个人简介：
梁陆军，男，博士，特聘教授青年拔尖人才。本科毕业于中国科学技术大学，博士毕业于清华大学。主要研究方向为蛋白质化学合成、蛋白质翻译后修饰、化学蛋白质组学等,及其在生物医学的应用。近年来以（共同）通讯或者第一作者在Nature，Nature Communications，J. Am. Chem. Soc., Angew. Chem. Int. Ed. 等高水平期刊发表研究论文十余篇。主持国家自然基金面上项目，青年科学基金项目（C类），郑州大学高层次人才科研启动项目等。任《科学通报》和 Science Bulletin 编辑委员会青年编委。
联系方式：liang_lujun@zzu.edu.cn
主持科研项目：
1. 国家自然科学基金委员会面上项目, 2026-01 至 2029-12, 主持；
2. 国家自然科学基金委员会青年科学基金项目（C类）[原青年科学基金项目], 2025-01 至 2027-12, 主持；
3. 郑州大学高层次人才科研启动项目，2026-04至2031-04，主持;
4. 中国科学技术大学青年创新重点基金, 2026-01至2027-12，主持;
5. 中国博士后科学基金站中特别资助，2022-01 至 2023-04，主持;
6. 中国博士后科学基金面上资助，2021-11 至 2023-04，主持;
7. 清华-北大生命联合中心优秀博士后基金，2021-12 至 2023-04，主持.
代表性文章
1. Li, Chuntong; Shi, Luyu; Liang, Lu-Jun*. Chemical Synthesis of Ubiquitinated Proteins and Ubiquitin Probes for Biochemical and Functional Analysis. Chem. Eur. J. 2026, 32, e03578.
2. Ding, Xiaoyang; Li, Chuntong; Wang, Xinyan; Liang, Lu-Jun*. Recent advances in chemoselective protein desulfurization: from VA-044 to emerging boron, photochemical, iron-catalyzed, and ultrasound methods. Org. Biomol. Chem., 2026, 24, 5583 - 5598
3. Li, Chuntong; Zhao, Fangyu; Zuo, Chong; Zhang, Liying; Jing, Yangwode; Li, Xu; Chu,Guo-Chao; Shi, Luyu; Zhang,Yingyue; Wang, Han; Sun, Shuzhe; Sun, Maoshen; Ai, Huasong*; Liang, Lu-Jun*; Li, Jinghong*. Design and Semi-synthesis of Ubiquitin Extension Probes for Structural Analysis of Cullin1 Mediated Substrate Polyubiquitination. J. Am. Chem. Soc., 2025, 147, 27, 23878–23890.
4. Han, Dongyang; Cui, Yan; Deng, Xiangyu; Li, Chuntong; Zhu, Xianglai; Wang, Bingji; Chu, Guo-Chao; Wang, Zhipeng A.; Tang, Shan; Zheng, Ji-Shen; Liang, Lu-Jun*; Liu, Lei*. Mechanically Triggered Protein Desulfurization, J. Am. Chem. Soc., 2025, 147, 4135-4146.
5. Wang, Bingjin#; Li, Chuntong#; Zhao, Fangyu; Shi, Luyu; Li, Xu; Liu, Yijie; Sun, Shuzhe; Yuan, Ligong; Sun, Maoshen; Zhang, Yingyue; Shi, Jing*, Liang, Lu-Jun*. Examining the role of threonine phosphorylation on ubiquitin’s function using chemical protein synthesis. JACS Au, 2025, 5, 2148-2158.
6. Ren, Yuxiang; Liu, Yanbo; Han, Dongyang; Liang, Lu-Jun*. An Integrated Solubilizing-Tag-Free Strategy for Chemical Synthesis of Mirror-Image Interleukin‑6. Org. Lett. 2025, 27, 10760−10765.
7. Tao, Shixian#; He, Wei#; Li, Chuntong; Liang, Jiawei; Tong, Zebin; Deng, Zhiheng; Zhang, Liying; Ai, Huasong*; Liang, Lu-Jun*; Liu, Lei*. Synthesis of an E2-Ub-Nucleosome Conjugate to Capture the E3 Ligase PHF7-Catalyzed H3K14 Ubiquitination Intermediate. Sci. China. Chem. 2025, 68, 5871-5880
8. Chu, Guo-Chao#; Liang, Lu-Jun#; Zhao, Rui#; Guo, Yan-Yan; Li, Chun-Tong; Zuo, Chong; Ai, Huasong; Hua, Xiao; Li, Zi-Chen; Li, Yi-Ming; Liu, Lei*. Ferricyanide-Promoted Oxidative Activation and Ligation of Protein Thioacids in Neutral Aqueous Media. CCS Chem. 2024, 6, 2031–2043
9. Wu, Xiangwei#, Du, Yunxiang#, Liang, Lu-Jun# *; Ding, Ruichao; Zhang, Tianyi; Cai, Hongyi; Tian, Xiaolin; Pan, Man*; Liu, Lei*. Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1, Nat. Communi., 2024, 15: 1266.
10. Liang, Lu-Jun#, Wang, Yu#; Hua, Xiao#; Yuan, Rujing; Xia, Qiong; Wang, Rongtian; Li, Chuntong; Chu, Guo-Chao; Liu, Lei*; Li, Yi-Ming*. Cell-Permeable Stimuli-Responsive Ubiquitin Probe for Time-Resolved Monitoring of Substrate Ubiquitination in Live Cells, JACS Au, 2023, 3: 2873-2883
11. Liang, Lu-Jun#; Chu, Guo-Chao#; Qu Qian#; Zuo, Chong; Mao, Junxiong; Zheng, Qingyun; Chen, Jingnan; Meng, Xianbin; Jing, Yangwode; Deng, Haiteng; Li, Yi-Ming; Liu Lei*. Chemical Synthesis of Activity-Based E2-Ubiquitin Probes for the Structural Analysis of E3 Ligase-Catalyzed Transthiolation. Angew. Chem. Int. Ed. 2021, 60, 17171 –17177.
12. Pan, Man#; Zheng, Qingyun#; Wang, Tian#; Liang, Lu-Jun#; Mao Junxiong; Zuo Chong; Ding Ruichao; Ai Huasong; Xie Yuan; Dong Si; Yu Yuanyuan*; Liu Lei*; Zhao Minglei*. Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature 2021; 600, 334-338
13. Liang, Lu-Jun; Si, Yanyan; Tang, Shan; Huang, Dongliang; Wang, Zhipeng A; Tian, Changlin; Zheng, Jishen*. Biochemical properties of K11,48-branched ubiquitin chains. Chin. Chem. Lett. 2018, 29, 1155–1159
14. Tang, Shan.#, Liang, Lu-Jun#; Si, Yanyan#, Gao, Shuai; Wang, Jia-Xing; Liang, Jun; Mei, Ziqing*; Zheng, Ji-Shen*; Liu, Lei*. Practical Chemical Synthesis of Atypical Ubiquitin Chains by Using an Isopeptide-Linked Ub Isomer. Angew. Chem. Int. Ed. 2017; 56: 13333 –13337
