职称：助理研究员

       邮箱：bbhao@zzu.edu.cn

       地址：河南省郑州市高新技术开发区科学大道100号

个人简介

2015年毕业于郑州大学，2020年获得中国科学院上海药物所博士学位，并于2020年至2023年在中国科学院上海药物所从事博士后研究。

主要研究方向

基于生物质谱技术的蛋白修饰调控疾病分子机制解析、疾病生物标志物鉴定和靶向干预策略发现

代表性成果

1.Q. Zhou#, B.B. Hao#, X.L. Cao, L. Gao, Z.Y. Yu, Y. Zhao, M.R. Zhu, G.X. Zhong, F.T. Chi, X.M. Dai, J.Z. Mao, Y.B. Zhu, P. Rong, L. Chen, X.L. Bai, C.Q. Ye, S. Chen, T.B. Liang, L. Li, X.H. Feng*, M.J. Tan*, B. Zhao*, Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha, Molecular Cell 82(24) (2022) 4700-+.

2.B.B. Hao#, K.F. Chen#, L.H. Zhai#, M.Y. Liu, B. Liu, M.J. Tan*, Substrate and Functional Diversity of Protein Lysine Post-translational Modifications Genomics Proteomics & Bioinformatics (2024) (in press)

3.B.B. Hao#, K. Ma#, J.Y. Xu#*, R.F. Fan#, W.S. Zhao, X.L. Jia, L.H. Zhai, S.K.Y. Lee, D. Xie*, M.J. Tan*, Proteomics analysis of histone deacetylase inhibitor-resistant solid tumors reveals resistant signatures and potential drug combinations, Acta Pharmacologica Sinica  (2024).

4.B.B. Hao#, X.J. Li, X.L. Jia, Y.X. Wang, L.H. Zhai, D.Z. Li, J. Liu, D. Zhang, Y.L. Chen, Y.H. Xu, S.K. Lee, G.F. Xu, X.H. Chen, Y.J. Dang, B. Liu*, M.J. Tan*, The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L, Acta Pharmacologica Sinica 41(9) (2020) 1246-1254.

5.L.H. Zhai#, K.F. Chen#, B.B. Hao#, M.J. Tan*, Proteomic characterization of post-translational modifications in drug discovery, Acta Pharmacologica Sinica 43(12) (2022) 3112-3129.

6.Q. Liu#, B.B. Hao#, M.Y. Zhang, Z.W. Liu, Y.Q. Huang, X.X. Zhao, H. Hu, M.J. Tan*, J.Y. Xu*, An Integrative Proteome-Based Pharmacologic Characterization and Therapeutic Strategy Exploration of SAHA in Solid Malignancies, Journal of Proteome Research 21(4) (2022) 953-964.

7.B.B. Hao#, M.W. Sun#, M. Zhang#, X.X. Zhao, L. Zhao, B.L. Li, L.H. Zhai, P. Liu, H. Hu, J.Y. Xu*, M.J. Tan*, Global characterization of proteome and lysine methylome features in EZH2 wild-type and mutant lymphoma cell lines, Journal of Proteomics 213 (2020).

8.M.Z. Zhao#, B.B. Hao#, H.H. Li, M. Cai, J.J. Xie, H.Y. Liu, M.J. Tan, L.H. Zhai*, Q. Yu#*, Peptidyl-Lys metalloendopeptidase (Lys-N) purified from dry fruit of demonstrates "mirror"digestion property with lysyl endopeptidase (Lys-C), Rapid Commun Mass Sp 34(2) (2020).

9.Y.P. Chen#, J.H. Wu#, L.H. Zhai, T.T. Zhang, H. Yin, H.Y. Gao, F. Zhao, Z. Wang, X.N. Yang, M.P. Jin, B.S. Huang, X. Ding, R. Li, J. Yang, Y.M. He, Q.W. Wang, W.B. Wang, J.A. Kloeber, Y.X. Li, B.B. Hao, Y.Y. Zhang, J.D. Wang, M.J. Tan, K. Li, P. Wang, Z.K. Lou, J. Yuan*, Metabolic regulation of homologous recombination repair by MRE11 lactylation, Cell 187(2) (2024).

10.L.J. Lao, I. Bourdeau, L. Gagliardi, X. He, W. Shi, B.B. Hao, M.J. Tan, Y. Hu, J.Z. Peng, B. Coulombe, D.J. Torpy, H.S. Scott, A. Lacroix, H.Y. Luo*, J.P. Wu*, ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia, Nucleic Acids Research 50(11) (2022) 6343-6367.

11.X. Huang#, J. Yan#, M. Zhang#, Y.F. Wang#, Y. Chen, X.H. Fu, R.R. Wei, X.L. Zheng, Z.W. Liu, X. Zhang, H. Yang, B.B. Hao, Y.Y. Shen, Y. Su, X.J. Cong, M. Huang, M.J. Tan*, J. Ding*, M.Y. Geng*, Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors, Cell 175(1) (2018) 186-+.