, Honglin Dai, Xiaojie Si, Yang Zhang, Yaqi Meng, Jiaxin Zheng, Yu Ke*, Hongmin Liu*, Qiurong Zhang*. Design, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives. Bioorganic &Medicinal Chemistry Letters, 51 (2021) 128268
3. Ling Fu, Bing-Kai Han, Fang-Feng Meng, Jun-Wei Wang, Tian-Ye Wang, Hui-Ju Li, Ying-ying Sun, Guo-na Zou, Xiao-rui Li, Wen Li, Yue-Feng Bi, Yu Ke*, Hong-Min Liu*. Jaridon 6, a new diterpene from Rabdosia rubescens (Hemsl.) Hara, can display anti-gastric cancer resistance by inhibiting SIRT1 and inducing autophagy. Phytotherapy Research, 2021; 1–14, DOI: 10.1002/ptr.7231
4. Jian-Jia Liang, Hang Xie, Rui-Hua Yang, Ni Wang, Zi-Jun Zheng, Chen Zhou, Ya-Lei Wang, Zhi-Jia Wang, Hong-Min Liu*, Li-Hong Shan*, Yu Ke*. Designed, synthesized and biological evaluation of proteolysis targeting chimeras (PROTACs) as AR degraders for prostate cancer treatment. Bioorganic &Medicinal Chemistry, 2021, 116331
5. Junhong Zhang, Ni Wang , Yuanyuan Zhou , Kaili Wang , Yaxin Sun, Hao Yan, Wenchao Han , Xinying Wang, Bo Wei* , Yu Ke*, Xia Xu*. Oridonin induces ferroptosis by inhibiting gamma-glutamyl cycle in TE1 cells, Phytotherapy Research. 2020; 1–10. https://doi.org/10.1002/ptr.6829
6. Jun-Feng Huo, Tian-Xing Hu, Ya-Long Dong, Jin-Zhu Zhao, Xiao-Jie Liu, Lei-Lei Li, Xue-Yan Zhang, Yun-Fan Li, Hong-Min Liu *, Yu Ke*, Cong Wang*. Synthesis and in vitro and in vivo biological evaluation of novel derivatives of flexicaulin A as antiproliferative agents. European Journal of Medicinal Chemistry, (208)2020, 112789
7. Hang Xie, Jian-Jia Liang, Ya-Lei Wang, Tian-Xing Hu, Jin-Yi Wang, Rui-Hua Yang, Jun-Ke Yan, Qiu-Rong Zhang, Xia Xu *, Hong-Min Liu *, Yu Ke*. The design, synthesis and anti-tumor mechanism study of new androgen receptor degrader. European Journal of Medicinal Chemistry, (204)2020, 112512
8. Erdong Li, Yaqi Meng, Luye Zhang, Yang Zhang, Jikuan Wang, Danqing Zhang, Panpan Song, Jingchao Xin, Na Li, Jiaxin Zheng, Yu Ke*, Hongmin Liu *, Qiurong Zhang*. Design, Synthesis and Antitumor Activity Evaluation of 4-Aminoquinazoline Derivatives Containing Urea Moiety. Chinese Journal of Organic Chemistry, 2019, 39, 2875-2881
9. Yaqi Meng, Erdong Li, Yang Zhang, Shuan Liu, Chongnan Bao, Peng Yang, Luye Zhang, Danqing Zhang, Jikuan Wang, Yaxin Chen, Na Li, Jingchao Xin, Peirong Zhao, Yu Ke*, Qiurong Zhang*, Hongmin Liu*. Synthesis and Antitumor Activity Evaluation of 2,4-Substituted Pyrimidine Derivatives Containing Trifluoromethyl. Chinese Journal of Organic Chemistry, 2019, 39, 2541-2548
