郝冰涛，理学博士，郑州大学特聘教授，博士生导师。主要研究方向染色质空间组织与淋巴细胞发育。中华医学会罕见病分会第一届委员会委员。曾经以第一作者或通讯作者在Nature、J Exp Med、J Immunology、Nucleic Acids Research、Nature Communications等杂志发表文章二十余篇。主持国家自然科学基金面上项目5项。
联系方式：
haobt123@163.com
国自然基金：
1. 2024/01-2027/12 国家自然科学基金面上项目 项目名称“隐秘重组信号序列INT-RSS在T细胞受体基因Tcra重排中的功能和机制研究”项目批准号：32370939
2. 2022/01-2025/12 国家自然科学基金面上项目 项目名称“转录因子Bcl6在胸腺DP细胞中的表达调控机制及其对Tcra基因重排的作用研究”项目批准号：321708853. 2020/01-2023/12 国家自然科学基金面上项目 项目名称“动态染色质空间组织对Tcra基因重排的调节研究”项目批准号：31970836
4. 2017/01-2020/12 国家自然科学基金面上项目 项目名称“B细胞发育过程中免疫球蛋白基因染色质构象调节研究”项目批准号：31670892
5. 2009/01-2011/12 国家自然科学基金面上项目 项目名称“KRAB型锌指蛋白家族中p53 调控分子的筛选及功能研究” 项目批准号：30871373
代表性文章：
1. Dai R*, Zhu Y*, Li Z, Qin L, Liu N#, Liao S#, Hao B#. Three-way contact analysis characterizes the higher order organization of the Tcra locus. Nucleic Acids Res. 2023 Sep 22;51(17):8987-9000.
2. Feng D*, Chen Y*, Dai R*, Bian S*, Xue W*, Zhu Y, Li Z, Yang Y, Zhang Y, Zhang J, Bai J, Qin L, Kohwi Y, Shi W, Kohwi-Shigematsu T, Ma J, Liao S#, Hao B#. Chromatin organizer SATB1 controls the cell identity of CD4+ CD8+ double-positive thymocytes by regulating the activity of super-enhancers. Nat Commun. 2022 Sep 22;13(1):5554.
3. Yang Y*, Ye X*, Dai R*, Li Z, Zhang Y, Xue W, Zhu Y, Feng D, Qin L, Wang X, Lei B, Liao S, Hao B#. Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation. Commun Biol. 2021 Aug 16;4(1):967. 一区 IF：6.548
4. Shi W, Yang F, Dai R, Sun Y, Chu Y, Liao S#, Hao B#. METTL3-Mediated N6-Methyladenosine Modification Is Involved in the Dysregulation of NRIP1 Expression in Down Syndrome. Front Cell Dev Biol. 2021 Apr 1;9:621374.
5. Gao W, Huang M, Chen X, Chen J, Zou Z, Li L, Ji K, Nie Z, Yang B, Wei Z, Xu P, Jia J, Zhang Q, Shen H, Wang Q, Li K, Zhu L, Wang M, Ye S, Zeng S, Lin Y, Rong Z, Xu Y, Zhu P, Zhang H, Hao B, Liu Q. The role of S-nitrosylation of PFKM in regulation of glycolysis in ovarian cancer cells. Cell Death Dis. 2021 Apr 15;12(4):408.
6. Zhao H*, Li Z*, Zhu Y*, Bian S*, Zhang Y, Qin L, Naik AK, He J, Zhang Z, Krangel MS, Hao B#. A role of the CTCF binding site at enhancer Ea in the dynamic chromatin organization of the Tcra–Tcrd locus. Nucleic Acids Research. 2020 Sept. 25; 48(17) 9621–9636 一区 IF：19.160
7. Zhang Y, Li Z, Bian S, Zhao H, Feng D, Chen Y, Hou Y, Liu Q#, Hao B#. HiCoP, a simple and robust method for detecting interactions of regulatory regions. Epigenetics Chromatin. 2020 Jul 1;13(1):27.
8. Ye S, Xu P, Huang M, Chen X, Zeng S, Wang Q, Chen J, Li K, Gao W, Liu R, Liu J, Shao Y, Zhang H, Xu Y, Zhang Q, Zhong Z, Wei Z, Wang J, Hao B#, Huang W#, Liu Q#. The heterocyclic compound Tempol inhibits the growth of cancer cells by interfering with glutamine metabolism. Cell Death Dis. 2020 May 4;11(5):312.
9. Aslam MA, Alemdehy MF, Hao B, Krijger PHL, Pritchard CEJ, de Rink I, Muhaimin FI, Nurzijah I, van Baalen M, Kerkhoven RM, van den Berk PCM, Skok JA, Jacobs H. The Ig heavy chain protein but not its message controls early B cell development. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31343-31352.
10. Xu Y, Ji K, Wu M, Hao B#, Yao KT#, Xu Y#. A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1. Protein Cell. 2019 Aug;10(8):595-605.
11. Hao B, Naik AK, Watanabe A, Tanaka H, Chen L, Richards HW, Kondo M, Taniuchi I, Kohwi Y, Kohwi-Shigematsu T, Krangel MS#. An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. J. Exp. Med. 2015 Vol. 212(5), 809-24.
12. Seitan VC*, Hao B*, Tachibana-Konwalski K*, Lavagnolli T, Mira-Bontenbal H, Brown KE, Teng G, Carroll T, TerryA, Horan K, Marks H, Adams DJ, Schatz DG, Aragon L, Fisher AG#, Krangel MS#, Nasmyth K, Merkenschlager M#. A role for cohesin in T-cell-receptor rearrangement and thymocytedifferentiation. Nature. 2011 Vol. 476(7361), 467-71.
13. Hao B, Krangel MS#. Long-Distance Regulation of Fetal Vdelta Gene Segment TRDV4 by the Tcrd Enhancer. J Immunol. 2011 Vol. 187(5), 2484-91.
14. Carabana J*, Watanabe A*, Hao B*, Krangel MS#. A barrier-type insulator forms a boundary between active andinactive chromatin at the murine TCRβ locus. J Immunol. 2011, Vol.186, 3556-62.
15. Hao B*, Miao X*, Li Y, Zhang X, Sun T, Liang G, Zhao Y, Zhou Y, Wang H, Chen X, Zhang L, Tan W, Wei Q, Lin D#, He F#. A Novel T-77C Polymorphism in DNA Repair Gene XRCC1 Contributes to Diminished Promoter Activity andIncreased Risk of Non-Small Cell Lung Cancer. Oncogene 2006, Vol.25, 3613-3620.
16. Hao B, Wang H, Zhou K, Li Y, Chen X, Zhou G, Zhu Y, Miao X, Tan W, Wei Q, Lin D#, and He F#. Identification of Genetic Variants in Base Excision Repair Pathway andTheir Associations with Risk of Esophageal Squamous Cell Carcinoma. Cancer Res. 2004, Vol.64, 4378-4384.
17. Callen E, Faryabi RB, Luckey M*, Hao B*, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A. The DNA Damage- and Transcription-Associated Protein Paxip1 Controls Thymocyte Development and Emigration. Immunity 2012, 37(6), 971-85.
