杨明：郑州大学特聘教授，博士生导师，中原英才。以第一作者或通讯作者身份在高水平期刊和学术会议发表多篇研究论文和发言，迄今共发表SCI国际知名学术期刊论文85篇， 所发表论文总被引超过3300次。根据Web of Science的数据，H-指数为33。多次被国际主要期刊邀请撰写相关研究方向的学术综述，并受邀在国际学术会议做学术报告。同时，相关领域的国际著名学术期刊也邀请本人作为论文评审者，包含：American Journal of Respiratory Cell and Molecular Biology, British Journal of Pharmacology, BioMed Central, BMC Pulmonary Medicine, Clinical & Experimental Allergy, Cell Reports，European Respiratory Journal，Cellular Signalling, Clinical Epigenetics, Journal of Leukocyte Biology, Journal of Allergy and Clinical Immunology， Respirology and Scientific Reports等。
联系方式：
Lab716@126.com
主要研究方向：
1) 以各种粒细胞、淋巴细胞和巨噬细胞为重点的基础免疫学和新基因的发现及免疫新分子功能的研究；
2) 感染性和慢性呼吸系统疾病的免疫治疗和基因治疗的基础与临床研究；
3) 呼吸道病毒感染导致重症哮喘的发病机制和治疗研究；
4) 应用转录组学、蛋白质组学和代谢组学等多组学技术和基因网络分析进行呼吸系统疾病和免疫性疾病发病机制的研究和治疗方法的探索。
已发表论文：
1) Inhibition of gamma-glutamyl transferase suppresses airway hyperresponsiveness and airway inflammation in a mouse model of steroid resistant asthma exacerbation. Front Immunol. 2023
2) Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations. Mucosal Immunol.2022
3) Single-cell transcriptomic analysis reveals the immune landscape of lung in steroid-resistant asthma exacerbation. Proc Natl Acad Sci U S A.2021
4) Understanding scRNA-seq data in the context of the tissue microenvironment requires clinical relevance. Proc Natl Acad Sci U S A.2021
5) A Selective α7 Nicotinic Acetylcholine Receptor Agonist, PNU-282987, Attenuates ILC2s Activation and Alternaria-Induced Airway Inflammation. Frontiers in Immunology.2021
6) Single-cell transcriptomic analysis reveals key immune cell phenotypes in the lungs of patients with asthma exacerbation. J Allergy Clin Immunol.2020
7) A critical role for the CXCL3/CXCL5/CXCR2 neutrophilic chemotactic axis in the regulation of Type 2 responses in a model of rhinoviral-induced asthma exacerbation. J Immunol.2020
8) Lipopolysaccharide induces steroid-resistant exacerbations in a mouse model of allergic airway disease collectively through IL-13 and pulmonary macrophage activation. Clin Exp Allergy.2020
9) GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1alpha-induced eosinophilic airway inflammation. Clin Exp Allergy.2020
10) Potential role of microRNAs in the regulation of anti-viral responses to influenza infection. Fronteris in Immunology.2018
11) Identification of IFN-γ and IL-27 as critical regulators of respiratory syncytial virus-induced exacerbation of allergic airways disease in a mouse model. Journal of Immunology.2018
