职称：副教授

      电话：0371-66658832

      邮箱：wanglinzz@zzu.edu.cn

      地址：河南省郑州市大学路北路40号郑州大学河南医学院

个人简介

王琳，郑州大学医学科学院，副教授，博士生导师，主要从事重金属及信号传导通路在细胞恶性转化、新的血管生成和肿瘤发生发展中的作用机理研究。近年来，主持了2项国家自然科学基金、1项河南省优秀青年基金、1项河南省科技研发计划培育项目、1项河南省高校重点科研项目、参与4项国家自然科学基金项目等。2019年至2021年在国家留学基金委的资助下，以访问学者身份在美国爱荷华大学和美国托马斯杰斐逊大学病理学系进行了两年的访问学习。目前在Science of The Total Environment，Ecotoxicology Environmental Safety，Seminars in cancer biology，Drug resistance updates和Cancer letters国际知名杂志发表SCI研究论文约40篇。发表论文他引次数约2000次。已指导培养博士及硕士研究生6人。现全职工作于郑州大学医学科学院信号转导与蛋白质组学研究中心。

主要研究方向

重金属诱导细胞恶性转化和肿瘤发生发展的机制研究

代表性成果

(1) Lin Wang, Zhi-Hao Zhou, Yun-Xia Xie, Wen-Jing Liu, Rui-Xiang Zhang, Nan Jiang, Ming-Liang He, Jian-Ge Qiu*, Bing-Hua Jiang*. Dysregulation of MiR-199a/IL8 pathway in chronic Cr (VI)-induced tumor growth and angiogenesis. Ecotoxicology Environmental Safety. 2023 Jun 19;262:115155. 中国科学院一区，IF=6.8。

(2) Wen-Jing Liu^#, Lin Wang^#, Feng-Mei Zhou, Shu-Wen Liu, Wei Wang, Er-Jiang Zhao, Quan-Jun Yao, Wei Li, Yan-Qiu Zhao, Zhi Shi, Jian-Ge Qiu*, Bing-Hua Jiang*. Elevated NOX4 promotes tumorigenesis and acquired EGFR-TKIs resistance via enhancing IL-8/PD-L1 signaling in NSCLC. Drug Resistance Updates. 2023 Jun 22;70:100987.中国科学院一区，IF=24.3。

(3) Ye Zhang^#, Jian-Ge Qiu^#, Xiao-Yu Jia, Yu Ke, Ming-Kun Zhang, David Stieg, Wen-Jing Liu, Ling-Zhi Liu, Lin Wang*, Bing-Hua Jiang*. METTL3-mediated N6-methyladenosine modification and HDAC5/YY1 promote IFFO1 downregulation in tumor development and chemo-resistance. Cancer Letters.2023 Jan 28;553:215971. 中国科学院一区，IF=9.756。

(4) Yun-Xia Xie, Zhi-Hao Zhou, Shu-Wen Liu, Ye Zhang, Wen-Jing Liu, Rui-Ke Zhang, Ming-Liang He, Jian-Ge Qiu, Lin Wang*, Bing-Hua Jiang*. MicroRNA-497 slows esophageal cancer development and reverses chemotherapy resistance through its target QKI. Aging (Albany NY). 2023 May 11;15(9):3791-3806.  中国科学院二区，IF=5.2。

(5) Lin Wang^#, Yan-Ling Yong^#, Kun-Kun Wang^#, Yun-Xia Xie, Ying-Chen Qian, Feng-Mei Zhou, Jian-Ge Qiu*, Bing-Hua Jiang*. MKRN2 knockout causes male infertility through decreasing STAT1, SIX4, and TNC expression. Front Endocrinol (Lausanne).2023 Mar 10;14:1138096. 中国科学院二区，IF=6.055。

(6) Xin Ge^#, Jun He^#, Lin Wang, Lei Zhao, Yifang Wang, Gang Wu, Wenjing Liu, Yongqian Shu, Wei Gong, Xin-Liang Ma, Yajing Wang, Bing-Hua Jiang*, Ling-Zhi Liu*. Epigenetic alterations of CXCL5 in Cr(VI)-induced carcinogenesis. Sci Total Environ.2022 Sep 10;838(Pt 1):155713. 中国科学院一区，IF=10.754。

