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蓝宇，博士，教授，博士生导师，河南省特聘教授，曾获国家自然科学基金优秀青年基金支持。 E-mail: lanyu@zzu.edu.cn 通讯地址：郑州市科学大道100号郑州大学化学学院 |
教育背景
2003~2008年——北京大学，博士研究生
1999~2003年——北京大学，本科
工作履历
2018至今——郑州大学，教授，博士生导师
2016~2018 ——重庆大学，教授，博士生导师
2012~2016年——重庆大学，特聘研究员，博士生导师
2009~2012年——加州大学，博士后研究员
学术兼职
中国化学会物理有机化学专业委员会委员；中国化学会奖励推荐委员会委员；《中国化学快报》第五届编委会编委；《有机化学》第七届编委会编委。
研究领域
1.自由基偶联反应相关机制；
2.电环化反应机理与选择性；
3.过渡金属促进烃类官能团化反应机理；
4.小分子催化反应立体化学。
科研项目
(1) 2019~2021年 自然科学基金优秀青年基金项目 《理论有机化学》130万，基金号21822303（主持）
(2) 2018~2021年 自然科学基金面上项目 《铜催化偶联反应中Cu(III)中间体生成机制的理论研究》64万，基金号21772020（主持）
(3) 2014~2017年 自然科学基金面上项目 《铑催化碳-硅键、碳-碳键断裂生成机理的理论研究》80万，基金号21372266（主持）
(4) 2014~2016年 自然科学基金青年项目 《单层石墨烯化学方法修饰的理论研究》25万，基金号51302327（主持）
学术成果
蓝宇教授的工作集中在通过计算进行偶联成键新模式的理论研究。通过基于量子化学的计算研究偶联反应机理，在分子层次上展示几何结构、电子结构、光谱信息及动力学信息，可以从本质上揭示有机化学反应历程，为实验有机化学提供新的思路。蓝宇教授科研工作的主要创新之处在于：（1）提出了铑催化碳氢官能团化中配基间电子转移新反应模式，并与实验合作预测和证明该模式，从而为偶联反应化学提供了新的途径和方法；（2）设计了膦催化联烯活化并与亲核试剂偶联新反应模式，并预测区域选择性机制；（3）提出了基于构建共价键和转化合成单元的机理分析方法，并应用于大量过渡金属催化和小分子催化偶联反应机理研究中，提出了一条全面系统的有机化学反应机理研究新模式，并被国内外同行广泛关注。
蓝宇教授近5年来在J. Am. Chem. Soc. (IF = 14.7，11篇)、Angew. Chem. Int. Ed. (IF = 12.3，14篇)、Nat. Commun. (IF = 11.9，4篇)这三大期刊上以通讯作者发表论文29篇，总计在各学术刊物上以通讯作者发表论文142篇，总引用次数已过3500次，18篇论文曾入选ESI高被引论文。
蓝宇教授2018年获得国家自然科学基金优秀青年基金支持。此外，还先后主持国家自然科学基金青年项目1项、面上项目2项。蓝宇教授获2018年重庆市自然科学奖一等奖（第一完成人）。蓝宇教授获得“2016年中国化学会青年化学奖”、“2015年中国化学会-物理有机化学新人奖”。蓝宇教授近5年在国内外学术会议作邀请报告20余次，并受邀在高校和科研院所作学术报告50余次。由于蓝宇教授在过渡金属和小分子催化偶联反应机理研究中的系统性进展，2017年至今在Acc. Chem. Res. (IF = 21.7)、Chem. Soc. Rev. (IF = 40.4)、Coor. Chem. Rev. (IF = 13.5)等期刊以通讯作者受邀发表多篇综述。最近，Angew. Chem. Int. Ed. (IF = 12.3)在其Author Profile发表了候选人的作者简介。（Angew. Chem. Int. Ed. 2018, 57, 11852.）
部分代表论文：
1. “Origin of Regiochemical Control in Rh(III)/Rh(V)-Catalyzed Reactions of Unsaturated Oximes and Alkenes to Form Pyrdines” Li, Y.; Chen, H.; Qu, L.-B.; Houk, K. N.*; Lan, Y.* ACS Catal. 2019, 9, accepted. (DOI: 10.1021/acscatal.9b02085)
2. “Inverse Electron-Demand, Pd-Catalyzed Asymmetric [4+2] Cycloadditions Enabled by Chiral P,S-Ligand and Hydrogen Bonding” Wang, Y.-N.; Xiong, Q.; Lu, L.-Q.*; Zhang, Q.-L.; Wang, Y.; Lan, Y.*; Xiao, W.-J.* Angew. Chem. Int. Ed. 2019, 58, accepted. (DOI: 10.1002/anie.201905993)
3. “S8-Catalyzed Triple Cleavage of Bromodifluoro Compounds for the Assembly of N-containing Heterocycles” Deng, S.; Chen, H.; Ma, X.; Zhou, Y.; Yang, K.; Lan, Y.*; Song, Q.* Chem. Sci. 2019, 10, accepted. (DOI: 10.1039/c9sc01333d)
4. “Key Intermediate in Copper-Mediated Arene Trifluoromethylation [nBu4N][Cu(Ar)(CF3)3]: Synthesis, Characterization and C(sp2)-CF3 Reductive Elimination” Lu, Z.; Liu, H.; Liu, S.; Leng, X.; Lan, Y.*; Shen, Q.* Angew. Chem. Int. Ed. 2019, 58, Accepted. (DOI: 10.1002/anie.201904041)
