职称：讲师

        邮箱：silingling@zzu.edu.cn

        地址：郑州大学二七区大学北路40号医学科学院细胞与基因治疗中心

个人简介

硕士生导师，2020年毕业于沈阳药科大学药理学专业；2020年被聘为郑州大学医学科学院讲师，主持国家青年科学基金项目、河南省科技攻关项目、河南省博士后基金各一项。

主要研究方向

主要从事CAR-T免疫治疗、天然药物抗肿瘤治疗过程中线粒体相关机制的探究。

 代表性成果

      (1) Lingling Si; Jianing Fu; Weiwei Liu; Toshihiko Hayashi; Kazunori Mizuno; Shunji Hattori; Hitomi Fujisaki; Satoshi Onodera; Takashi Ikejima ; Silibinin-induced mitochondria fission leads to mitophagy, which attenuates silibinin-induced apoptosis in MCF-7 and MDA-MB-231 cells, Archives of Biochemistry and Biophysics, 2020, 685: 108284-108323.

(2) Lingling Si; Weiwei Liu; Toshihiko Hayashi; Yachao Ji; Jianing Fu; Yuheng Nie; Kazunori Mizuno; Shunji Hattori; Satoshi Onodera; Takashi Ikejima ; Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment, Archives of Biochemistry and Biophysics, 2019,671: 0003-9861.

(3) Lingling Si; Jianing Fu; Weiwei Liu; Toshihiko Hayashi; Yuheng Nie; Kazunori Mizuno; Shunji Hattori; Hitomi Fujisaki; Satoshi Onodera; Takashi Ikejima ; Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion, Molecular and Cellular Biochemistry, 2019, 463: 186-201.

(4) Yuanyuan Zhao; Louisa S Chard Dunmall; Zhenguo Cheng; Yaohe Wang; Lingling Si; Natural products targeting glycolysis in cancer, Frontiers in Pharmacology, 2022, 13.