(7) Lin Wang^#, Khaliunaa Bayanbold^#, Lei Zhao, Yifang Wang, Andrea Adamcakova-Dodd, Peter S Thorne, Hushan Yang, Bing-Hua Jiang*, Ling-Zhi Liu*. Redox sensitive miR-27a/b/Nrf2 signaling in Cr(V I)-induced carcinogenesis, Science of the Total Environment, 2022, 809(151118). 中国科学院一区，IF=10.754。

(8) Lin Wang, Ling-Zhi Liu*, Bing-Hua Jiang*. Dysregulation of microRNAs in metal-induced angiogenesis and carcinogenesis. Seminars in Cancer Biology, 2021, 76: 279-286. 中国科学院一区，IF=17.012。

(9) Lin Wang*, Xiang-Bo Ji, Li-Hong Wang, Zhong-Kun Xia, Yun-Xia Xie, Wen-Jing Liu, Jian-Ge Qiu, Bing-Hua Jiang, Ling-Zhi Liu*. MiRNA-30e downregulation increases cancer cell proliferation, invasion and tumor growth through targeting RPS6KB1. Aging (Albany NY).2021 Nov 2;13(21):24037-24049. 中国科学院二区，IF=5.955。

(10) Lin Wang，Yi-Fan Lu, Chao-Shan Wang, Yun-Xia Xie, Yan-Qiu Zhao, Ying-Chen Qian, Wei-Tao Liu, Min Wang*, Bing-Hua Jiang*. HB-EGF Activates the EGFR/HIF-1α Pathway to Induce Proliferation of Arsenic-Transformed Cells and Tumor Growth. Frontiers in Oncology, 2020, 10(1019). 中国科学院二区，IF=6.244。

(11) Lin Wang, Xiang-Bo Ji, Li-Hong Wang, Jian-Ge Qiu, Feng-Mei Zhou, Wen-Jing Liu, Di-di Wan, Marie Chai-mi Lin, Ling-Zhi Liu, Jian-Ying Zhang*, Bing-Hua Jiang*. Regulation of MicroRNA-497-Targeting AKT2 Influences Tumor Growth and Chemoresistance to Cisplatin in Lung Cancer. Frontiers in Cell and Developmental Biology, 2020, 8(840). 中国科学院二区，IF=6.684。

(12) Hui-Fang Jin*, Ju-Feng Wang, Ting-Ting Song, Jun Zhang, Lin Wang*. MiR-200b Inhibits Tumor Growth and Chemoresistance via Targeting p70S6K1 in Lung Cancer. Front Oncol.2020 May 6;10:643. 中国科学院二区，IF=6.244

(13) Lin Wang^#，Jian-Ge Qiu^#, Jun He, Wen-Jing Liu, Xin Ge, Feng-Mei Zhou, Ying-Xue Huang, Bing Hua Jiang*, Ling-Zhi Liu*. Suppression of miR-143 contributes to overexpression of IL-6, HIF-1α and NF-κB p65 in Cr(VI)-induced human exposure and tumor growth. Toxicology and Applied Pharmacology, 2019, 378(114603). 中国科学院二区，IF=3.347。

(14) Li Wei^#, Wang Lin^#, Ji Xiang-Bo, Wang Li-Hong, Ge Xin, Liu Wei-Tao, Chen Ling, Zheng Zhong, Shi Zhu-Mei, Liu Ling-Zhi, Lin Marie C, Chen Jie-Yu*, Jiang Bing-Hua*. MiR-199a Inhibits Tumor Growth and Attenuates Chemoresistance by Targeting K-RAS via AKT and ERK Signalings. Front Oncol. 2019 Oct 15;9:1071. 中国科学院二区，IF=4.848。

(15) Qiu Jian-Ge, Wang Lin, Liu Wen-Jing, Wang Ju-Feng, Zhao Er-Jiang, Zhou Feng-Mei, Ji Xiang-Bo, Wang Li-Hong, Xia Zhong-Kun, Wang Wei, Lin Marie C, Liu Ling-Zhi, Huang Ying-Xue*, Jiang Bing-Hua*. Apigenin Inhibits IL-6 Transcription and Suppresses Esophageal Carcinogenesis. Front Pharmacol. 2019 Sep 11;10:1002. 中国科学院二区，IF=4.225。