5. “Theoretical Study of the Addition of Cu–Carbenes to Acetylenes to Form Chiral Allenes” Zhong, K.; Shan, C.; Zhu, L.; Liu, S.; Zhang, T.; Liu, F.; Shen, B.; Lan, Y.*; Bai, R.* J. Am. Chem. Soc. 2019, 141, 5227-5280. (DOI: 10.1021/jacs.8b13055)
6. “Enantioselective Synthesis of Biaryl Atropisomers via Pd‐Catalyzed C–H Olefination using Chiral Spiro Phosphoric Acid Ligands” Luo, J.; Zhang, T.; Wang, L.; Liao, G.; Yao, Q.-J.; Wu, Y.-J.; Zhan, B.-B.; Lan, Y.*; Lin, X.-F.*; Shi, B.-F.* Angew. Chem. Int. Ed. 2019, 58, 6708-6712. (DOI: 10.1002/anie.201902126)
7. “Asymmetric Propargylic Radical Cyanation Enabled by Dual Organophotoredox and Copper Catalysis” Lu, F.-D.; Liu, D.; Zhu, L.; Lu, L.-Q.*; Yang, Q.; Zhou, Q.-Q.; Wei, Y.; Lan, Y.*; Xiao, W.-J.* J. Am. Chem. Soc. 2019, 141, 6167-6172. (DOI: 10.1021/jacs.9b02338)
8. “Kinetic Resolution of Allylic Alcohol with Chiral BINOL-based Alkoxides: A Combination of Experimental and Theoretical Studies” Liu, Y.; Liu, S.; Li, D.; Zhang, N.; Peng, L.; Ao, J.; Eui, C.; Lan, Y.*; Yan, H. J. Am. Chem. Soc. 2019, 141, 1150-1159. (DOI: 10.1021/jacs.8b12796)
9. “Well-Designed Phosphine–Urea Ligand for Highly Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Methacrylonitrile: A Combined Experimental and Theoretical Study” Xiong, Y.; Du, Z.; Chen, H.; Yang, Z.; Tan, Q.; Zhang, C.; Zhu, L.; Lan, Y.*; Zhang, M.* J. Am. Chem. Soc. 2019, 141, 961-971. (DOI: 10.1021/jacs.8b10939)
10. “Gas molecule adsorption on twisted nanographene C96H36 derivative: A theoretical study” Cui, C.-X.*; Tian, Y.; Zhang, Y.-P.; Qu, L.-B.; Lan, Y.* Carbon 2019, 143, 385-390. (DOI: 10.1016/j.carbon.2018.11.030)
11. “Mechanistic View of Ru-Catalyzed C–H Bond Activation and Functionalization: Computational Advances” Shan, C.; Zhu, L.; Qu, L.-B.; Bai, R.*; Lan, Y.* Chem. Soc. Rev. 2018, 47, 7552-7576. (DOI: 10.1039/c8cs00036k)
12. “Experimental and Theoretical Studies on Ru(II)-Catalyzed Oxidative C−H/C−H Coupling of Phenols with Aromatic Amides Using Air as Oxidant: Scope, Synthetic Applications and Mechanistic Insights” Zhang, L.; Zhu, L.; Zhang, Y.; Yang, Y.; Wu, Y.; Ma, W.; Lan, Y.*; You, J.* ACS Catal. 2018, 8, 8324-8335. (DOI: 10.1021/acscatal.8b02816)
13. “Ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2” Yan, S.-S.; Zhu, L.; Ye, J.-H.; Zhang, Z.; Huang, H.; Zeng, H.; Li, C.-J.*; Lan, Y.*; Yu, D.-G.* Chem. Sci. 2018, 9, 4873-4878. (DOI: 10.1039/c8sc01299g)
14. “Author Profile” Lan, Yu* Angew. Chem. Int. Ed. 2018, 57, 11852. (DOI: 10.1002/anie.201804435)
15. “Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives” Yuan, C.; Zhu, L.; Chen, C.; Chen, X.; Yang, Y.; Lan, Y.*; Zhao, Y.* Nat. Commun. 2018, 9, 1189. (DOI: 10.1038/s41467-018-03341-6)
