姓 名： 潘振瑞

学 历： 博士研究生

毕业院校： 巴黎萨克雷大学

邮 箱： panzhenrui@zzu.edu.cn

2025.01-至今 郑州大学基础医学院

肿瘤发生发展，肿瘤耐药机制研究；鉴定与发掘肿瘤标志物及治疗策略；抗肿瘤药物的筛选与功能验证

科研成果

1. ZhenruiPan;HanxiaoZhang;XiaXiao;CatherineBrennerandSvetlanaDokudovskaya.GATOR1complex controls cisplatin sensitivity.CellDeath & Disease, 2025.

2. Zhe Lei; Ning Su; Menglong Li; Yanan Sun; Zhenrui Pan#; Kangdong Liu#; Yueteng Zhang#.Unraveling the role of deuterium in cancer: mechanisms, detection techniques, and therapeutic potential.Molecular Diversity, 2025.

3. Zhenrui Pan, Hanxiao Zhang and Svetlana Dokudovskaya. TheRoleofmTORC1PathwayandAutophagy in Resistance to Platinum-Based Chemotherapeutics.International Journal of MolecularSciences, 2023.

4. ZhenruiPan*,YuanyuanZhang*, JianhuaLuo*,DanyangLi, YaoZhou,LiuqingHe,QiYang,MinDong, Liang Tao. Functional analyses of epidemic Clostridioides difficile toxin B variants reveal theirdivergence in utilizing receptors and inducing pathology.Plos pathogens, 2021.

5. MingtaoAo*, Zhenrui Pan*,Yuqing Qian*, BowenTang, Zeming Feng, Hua Fang, Zhen Wu, JingweiChen, Yuhua Xue and MeijuanFang.Design,synthesis,and biologicalevaluationofAV6derivativesas novel dual reactivators of latent HIV-1.RSC Advances, 2018.

6. Cong Wang*, Huiru Wang*,Zhenrui Pan*, Jun Wu, Yafei Guo, Jing Zhang, Zixun Xiang, WeiLu, Yuhua Xue. Polyphenol Extracts from Grape Seeds andApple Can Reactivate Latent HIV-1Transcription through Promoting P-TEFb Release from 7SK snRNP.Disease Markers, 2022.

7. Hanxiao Zhang,XiaXiao, ZhenruiPanandSvetlanaDokudovskaya.mTORsignalingnetworks:mechanistic insights and translational frontiers in disease therapeutics. Signal Transduction andTargeted Therapy, 2025.

8. Cong Wang,ChunjingChen,ZhenruiPan, YaohuiHe,RongdiaoLiu, YuhuaXue,QiangZhou,andXiang Gao. Quantitative Proteomics of the CDK9 Interactome RevealsaFunctionoftheHSP90-CDC37-P-TEFb Complex for BETi-Induced HIV-1 Latency Reactivation. Journal of ProteomeResearch, 2023.

9. Enhui Shen, Kangli Zhu, Danyang Li,Zhenrui Pan, Yun Luo, Qiao Bian,Liuqing He, XiaojunSong, Ying Zhen, Dazhi Jin, Liang Tao.Subtyping analysis reveals new variants and acceleratedevolution of Clostridioides difficile toxin B.Communications biology, 2020.

10. Yao Zhou, Diyin Li, Jianhua Luo, Aizhong Chen, Xingxing Li,Zhenrui Pan, Li Wan, LiuqingHe, Danyang Li, Yanyan Li, Min Dong, Liang Tao. Sulfated glycosaminoglycans and low-densitylipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin.Cell Research,2021.

11. Xingxing Li, Liuqing He,JianhuaLuo,YanglingZheng,YaoZhou,DanyangLi,YuanyuanZhang,Zhenrui Pan, Yanyan Li, and Liang Tao. Paeniclostridium sordellii hemorrhagic toxin targetsTMPRSS2 to induce colonic epitheliallesions.NatureCommunications, 2022.

12. Yao Zhou, Xiechao Zhan, Jianhua Luo, Diyin Li, Ruoyu Zhou, Jiahao Zhang,Zhenrui Pan,YuanyuanZhang, Tianhui Jia, Xiaofeng Zhang,Yanyan Li, Liang Tao. Structural dynamics ofthe CROPs domaincontrol stability and toxicity of Paeniclostridium sordellii lethal toxin.Nature Communications, 2023.