王振亚
郑州大学药学院副教授,硕士生导师
邮箱:zhenyawang@zzu.edu.cn
个人简介
1985年生于郑州,2014年4月毕业于德国柏林自由大学,以优等生成绩毕业。2014年7月到郑州大学药学院工作。2015年获得香港方润华基金280万,主持建设“润良”抗病毒药物安全重点实验室。出版英文专著一本,发表SCI论文40多篇,参编英文教材一部。2020年和一安水性高分子材料有限公司合作,“新型长效抑菌抗菌涂层”相关研发成果被中华网,凤凰网等媒体报道。近几年在我院药物化学团队的支持下,我们结合合成的大量的内酯类化合物,萘类化合物,烯酰胺类化合物,苯并咪唑类化合物,甾体类药物,在呼吸道合胞病毒与流感病毒上进行了上千个化合物筛选并成功建立了基于模式受体的信号通路模型,在病毒凋亡,自噬和递送系统方面有深入的研究。近五年以第一作者或通讯作者身份发表 SCI 文章 23 篇,其中包括 Science 子刊一篇,中科院一区八篇。
教学与教研:
主要讲授生物化学,留学生医学微生物,留学生生物化学,研究生高等病毒学
主持郑州大学“四新”教学改革研究与实践重点项目,2022ZZUSX018
科研项目:
(1)香港方润华基金,“润良”抗病毒药物研发重点实验室(280万),2015-2025,主持,正在进行。
(2)河南省科技攻关项目,242102311231,吲哚类化合物靶向RIG-I/p62/Nrf2通路抗流感病毒分子机制研究,2024-2025,主持,正在进行
(3)河南省科技攻关项目,222102310081,基于RIG-I/p62/Nrf2通路内酯类化合物抗猪德尔塔冠状病毒分子机制研究,2022-2023,已结项,主持;
(4)河南省科技攻关项目,182102310098,基于模式识别受体相关蛋白抗呼吸道合胞病毒的药物药效学研究,2018-2019,已结项,主持;
(5)河南省重点科研项目,18A350012,基于RIG-I信号通路抗呼吸道合胞病毒药物筛选新方法的建立 2018-2019,已结项,主持;
科研成果
近两年文章如下:
(1)Lu Mao, Song Wang, Ying Qu, Haixia Wang, Yifan Zhao, Chuantao Zhu, Zhongmou Zhang, Chengyun Jin, Piet Herdewijn, Feng-Wu Liu, Zhenya Wang, Design, synthesis, and anti-respiratory syncytial virus potential of novel 3-(1,2,3-triazol-1-yl)furoxazine-fused benzimidazole derivatives. European Journal of Medicinal Chemistry 261 (2023) 115799(通讯)
(2)Na Yin, Zhongmou Zhang, Yongzhuang Ge, Yuzhen Zhao, Zichen Gu, Yue Yang, Lu Mao, Zhanyong Wei, Junjie Liu, Jinjin Shi, Zhenya Wang, Polydopamine-based nanomedicines for efficient antiviral and secondary injury protection therapy, SCIENCE ADVANCES, 9, eadf4098 (2023) (通讯)
(3)Zhenzhen Liu, Yongzhuang Ge, Lixia Ding, Zhongmou Zhang, Ying Qu, Chengyun Jin, Xiao-Na Wang, Zhenya Wang, Synthesis and evaluation of alkoxy-substituted enamides against influenza A virus in vitro and in vivo, Bioorganic Chemistry 139 (2023) 106712(通讯)
(4)Yongzhuang Ge , Chaofeng Zhang, Ying Qu, Lixia Ding, Xinbo Zhang, Zhongmou Zhang, Chengyun Jin, Xiao-Na Wang, Zhenya Wang, Synthesis and pharmacodynamic evaluation of naphthalene derivatives against influenza A virus in vitro and in vivo, European Journal of Medicinal Chemistry 259 (2023) 115660(通讯)
(5)Ximeng Che, Hongxuan Li, Qianlei Zhu, Hongying Chen, Zhenya Wang, Lanlan Zheng ,Fang Liu and Zhanyong Wei, Serological Investigation and Genetic Characteristics of Pseudorabies Virus between 2019 and 2021 in Henan Province of China, Viruses 2022, 14, 1685(通讯)
(6)Hui-Hua Zheng, Peng-Fei Fu, Hong-Ying Chen and Zhen-Ya Wang, Pseudorabies Virus: From Pathogenesis to Prevention Strategies, Viruses 2022, 14, 1638(通讯)
(7)Jingwei Geng, Xiaoning Hu, Zhongmou Zhang, Zichen Gu, Yuanyuan Li, Xiaodong Mou, Lu Mao, Yongzhuang Ge, Xinyu Yang, Yihui Song, Hongmin Liu, Linqing Wang, Zhanyong Wei, Zhenya Wang, Haiwei Xu, Discovery and pharmacodynamic evaluation of the novel butene lactone derivative M355 against influenza A virus in vitro and in vivo, J Med Virol. 2022; 94: 4393–4405(通讯)
(8)Avishak Sarker, Zichen Gu, Lu Mao, Yongzhuang Ge, Duoduo Hou, Jieyu Fang, Zhanyong Wei, Zhenya Wang, Influenza-existing drugs and treatment prospects, European Journal of Medicinal Chemistry, 232 (2022) 114189(通讯)