职称：讲师

        邮箱：luma@zzu.edu.cn

        地址：郑州大学基础医学院6楼601室

个人简介

马璐，郑州大学医学科学院讲师，硕士研究生导师。2016年获得南昌大学理学学士学位，2021年获得沈阳药科大学博士学位，期间从事天然活性小分子的结构优化及抗肿瘤活性研究。2021年8月入职郑州大学医学科学院。作为课题负责人主持了国家自然科学基金青年基金项目1项，河南省博士后科研基金项目1项。

主要研究方向：

研究方向一：基于靶点的抗肿瘤药物小分子的创新性发现、优化与生物活性评价。

研究方向二：基于活性天然产物的结构改造及抗肿瘤活性研究。

代表性成果：

(1)Lu Ma; Menglong Li; Yueteng Zhang; Kangdong Liu; Recent advances of antitumor leading compound Erianin: Mechanisms of action and structural modification, European Journal of Medicinal Chemistry, 2023, 261.

(2)Lu Ma; Menglong Li; Shanshan Gou; Wei Wan; Kangdong Liu; Yueteng Zhang; Native-compoundCoupled Affinity Matrix (NCAM) in target identification and validation of bioactive compounds: Application, mechanism and outlooks, Bioorganic Chemistry, 2023, 140.

(3)Yueteng Zhang; Junjie Zhang; Menglong Li; Yan Qiao; Wei Wang; Lu Ma; Kangdong Liu; Target discovery of bioactive natural products with Native-compound-Coupled CNBr-activated Sepharose 4B Beads (NCCB): applications, mechanisms and outlooks, Bioorganic & Medicinal Chemistry, 2023, 96: 117483.

(4)Lu Ma; Dongyu Miao; Jung Joon Lee; Tao Li; Yu Chen; Guangyue Su; Yuqing Zhao; Synthesis and biological evaluation of heterocyclic ring-fused dammarane-type ginsenoside derivatives as potential anti-tumor agents, Bioorganic Chemistry, 2021, 116: 105365.

(5)Lu Ma; Xude Wang; Wei Li; Dongyu Miao; Yan Li; Jincai Lu; Yuqing Zhao; Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives, European Journal of Medicinal Chemistry, 2020, 187: 111964.

(6)Lu Ma; Xude Wang; Wei Li; Tao Li; Shengnan Xiao; Jincai Lu; Jing Xu; Yuqing Zhao; Rational design, synthesis and biological evaluation of triphenylphosphonium-ginsenoside conjugates as mitochondria-targeting anti-cancer agents, Bioorganic Chemistry, 2020, 103: 104150

(7)Lu Ma; Xude Wang; Wei Li; Fanzhi Qu; Yafei Liu; Jincai Lu; Guangyue Su; Yuqing Zhao; Conjugation of Ginsenoside with Dietary Amino Acids: A Promising Strategy To Suppress Cell Proliferation and Induce Apoptosis in Activated Hepatic Stellate Cells, Journal of Agricultural and Food Chemistry, 2019, 67(36): 10245-10255.

(8)Lu Ma; Yuancai Chen; Xude Wang; Mingzhou Xiong; Yuanyuan Sun; Xiaoshu Zhang; Yuqing Zhao; Design, characterization, and in vitro antiproliferative efficacy of gemcitabine conjugates based on carboxymethyl glucan, Bioorganic & Medicinal Chemistry Letters, 2018, 28(17): 2920-2924.

(9)赵余庆；马璐；王旭德；四环三萜衍生物及其药物组合物和应用，2019-12-9，中国，ZL201911253606.5。（专利）