10. Yu Ke1, Tian-Xing Hu1, Jun-Feng Huo, Jun-Ke Yan, Jin-Yi Wang, Rui-Hua Yang, Hang Xie, Ying Liu, Ni Wang, Zi-Jun Zheng, Ya-Xin Sun, Cong Wang*, Juan Du*, Hong-Min Liu*. Synthesis and in vitro biological evaluation of novel derivatives of Flexicaulin A condensation with amino acid trifluoroacetate. European Journal of Medicinal Chemistry, 2019, 182, 111645
11. Na Li, Jingchao Xin, Qisheng Ma, Erdong Li, Yaqi Meng, Chongnan Bao, Peng Yang, Panpan Song, Fei Cui, Pengju Cheng, Yifei Gu, Peirong Zhao, Yu Ke*, Hongmin Liu*, Qiurong Zhang*. Synthesis and Antitumor Activities of Novel 1,2,3-Triazolo[4,5-d]pyrimidine Derivatives. Chinese Journal of Organic Chemistry, 2018, 38, 665～671
12. Yu Ke1, Jian-Jia Liang1, Rui-Juan Hou, Ming-Ming Li , Long-Fei Zhao, Wang Wang, Ying Liu, Hang Xie, Rui-Hua Yang , Tian-Xing Hu, Jin-Yi Wang, Hong-Min Liu*. Synthesis and biological evaluation of novel Jiyuan Oridonin A-1,2,3- triazole-azole derivatives as antiproliferative agents. European Journal of Medicinal Chemistry, 157 (2018) 1249-1263
13. Yu Ke, Wang Wang, Long-Fei Zhao, Jian-Jia Liang, Ying Li , Xiao Zhang, Kai Feng*, Hong-Min Liu*. Design, synthesis and biological mechanisms research on 1,2,3-triazole derivatives of Jiyuan Oridonin A. Bioorganic & Medicinal Chemistry, 26 (2018) 4761–4773
14. 宋攀攀，栗 娜，崔 飞，辛景超，张孝松，曹钦坡，王超杰， 戴文杰，孟祥川，刘 梦 ，常通航，柳晴怡，孙月红，可 钰* ,张秋荣* , 刘宏民*，2,4,6-三取代嘧啶衍生物的合成及体外抗肿瘤活性研究, 有机化学，2017, 37, 2725～2735
15. Panpan Song, Fei Cui, Na Li, Jingchao Xin, Qisheng Ma, Xiangchuan Meng, Chaojie Wang, Qinpo Cao, Yifei Gu, Yu Ke* , Qiurong Zhang*, and Hongmin Liu*. Synthesis, Cytotoxic Activity Evaluation of Novel 1,2,3-Triazole Linked Quinazoline Derivatives. Chinese Journal of Chemistry, 2017, 35, 1633—1639
16. Jingchao Xin, Na Li, Qisheng Ma, Erdong Li, Xiangchuan Meng, Yu Ke*, Hongmin Liu*, Qiurong Zhang*. Synthesis and Antitumor Activity of 1-Phenyl-4-substituted Phthalazine Derivatives. Chinese Journal of Organic Chemistry, 2018, 38, 451～456
17. Ling Fu , Yu-Qing Wang , Bing-Kai Han , Xiao-Rui Li , Xiao-Jing Shi ,Fen Yin , Jun-Wei Wang , Pei-Rong Zhao, Yu Ke*, Hong-Min Liu*. Gene expression profiling and pathway network analysis of anti-tumoractivity by Jaridon 6 in esophageal cancer, European Journal of Pharmacology, 2017, 815, 476-487
18. Sai-Qi Wang, Cong Wang, Jun-Wei Wang, Dong-Xiao Yang, Ran Wang, Chuan-Jin Wang, Hui-Ju Li, Hong-Ge Shi, Yu Ke* and Hong-Min Liu*. Geridonin, a novel derivative of oridonin, inhibits proliferation of MGC 803 cells both in vitro and in vivo through elevating the intracellular ROS. Journal of Pharmacy and Pharmacology, 2017, 69（2）, 213-221
19. Xiao-Jing Shi, Lina Ding, Wenjuan Zhou, Yage Ji, Junwei Wang, Huimin Wang, Yongcheng Ma, Guozhong Jiang, Kai Tang, Yu Ke*,Wen Zhao*,and Hong-Min Liu*. Pro-Apoptotic Effects of JDA-202, a Novel Natural Diterpenoid, on Esophageal Cancer Through Targeting Peroxiredoxin I. Antioxidants & Redox Signaling，2017, Volume 27（2）, Number 2, 73-92
