职称：教授、博士生导师
头衔：国家杰青
职务：郑州大学医学院学科与科研办公室主任
电话：0371-86566657
邮箱：yuzhq99@hotmail.com
地址：郑州大学医学科学院博后楼404室
个人简介：
2022.07 – 现在：郑州大学医学科学院
2016.01 – 现在：中国农业大学教授
2010.11 – 2015.12：中国农业大学副教授
2009.03 – 2010.12：宾夕法尼亚大学医学院，基础医学，Research Associate
2008.01 – 2009.03：加州大学，尔湾分校(Irvine) 医学系，助理研究科学家(Assistant Project Scientist)
2004.03 – 2008.01：加州大学，尔湾分校(Irvine) 生化和医学系，博士后
2000.09 – 2003.07：中国农业大学生物学院，博士
主要研究方向
肠道疾病在中国普遍高发，已成大众高度关切的健康问题。本课题组长期从事肠道稳态研究，围绕肠上皮在炎症反应中的修复机制取得了一系列前沿性成果：①发现了炎症信号激活肠上皮修复的新机制，并在此基础上利用食源性材料制备了结直肠靶向的炎症干预核酸药物递送系统；②针对干细胞修复功能，揭示了肠道静息态干细胞激活和快速增殖干细胞能量供给的关键调控机制；③阐明了间充质微环境信号促进肠上皮修复和菌群紊乱破坏肠屏障的机制。以通讯(含共同)作者发表SCI论文29篇，包括Gastroenterology、Gut、2篇Cell Res、EMBO J、PNAS、2篇eLife、2篇Nat Commun 和3篇Cell Rep等。成果获F1000等点评推荐，编写到专著中；授权专利4项。主持国家自然科学基金4项和科技部项目2项；入选教育部新世纪优秀人才。
课题组成员
田玉华，石晓静，张亚莉，杜素娟
主要学术任职
担任Experimental Dermatology和Fundamental Research杂志编委
担任Frontiers in Pharmacology客座主编
中国民族卫生协会临床医学分会第二届常务理事 2020
主持或参加的科研项目
1.主持国家自然科学基金重点项目：“肠道干细胞Lepr+间充质微环境在炎症性肠病中的功能及机制”（编号82230017），起止时间为2023.1-2027.12，经费来源：国家基金委。
2.主持国家杰出青年科学基金项目：“肠道稳态的分子基础”（编号82025006），起止时间为2021.1-2024.12，经费来源：国家基金委。
3.主持自然基金面上项目：“miR-31在小肠干细胞和结肠癌中的功能和机制研究”（编号：81772984）起止时间为2018.1-2021.12，经费来源：国家基金委。
4.主持自然基金面上项目：“高侵袭转移能力基底样乳腺癌小鼠模型的构建”（编号：81572614），起止时间为2016.1-2019.12，经费来源：国家基金委。
5.主持完成自然基金面上项目：“miR-31调控乳腺干细胞的功能分析”（编号：31271584），起止时间为2013.1-2016.12，经费来源：国家基金委。
6.主持完成“973”子课题1项：“小型猪疾病模型的建立” (2011CB944103), 起止时间为2011.1-2015.8，经费来源：科技部。
7.主持完成“863”子课题1项：“家畜ES诱导为生殖细胞技术”（编号：2010AA10A103），起止时间为2010.1-2010.11，经费来源：科技部。
8.教育新世纪优秀人才计划：起止时间为2011.2-2014.1，经费来源：教育部。
9.主持完成加州乳腺癌研究计划1项：“LMO4在乳腺癌中的作用”（编号：11FB-0142），起止时间为2005.7-2008.6，经费来源：加州政府。
10.中国农业大学优秀人才引进计划。
主要科研奖励
（1)入选2010年度教育部“新世纪优秀人才支持计划”
（2)2005年加州乳腺癌研究奖励计划：“LMO4在乳腺癌中的作用（The role of LMO4 in breast cancer”(编号：11FB-0142)
已授权专利
1.microRNA-22在毛发发育和雄激素诱导脱发中的应用。ZL 2014 1 0675650.6，2018-2-16，于政权、袁树楷、李菲菲。
2.Largozole在制备治疗由Msi1基因异位过表达引起疾病的药物中的应用，ZL201810835428.6，2018-7-26，于政权、宋永利、毕雪云。
3.雷帕霉素及其结构类似物在制备治疗由Msi1基因异位过表达引起疾病的药物中的应用，ZL 2018 1 0837686.8，2022-09-30，于政权、宋永利。
4.乳腺外Paget小鼠模型的建立，ZL 2018 1 0836812.8，2021-02-02，于政权、宋永利。
5.一种常染色体显性多囊肾病基因突变猪的生产方法及其应用，ZL 2014 1 0021170.8，2017-12-26，李宁、贺津、胡晓湘、赵要风、李秋艳、于政权。
6.一种促进哺乳动物肠道发育的方法，ZL 201510166923.9，2019-9-27，李宁、马金、李秋艳、于政权。
代表性成果
（*通讯或者共同通讯，#共同第一）
1.Yang Xu#, Li G#, Lou P, Zhang M, Yao K, Xiao J, Chen Y, Xu J, Tian S, Deng M, Pan Y, Li M, Wu X, Liu R, Shi X, Tian Y, Yu L, Ke H, Jiao B, Cong Y, Plikus MV, Liu X, Yu Z*, Lv C*. Excessive nucleic acid R-loops induce mitochondria-dependent epithelial cell necroptosis and drive spontaneous intestinal inflammation. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2307395120.
