孙朋超
郑州大学药学院助理研究员，硕士生导师
邮箱：Pengchao_Sun@zzu.edu.cn
个人简介
2020年10月博士毕业于德国卡尔斯鲁厄理工学院化学与生命科学学院。主要从事多功能复合材料的设计、合成及其对肿瘤、类风湿性关节的炎治疗作用研究。以第一作者或通讯作者在Nano Today, J Control Release, Small, Small Methods等杂志发表论文15篇，授权专利2项。主持河南省青年科学基金1项，河南省博后基金1项。
科研项目
1、河南省青年科学基金，222300420301，生物响应型复合水凝胶细胞涂层靶向治疗宫颈癌研究，2022.01-2023.12，主持
2、河南省博士后科研启动项目，202101017，靶向生物响应型复合水凝胶屏障治疗宫颈癌研究，一等资助，2022.01-2023.12，主持
3、国家自然科学基金委员会, 面上项目，82172591，基于双金属单原子催化和透明质酸受体阻断的可溶微针设计及其治疗黑色素瘤研究，2022-01-01至2025-12-31，55万元，在研，参与
4、郑州大学科研启动基金项目，靶向生物响应型复合水凝胶细胞涂层抗宫颈癌研究，2021.01-2022.12，主持
5、Helmholtz program: BioInterfaces in Technology and Medicine. 参加
6、Helmholtz program: “Materials Systems Engineering” under the topic “Adaptive and Bioinstructive Materials Systems”. 参加
7、国家自然科学基金（81573011），基于核酸适配体精准识别的肿瘤靶向生物治疗与化疗协同作用研究，2016.1-2019.12，62万元，参加，国家自然科学基金委员会
研究与成果
已发表文章（#为共同第一作者，*为通讯作者）
1、Rongrong Luo, Jingjing Su, Wenying Zhang, Wenguang Huang, Qianqian Zhou, Pengchao Sun *, Yongxing Zhao *. Targeted delivery of NO donor and ROS scavenger for synergistic treatment of rheumatoid arthritis. Biomedicine & Pharmacotherapy. 2024, 174:116540. IF7.5 中科院一区
2、Jingnan Zhao, Fanfan Guo, Lin Hou, Yongxing Zhao, Pengchao Sun*. Electron transfer-based antioxidant nanozymes: Emerging therapeutics for inflammatory diseases. Journal of Controlled Release 2023, 355:273-291 IF10.8 中科院一区
3、Xiaonan Wang, Fanfan Guo, Yi Zhang, Ziyi Wang, Jiaqi Wang, Rongrong Luo, Xiao Chu, Yongxing Zhao*, Pengchao Sun*. Dual-targeting inhibition of TNFR1 for alleviating rheumatoid arthritis by a novel composite nucleic acid nanodrug. International Journal of Pharmaceutics: X 2023, 5:100126 IF4.7中科院一区
4、Yi Zhang, Jiaqi Wang, Rongrong Luo, Fanfan Guo, Xiaonan Wang, Xiao Chu, Yongxing Zhao*, Pengchao Sun*. Stimulus-responsive and dual-target DNA nanodrugs for rheumatoid arthritis treatment, International Journal of Pharmaceutics 2023, 632:122543 IF5.8中科院二区
5、Ruigeng Yang, Yueru Wei, Mengyang Zhao, Mengxiao Shi, Yongxing Zhao*, Pengchao Sun*. PBA functionalized single-atom Fe for efficient therapy of multidrug-resistant bacterial infections. Colloids and surfaces B: Biointerfaces 2022, 219:112811. IF 5.999 中科院二区
6、Mengchen An, Mengxiao Shi, Jingjing Su, Yueru Wei, Rongrong Luo, Pengchao Sun*, Yongxing Zhao*. Dual-Drug Loaded Separable Microneedles for Efficient Rheumatoid Arthritis Therapy. Pharmaceutics 2022,14(7):1518. IF 6.525 中科院二区
7、Mengyang Zhao, Ruigeng Yang, Yueru Wei, Jingjing Su, Xiaonan Wang, Nan Zhang, Pengchao Sun*, Deliang Chen*, Yongxing Zhao*. Dual Isolated Bimetal Single-Atom Catalysts for Tumor ROS Cycle and Parallel Catalytic Therapy. Nano Today 2022, 44:101493. IF17.4 中科院一区
8、Pengchao Sun#, Jingjing Su#, Xiaonan Wang, Mo Zhou, Yongxing Zhao*, Hongzhou Gu*, Nucleic Acids for Potential Treatment of Rheumatoid Arthritis. ACS Applied Biomaterials 2022, 5(5):1990-2008.
