黄利华，教授 ，博士生导师
邮箱：hlh606@zzu.edu.cn
学习经历：
2007.09-2011.03郑州大学药学院攻读药物化学博士学位；
2002.09-2005.06 郑州大学化学学院攻读有机化学硕士学位;
1991.09-1995.06 湖南师范大学化学系攻读化学教育学士学位。
工作经历：
2022.03 - 至今郑州大学化学学院有机化学教研室任教授；
2011.04 - 至2022.02郑州大学化学学院有机化学教研室任副教授；
2002.04- 2011.03 郑州大学无机化学教研室任讲师；
1995.07- 2002.03 河南医科大学(现郑州大学医学院)无机化学教研室任助教。
研究方向：
靶向蛋白小分子抑制剂的设计、合成以及生物活性评价
主持项目：
1. SQS处方抗癌有效成分研究，横向课题，在研，主持；
2. 有机荧光发光材料及其柔性器件研究与开发，横向课题，已结题，主持；
3. 新型前列腺癌靶向抑制剂的设计、合成及抗肿瘤活性评价，河南省科技厅，182102310121，已结题，主持；
4. 表观遗传抗肿瘤靶向药物的研究与开发，横向课题，已结题，主持；
5. 甾体核苷类似物的设计、合成与抗癌活性研究，横向课题，已结题，主持。
6. 4-氮杂甾体氮苷类似物的设计、合成及抗癌活性研究，河南省科技厅，142102310309，已结题，主持；
7. 碱基为6-哌嗪衍生物取代的嘌呤甾体氮苷类似物的合成及抗癌活性研究，郑州市科技局，121PPTGG507，已结题，主持；
代表论文：
1. Wenjuan Zhu, Hui Xi, Wenyang Jiao, Lihua Huang*, Lianjie Wang,* and Junliang Wu*, Difunctionalization of gem-Difluoroalkenes via Photoredox Catalysis: Synthesis of Diverse α,α-Difluoromethyl-β-alkoxysulfones. Organic Letter, 2022, 24(2), 720-72.
2. Yazhen You , Yundong Fu, Mingjie Huang, Dandan Shen, Bing Zhao, Hongmin Liu*, Yichao Zheng*, Lihua Huang*, Recent Advances of m6A Demethylases Inhibitors and Their Biological Functions in Human Diseases. International journal of Molecular Sciences, 2022, 23, 5815.
3. Ming-jie Huang, Jia-Wen Guo , Yun-Dong Fu, Ya-Zhen You, Wen-Yu Xu, Ting-Yu Song, Ran Li, Zi-Tong Chen, Li-Hua Huang*, Hong-Min Liu*, Discovery of new tranylcypromine derivatives as highly potent LSD1 inhibitors . Bioorganic and Medicinal Chemistry Letters, 2021, 41, 127993.
4. Yun-Dong Fu, Ming-Jie Huang, Jia-Wen Guo, Ya-Zhen You, Hong-Min Liu, Li-Hua Huang*, Bin Yu**, Targeting histone demethylase KDM5B for cancer treatment. European Journal of Medicinal Chemistry, 2020, 208, 112760.
5. Jian-Wei Zhao,Zeng-Hui Wu, Jia-Wen Guo, Ming-Jie Huang, Ya-Zhen You, Hong-Min Liu*, Li-Hua Huang*,Synthesis and anti-gastric cancer activity evaluation of novel triazole nucleobase analogues containing steroidal/coumarin/quinoline moieties. European Journal of Medicinal Chemistry, 2019, 181, 111520.
6. Jian-Wei Zhao, Jia-Wen Guo, Ming-Jie Huang, Ya-Zhen You, Zeng-Hui Wu, Hong-Min Liu*, Li-Hua Huang*,Design, synthesis and biological evaluation of new steroidal β-triazoly enones as potent antiproliferative agents. Steroids, 2019, 150, 108431-108437.
7. Li-Hua Huang, Hong-De Xu, Zhuo-Ya Yang, Yong-Fei Zheng, Hong-Min Liu*, Synthesis and anticancer activity of novel C6-piperazine substituted purine steroid–nucleosides analogues. Steroids, 2014, 82, 1-6.
8. Li-Hua Huang, Yang Li, Hong-De Xu, Yong-Fei Zheng, Hong-Min Liu*, Synthesis and biological evaluation of novel C6-cyclo secondary amine substituted purine steroid-nucleosides analogues. Steroids, 2014, 85, 13-17.
9. Li-Hua Huang, Yong-Fei Zheng, Chuan-Jun Song, Yan-Guang Wang, Zhi-Yu Xie, Yao-Wen Lai, Yong-Zheng Lu, Hong-Min Liu*, Synthesis and biological evaluation of novel steroidal[17,16-d][1,2,4]triazolo [1,5-a]pyrimidines. Steroids, 2012, 77, 710-715.
10. Li-Hua Huang, Yong-Fei Zheng, Yong-Zheng Lu, Chuan-Jun Song, Yan-Guang Wang, Bin Yu, Hong-Min Liu*, Synthesis of novel D-ring fused 7’-aryl-androstano[17,16-d][1,2,4] triazolo[1,5-a]pyrimidines. Steroids, 2012, 77, 367-374.
11. Li-Hua Huang, Yan-Guang Wang, Gong Xu, Xiang-Hua Zhang, Yong-Fei Zheng, Hui-Li He, Wen-Zheng Fu, Hong-Min Liu*, Novel 4-azasteroidal N-glycoside analogues bearing sugar-like D-ring: Synthesis and anticancer activities. Bioorganic and Medicinal Chemistry Letters, 2011, 21, 6203-6205.
12. Li-Hua Huang, Juan Li, Gong Xu, Xiang-Hua Zhang, Yang-Guang Wang, Ye-Lin Yin, Hong-Min Liu*, Biotransformation of dehydroepiandrosterone (DHEA) with Penicillium griseopurpureum Smith and Penicillium glabrum (Wehmer) Westling. Bioorganic and Medicinal Chemistry Letters, 2010, 75, 1039-1046.