2.Deng M#, Guerrero-Juarez CF#, Sheng X, Xu J, Wu X, Yao K, Li M, Yang X, Li G, Xiao J, Liu X, Wu K, Ren F, Nie Q, Plikus MV, Yu Z*, Lv C*. Lepr+ mesenchymal cells sense diet to modulate intestinal stem/progenitor cells via Leptin-Igf1 axis. Cell Res. 2022 Jul;32(7):670-686.
3.Xu Yang#, Guilin Li#, Yuhua Tian, Xin Wang, Jiuzhi Xu, Ruiqi Liu, Min Deng, Chunlei Shao, Yuwei Pan, Xi Wu, Mengzhen Li, Chaowei Zhang, Rui Liu, Jun Qin, Chen Zhang, Zhanju Liu, Xin Wu, Maksim V. Plikus, Christopher J. Lengner, Zongheng Zheng*, Cong Lv*, Zhengquan Yu*. Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state. Theranostics 2022 12(16): 6865-6882.
4.Ruiqi Liu, Huan Hu, Melissa McNeil, Jiuzhi Xu, Xueyun Bi, Pengbo Lou, Christian F. Guerrero-Juarez, Xing Dai, Maksim V. Plikus, Jianwei Shuai, Zhengquan Yu*, Cong Lv*. Dormant Nfatc1 reporter-marked basal stem/progenitor cells contribute to mammary lobuloalveoli formation. iScience 2022 25(3) :103982.
5.Min Deng#, Xi Wu#, Xiaoyue Duan, Jiuzhi Xu, Xu Yang, Xiaole Sheng, Pengbo Lou, Chunlei Shao, Cong Lv*, Zhengquan Yu*. Lactobacillus paracasei L9 improves colitis by expanding butyrate-producing bacteria that inhibit the IL 6/STAT3 signaling pathway, Food & Function 2021 12(21): 10700-10713.
6.Xueyun Bi#, Pengbo Lou#, Yongli Song, Xiaole Sheng, Ruiqi Liu, Min Deng, Xu Yang, Guilin Li, Shukai Yuan, Bing Zhang, Lixiang Xue, Zhihua Liu, Maksim V. Plikus, Fazheng Ren, Shan Gao, Li Zhao*, Zhengquan Yu*. Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3-Mmp9 pathway. Oncogene 2021 40(29): 4832-4845.
7.Chunlei Shao, Pengbo Lou, Ruiqi Liu, Xueyun Bi, Guilin Li, Xu Yang, Xiaole Sheng, Jiuzhi Xu, Cong Lv*, Zhengquan Yu*. Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland. Front Cell Dev Biol. 2021 9: 691050.
8.Pengbo Lou#, Xueyun Bi#, Yuhua Tian#, Guilin Li, Qianqian Kang, Cong Lv, Yongli Song, Jiuzhi Xu, Xiaole Sheng, Xu Yang, Ruiqi Liu, Qingyong Meng, Fazheng Ren, Maksim V Plikus, Bin Liang, Bing Zhang*, Huiyuan Guo*, Zhengquan Yu*. MiR-22 modulates brown adipocyte thermogenesis by synergistically activating the glycolytic and mTORC1 signaling pathways. Theranostics 2021 11(8): 3607-3623.