16. “Mechanistic Insight Into Cobalt-Catalyzed Stereodivergent Semihydrogenation of Alkynes: The Story of Selectivity Control” Qi, X.; Liu, X.; Qu, L.-B.; Liu, Q.*; Lan, Y.* J. Catal. 2018, 362, 25-34. (DOI: 10.1016/j.jcat.2018.03.016)
17. “Theoretical insight into phosphoric acid-catalyzed asymmetric conjugate addition of indolizines to α,β-unsaturated ketones” Chen, H.; Zhu, L.; Zhong, K.; Yue, X.; Qu, L.-B.; Bai, R.*; Lan, Y.* Chin. Chem. Lett. 2018, 29, 1237-1241. (DOI: 10.1016/j.cclet.2018.03.018)
18. “Regioselective Palladium-Catalyzed C‑H Bond Trifluoroethylation of Indoles: Exploration and Mechanistic Insight” Zhang, H.; Wang, H.-Y.; Luo, Y.; Chen, C.; Cao, Y.; Chen, P.; Guo, Y.-L.; Lan, Y.*; Liu, G.* ACS Catal. 2018, 8, 2173-2180. (DOI: 10.1021/acscatal.7b03220)
19. “Palladium-Catalyzed Intermolecular Ditrifluoromethoxylation of Unactivated Alkenes: CF3O- Palladation Initiated by Pd(IV)” Chen, C.; Luo, Y.; Fu, L.; Chen, P.; Lan, Y.*; Liu, G.* J. Am. Chem. Soc. 2018, 140, 1207-1210. (DOI: 10.1021/jacs.7b11470)
20. “Ruthenium(II)-catalyzed C-H Difluoromethylation of Ketoxime: Tuning the Regioselectivity from meta to para Position” Yuan, C.; Zhu, L.; Zeng, R.; Lan, Y.*; Zhao, Y.* Angew. Chem. Int. Ed. 2018, 57, 1277-1281. (DOI: 10.1002/anie.201711221)
21. “Mechanism of Rhodium-Catalyzed C−H Functionalization: Advances in Theoretical Investigation” Qi, X.; Li, Y.; Bai, R.; Lan, Y.* Acc. Chem. Res. 2017, 50, 2799-2808. (DOI: 10.1021/acs.accounts.7b00400)
22. “Radical Trifluoromethylative Dearomatization of Indoles and Furans with CO2” Ye. J.-H.; Zhu, L.; Yan, S.-S.; Miao, M.; Zhang, X.-C.; Zhou, W.-J.; Li, J.; Lan, Y.*; Yu, D.-G.* ACS Catal. 2017, 7, 8324-8330. (DOI: 10.1021/acscatal.7b02533)
23. “Rhodium/Copper Cocatalyzed Highly trans-Selective 1,2- Diheteroarylation of Alkynes with Azoles via C−H Addition/Oxidative Cross-Coupling: A Combined Experimental and Theoretical Study” Tan, G.; Zhu, L.; Liao, X.; Lan, Y.*; You, J.* J. Am. Chem. Soc. 2017, 139, 15724-15737. (DOI: 10.1021/jacs.7b07242)
24. “Nine-Membered Benzofuran-Fused Heterocycles: Enantioselective Synthesis by Pd-Catalysis and Rearrangement via Transannular Bond Formation” Rong, Z.-Q.; Yang, L.-C.; Liu, S.; Yu, Z.; Wang, Y.-N.; Tan, Z. Y.; Huang, R.-Z.; Lan, Y.*; Zhao, Y.* J. Am. Chem. Soc. 2017, 139, 15304-15307. (DOI: 10.1021/jacs.7b09161)
25. “Cp*CoIII-Catalyzed Branch-Selective Hydroarylation of Alkynes via C−H Activation: Efficient Access to α-gem-Vinylindoles” Zhou, X.; Luo, Y.; Kong, L.; Xu, Y.; Zheng, G.; Lan, Y.*; Li, X.* ACS Catal. 2017, 7, 7296-7304. (DOI: 10.1021/acscatal.7b02248)
