张俊利
郑州大学药学院直聘副研究员，硕士生导师
邮箱：zhangjunli0927@zzu.edu.cn
个人简介
先后主持国家自然科学基金青年项目、中国博士后面上项目、河南省高等学校重点科研项目、郑州大学求是计划项目，参与多项国家自然科学基金面上项目。以第一或通讯作者在Journal of Extracellular Vesicles（IF：25.8）、ACS Nano（IF：17.1）、ACS Sensors（IF：8.9）、Analytical Chemistry（IF：7.4）等国际著名期刊发表SCI论文10篇。授权国家发明专利1项，正在申请国家发明专利2项。
教学与教研
承担本科药学专业和药物制剂专业学生的生物药剂学与药代动力学等课程的理论与相关实验教学工作。
科研项目
1. 国家自然科学基金青年项目，2024/01—2026/12，在研，主持
2. 中国博士后科学基金第72批面上资助，2022/07—2024/07，在研，主持
3. 河南省高等学校重点科研项目 2023/01—2024/12，在研，主持
研究与成果
[1] M. Gu#, H. Zhang#, Y. Liu, X. Li, M. Lv, J. Zhao*, J. Zhang*. Accurate and Highly Sensitive Detection of Alzheimer’s Disease-Related Extracellular Vesicles via Forster Resonance Energy Transfer, Analytica Chimica Acta, 2024. DOI.org/10.1016/j.aca.2024.342779.
[2] C. Ma#, Q. Zhou#, J. Shi, H. Gao, D. Huang, H. Xue, H. Wang, Z. Zhang, S.Yang*, J. Zhang*, K. Zhang*, CRISPR-empowered electrochemical biosensor for target amplification-free and sensitive detection of miRNA, Talanta, 2024, 266, 125125.
[3] J. Zhang, M. Guan, M. Lv, Y. Liu, H. Zhang,* Z. Zhang,* and K. Zhang*，Localized Imaging of Programmed Death Ligand 1 on Individual Tumor-Derived Extracellular Vesicles for Prediction of Immunotherapy Response，ACS Nano, 2023, 17, 20120−20134.
[4] J. Zhang#, M. Guan#, C. Ma, Y. Liu, M. Lv, Z. Zhang, H. Gao*, Kaixiang Zhang*. Highly effective detection of exosomal miRNAs in plasma using liposome-mediated transfection CRISPR/Cas13a. ACS Sensors, 2023, 2023, 8, 565-575.
[5] Y. Li, D. Huang, Y. Pei, Y. Wu, R. Xu, F. Quan, H. Gao, J. Zhang*, H. Hou*, K. Zhang*, and J. Li. CasSABER for programmable in situ visualization of low and nonrepetitive gene loci. Analytical Chemistry, 2023, 95, 2992-3001.
[6] J. Zhang, Y. Zhu, M. Guan, Y. Liu, M. Lv, C. Zhang, H. Zhang*, Z. Zhang*, Isolation of circulating exosomes and identification of exosomal PD-L1 for predicting immunotherapy response. Nanoscale, 2022, 14, 8995.
[7] J. Zhang, K. Wei, J. Shi, Y. Zhu, M. Guan, X. Fu*, Z. Zhang*. Biomimetic nanoscale erythrocyte delivery system for enhancing chemotherapy via overcoming biological barriers. ACS Biomaterials Science & Engineering, 2021, 7(4), 1496-1505.
[8] J. Zhang#, J. Shi#, H. Zhang, Y. Zhu, W. Liu, K. Zhang, Z. Zhang. Localized fluorescent imaging of multiple proteins on individual extracellular vesicles using rolling circle amplification for cancer diagnosis. Journal of Extracellular Vesicles, 2020, 10(1), e12025.
[9] J. Zhang#, Y. Zhu#, J. Shi, K. Zhang, Z. Zhang, and H. Zhang*. Sensitive signal amplifying a diagnostic biochip based on a biomimetic periodic nanostructure for detecting cancer exosomes. ACS Applied Materials & Interfaces, 2020, 12(30), 33473-33482.
[10] J. Zhang, J. Shi, W. Liu, K. Zhang, H. Zhao, H. Zhang*, Z. Zhang*. A simple, specific and “on-off” type MUC1 fluorescence aptasensor based on exosomes for detection of breast cancer. Sensors and Actuators B: Chemical, 2018, 276, 552-559.