9.Xiaole Sheng#, Ziguang Lin#, Cong Lv#, Chunlei Shao, Xueyun Bi, Min Deng, Jiuzhi Xu, Christian F. Guerrero-Juarez, Mengzhen Li, Xi Wu, Ran Zhao, Xu Yang, Guilin Li, Xiaowei Liu, Qingyu Wang, Qing Nie, Wei Cui, Shan Gao, Hongquan Zhang, Zhihua Liu, Yingzi Cong, Maksim V. Plikus, Christopher J. Lengner, Bogi Andersen, Fazheng Ren*, Zhengquan Yu*. Cycling Stem Cells Are Radioresistant and Regenerate the Intestine. Cell Reports 2020 32(4): 107952.
10.Yongli Song#, Christian F. Guerrero-Juarez#, Zhongjian Chen#, Yichen Tang, Xianghui Ma, Cong Lv, Xueyun Bi, Min Deng, Lina Bu, Yuhua Tian, Ruiqi Liu, Ran Zhao, Jiuzhi Xu, Xiaole Sheng, Sujuan Du, Yeqiang Liu, Yunlu Zhu, Shi-jun Shan, Hong-duo Chen, Yiqiang Zhao, Guangbiao Zhou, Jianwei Shuai, Fazheng Ren, Lixiang Xue, Zhaoxia Ying, Xing Dai, Christopher J. Lengner, Bogi Andersen, Maksim V. Plikus, Qing Nie, Zhengquan Yu*. The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease. Cell Research 2020 30(10): 854-872.
11.Xifan Wang, Songtao Yang, Shenghui Li, Liang Zhao, Yanling Hao, Junjie Qin, Lian Zhang, Chengying Zhang, Weijing Bian, Li Zuo, Xiu Gao, Baoli Zhu, Xin Gen Lei, Zhenglong Gu, Wei Cui, Xiping Xu, Zhiming Li, Benzhong Zhu, Yuan Li, Shangwu Chen, Huiyuan Guo, Hao Zhang, Jing Sun, Ming Zhang, Yan Hui, Xiaolin Zhang, Xiaoxue Liu, Bowen Sun, Longjiao Wang, Qinglu Qiu, Yuchan Zhang, Xingqi Li, Weiqian Liu, Rui Xue, Hong Wu, DongHua Shao, Junling Li, Yuanjie Zhou, Shaochuan Li, Rentao Yang, Oluf Borbye Pedersen, Zhengquan Yu*, Stanislav Dusko Ehrlich*, Fazheng Ren*. Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents. Gut 2020 69(12): 2131-2142.
12.Jiuzhi Xu#, Yang Tang#, Xiaole Sheng, Yuhua Tian, Min Deng, Sujuan Du, Cong Lv, Guili Li, Yuwei Pan, Yongli Song, Pengbo Lou, Yongting Luo, Yuan Li, Bing Zhang, Yanmei Chen, Zhanju Liu, Yingzi Cong, Maksim V Plikus, Qingyong Meng, Zhaocai Zhou*, Zhengquan Yu*. Secreted Stromal Protein ISLR Promotes Intestinal Regeneration by Suppressing Epithelial Hippo Signaling. The EMBO journal 2020 39(7): e103255.
13.Ran Zhao#, Sujuan Du#, Ying Liu, Cong Lv, Yongli Song, Xinchun Chen, Bing Zhang, Dan Li, Shan Gao, Wei Cui, Maksim V. Plikus, Xiaohua Hou, Kaichun Wu, Zhanju Liu, Zhihua Liu, Yingzi Cong, Yuan Li*, Zhengquan Yu*. Mucoadhesive-to-penetrating controllable peptosomes-in-microspheres co-loaded with anti-miR-31 oligonucleotide and Curcumin for targeted colorectal cancer therapy. Theranostics 2020 10(8): 3594-3611.
14.Ting Gao, Zixu Wang, Yulan Dong, Jing Cao, Rutao Lin, Xintong Wang, Zhengquan Yu*, Yaoxing Chen*. Role of melatonin in sleep deprivation‐induced intestinal barrier dysfunction in mice. Journal of Pineal Research 2019 67(1): e12574.
15.Mengxu Ge, Chuncheng Liu, Lei Li, Miaomiao Lan, Yingying Yu, Lijie Gu, Yang Su, Kuo Zhang, Yuying Zhang, Tongtong Wang, Chang Liu, Fan Liu, Min Li, Lei Xiong, Kun Wang, Ting He, Yunping Dai, Yaofeng Zhao, Ning Li, Zhengquan Yu*, Qingyong Meng*. miR-29a/b1 Inhibits Hair Follicle StemCell Lineage Progression by Spatiotemporally Suppressing WNT and BMP Signaling. Cell Reports 2019 29(8): 2489–2504.