26. “Catalyst-controlled regioselectivity in phosphine catalysis: the synthesis of spirocyclic benzofuranones via regiodivergent [3+2] annulations of aurones and an allenoate” Ni, H.; Yu, Z.; Yao, W.; Lan, Y.*; Ullah, N.*; Lu, Y.* Chem. Sci. 2017, 8, 5699-5704. (DOI: 10.1039/c7sc02176c)
27. “Chiral phosphine-mediated intramolecular [3+2] annulation: enhanced enantioselectivity by achiral Brønsted acid” Yao, W.; Yu, Z.; Wen, S.; Ni, H.; Ullah, N.*; Lan, Y.*; Lu, Y.* Chem. Sci. 2017, 8, 5196-5200. (DOI: 10.1039/c7sc00952f)
28. “Bioinspired Total Synthesis of Homodimericin A” Huang, J.; Gu, Y.; Guo, K.; Zhu, L.; Lan, Y.*; Gong, J.*; Yang, Z.* Angew. Chem. Int. Ed. 2017, 56, 7890-7894. ( DOI: 10.1002/anie.201702768)
29. “Bioinspired Asymmetric Synthesis of Hispidanin A” Li, F.; Tu, Q.; Chen, S.; Zhu, L.; Lan, Y.*; Gong, J.*; Yang, Z.* Angew. Chem. Int. Ed. 2017, 56, 5844-5848. (DOI: 0.1002/anie.201700838)
30. “C−O Functionalization of α Oxyboronates: A Deoxygenative gemDiborylation and gem-Silylborylation of Aldehydes and Ketones” Wang, L.; Zhang, T.; Sun, W.; He, Z.; Xia, C.; Lan, Y.*; Liu, C.* J. Am. Chem. Soc. 2017, 139, 5257-5264. (DOI: 10.1021/jacs.7b02518)
31. “Regioselective a-Addition of Deconjugated Butenolides: Enantioselective Synthesis of Dihydrocoumarins” Wu, B.; Yu, Z.; Gao, X.; Lan, Y.*; Zhou, Y.* Angew. Chem. Int. Ed. 2017, 56, 4006-4010. (DOI:10.1002/anie.201700437)
32. “Biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone A” Han, Y.; Jiang, Y.; Li, Y.; Yu, H.; Tong, B.; Niu, Z.; Zhou, S.; Liu, S.; Lan, Y.;* Chen, J.;* Yang, Z.;* Nat. Commun. 2017, 8, 14233. (DOI: 10.1038/ncomms14233)
33. “Mild Acylation of C(sp3)−H and C(sp2)−H Bonds under Redox-Neutral Rh(III) Catalysis” Yu, S.; Li, Y.; Kong, L.; Zhou, X.; Tang, G.; Lan, Y.;* Li, X.* ACS Catal. 2016, 6, 7744-7748. (DOI: 10.1021/acscatal.6b02668)
34. “Asymmetric Transfer Hydrogenation of Imines using Alcohol: Efficiency and Selectivity are Influenced by the Hydrogen Donor” Pan, H. J.; Zhang, Y.; Shan, C.; Yu, Z.; Lan, Y.;* Zhao, Y.* Angew. Chem. Int. Ed. 2016, 55, 9615-9619. (DOI:10.1002/anie.201604025)
35. “Anthranil: An Aminating Reagent Leading to Bifunctionality for Both C(sp3)-H and C(sp2)-H under Rhodium(III) Catalysis” Yu, S.; Tang, G.; Li, Y.; Zhou, X.; Lan, Y.;* Li, X.* Angew. Chem. Int. Ed. 2016, 55, 8696-8700. (DOI: 10.1002/anie.201602224)
36. “Rhodium(III)-Catalyzed Annulation between N Sulfinyl Ketoimines and Activated Olefins: C−H Activation Assisted by an Oxidizing N−S Bond” Wang, Q.; Li, Y.; Qi, Z.; Xie, F.; Lan, Y.*; Li, X.* ACS Catal. 2016, 6, 1971-1980. (DOI: 10.1021/acscatal.5b02297)
