叶中菊

作者: 时间:2021-03-13 点击数:

个人简历

叶中菊,中共党员,郑州大学“青年拔尖人才”

邮箱:zhongjuye@163.com

基本信息

叶中菊,博士。郑州大学化学学院、绿色催化中心、生命分析化学研究所助理研究员。

教育背景

2017.09-2020.06 理学博士,南开大学,导师:肖乐辉 研究员

2014.09-2017.06 理学硕士,湖南师范大学,导师:肖乐辉 教授2010.09-2014.06 理学学士,平顶山学院

工作经历

2020.12-至今 郑州大学,化学学院,助理研究员

研究领域

本人主要围绕分子识别、动态示踪和纳米催化超分辨成像等方面开展研究。主要以功能纳米材料或有机分子为探针,利用光学显微成像技术的高灵敏、高通量检测分析能力,发展一系列先进成像技术,并且针对目前化学生物学、分析化学以及光物理化学中的基础原理和前沿应用进行深入探究。在单分子、单颗粒水平,探讨功能材料的光物理学特性,分子的自组装机理,重大疾病的致病起因等,从而为上述问题的解决提供参考依据。在活细胞层面,我们探讨功能化纳米材料与细胞膜的作用方式和机制,建立高效运输药物的途径,提供定向、可控且方便易行的药物释放方法,从而为重大疾病的早期诊断与治疗提供有效策略。本课题组基于光学显微成像技术,围绕分子识别、纳米示踪以及超分辨光学显微成像等开展了一系列研究工作,在J. Am. Chem. Soc., ACS Nano, Chem. Sci., Anal. Chem.等著名国际学术刊物发表SCI收录论文30余篇。

代表性论文

1.      Ye, Z.; Geng, X.; Wei, L.; Lin, S.; Li, Z.; Xiao, L.*, Length Dependent Distinct Cytotoxic Effect of Amyloid Fibrils beyond Optical Diffraction Limit Revealed by Nanoscopic Imaging. ACS Nano 2021, 15(1), 934-943.

2.      Zhang, D.#; Ye Z.#; Liu, H.; Wang, X.; Hua, J.; Ling, Y.; Wei, L., Xia, Y.*, Sun, S.*, Xiao, L.*, Cell Membrane Coated Smart Two-Dimensional Supraparticle for In Vivo Homotypic Cancer Targeting and Enhanced Combinational Theranostics. Nanotheranostics 2021, 5(3), 275-287. (contributed equally)

3.      Ye, Z.; Wei, L.; Geng, X.; Wang, X.; Li, Z.; Xiao, L.*, Mitochondrion-Specific Blinking Fluorescent Bioprobe for Nanoscopic Monitoring of Mitophagy. ACS Nano 2019, 13(10), 11593-11602.

4.      Ye, Z.; Wei, L.; Xiao, L.*; Wang, J., Laser Illumination-Induced Dramatic Catalytic Activity Change on Au Nanospheres. Chem. Sci. 2019, 10, 5793-5800.

5.      Ye, Z.; Liu, H.; Wang, F.; Wang, X.; Wei, L.; Xiao, L.*, Single-Particle Tracking Discloses Binding-Mediated Rocking Diffusion of Rod-Shaped Biological Particle on Lipid Membrane. Chem. Sci. 2019, 10, 1351-1359.

6.      Ye, Z.#; Wang, X.#; Xiao, L.*, Single-Particle Tracking with Scattering-Based Optical Microscopy. Anal. Chem. 2019, 91(24), 15327-15334. (contributed equally)

7.      Ye, Z.; Wei, L.; Li, Y.; Xiao, L.*, Efficient Modulation of β-Amyloid Peptide Fibrillation with Polymer Nanoparticles Revealed by Super-Resolution Optical Microscopy. Anal. Chem. 2019, 91(13), 8582-8590.

8.      Ye, Z.#; Weng, R.#; Ma, Y.; Wang, F.; Liu, H.; Wei, L.*; Xiao, L.*, Label-Free Single-Particle Colorimetric Detection of Permanganate by GNPs@Ag Core-Shell Nanoparticle with Dark-Field Optical Microscopy. Anal. Chem. 2018, 90(21), 13044-13050. (contributed equally)

9.      Ye, Z.; Liu H.; Xiao L.*, Recent Advances of Single Molecule/Particle Imaging with Optical Microscopic Methods. Sci. Sin. Chem. 2018, 49(5), 787-800.

10.  Ye, Z.; Wei, L.; Zeng, X.; Weng, R.; Shi, X.; Wang, N.; Chen, L.; Xiao L.*, Background-Free Imaging of Viral Capsid Proteins-Coated Anisotropic Nanoparticle on Living Cell Membrane with Dark-Field Optical Microscopy. Anal. Chem. 2018, 90(2), 1177-1185.

11.  Wei, L.#; Ye, Z.#; Xu, Y.; Chen, B.; Yeung, E. S.; Xiao, L.*, Single Particle Tracking of Peptides-Modified Nanocargo on Lipid Membrane Reveals Bulk-Mediated Diffusion. Anal. Chem. 2016, 88(24), 11973-11977. (contributed equally)

12.  Yang, Q.#; Ye, Z.#; Zhong, M.; Chen, B.; Chen, J.; Zeng, R.; Wei, L.*; Li, H.*; Xiao, L.*, Self-Assembled Fluorescent Bovine Serum Albumin Nanoprobes for Ratiometric pH Measurement inside Living Cells. ACS Appl. Mater. Inter. 2016, 8(15), 9629-9634. (contributed equally)

13.  Yan, Z.; Wang, D.; Ye, Z.; Fan, T.; Wu, G.; Deng, L.; Yang, L.; Li, B.; Liu, J.; Ma, T.; Dong, C.; Li, Z.; Xiao, L.*; Wang, Y.*; Wang, W.*; Hou, L.*, Artificial Aquaporin That Restores Wound Healing of Impaired Cells. J. Am. Chem. Soc. 2020, 142(37), 15638-15643.

14.  Ma, Y.; Ye, Z.; Zhang, C.; Li, H.-W.; Wong, M.; Luo, H.*; Xiao, L.*, Deep Red Blinking Fluorophore for Nanoscopic Imaging and Inhibition of β-Amyloid Peptide Fibrillation. ACS Nano 2020. 14(9), 11341-11351.

15.  Zhang, D.; Ye, Z.; Wei, L.*; Luo, H.*; Xiao, L.*, Cell Membrane-Coated Porphyrin Metal-Organic Frameworks for Cancer Cell Targeting and O2-Evolving Photodynamic Therapy. ACS Appl. Mater. Interfaces 2019, 11(43), 39594-39602.

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