职称：学科特聘教授

      电话：0371-86566657

      邮箱：yuhuat2024@163.com

      地址：郑州大学医学科学院博后楼403室

个人简介

2024/03-至今，郑州大学医学科学院/天健先进生物医学实验室，学科特聘教授

2023/06-2024/02，郑州大学医学科学院，研究员

2018/04-2023/04，美国宾夕法尼亚大学兽医学院生物医学系，博士后

2012/09-2017/06，中国农业大学生物学院，博士

主要研究方向

主要围绕营养物质代谢对于维持肠道稳态平衡和参与肠道疾病发生发展的分子机制进行研究。利用分子生物学、蛋白组学、代谢组学和生物信息学等手段解析营养物质及其代谢产物维持肠道健康和介导肠炎、肠癌等重大肠道疾病发生发展的分子机制。

荣誉及获奖情况

1.2023年，入选河南省“中原英才计划（引才系列）”

2.2017年，中国农业大学优秀毕业生

代表性成果

（#第一或共同第一）

1. Yuhua Tian, Xin Wang, Zvi Cramer, Joshua Rhoades, Katrina N. Estep, Xiang hui Ma, Stephanie Adams-Tzivelekidis, Bryson W. Katona, F. Brad Johnson, Zhengquan Yu, M. Andres Blanco, Christopher J. Lengner*, Ning Li*. APC and P53 mutations synergize to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer. GUT Published Online First: 17 August 2023.

2. Yuhua Tian^#, Jiuzhi Xu^#, Yuan Li^#, Ran Zhao, Sujuan Du, Cong Lv, Wei Wu, Ruiqi Liu, Xiaole Sheng, Yongli Song, Xueyun Bi, Guilin Li, Mengzhen Li, Xi Wu, Pengbo Lou, Huiwen You, Wei Cui, Jinyue Sun, Jianwei Shuai, Fazheng Ren, Bing Zhang, Mingzhou Guo, Xiaohua Hou, Kaichun Wu, Lixiang Xue, Hongquan Zhang, Maksim V. Plikus, Yingzi Cong, Christopher J. Lengner, Zhanju Liu*, and Zhengquan Yu*. MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice, Gastroenterology. 2019 156:2281–2296.

3.Yuhua Tian^#, Ma X^#, Lv C^#, Sheng X, Li X, Zhao R, Song Y, Andl T, Plikus MV, Sun J, Ren F, Shuai J, Lengner CJ, Cui W, Yu Z*. Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis. eLife.2017 6. pii: e29538.

4.Ma X^#, Tian Y^#, Song Y, Shi J, Xu J, Xiong K, Li J, Xu W, Zhao Y, Shuai J, Chen L, Plikus MV, Lengner CJ, Ren F, Xue L, Yu Z. Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hh Signaling Pathway. J Invest Dermatol. 2017 May;137(5):1015-1024.

5. Cong Lv^#, Fengyin Li^#, Xiang Li^#, Yuhua Tian^#, Yue Zhang, Xiaole Sheng, Yongli Song, Qingyong Meng, Shukai Yuan, Liming Luan, Thomas Andl, Xu Feng, Baowei Jiao, Mingang Xu, Maksim V. Plikus, Xing Dai, Christopher Lengner, Wei Cui, Fazheng Ren, Jianwei Shuai, Sarah E. Millar, Zhengquan Yu*. MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Nature Communications. 2017 8(1): 1036.

6. Lou P^#, Bi X^#, Tian Y^#, Li G, Kang Q, Lv C, Song Y, Xu J, Sheng X, Yang X, Liu R, Meng Q, Ren F, Plikus MV, Liang B, Zhang B, Guo H*, Yu Z*. MiR-22 modulates brown adipocyte thermogenesis by synergistically activating the glycolytic and mTORC1 signaling pathways. Theranostics. 2021 Jan 25;11(8):3607-3623.

7. Kolev HM^#, Tian Y^#, Kim MS, Leu NA, Adams-Tzivelekidis S, Lengner CJ, Li N, Kaestner KH*. A FoxL1-CreERT-2A-tdTomato Mouse Labels Subepithelial Telocytes. Cell Mol Gastroenterol Hepatol. 2021;12(3):1155-1158.e4.