37. “Iron-Catalyzed Decarboxylative (4+1) Cycloadditions: Exploiting the Reactivity of Ambident Iron-Stabilized Intermediates” Wang, Q.; Qi, X.; Lu, L. Q.*; Li, T. R.; Yuan, Z. G.; Zhang, K.; Li, B. J.; Lan, Y.*; Xiao, W. J.* Angew. Chem. Int. Ed. 2016, 55, 2840-2844. (DOI: 10.1002/anie.201510413)
38. “Regiodivergent Enantioselective γ Additions of Oxazolones to 2,3-Butadienoates Catalyzed by Phosphines: Synthesis of α,α-Disubstituted α Amino Acids and N,O Acetal Derivatives” Wang, T.; Yu, Z.; Hoon, D. L.; Phee, C. Y.; Lan, Y.*; Lu, Y.* J. Am. Chem. Soc. 2016, 138, 265-271. (DOI: 10.1021/jacs.5b10524)
39. “Silver Migration Facilitates Isocyanide-Alkyne [3+2] Cycloaddition Reactions: Combined Experimental and Theoretical Study” Qi, X.; Zhang, H.; Shao, A.; Zhu, L.; Xu, T.; Gao, M.*; Liu, C.*; Lan, Y.* ACS Catal. 2015, 5, 6640-6647. ( DOI: 10.1021/acscatal.5b02009)
40. “Highly enantioselective construction of tertiary thioethers and alcohols via phosphine-catalyzed asymmetric γ-addition reactions of 5H-thiazol-4-ones and 5H-oxazol-4-ones: scope and mechanistic understandings” Wang, T.; Yu, Z.; Hoon, D. L.; Huang, K.-W.; Lan, Y.*; Lu, Y.* Chem. Sci. 2015, 6, 4912-4922. (DOI: 10.1039/c5sc01614b)
41. “Transition-Metal-Free Formal Decarboxylative Coupling of a-Oxocarboxylates with a-Bromoketones under Neutral Conditions: A Simple Access to 1,3-Diketones” He, Z.; Qi, X.; Li, S.; Zhao, Y.; Gao, G.*; Lan, Y.*; Wu, Y.; Lan, J.; You, J.* Angew. Chem. Int. Ed. 2015, 54, 855-859. (DOI: 10.1002/anie.201409361)
42. “Rhodium-Catalyzed C−H Activation of Phenacyl Ammonium Salts Assisted by an Oxidizing C−N Bond: A Combination of Experimental and Theoretical Studies” Yu, S.; Liu, S.; Lan, Y.*; Wan, B.*; Li, X.* J. Am. Chem. Soc. 2015, 137, 1623-1631. (DOI: 10.1021/ja511796h)
43. “Chemoselective Carbophilic Addition of a-Diazoesters through Ligand-Controlled Gold Catalysis” Xi, Y.; Su, Y.; Yu, Z.; Dong, B.; McClain, E. J.; Lan, Y.*; Shi, X.* Angew. Chem. Int. Ed. 2014, 53, 9817-9821. (DOI: 10.1002/anie.201404946)
44. “Visible-Light-Mediated Decarboxylation/Oxidative Amidation of α-Keto Acids with Amines under Mild Reaction Conditions Using O2” Liu, J.; Liu, Q.; Yi, H.; Qin, C.; Bai, R.; Qi, X.; Lan, Y.*; Lei, A.* Angew. Chem. Int. Ed. 2014, 53, 502-506. (DOI: 10.1002/anie.201308614)
45. “Cu(II)−Cu(I) Synergistic Cooperation to Lead the Alkyne C−H Activation” Bai, R.; Zhang, G.; Yi, H.; Huang, Z.; Qi, X.; Liu, C.; Miller, J. T.; Kropf, A. J.; Bunel, E. E.; Lan, Y.*; Lei, A.* J. Am. Chem. Soc. 2014, 136, 16760-16763. (DOI: 10.1021/ja5097489)
46. “Asymmetric total synthesis of (-)-lingzhiol via a Rh-catalysed [3+2] cycloaddition” Long, R.; Huang, J.; Shao, W.; Liu, S.; Lan, Y.*; Gong, J.*; Yang, Z.* Nat. Commun. 2014, 5, 5707. (DOI: 10.1038/ncomms6707)
