张海风，女，分子药理学专业博士，教授，硕士研究生导师，现任郑州大学基础医学院生物化学与分子生物学系副主任，河南省生物化学与分子生物学学会理事，河南省药理学会理事。主要从事尼古丁生物学效应、肝癌发生的分子生物学机制及肝脏药物代谢研究。主持省级课题4项，主持横向课题5项，参与国家自然基金课题2项。在J Transl Med，J Nutr Biochem, J Immunol, J Pharmacol Exp Ther, Drug Metab Dispos, Mol Pharm, Toxicol Appl Pharmacol等国际国内杂志发表论文30多篇，参编英文论著《生物化学》3部，获得河南省科学技术进步三等奖一项，获得全国教育系统技能竞赛二等奖1项。联系邮箱：zhanghaifeng@zzu.edu.cn
主持科研项目
1. 肝细胞癌中CYP1A2基因转录抑制的组蛋白修饰调节机制，河南省重点研发与推广专项项目，222102310173，202201-202312，主持
2. 基于CYP2E1基因过表达的ROS含量上调对肝癌细胞恶性生物学行为的影响，河南省重点研发与推广专项项目，182102310329，201801-201812，主持
3. CYP2E1通过上调ROS含量调控Wnt/β-catenin通路抑制肝细胞肝癌的发生，河南省自然科学基金项目，182300410354，201801-201912，主持
4. 烟草提取物产品标准研究-卫生指标，烟草行业标准项目，国科烟[2021]169号， 202201-202312，主持
5. 实验动物风味暴露神经效应分析：代谢酶及相关受体的表达分析，横向项目，20210073A， 202101-202312，主持
6. 虫草素对烟气口鼻暴露小鼠肺部损伤的影响及机制研究，郑州大学教授团队助力企业创新驱动发展专项，202208-202307，主持
7. 可可碱的生物学机制研究，横向项目，20220591A，202206-202412，主持
代表性文章
1. Yi Zhang#, Jingyu Feng#, Yang Mi, Wu Fan, Runwen Qin, Yingwu Mei, Ge Jin, Jian Mao*, Haifeng Zhang*. Epigenetic Activation of Cytochrome P450 1A2 Sensitizes Hepatocellular Carcinoma Cells to Sorafenib. Drug Metab Dispos: 2024;52(6):555-564.
2. Linhui Qin, Yingwu Mei, Chengcheng An, Rui Ning, Haifeng Zhang*. Docosahexaenoic acid administration improves diabetes-induced cardiac fibrosis through enhancing fatty acid oxidation in cardiac fibroblast. J Nutr Biochem: 2022; 109244.doi: 10.1016/j.jnutbio.2022.109244.
3. Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin, Haifeng Zhang*. CYP2E1 plays a suppressive role in hepatocellular carcinoma by regulating Wnt/Dvl2/β-catenin signaling.J Transl Med: 2022; 20(1):194.
4. Min Li#, Haifeng Zhang#, Yameng Zhang, Jinting Fan, Jinhao Zhu, Xinyue Gu, Zhonghui Li, Chengyang Zhang, Zhen Liu, Yuebai Li, Mingxi Zang, Ge Jin, Guoping Li, Yang Mi. Berberine Modulates Macrophage Activation by Inducing Glycolysis. J Immunol: 2022; 208(10):2309-2318.
5. Hai-Feng Zhang, Li-Li Zhu , Xiao-Bei Yang , Na Gao , Yan Fang , Qiang Wen , Hai-Ling Qiao. Variation in the expression of cytochrome P450-related miRNAs and transcriptional factors in human livers: Correlation with cytochrome P450 gene phenotypes. Toxicol Appl Pharmacol: 2021; 412:115389.
6. Hai-Feng Zhang, Huan-Huan Wang, Na Gao, Junying Wei, xin tian, Yan Zhao, Yan Fang, Jun Zhou, Qiang Wen, Jie Gao, Yang-Jun Zhang, Xiao-Hong Qian, and Hai-Ling Qiao*. Physiological content and intrinsic activities of 10 cytochrome P450 isoforms in human normal liver microsomes. J Pharmacol Exp Ther:2016, 358:1-11.
7. Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Hai-Ling Qiao*. Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Livers. Drug Metab Dispos: 2016; 44(8):1193-1200.
8. Haifeng Zhang, Na Gao, Xin Tian, Tingting Liu, Yan Fang, Jun Zhou, Qiang Wen, Binbin Xu, Bing Qi, Jie Gao, Hongmeng Li, Linjing Jia & Hailing Qiao*. Content and activity of human liver microsomal protein and prediction of individual hepatic clearance in vivo. Scientific Reports, 2015: 5:17671.
9. Haifeng Zhang, Na Gao, Tingting Liu, Yan Fang, Bing Qi, Qiang Wen, Jun Zhou, Linjing Jia, Hailing Qiao*. Effect of Cytochrome b5 Content on the Activity of Polymorphic CYP1A2, 2B6, and 2E1 in Human Liver Microsomes. PLoS One: 2015; 10(6):e0128547.
10. Huanhuan Wang#, Haifeng Zhang#, Jiabin Li, Junying Wei, Rui Zhai, Bo Peng,Hailing Qiao, Yangjun Zhang* and Xiaohong Qian *. A new calibration curve calculation method for absolute quantification of drug metabolizing enzymes in human liver microsomes by stable isotope dilution mass spectrometry. Anal. Methods: 2015, 7, 5934.
11. Haifeng Zhang, Xiaobei Yang, Lili Zhu , Zhihui Li, Peipei Zuo, Peng Wang , Jingyu Feng , Yang Mi , Chengjuan Zhang , Yan Xu , Ge Jin , Jianying Zhang , Hua Ye. ASPM promotes hepatocellular carcinoma progression by activating Wnt/β-catenin signaling through antagonizing autophagy-mediated Dvl2 degradation. FEBS Open Bio; 2021:11(10):2784-2799.
