路翔

郑州大学药学院讲师，硕士研究生导师

邮箱：yxyxianglu@zzu.edu.cn

个人简介

博士毕业于中国药科大学药物化学专业，近年来主要研究方向为靶向蛋白降解纳米系统的构建及金属多吡啶配合物光敏剂的研究。近年来以第一或通讯作者在国际高水平期刊ACS Applied Materials & Interfaces, European Journal of Medicinal Chemistry 和 Bioorganic Chemistry发表SCI论文7篇。申请国家专利5项，授权1项。主持河南省自然科学基金青年项目1项

科研项目

河南省自然科学基金青年项目, 222300420300, 针对吡非尼酮代谢位点结构修饰及抗特发性肺纤维化活性研究, 2022-01 至 2023-12, 5万元, 结题, 主持

研究与成果

1. Xiang Lu, Chaoran Zhu, Yiwen Gao, Zhenqiang Yu, Qingqing Yan, Yang Liu, Mingjin Luo, Xiufang Shi*（第一作者）; Design, Synthesis, and Evaluation of pirfenidone-NSAIDs conjugates for the treatment of idiopathic pulmonary fibrosis, Bioorg. Chem., 2024, 143: 107018. (IF:5.1)

2. Xiang Lu; Jing Li; Meng Xue; Mingjin Wang; Rong Guo; Binghua Wang; Hongling Zhang*（第一作者）; Net-Neutral Nanoparticles-Extruded Microcapsules for Oral Delivery of Insulin, ACS Appl. Mater. Interfaces, 2023, 15: 33491-33503. (IF: 9.5)

3. Xiang Lu, Chaoran Zhu, Chongwei Zhang, Xiujun Li, Zhenqiang Yu, Zhangzhen Zhong*, Xiufang Shi*（第一作者）; Design, synthesis and biological evaluation of 3-aryl-7-hydroxy scopoletin derivatives as autophagy activators against tumorigenesis, Eur. J. Med. Chem., 2022, 244: 114805. (IF: 6.7)

4. Xiufang Shi, Zhenqiang Yu, Chaoran Zhu, Linlin Jiang, Nanqi Geng, Xingting Fan, Zhanghui Guan, Xiang Lu*（通讯作者）; Synthesis and structure–activity relationships of pirfenidone derivatives as anti-fibrosis agents in vitro, RSC Med. Chem., 2022, 13: 610-621. (IF: 4.1)

5. Shudong Zhang; Xiang Lu; Binghua Wang; Ge Zhang; Mengyuan Liu; Shizhen Geng; Lulu Sun; Jingyi An; Zhenzhong Zhang*; Hongling Zhang*（共同第一作者）; A soft anti-virulence liposome realizing the explosive release of antibiotics at an infectious site to improve antimicrobial therapy, J. Mater. Chem. B, 2021, 9: 147-158. (IF: 7.0)

6. Xiang Lu, Yu Teng, Xin Lin, Maoxu Xiao, Chenna Liu, Xinglong Chi, Yulan Zhang, Guoshun Luo*, Hua Xiang*（第一作者）; Discovery of novel 2H-chromene-3-carbonyl derivatives as selective estrogen receptor degraders (SERDs): Design, synthesis and biological evaluation; Bioorg. Chem., 2021, 109: 1047143. (IF: 5.1)

7. Xiang Lu, Ali Huang, Maoxu Xiao, Liang Sun, Jianshun, Mao, Guoshun Luo*, Hua Xiang*（第一作者）; A new class of 1,3,5-triazine-based selective estrogen receptor degraders (SERDs): Lead optimization, molecular docking and dynamic simulation; Bioorg. Chem., 2020, 97: 103666. (IF: 5.1)