20. Jinzhu Zhao, Leilei Li, Zhijia Wang, Linlin Li, Mingjing He, Shuhua Han, Yalong Dong, Xiaojie Liu, Wen Zhao, Yu Ke, Cong Wang*. Luteolin attenuates cancer cell stemness in PTX-resistant oesophageal cancer cells through mediating SOX2 protein stability. Pharmacological Research, Volume 174, December 2021, 105939
21. Zhengjie Wang, Limin Liu, Honglin Dai, Xiaojie Si, Luye Zhang, Erdong Li, Zhang Yang , Gao Chao, Jiaxin Zheng, Yu Ke, Shan Lihong,*, Qiurong Zhang *, Hongmin Liu*. Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway. Bioorganic &Medicinal Chemistry, 43 (2021), 116265
22. Ying Liu, Zan Song, Yajie Liu, Xubin Ma, Wang Wang, Yu Ke, Yichao Xu*, Dequan Yu*, Hongmin Liu*. Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer. Acta Pharmaceutica Sinica B, 2021;11(6):1513-1525
23. Mei Qu , Yu Duan , Min Zhao, Zhanju Wang , Mengjie Zhao, Yao Zhao , Haihua Wang , Yu Ke, Ying Liu , Hong-Min Liu , Liuya Wei* and Zhenbo Hu*. Jiyuan Oridonin A Overcomes Differentiation Blockade in Acute Myeloid Leukemia Cells With MLL Rearrangements via Multiple Signaling Pathways. Frontiers in Oncology, DOI: 10.3389 /fonc. 2021.659720
24. Min Zhao, Jiangyun Wang, Mei Qu, Yao Zhao, Haihua Wang, Yu Ke, Ying Liu, Zi-Ning Lei, Hong-Min Liu, Zhenbo Hu, Liuya Wei, Zhe-Sheng Chen. OGP46 Induces Differentiation of Acute Myeloid Leukemia Cells via Different Optimal Signaling Pathways. Frontiers in Cell and Developmental Biology, DOI: 10.3389/fcell.2021.652972
25. Peilu Zhai, Yeming Shen, Pengxuan Xi, Minghuo Wu, Xinping Wu, Li Li, Wanxue Cao, Yu Ke, Jianye Zhang*. Identification of chloramination disinfection by-products from phenylalanine in tap drinking water. Chemosphere, DOI: 10.1016/ j.chemosphere. 2021.130403
26. Liuya Wei， Yang Yang, Pranav Gupta, Aihong Wang, Min Zhao, Yao Zhao, Mei Qu, Yu Ke, Ying Liu, Hong-Min Liu, Xin Xu, Yanli Sun, Zhe-Sheng Chen*, and Zhenbo Hu*. A Small Molecule Inhibitor, OGP46, Is Effective against Imatinib-Resistant BCR-ABL Mutations via the BCR-ABL/JAK-STAT Pathway. Molecular Therapy: Oncolytics, Vol. 18 September 2020, 137-148
27. Juan Li, Qing-Li Wang, Ying Liu, Yu Ke, Qi-Qi Fan, Piao Zhou, Meng-Chen An, Hong-Min Liu*. Simultaneous determination of 24 free amino acids in MGC803 cells by hydrophilic interaction liquid chromatography with tandem mass spectrometry. Journal of Chromatography B, 1132 (2019) 121792