16.Xifan Wang, Yanling Hao, Xiaoxue Liu, Shoujuan Yu, Weibo Zhang, Songtao Yang, Zhengquan Yu*, Fazheng Ren*. Gut microbiota from end-stage renal disease patients disrupt gut barrier function by excessive production of phenol. Journal of Genetics and Genomics 2019 46(8): 409-412.
17.Jie Luo, Chen Xiao, Hao Zhang, Fazheng Ren, Xingen Lei, Zibiao Yang, Zhengquan Yu*. Characterization and milk coagulating properties of Cynanchum otophyllum Schneid. Proteases. J. Dairy Sci. 2018 101(4): 2842-2850.
18.Jianyun Shi, Xianghui Ma, Yang Su, Yongli Song, Yuhua Tian, Shukai Yuan, Xiuqing Zhang, Dong Yang, Hao Zhang, Jianwei Shuai, Wei Cui, Fazheng Ren, Maksim V. Plikus, Yaoxing Chen*, Jie Luo*, Zhengquan Yu*. MiR-31 Mediates Inflammatory Signaling to Promote Re-Epithelialization during Skin Wound Healing. J Invest Dermatol. 2018 138(10): 2253-2263.
19.Yuhua Tian#, Jiuzhi Xu#, Yuan Li#, Ran Zhao, Sujuan Du, Cong Lv, Wei Wu, Ruiqi Liu, Xiaole Sheng, Yongli Song, Xueyun Bi, Guilin Li, Mengzhen Li, Xi Wu, Pengbo Lou, Huiwen You, Wei Cui, Jinyue Sun, Jianwei Shuai, Fazheng Ren, Bing Zhang, Mingzhou Guo, Xiaohua Hou, Kaichun Wu, Lixiang Xue, Hongquan Zhang, Maksim V. Plikus, Yingzi Cong, Christopher J. Lengner, Zhanju Liu*, Zhengquan Yu*. MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice. Gastroenterology 2019 156(8): 2281–2296.
20.Cong Lv#, Fengyin Li#, Xiang Li#, Yuhua Tian#, Yue Zhang, Xiaole Sheng, Yongli Song, Qingyong Meng, Shukai Yuan, Liming Luan, Thomas Andl, Xu Feng, Baowei Jiao, Mingang Xu, Maksim V. Plikus, Xing Dai, Christopher Lengner, Wei Cui, Fazheng Ren, Jianwei Shuai, Sarah E. Millar, Zhengquan Yu*. MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Nature Communications 2017 8(1): 1036.
21.Yuhua Tian#, Xianghui Ma#, Cong Lv#, Xiaole Sheng, Xiang Li, Ran Zhao, Yongli Song, Thomas Andl, Maksim V Plikus, Jinyue Sun, Fazheng Ren, Jianwei Shuai, Christopher J Lengner, Wei Cui, Zhengquan Yu*. Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis. eLife 2017 6: e29538.
22.Xianghui Ma#, Yuhua Tian#, Yongli Song, Jianyun Shi, Jiuzhi Xu, Kai Xiong, Jia Li, Wenjie Xu, Yiqiang Zhao, Jianwei Shuai, Lei Chen, Maksim V. Plikus, Christopher Lengner, Fazheng Ren*, Lixiang Xue*, Zhengquan Yu*. Msi2 maintains quiescent state of hair follicle stem cells by directly repressing the Hh signaling pathway. Journal of Investigative Dermatology 2017 137(5): 1015-1024 (封面文章).
23.Yue Zhang#, Fengyin Li#, Yongli Song, Xiaole Sheng, Kai Xiong, Lei Chen, Dequan Liu, Christopher Lengner, Lixiang Xue*, Zhengquan Yu*. Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis. The FASEB Journal 2016 30(10): 3474-3488.
24.Ning Li, Maryam Yousefi, Angela Nakauka-Ddamba, Fan Li, Lee Vandivier, Kimberly Parada, Dong-Hun Woo, Shan Wang, Ammar S. Naqvi, Shilpa Rao, John Tobias, Gerard Minuesa, Katz Y, Trevor S. Barlowe, Alexander Valvezan, Sheila Shanka, Raquel P. Deering, Peter S. Klein, Shane T. Jensen, Michael G. Kharas, Brian D. Gregory, Zhengquan Yu*, Christopher J. Lengner*. The Msi family of RNA binding proteins function redundantly as intestinal oncoproteins. Cell Reports 2015 13(11): 2440-55.
25.Shukai Yuan#, Feifei Li#, Qingyong Meng, Yiqiang Zhao, Lei Chen, Hongquan Zhang, Lixiang Xue, Xiuqing Zhang, Christopher Lengner, Zhengquan Yu*. Post-transcriptional regulation of keratinocyte progenitor cell expansion, differentiation and hair follicle regression by miR-22. Plos Genetics 2015 11(5): e1005253 (月刊封面文章).
