柳继锋
郑州大学药学院教授，硕士生导师
邮箱：liujf2009y@126.com
个人简介
柳继锋，郑州大学药学院教授，硕士生导师，博士毕业于中国科学院昆明植物研究所，研究方向为基于天然产物的抗耐药菌、抗病毒创新药物研究，即从中药中寻找具有抗菌、抗病毒活性的天然产物，对活性分子进行结构修饰和成药性优化，发现药物先导物。以第一或通讯作者发表论文50余篇，其中在Journal of Medicinal Chemistry, Organic Letters，ACS Infectious Diseases，Bioorganic & Medicinal Chemistry等国际著名期刊发表SCI论文30余篇，作为项目负责人获得了3项国家自然科学基金和3项省级基金的支持。研究方向：① 天然药物化学：活性天然产物的发现、结构优化、机制和成药性研究；② 药物化学：基于中药的创新药物研究。
教学与教研
讲授天然药物化学，天然药物化学实验等课程
科研项目
① 2024 — 2027主持国家自然科学基金面上项目（NSFC No. 82373754）：抗多重耐药菌天然木脂素的发现、新型木脂素-抗菌肽模拟偶联物的构建和活性研究（49万元）；
② 2020 — 2022主持国家自然科学基金联合基金项目（NSFC-河南联合基金，U1904136）：八角属倍半新木脂素类化合物抗多重耐药性金黄色葡萄球菌（MRSA）的发现、构效关系和作用机制研究（49万元）；
③ 2012 — 2015主持国家自然科学基金面上项目（NSFC No. 81172961）：八角属化学成分及抗乙型肝炎病毒（HBV）活性研究（50万元）；
④ 2018 — 2020主持河南省教育厅科技攻关—社会发展项目，倍半新木脂素类化合物对耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌作用研究（182102310063，10万元）。
研究与成果
① Fushan Zhang, Hui Fang, Yuxin Zhao, Buhui Zhao, Shangshang Qin, Yu Wang, Yong Guo*, Jifeng Liu*, Ting Xu*. A membrane-targeting magnolol derivative for the treatment of methicillin-resistant Staphylococcus aureus infections, Frontiers in Microbiology, online, 2024, https://doi.org/10.3389/fmicb.2024.1385585.
② Junyan Chu, Ruige Yang, Wanqing Cheng, Liping Cui, Hanchen Pan, Jifeng Liu*, Yong Guo*, Semisynthesis, biological activities, and mechanism studies of Mannich base analogues of magnolol/honokiol as potential α-glucosidase inhibitors, Bioorganic & Medicinal Chemistry, 2022, 75, 1, 117070.
③ Ruige Yang, Enhua Hou, Wanqing Cheng, Xiaoting Yan, Tingting Zhang, Shihong Li, Hong Yao*, Jifeng Liu*, Yong Guo*, Membrane-Targeting Neolignan-Antimicrobial Peptide Mimic Conjugates to Combat Methicillin-Resistant Staphylococcus aureus (MRSA) Infections, Journal of Medicinal Chemistry, 2022, 65, 24, 16879–16892.
④ Huijuan Li, Xinghui Song, Huiru Li, Lifei Zhu, Shengbo Cao,* Jifeng Liu.*. Sesquiterpenes and Monoterpenes from the Leaves and Stems of Illicium simonsii and Their Antibacterial Activity. Molecules, 2022, 27, 1115.
⑤ Ruige Yang, Yingying Fu, Junyan Chu, Feixia Hu, Shudan Zheng, Lei Wang, Mengqi Liu*, Jifeng Liu*. Semisynthesis and neurotrophic activity studies of novel neomajucin/majucin derivatives as neurotrophin small molecule mimetics. Bioorganic & Medicinal Chemistry Letters, 2022, 60, 128580.
⑥ Yong Guo*, Enhua Hou, Tingyu Wen, Xiaoting Yan, Meiyue Han, Li-Ping Bai, Xiangjing Fu, Jifeng Liu*, Shangshang Qin*. Development of Membrane-Active Honokiol/Magnolol Amphiphiles as Potent Antibacterial Agents against Methicillin-Resistant Staphylococcus aureus (MRSA). Journal of Medicinal Chemistry, 2021, 64, 12903-12916.
⑦ Yong Guo,* Ruige Yang, Fangfang Chen, Tingting Yan, Tingyu Wen, Fang Lia, Xiaoyu Su, Lei Wang, Juan Du,* Jifeng Liu*. Triphenyl-sesquineolignan analogues derived from Illicium simonsii Maxim exhibit potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) by disrupting bacterial membranes. Bioorganic Chemistry, 2021, 110: 104824.
⑧ Fang Li, Ting-Ting Yan, Ying-Ying Fu, Nen-Ling Zhang, Lei Wang, Yan-Bing Zhang, Juan Du,* Ji-Feng Liu*. New Phenylpropanoid Glycosides from Illicium majus and Their Radical Scavenging Activities. Chemistry & Biodiversity, 2021, 18 (4): e2001012.
⑨ Tingyu Wen, Junyan Chu, Wanqing Cheng, Yingying Fu, Feixia Hu, Ruige Yang, Yong Guo*, Yanbing Zhang, Jifeng Liu*. Discovery, semisynthesis and neurite outgrowth-promoting activity of novel merrillianone/cycloparviforalone based esters as neurotrophic agents. Bioorg. Med. Chem. Lett. 2021, 36: 127832.
⑩ Guo Yong, Bao Chong-Nan, Li Fang, Hou En-Hua, Qin Shang-Shang,* Zhang Qiu-Rong,* Liu Ji-Feng*.Discovery, Synthesis, and Biological Evaluation of Dunnianol-Based Mannich Bases against Methicillin-Resistant Staphylococcus aureus (MRSA). ACS Infectious Diseases. 2020, 6, 2478-2489.
