基本信息

张珂珂，副研究员

导师类别：硕士生导师

邮箱：zhangkeke@zzu.edu.cn

教育/工作经历

2024.01至今    郑州大学  副研究员

2021.12-2023.12    郑州大学  助理研究员

2021.12-2023.12    郑州大学  博士后  合作导师：应汉杰

2017.09--2021.06 天津大学    博士  化学工程  导师：龚俊波

2018.10-2019.10    纽约大学  访问学者  合作导师：Michael D. Ward

2015.09--2017.06 天津大学 硕士  化学工程  导师：龚俊波

2011.09--2015.06 长沙理工大学   本科  化学工程与工艺

招生方向/要求

本科专业为化工、材料等相关专业。具有较强学习能力，有良好的英语听说读写能力，对科研具有强烈兴趣，积极主动，为人正直，勤奋踏实。

研究方向

智能材料、刺激响应晶体、手性结晶、限域结晶

主持科研项目（主持）

1.主持国家自然科学基金青年项目（22208319）：纳米限域条件下晶型调控及晶体的成核、生长过程研究。

2.主持中国博士后科学基金第16批特别资助（站中）（2023T160598）：利用固体核磁技术探究纳米限域条件下分子成核机理。

代表性成果

(1) Keke Zhang; Mengyang Cai; Mengwei Wang; Pengpeng Yang; Kongying Zhu; Zhenfu Wang; Junbo Gong; Hanjie Ying; Exploring the Effect of Nanopore Microstructures on Crystallization and the Evolution of Molecular Assembly Structure by 19F Solid-State Nuclear Magnetic Resonance Spectroscopy, Analytical Chemistry, 2025,97.

(2) Yuzhong Shi; Jinqiu Fu; Yingying Wang; Yihang Hou; Rongxi Guo; Mengyang Cai; Yajie Zhang; Hanjie Ying; Pengpeng Yang; Keke Zhang; Research on even-odd effects of bio-based Nylon nF salts, Journal of MolecularLiquids, 2024, 395.

(3) Mengyang Cai; Pengpeng Yang; Jinqiu Fu; Guiyu Chen; Keke Zhang; Insights into the Effect of Nanoconfinement Surface Chemistry on Celecoxib Aggregation and Dissolution by 19F NMR Spectroscopy, Crystal Growth Design, 2025, 25(16)：6678-6685.

(4) Huanfa Feng; Pengpeng Yang; Jinqiu Fu; Mingyu Qin; Keke Zhang; Substituent-Engineered

Multi-Stimuli-Responsive Schiff Base Crystals: from Proton Transfer Mechanisms to Smart Device Prototypes, Crystal Growth Design, 2025, 25(19)：8203-8216.

(5) Guiyu Chen; Pengpeng Yang; Mengyang Cai; Keke Zhang; The Confinement Crystallization Behavior of Isonicotinamide within Functionalized Pores: Correlation between Polymorph Selection and Surface Chemistry, Crystal Growth Design, 2025, 25(18)：7785-7795.

(6) Ren, Zheng; Yang, Pengpeng; Fu, Jinqiu; Zhu, Mengdan; Zhang, Keke; Exploration of glycyl-L-valinespherulites: Solvent-induced control over nonclassical crystallization pathways, Powder Technology, 2025,469(121805).

(7) Rongxi Guo; Mengyang Cai; Jingjing Zhao; Pengpeng Yang; Hanjie Ying; Keke Zhang; Strategy for Regulation from Heterogeneous Nucleation to Homogeneous Nucleation: Application of Ultrasound, Crystal Growth Design, 2024, 24.

(8) Jinqiu Fu; Mengyang Cai; Yuzhong Shi; Yihang Hou; Rongxi Guo; Chiyi Wang; Jingjing Zhao; Wei Zhuang; Hanjie Ying; Pengpeng Yang; Keke Zhang; Discovery and Exploration of New Solid Forms of Dipeptide: L-Alanyl-L-Glutamine, CrystEngComm, 2024, 26：943-950.

(9) Yihang Hou; Pengpeng Yang; Jinqiu Fu; Yuzhong Shi; Rongxi Guo; Mengyang Cai; Chiyi Wang; Jingjing Zhao; Hanjie Ying; Keke Zhang; Mechanical Modulation of Flexible Schiff Base Derivatives with Fluorescence Properties Based on Crystal Engineering, Crystal Growth Design, 2024, 24(3)：1465-1473.

(10) Yihang Hou; Pengpeng Yang; Jingjing Zhao; Jinqiu Fu; Chiyi Wang; Yuzhong Shi; Wei Zhuang; Keke Zhang; Hanjie Ying; Integrating 2D elasticity and elastoplasticity into a multi-stimuli-responsive crystal through phase transitions, Journal of Materials Chemistry C, 2023, 11(11500)：11500-11508.

(11) Keke Zhang; Changquan Calvin Sun; Yu Liu; Chenguang Wang; Peng Shi; Jun Xu; Songgu Wu; Junbo Gong ; Structural Origins of Elastic and 2D Plastic Flexibility of Molecular Crystals Investigated with Two Polymorphs of Conformationally Rigid Coumarin, Chemistry of Materials, 2021, 33: 1053-1060. (中科院一区)

(12) Zhang Keke; Fellah Noalle; Shtukenberg Alexander G.; Fu Xiaoyan; Hu Chunhua; Ward Michael D. Discovery of new polymorphs of the tuberculosis drug isoniazid. CrystEngComm, 2020, 22(16): 2705-2708 (中科院二区)

(13) Zhang, Keke; Xu, Shijie; Gong, Junbo; Tang, Weiwei; Revealing the critical role of template functional group ordering in the template-directed crystallization of pyrazinamide. CrystEngComm, 2019, 21(42): 6382-6389(中科院二区)

(14) Zhang, Keke; Xu, Shijie; Liu, Shiyuan; Tang, Weiwei; Fu, Xiaoyan; Gong, Junbo; Novel Strategy to Control Polymorph Nucleation of Gamma Pyrazinamide by Preferred Intermolecular Interactions during Heterogeneous Nucleation. Crystal Growth & Design, 2018, 9(18): 4874-4879(中科院二区)

(15) Zhang, Keke; Shen, Huan; Xu, Shijie; Zhang, Huihui; Zhu, Minghe; Shi, Peng; Fu, Xiaoyan; Yang, Yaoyao; Gong, Junbo;Thermodynamic study of solubility for pyrazinamide in ten solvents from T = (283.15 to 323.15) K. JOURNAL OF CHEMICAL THERMODYNAMICS, 2017, 112(112): 204-212(中科院二区)

(16) Zhang Keke; Fellah Noalle; Loṕez-Mejías Vilmalí; Ward Michael D. Polymorphic Phase Transformation Pathways under Nanoconfinement: Flufenamic Acid. Crystal Growth & Design, 2020, 20(11): 7098-7103(中科院二区)

发明专利

（1） 杨朋朋; 张珂珂; 石裕中; 张啸涵; 王莹莹; 庄伟; 李明; 柳东; 沈涛; 应汉杰 ; 脂肪族二胺呋喃二甲酸盐及其晶体, 2023-07-17, 中国, CN202310873748.1 (专利)

（2） 应汉杰; 杨朋朋; 张珂珂; 汪迟意; 李子涵; 付进秋; 李姝姝; 赵静静; 石裕中; 候一航; 陈天鹏;朱晨杰 ; 千金藤素二甲基亚砜溶剂化物晶体及其制备方法, 2023-03-21, 中国, CN202310289809.X (专利)