28. Yong-Cheng Ma, Ying-Li Zhua, Nan Su, Yu Ke, Xia-Xia Fan, Xiao-Jing Shi, Hong-Min Liu*, Ai-Feng Wang*. A novel ent-kaurane diterpenoid analog, DN3, selectively kills human gastric cancer cells via acting directly on mitochondria. European Journal of Pharmacology, 2019, 848, 11-22
29. Danielle D. Jandial , Lauren S. Krill , Lixia Chen , Chunli Wu , Yu Ke, Jun Xie, Bang H. Hoang , and Xiaolin Zi*. Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin. Molecules, 22(3): doi: 10.3390/molecules 22030462
30. Zhongbo Liu, U-Syn Ha, Yu Ke, Chunli Wu, Noriko Yokoyama , Xiaolin Zi*. Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway. The Journal of Biomedical Research, 2017, 31(5): 408–418
31. Cong Wang, Liubing Guo , Saiqi Wang, Junwei Wang, Yongmei Li ,Yinhui Dou, Ran Wang , Hongge Shi, Yu Ke and Hongmin Liu*. Anti-proliferative effect of Jesridonin on paclitaxel-resistant EC109 human esophageal carcinoma cells. International Journal of Molecular Medicine, 2017, 39: 645-653
32. Cong Wang, Dongxiao Yang, Liping Jiang, Saiqi Wang, Junwei Wang, Kairui Zhou, Xiaoli Shi , Liming Chang, Ying Liu, Yu Ke, Hongmin Liu*. Jesridonin in combination with paclitaxel demonstrates synergistic anti-tumor activity in human esophageal carcinoma cells. Bioorganic & Medicinal Chemistry Letters, 2017, 27, 2058-2062
33. Ke-Zheng Peng, Yu Ke, Qi Zhao, Fei Tian, Hong-Min Liu, Guiqin Hou, Zhaoming Lu. OP16, a novel ent-kaurene diterpenoid, potentiates the antitumor effect of rapamycin by inhibiting rapamycin-induced feedback activation of Akt signaling in esophageal squamous cell carcinoma. Biochemical Pharmacology, 2017, 140, 16-27
国家发明专利：
1、可钰，贾小苹，张怡欣，肖泽霖，张建业，徐霞，刘宏民；济源冬凌草甲素含磷系列衍生物及其制备方法和用途；2023.11.17；中国；申请号（专利）号：ZL 2022 1 0538036.X
2、可钰，赵梦圆，贾小苹，王妮，张怡欣，刘玥，刘宏民，徐霞；11-羰基-20-乙氧基济源冬凌草甲素及其14-OH酯化系列衍生物和用途；2023.08.22；中国；申请（专利）号：ZL 2022 1 0194699.4
3、可钰，周臣，张峻源，刘涵博，刘宏民；济源冬凌草甲素-萘酰亚胺类荧光探针及其制备方法和应用；2021.03.05；中国；专利号：ZL 2021 1 0242718.1
4、可钰，王妮，赵梦圆，贾小苹，刘宏民，徐霞；11,20-二羰基冬凌草甲素14-O酯化系列衍生物及其用途；2021.03.05；中国；ZL 2021 1 0242749.7
5、徐霞，王馨迎，崔伟琪，可钰；冬凌草甲素在制备治疗高尿酸血症和抗痛风药物中的应用；2020.12.21；中国；ZL 20201 1 514565.3
6、可钰，杨瑞华，王妮，刘宏民，徐霞，姬小明；3,4-二羟基肉桂酸酯类衍生物及其制备方法和应用；2020.06.22；中国；申请（专利）号：ZL 2020 1 0572578.X
7、可钰，王淙，刘宏民，徐霞，胡天星，郑姿君，王妮；柔茎香茶菜甲素O-14苯甲酸酯化衍生物及其制备方法和用途；2020.06.03；中国；申请（专利）号：ZL 2020 1 0492454.0
8、徐霞，刘宏民，可钰，梁坚家，谢航；一种邻苯二甲酰亚胺类选择性雄激素受体降解剂及制备方法和用途；2019.11.07；中国；ZL 20191 1 080765.X
9、张建业，刘宏民，可钰，谢航，梁坚家，周臣；一种靶向雄激素受体的荧光探针及其制备方法；2019.11.07；ZL 2019 1 1080525.X
10、可钰，谢航，刘宏民，徐霞，梁坚家；含三氮唑基的疏水金刚烷类选择性雄激素受体降解剂及其制备方法；2019.11.07；中国；申请（专利）号：CN201911080541.9
11、刘宏民，胡天星，可钰，王淙；L-氨基酸-14-(7-醚-柔茎香茶菜甲素）酯三氟乙酸盐类化合物及其制备方法；2019.09.12；中国；ZL 2019 1 0863834.8
12、刘宏民，刘瀛，可钰，王望；11,20-二羰基济源冬凌草甲素及其L-氨基酸-14-酯三氟乙酸盐；2019.06.25；中国；ZL 2019 1 0555504.2
13、李雯，刘宏民，郭珊珊，施秀芳，可钰，杨晨，周照青，李鹏坤，李宏；一种腺苷钴胺晶型及其制备方法与应用；2017.06.13；中国；ZL 2017 1 0445525.X
