主要成果与奖励 |
一、 科研项目 1.国家自然科学基金青年项目:“猪繁殖与呼吸综合征病毒Nsp4蛋白纳米抗体抗病毒机制研究”,项目批准号:31702246,主持,2018.1-2020.12; 2.国家重点研发计划子课题:“ASF亚单位疫苗对猪的免疫代谢调控及机制”,项目编号:2021YFD1801305-5,主持,2021.12-2024.11; 3.中国博士后科学基金第62批面上项目:“蓝耳病病毒非结构蛋白Nsp4纳米抗体抗病毒功能研究”, 项目编号:2017M622376,主持,2017.6-2018.12。 二、代表性论文: 1. Liu Hongliang, Wang Aiping, Yang Weiru, Liang Chao, Zhou Jingming, Chen Yumei, Liu Yankai, Zhou Yongmeng, Zhang Gaiping *. Expression of extracellular domain of ASFV CD2v protein in mammalian cells and identification of B cell epitopes. Virus Research,2023, 323: 199000. 2.Liu Hongliang, Liang Chao, Duan Hong, Zhang Xiaobin, Wang Xiangpeng, Xiao Shuqi, Zhou En-Min*, Intracellularly expressed nanobodies against non-structural protein 4 of porcine reproductive and respiratory syndrome virus inhibit virus replication, Biotechnology Letters, 2016, 38(7): 1081-1088 3. Liu Hongliang, Wang Yan, Duan Hong, Zhang Angke, Liang Chao, Gao Jiming, Zhang Chong, Huang Baicheng, Li Qiongyi, Li Na, Xiao Shuqi*, Zhou En-Min*, An intracellularly expressed Nsp9-specific nanobody in MARC-145 cells inhibits porcine reproductive and respiratory syndrome virus replication, Veterinary Microbiology, 2015, 181(3-4): 252-260 三、授权发明专利: 1. 一种特异性结合PRRS病毒非结构蛋白Nsp9纳米抗体及其应用,国家发明专利,专利号:ZL 2015 1 0111199.X 2. 一种特异性结合PRRS病毒非结构蛋白Nsp4纳米抗体及其应用,国家发明专利,专利号:ZL 2016 1 0142887.7 四、获得奖励: 粮食与饲料中霉菌毒素、抗营养因子及兽药监控检测技术与应用,河南省科技进步一等奖, (11/15), 2023 |