注：受邀在Plos blog发表文章亮点介绍内容：
Zhengquan Yu. Understanding images: microRNAs contribute to hair loss and follicle regression. Plos Blog. 2015, june 15.
http://blogs.plos.org/biologue/2015/06/16/understanding-images-micrornas-contribute-to-hair-loss-and-follicle-regression/
26.Shan Wang#, Ning Li#, Maryam Yousefi, Angela Nakauka-Ddamba, Fan Li, Kimberly Parada, Shilpa Rao, Gerard Minuesa, Brian D. Gregory, Michael G. Kharas, Zhengquan Yu*, Christopher J. Lengner*. Transformation of the intestinal epithelium by the MSI2 RNA binding protein. Nature Communications 2015 6: 6517.
27.Yarden Katz#, Feifei Li#, Nicole J. Lambert, Ethan M. Sokol, Wai-Leong Tam, Albert W. Cheng, Edoardo M. Airoldi, Christopher J. Lengner, Piyush B. Gupta, Zhengquan Yu*, Rudolf Jaenisch*, Christopher B. Burge*. Musashi Proteins are Post-transcriptional Regulatorsof the Epithelial-Luminal Cell State. eLife 2014 3: e03915.
注：Science published a short comment on this paper.
Lisa D. Chong, Blocking tumor cell transition, Science. 16 January 2015. 347.6219.245-b: [DOI:10.1126/science.347.6219.245-b]
28.Liming Luan#, Jianyun Shi#, Zhengquan Yu*, Thomas Andl*. The major miR-31 target genes STK40 and LATS2 and their implications in the regulation of keratinocyte growth and hair differentiation. Experimental Dermatology 2017 26(6): 497-504.
29.Yu Zheng, Yongli Song, Qi Han, Wenjie Liu, Jiuzhi Xu, Zhengquan Yu*, Ran Zhang*, Ning Li. Intestinal epithelial cell-specific IGF1 promotes the expansion of intestinal stem cells during epithelial regeneration and functions on the intestinal immune homeostasis. Am J Physiol Endocrinol Metab. 2018 315(4): E638-E649.
30.Zhengquan Yu, J Mannik, A Soto, K Lin, B Andersen. The epidermal differentiation associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation. The EMBO Journal 2009 28(13): 1890-903.
31.Zhengquan Yu, Ambica Bhandari, Jaana Mannik, Thu Pham, Xiaoman Xu, Bogi Andersen. Grainyhead-like factor Get1/Grhl3 regulates formation of the epidermal leading edge during eyelid closure. Developmental Biology 2008 319(1): 56-67.
32.Zhengquan Yu, Kevin K. Lin, Ambica Bhandari, Joel A. Spencer, Xiaoman Xu, Ning Wang, Zhongxian Lu, Gordon N. Gill, Dennis R. Roop, Philip Wertz, Bogi Andersen. The Grainyhead-like Epithelial Transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Developmental Biology 2006 299(1): 122-36.
33.Zhengquan Yu, Meng Qingyong, Yu Hongzhi, Fan Baoliang, Yu Shuyang, Fei Jing, Wang Lili, Dai Yunping, Li Ning. Expression and bioactivity of recombinant human lysozyme in the milk of transgenic mice. J. Dairy Sci. 2006 89: 2911-2918.
34.Zhengquan Yu, Li Yan, Meng Qingyong, Zhao Zhihui, Li Wei, Yuan Jing, Hu Xiaoxiang, Yan Bingxue, Fan Baoliang, Yu Shuyang, Li Ning. Comparative analysis of the pig BAC sequence involved in the myostatin gene regulation. Science in China C life sciences 2005 48(2): 168-180.
35.Sun Ying#, Liu Delong#, Zhengquan Yu#, Zhang Qian, Bai Juan, Sun Daye. An apoplastic mechanism for short term effects of rare earth elements at lower concentrations. Plant Cell & Environment 2003 26(6): 887-896.
36.Zhengquan Yu, Fan Baoliang, Dai Yunping, Zheng Ming, Niu Huiling, Wang Meili, Wang Lili, Fei Jing, Li Ning. Expression of recombinant human lysozyme in the milk of transgenic mice. Chinese Science Bulletin 2003 48(21): 2331-2335.
37.Zhengquan Yu, Ning Li. Animal cloning: the possible mechanisms and research advancement. Letters in biotechnology 2001 12(4): 324-328 (In Chinese).