9、Ziyi Wang#, Pengchao Sun#, Jingjing Su, Nan Zhang*, Hongzhou Gu*, Yongxing Zhao*. DNA nanotechnology-facilitated ligand manipulation for targeted therapeutics and diagnostics. Journal of Controlled Release 2021, 340:292-307. IF 9.776 中科院一区
10、Pengchao Sun, Tim Scharnweber, Peter Wadhwani, Kersten S. Rabe, Christof M. Niemeyer*, DNA-Directed Assembly of a Cell-Responsive Biohybrid Interface for Cargo Release. Small Methods 2021, 5:2001049. IF14.188 中科院一区
11、Pengchao Sun, Arnold Leidner, Simone Weigel, Peter G. Weidler, Stefan Heissler, Tim Scharnweber, Christof M. Niemeyer*, Biopebble Containers: DNA-Directed Surface Assembly of Mesoporous Silica Nanoparticles for Cell Studies. Small 2019, 15:e1900083. IF13.281 中科院一区
12、Pengchao Sun#, Nan Zhang#, Yafang Tang, Yanan Yang, Xiao Chu, Yongxing Zhao*, SL2B aptamer and folic acid dual-targeting DNA nanostructures for synergic biological effect with chemotherapy to combat colorectal cancer. International Journal of Nanomedicine 2017, 12:2657-2672. IF6.400 中科院二区
13、Run Chen#, Pengchao Sun#, Xiao Chu, Xiaorong Pu, Yang Yang, Nan Zhang*, Yongxing Zhao*, Synergistic Treatment of Tumor by Targeted Biotherapy and Chemotherapy via Site-Specific Anchoring of Aptamers on DNA Nanotubes. International Journal of Nanomedicine 2020, 15:1309-1320. IF6.400 中科院二区
14、Pengchao Sun#, Nan Zhang#, Yafang Tang, Yanan Yang, Jie Zhou*, Yongixng Zhao*, Site-specific anchoring aptamer C2NP on DNA origami nanostructures for cancer treatment. Rsc Advances 2018, 8:26300-26308.
15、Pengchao Sun#, Nan Zhang#, Haiying Hua, Qian Liang, Xuexiao Zhang, Qian Sun, Yongxing Zhao*, Low density lipoprotein peptide conjugated submicron emulsions for combating prostate cancer. Biomedicine & Pharmacotherapy 2017, 86:612-619. IF7.5 中科院一区
发明专利
1、孙朋超, 赵永星, 张译, 王肖楠, 一种刺激-响应型双靶点核酸纳米治疗体系及其构建方法和应用, 授权, ZL 2022 1 0486581.9，申请日：2022-05-06；授 权 公 告 日： 2023.05.23；授 权 公 告 号： CN 114699421 B。
2、赵永星，王肖楠，代丽君，孙朋超，张译，杨龙华，一种核酸适配体和多肽交联的双靶点复合核酸纳米药物制备方法与应用，授权，ZL 2022 1 0486576.8，专 利 申 请 日： 2022年05月06日；授 权 公 告 日： 2023.05.09；授 权 公 告 号： CN 114699533 B。
